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<link:roleType roleURI="http://OPRX/role/DocumentAndEntityInformation" id="DocumentAndEntityInformation">
<link:definition>001 - Document - Document and Entity Information</link:definition>
<link:usedOn>link:presentationLink</link:usedOn>
<link:usedOn>link:definitionLink</link:usedOn>
<link:usedOn>link:calculationLink</link:usedOn>
</link:roleType>
<link:roleType roleURI="http://OPRX/role/BalanceSheetsUnaudited" id="BalanceSheetsUnaudited">
<link:definition>002 - Statement - Balance Sheets (Unaudited)</link:definition>
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<link:usedOn>link:definitionLink</link:usedOn>
<link:usedOn>link:calculationLink</link:usedOn>
</link:roleType>
<link:roleType roleURI="http://OPRX/role/BalanceSheetsUnauditedParenthetical" id="BalanceSheetsUnauditedParenthetical">
<link:definition>003 - Statement - Balance Sheets (Unaudited) (Parenthetical)</link:definition>
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<link:usedOn>link:definitionLink</link:usedOn>
<link:usedOn>link:calculationLink</link:usedOn>
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<link:roleType roleURI="http://OPRX/role/ConsolidatedStatementsOfOperationsUnaudited" id="ConsolidatedStatementsOfOperationsUnaudited">
<link:definition>004 - Statement - Consolidated Statements of Operations (Unaudited)</link:definition>
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<link:usedOn>link:definitionLink</link:usedOn>
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</link:roleType>
<link:roleType roleURI="http://OPRX/role/ConsolidatedStatementsOfCashFlowsUnaudited" id="ConsolidatedStatementsOfCashFlowsUnaudited">
<link:definition>005 - Statement - Consolidated Statements of Cash Flows (Unaudited)</link:definition>
<link:usedOn>link:presentationLink</link:usedOn>
<link:usedOn>link:definitionLink</link:usedOn>
<link:usedOn>link:calculationLink</link:usedOn>
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<link:roleType roleURI="http://OPRX/role/NatureOfBusinessAndBasisOfPresentation" id="NatureOfBusinessAndBasisOfPresentation">
<link:definition>006 - Disclosure - Nature of Business and Basis of Presentation</link:definition>
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<link:usedOn>link:definitionLink</link:usedOn>
<link:usedOn>link:calculationLink</link:usedOn>
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<link:definition>007 - Disclosure - Stockholders Equity</link:definition>
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<link:usedOn>link:definitionLink</link:usedOn>
<link:usedOn>link:calculationLink</link:usedOn>
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<link:definition>008 - Disclosure - Share Based Payments - Options</link:definition>
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<link:usedOn>link:definitionLink</link:usedOn>
<link:usedOn>link:calculationLink</link:usedOn>
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<link:definition>009 - Disclosure - Contingencies</link:definition>
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<link:usedOn>link:calculationLink</link:usedOn>
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<link:roleType roleURI="http://OPRX/role/Restatement" id="Restatement">
<link:definition>010 - Disclosure - Restatement</link:definition>
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<link:usedOn>link:calculationLink</link:usedOn>
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<link:definition>011 - Disclosure - Subsequent Events</link:definition>
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<link:usedOn>link:definitionLink</link:usedOn>
<link:usedOn>link:calculationLink</link:usedOn>
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<link:definition>012 - Disclosure - Restatement (Tables)</link:definition>
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<link:usedOn>link:calculationLink</link:usedOn>
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<link:definition>013 - Disclosure - Stockholders Equity (Details)</link:definition>
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<link:usedOn>link:calculationLink</link:usedOn>
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<link:roleType roleURI="http://OPRX/role/Sharebasedpaymentsoptionsdetails" id="Sharebasedpaymentsoptionsdetails">
<link:definition>014 - Disclosure - Share Based Payments - Options (Details)</link:definition>
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<link:usedOn>link:definitionLink</link:usedOn>
<link:usedOn>link:calculationLink</link:usedOn>
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<link:definition>015 - Disclosure - Contingencies (Details)</link:definition>
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<link:usedOn>link:definitionLink</link:usedOn>
<link:usedOn>link:calculationLink</link:usedOn>
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<link:definition>016 - Disclosure - Restatement (Details)</link:definition>
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<link:usedOn>link:calculationLink</link:usedOn>
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<link:definition>017 - Disclosure - Subsequent Events (Details)</link:definition>
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<link:usedOn>link:definitionLink</link:usedOn>
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