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	  <link:definition>0001 - Document - Document and Entity Information</link:definition>
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	  <link:usedOn>link:calculationLink</link:usedOn>
	  <link:usedOn>link:definitionLink</link:usedOn>
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	<link:roleType roleURI="http://OPRX/role/BalanceSheets" id="BalanceSheets">
	  <link:definition>0002 - Statement - Balance Sheets</link:definition>
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	  <link:usedOn>link:calculationLink</link:usedOn>
	  <link:usedOn>link:definitionLink</link:usedOn>
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	<link:roleType roleURI="http://OPRX/role/BalanceSheetsParenthetical" id="BalanceSheetsParenthetical">
	  <link:definition>0003 - Statement - Balance Sheets (Parenthetical)</link:definition>
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	  <link:usedOn>link:calculationLink</link:usedOn>
	  <link:usedOn>link:definitionLink</link:usedOn>
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	  <link:definition>0004 - Statement - Statements of Operations</link:definition>
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	  <link:definition>0005 - Statement - Statements of Cash Flows</link:definition>
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	  <link:definition>0006 - Disclosure - NATURE OF BUSINESS</link:definition>
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	  <link:usedOn>link:definitionLink</link:usedOn>
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	  <link:definition>0007 - Disclosure - SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES</link:definition>
	  <link:usedOn>link:presentationLink</link:usedOn>
	  <link:usedOn>link:calculationLink</link:usedOn>
	  <link:usedOn>link:definitionLink</link:usedOn>
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	  <link:definition>0008 - Disclosure - PREPAID EXPENSES</link:definition>
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	  <link:usedOn>link:calculationLink</link:usedOn>
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	  <link:definition>0009 - Disclosure - PROPERTY AND EQUIPMENT</link:definition>
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	  <link:usedOn>link:calculationLink</link:usedOn>
	  <link:usedOn>link:definitionLink</link:usedOn>
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	  <link:definition>0010 - Disclosure - WEBSITE DEVELOPMENT COSTS</link:definition>
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	  <link:usedOn>link:calculationLink</link:usedOn>
	  <link:usedOn>link:definitionLink</link:usedOn>
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	<link:roleType roleURI="http://OPRX/role/PatentRightsAndIntangibleAssets" id="PatentRightsAndIntangibleAssets">
	  <link:definition>0011 - Disclosure - PATENT RIGHTS AND INTANGIBLE ASSETS</link:definition>
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	  <link:usedOn>link:calculationLink</link:usedOn>
	  <link:usedOn>link:definitionLink</link:usedOn>
	</link:roleType>
	<link:roleType roleURI="http://OPRX/role/AccruedExpenses" id="AccruedExpenses">
	  <link:definition>0012 - Disclosure - ACCRUED EXPENSES</link:definition>
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	  <link:usedOn>link:calculationLink</link:usedOn>
	  <link:usedOn>link:definitionLink</link:usedOn>
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	<link:roleType roleURI="http://OPRX/role/DeferredRevenue" id="DeferredRevenue">
	  <link:definition>0013 - Disclosure - DEFERRED REVENUE</link:definition>
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	  <link:usedOn>link:calculationLink</link:usedOn>
	  <link:usedOn>link:definitionLink</link:usedOn>
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	<link:roleType roleURI="http://OPRX/role/NotePayable" id="NotePayable">
	  <link:definition>0014 - Disclosure - NOTE PAYABLE</link:definition>
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	  <link:usedOn>link:calculationLink</link:usedOn>
	  <link:usedOn>link:definitionLink</link:usedOn>
	</link:roleType>
	<link:roleType roleURI="http://OPRX/role/CommonStock" id="CommonStock">
	  <link:definition>0015 - Disclosure - COMMON STOCK</link:definition>
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	  <link:usedOn>link:calculationLink</link:usedOn>
	  <link:usedOn>link:definitionLink</link:usedOn>
