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  <xs:element name="ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionEquityInstrumentswithheldandcancelled" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="oprx_ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionEquityInstrumentswithheldandcancelled"/>
  <xs:element name="WeightedgrantdatefairvalueWithheldandcancelled" type="dtr:perShareItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="oprx_WeightedgrantdatefairvalueWithheldandcancelled"/>
  <xs:element name="TotalLeaseLiabilities" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="credit" nillable="true" substitutionGroup="xbrli:item" id="oprx_TotalLeaseLiabilities"/>
  <xs:element name="ConcentrationRiskPercentage" type="dtr:percentItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="oprx_ConcentrationRiskPercentage"/>
  <xs:element name="FederalIncomeTaxStateTaxEffectNetOfFederalBenefit" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="credit" nillable="true" substitutionGroup="xbrli:item" id="oprx_FederalIncomeTaxStateTaxEffectNetOfFederalBenefit"/>
  <xs:element name="FederalIncomeTaxOptionExerciseBenefitsNetOfSection162MLimitations" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="credit" nillable="true" substitutionGroup="xbrli:item" id="oprx_FederalIncomeTaxOptionExerciseBenefitsNetOfSection162MLimitations"/>
  <xs:element name="FederalIncomeTaxOtherAdjustments" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item" id="oprx_FederalIncomeTaxOtherAdjustments"/>
  <xs:element name="FederalIncomeTaxNetOperatingLossExpiring" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item" id="oprx_FederalIncomeTaxNetOperatingLossExpiring"/>
  <xs:element name="FederalIncomeTaxExpensesBenefitValueAllowance" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="credit" nillable="true" substitutionGroup="xbrli:item" id="oprx_FederalIncomeTaxExpensesBenefitValueAllowance"/>
  <xs:element name="DeferredTaxAssetsOperatingLeaseLiability" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item" id="oprx_DeferredTaxAssetsOperatingLeaseLiability"/>
  <xs:element name="DeferredTaxLiabilitiesOperatingLeaseRightOfUseAssets" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" xbrli:balance="credit" nillable="true" substitutionGroup="xbrli:item" id="oprx_DeferredTaxLiabilitiesOperatingLeaseRightOfUseAssets"/>
  <xs:element name="DeferredTaxAssetNetOfValuationAllowance" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="credit" nillable="true" substitutionGroup="xbrli:item" id="oprx_DeferredTaxAssetNetOfValuationAllowance"/>
  <xs:element name="USHealthcareProvidersPercentage" type="dtr:percentItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="oprx_USHealthcareProvidersPercentage"/>
  <xs:element name="SummaryofSignificantAccountingPoliciesDetailsTable" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrldt:hypercubeItem" id="oprx_SummaryofSignificantAccountingPoliciesDetailsTable"/>
  <xs:element name="SummaryofSignificantAccountingPoliciesDetailsLineItems" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="oprx_SummaryofSignificantAccountingPoliciesDetailsLineItems"/>
  <xs:element name="AcquisitionsDetailsTable" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrldt:hypercubeItem" id="oprx_AcquisitionsDetailsTable"/>
  <xs:element name="AcquisitionsDetailsLineItems" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="oprx_AcquisitionsDetailsLineItems"/>
  <xs:element name="IssuanceOfSharesOfCommonStock" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="instant" nillable="true" substitutionGroup="xbrli:item" id="oprx_IssuanceOfSharesOfCommonStock"/>
  <xs:element name="BusinessAcquisitionCommonStockValue" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="credit" nillable="true" substitutionGroup="xbrli:item" id="oprx_BusinessAcquisitionCommonStockValue"/>
  <xs:element name="PurchasePrice" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item" id="oprx_PurchasePrice"/>
  <xs:element name="StockholdersEquityDetailsTable" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrldt:hypercubeItem" id="oprx_StockholdersEquityDetailsTable"/>
  <xs:element name="StockholdersEquityDetailsLineItems" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="oprx_StockholdersEquityDetailsLineItems"/>
  <xs:element name="GrossProceedsOfCommonStockAmount" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item" id="oprx_GrossProceedsOfCommonStockAmount"/>
  <xs:element name="IssuanceOfCommonStockExerciseValue" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="credit" nillable="true" substitutionGroup="xbrli:item" id="oprx_IssuanceOfCommonStockExerciseValue"/>
  <xs:element name="PaymentsToAdvisorsAndLegalFees" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item" id="oprx_PaymentsToAdvisorsAndLegalFees"/>
  <xs:element name="StockBasedCompensationDetailsTable" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrldt:hypercubeItem" id="oprx_StockBasedCompensationDetailsTable"/>
  <xs:element name="StockBasedCompensationDetailsLineItems" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="oprx_StockBasedCompensationDetailsLineItems"/>
  <xs:element name="SharesOfCommonStockOptions" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="oprx_SharesOfCommonStockOptions"/>
  <xs:element name="CommonStockRestrictedStockUnit" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="oprx_CommonStockRestrictedStockUnit"/>
  <xs:element name="FairMarketValueRate" type="dtr:percentItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="oprx_FairMarketValueRate"/>
  <xs:element name="OptionsExercisedValue" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="credit" nillable="true" substitutionGroup="xbrli:item" id="oprx_OptionsExercisedValue"/>
  <xs:element name="SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsExercisableWeightedAverageRemainingContractualTerm2" type="xbrli:durationItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="oprx_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsExercisableWeightedAverageRemainingContractualTerm2"/>
  <xs:element name="GrantedRestrictedStockDescription" type="xbrli:stringItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="oprx_GrantedRestrictedStockDescription"/>