	</link:roleType>
	<link:roleType roleURI="http://OPRX/role/PreferredStock" id="PreferredStock">
	  <link:definition>0016 - Disclosure - PREFERRED STOCK</link:definition>
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	  <link:usedOn>link:calculationLink</link:usedOn>
	  <link:usedOn>link:definitionLink</link:usedOn>
	</link:roleType>
	<link:roleType roleURI="http://OPRX/role/StockOptionsAndWarrants" id="StockOptionsAndWarrants">
	  <link:definition>0017 - Disclosure - STOCK OPTIONS AND WARRANTS</link:definition>
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	  <link:usedOn>link:calculationLink</link:usedOn>
	  <link:usedOn>link:definitionLink</link:usedOn>
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	  <link:definition>0018 - Disclosure - OPERATING LEASES</link:definition>
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	  <link:usedOn>link:calculationLink</link:usedOn>
	  <link:usedOn>link:definitionLink</link:usedOn>
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	  <link:definition>0019 - Disclosure - RELATED PARTY TRANSACTIONS</link:definition>
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	  <link:usedOn>link:calculationLink</link:usedOn>
	  <link:usedOn>link:definitionLink</link:usedOn>
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	  <link:definition>0020 - Disclosure - MAJOR CUSTOMERS</link:definition>
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	  <link:usedOn>link:calculationLink</link:usedOn>
	  <link:usedOn>link:definitionLink</link:usedOn>
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	<link:roleType roleURI="http://OPRX/role/IncomeTaxes" id="IncomeTaxes">
	  <link:definition>0021 - Disclosure - INCOME TAXES</link:definition>
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	  <link:usedOn>link:calculationLink</link:usedOn>
	  <link:usedOn>link:definitionLink</link:usedOn>
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	  <link:definition>0022 - Disclosure - OPERATING EXPENSES</link:definition>
	  <link:usedOn>link:presentationLink</link:usedOn>
	  <link:usedOn>link:calculationLink</link:usedOn>
	  <link:usedOn>link:definitionLink</link:usedOn>
	</link:roleType>
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	  <link:definition>0023 - Disclosure - GOING CONCERN</link:definition>
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	  <link:usedOn>link:calculationLink</link:usedOn>
	  <link:usedOn>link:definitionLink</link:usedOn>
	</link:roleType>
	<link:roleType roleURI="http://OPRX/role/Restatement" id="Restatement">
	  <link:definition>0024 - Disclosure - RESTATEMENT</link:definition>
	  <link:usedOn>link:presentationLink</link:usedOn>
	  <link:usedOn>link:calculationLink</link:usedOn>
	  <link:usedOn>link:definitionLink</link:usedOn>
	</link:roleType>
	<link:roleType roleURI="http://OPRX/role/SubsequentEvents" id="SubsequentEvents">
	  <link:definition>0025 - Disclosure - SUBSEQUENT EVENTS</link:definition>
	  <link:usedOn>link:presentationLink</link:usedOn>
	  <link:usedOn>link:calculationLink</link:usedOn>
	  <link:usedOn>link:definitionLink</link:usedOn>
	</link:roleType>
	<link:roleType roleURI="http://OPRX/role/SummaryOfSignificantAccountingPoliciesPolicies" id="SummaryOfSignificantAccountingPoliciesPolicies">
	  <link:definition>0026 - Disclosure - SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES (Policies)</link:definition>
	  <link:usedOn>link:presentationLink</link:usedOn>
	  <link:usedOn>link:calculationLink</link:usedOn>
	  <link:usedOn>link:definitionLink</link:usedOn>
	</link:roleType>
	<link:roleType roleURI="http://OPRX/role/PrepaidExpensesTables" id="PrepaidExpensesTables">
	  <link:definition>0027 - Disclosure - PREPAID EXPENSES (Tables)</link:definition>
	  <link:usedOn>link:presentationLink</link:usedOn>
	  <link:usedOn>link:calculationLink</link:usedOn>
	  <link:usedOn>link:definitionLink</link:usedOn>
	</link:roleType>
	<link:roleType roleURI="http://OPRX/role/PropertyAndEquipmentTables" id="PropertyAndEquipmentTables">
	  <link:definition>0028 - Disclosure - PROPERTY AND EQUIPMENT (Tables)</link:definition>
	  <link:usedOn>link:presentationLink</link:usedOn>
	  <link:usedOn>link:calculationLink</link:usedOn>
	  <link:usedOn>link:definitionLink</link:usedOn>
	</link:roleType>
	<link:roleType roleURI="http://OPRX/role/WebsiteDevelopmentCostsTables" id="WebsiteDevelopmentCostsTables">