  <xs:element name="RestrictedStockGrantedRemainsValue" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item" id="oprx_RestrictedStockGrantedRemainsValue"/>
  <xs:element name="RemainsToBeRecognizedOverAPeriod" type="xbrli:durationItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="oprx_RemainsToBeRecognizedOverAPeriod"/>
  <xs:element name="CumulativeNetSharesIssuedSurrendered" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="oprx_CumulativeNetSharesIssuedSurrendered"/>
  <xs:element name="CumulativeNetSharesIssuedCancelled" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="oprx_CumulativeNetSharesIssuedCancelled"/>
  <xs:element name="RestrictedStockUnitsDescription" type="xbrli:stringItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="oprx_RestrictedStockUnitsDescription"/>
  <xs:element name="ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsGrantsInPeriodGross" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="oprx_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsGrantsInPeriodGross"/>
  <xs:element name="StockIssuedDuringPeriodSharesRestrictedStocksAwardGross" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="oprx_StockIssuedDuringPeriodSharesRestrictedStocksAwardGross"/>
  <xs:element name="ShareBasedCompensationsArrangementByShareBasedPaymentAwardOptionsGrantsInPeriod" type="xbrli:durationItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="oprx_ShareBasedCompensationsArrangementByShareBasedPaymentAwardOptionsGrantsInPeriod"/>
  <xs:element name="LeasesDetailsTable" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrldt:hypercubeItem" id="oprx_LeasesDetailsTable"/>
  <xs:element name="LeasesDetailsLineItems" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="oprx_LeasesDetailsLineItems"/>
  <xs:element name="OperatingLeasesExpiresPeriod" type="xbrli:dateItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="oprx_OperatingLeasesExpiresPeriod"/>
  <xs:element name="OperatingLeasesRentPayable" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item" id="oprx_OperatingLeasesRentPayable"/>
  <xs:element name="MeasurementOfLeaseLiabilities" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="credit" nillable="true" substitutionGroup="xbrli:item" id="oprx_MeasurementOfLeaseLiabilities"/>
  <xs:element name="MajorCustomersandVendorsDetailsTable" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrldt:hypercubeItem" id="oprx_MajorCustomersandVendorsDetailsTable"/>
  <xs:element name="MajorCustomersandVendorsDetailsLineItems" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="oprx_MajorCustomersandVendorsDetailsLineItems"/>
  <xs:element name="CommitmentsandContingentLiabilitiesDetailsTable" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrldt:hypercubeItem" id="oprx_CommitmentsandContingentLiabilitiesDetailsTable"/>
  <xs:element name="CommitmentsandContingentLiabilitiesDetailsLineItems" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="oprx_CommitmentsandContingentLiabilitiesDetailsLineItems"/>
  <xs:element name="UnderpaymentPercentage" type="dtr:percentItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="oprx_UnderpaymentPercentage"/>
  <xs:element name="FutureMinimumPayments" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item" id="oprx_FutureMinimumPayments"/>
  <xs:element name="MinimumPaymentsDue" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="credit" nillable="true" substitutionGroup="xbrli:item" id="oprx_MinimumPaymentsDue"/>
  <xs:element name="CustomerAMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="oprx_CustomerAMember"/>
  <xs:element name="CustomerBMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="oprx_CustomerBMember"/>
  <xs:element name="CustomerOneMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="oprx_CustomerOneMember"/>
  <xs:element name="CustomerThreeMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="oprx_CustomerThreeMember"/>
  <xs:element name="CustomerTwoMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="oprx_CustomerTwoMember"/>
  <xs:element name="EvinceMedMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="oprx_EvinceMedMember"/>
  <xs:element name="ExercisePriceRangeFiveMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="oprx_ExercisePriceRangeFiveMember"/>
  <xs:element name="ExercisePriceRangeFourMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="oprx_ExercisePriceRangeFourMember"/>
  <xs:element name="ExercisePriceRangeMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="oprx_ExercisePriceRangeMember"/>
  <xs:element name="ExercisePriceRangeOneMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="oprx_ExercisePriceRangeOneMember"/>
  <xs:element name="ExercisePriceRangeThreeMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="oprx_ExercisePriceRangeThreeMember"/>
  <xs:element name="ExercisePriceRangeTwoMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="oprx_ExercisePriceRangeTwoMember"/>
  <xs:element name="KeyPartnersMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="oprx_KeyPartnersMember"/>
  <xs:element name="NonemployeeDirectorsCompensationMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="oprx_NonemployeeDirectorsCompensationMember"/>
  <xs:element name="PartnerAMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="oprx_PartnerAMember"/>
  <xs:element name="PartnerBMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="oprx_PartnerBMember"/>
  <xs:element name="PartnerCMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="oprx_PartnerCMember"/>
  <xs:element name="TotalIntanbleAssetsMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="oprx_TotalIntanbleAssetsMember"/>
  <xs:element name="TotalOptionOutstandingMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="oprx_TotalOptionOutstandingMember"/>
  <xs:element name="TwoEntitiesMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="oprx_TwoEntitiesMember"/>
  <xs:element name="VestedOptionsOutstandingMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="oprx_VestedOptionsOutstandingMember"/>
  <xs:element name="DocumentAndEntityInformationAbstract" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="oprx_DocumentAndEntityInformationAbstract"/>
</xs:schema>