	  <link:definition>0029 - Disclosure - WEBSITE DEVELOPMENT COSTS (Tables)</link:definition>
	  <link:usedOn>link:presentationLink</link:usedOn>
	  <link:usedOn>link:calculationLink</link:usedOn>
	  <link:usedOn>link:definitionLink</link:usedOn>
	</link:roleType>
	<link:roleType roleURI="http://OPRX/role/PatentRightsAndIntangibleAssetsTables" id="PatentRightsAndIntangibleAssetsTables">
	  <link:definition>0030 - Disclosure - PATENT RIGHTS AND INTANGIBLE ASSETS (Tables)</link:definition>
	  <link:usedOn>link:presentationLink</link:usedOn>
	  <link:usedOn>link:calculationLink</link:usedOn>
	  <link:usedOn>link:definitionLink</link:usedOn>
	</link:roleType>
	<link:roleType roleURI="http://OPRX/role/AccruedExpensesTables" id="AccruedExpensesTables">
	  <link:definition>0031 - Disclosure - ACCRUED EXPENSES (Tables)</link:definition>
	  <link:usedOn>link:presentationLink</link:usedOn>
	  <link:usedOn>link:calculationLink</link:usedOn>
	  <link:usedOn>link:definitionLink</link:usedOn>
	</link:roleType>
	<link:roleType roleURI="http://OPRX/role/OperatingLeasesTables" id="OperatingLeasesTables">
	  <link:definition>0032 - Disclosure - OPERATING LEASES (Tables)</link:definition>
	  <link:usedOn>link:presentationLink</link:usedOn>
	  <link:usedOn>link:calculationLink</link:usedOn>
	  <link:usedOn>link:definitionLink</link:usedOn>
	</link:roleType>
	<link:roleType roleURI="http://OPRX/role/IncomeTaxesTables" id="IncomeTaxesTables">
	  <link:definition>0033 - Disclosure - INCOME TAXES (Tables)</link:definition>
	  <link:usedOn>link:presentationLink</link:usedOn>
	  <link:usedOn>link:calculationLink</link:usedOn>
	  <link:usedOn>link:definitionLink</link:usedOn>
	</link:roleType>
	<link:roleType roleURI="http://OPRX/role/OperatingExpensesTables" id="OperatingExpensesTables">
	  <link:definition>0034 - Disclosure - OPERATING EXPENSES (Tables)</link:definition>
	  <link:usedOn>link:presentationLink</link:usedOn>
	  <link:usedOn>link:calculationLink</link:usedOn>
	  <link:usedOn>link:definitionLink</link:usedOn>
	</link:roleType>
	<link:roleType roleURI="http://OPRX/role/RestatementTables" id="RestatementTables">
	  <link:definition>0035 - Disclosure - RESTATEMENT (Tables)</link:definition>
	  <link:usedOn>link:presentationLink</link:usedOn>
	  <link:usedOn>link:calculationLink</link:usedOn>
	  <link:usedOn>link:definitionLink</link:usedOn>
	</link:roleType>
	<link:roleType roleURI="http://OPRX/role/NatureOfBusinessDetailsNarrative" id="NatureOfBusinessDetailsNarrative">
	  <link:definition>0036 - Disclosure - NATURE OF BUSINESS (Details Narrative)</link:definition>
	  <link:usedOn>link:presentationLink</link:usedOn>
	  <link:usedOn>link:calculationLink</link:usedOn>
	  <link:usedOn>link:definitionLink</link:usedOn>
	</link:roleType>
	<link:roleType roleURI="http://OPRX/role/PrepaidExpenses-ScheduleOfPrepaidExpensesDetails" id="PrepaidExpenses-ScheduleOfPrepaidExpensesDetails">
	  <link:definition>0037 - Disclosure - PREPAID EXPENSES - SCHEDULE OF PREPAID EXPENSES (Details)</link:definition>
	  <link:usedOn>link:presentationLink</link:usedOn>
	  <link:usedOn>link:calculationLink</link:usedOn>
	  <link:usedOn>link:definitionLink</link:usedOn>
	</link:roleType>
	<link:roleType roleURI="http://OPRX/role/PropertyAndEquipment-PropertyAndEquipmentDetails" id="PropertyAndEquipment-PropertyAndEquipmentDetails">
	  <link:definition>0038 - Disclosure - PROPERTY AND EQUIPMENT - PROPERTY AND EQUIPMENT (Details)</link:definition>
	  <link:usedOn>link:presentationLink</link:usedOn>
	  <link:usedOn>link:calculationLink</link:usedOn>
	  <link:usedOn>link:definitionLink</link:usedOn>
	</link:roleType>
	<link:roleType roleURI="http://OPRX/role/PropertyAndEquipmentDetailsNarrative" id="PropertyAndEquipmentDetailsNarrative">
	  <link:definition>0039 - Disclosure - PROPERTY AND EQUIPMENT (Details Narrative)</link:definition>
	  <link:usedOn>link:presentationLink</link:usedOn>
	  <link:usedOn>link:calculationLink</link:usedOn>
	  <link:usedOn>link:definitionLink</link:usedOn>
	</link:roleType>
	<link:roleType roleURI="http://OPRX/role/WebsiteDevelopmentCosts-WebsiteDevelopmentCostsDetails" id="WebsiteDevelopmentCosts-WebsiteDevelopmentCostsDetails">
	  <link:definition>0040 - Disclosure - WEBSITE DEVELOPMENT COSTS - WEBSITE DEVELOPMENT COSTS (Details)</link:definition>
	  <link:usedOn>link:presentationLink</link:usedOn>
	  <link:usedOn>link:calculationLink</link:usedOn>
	  <link:usedOn>link:definitionLink</link:usedOn>
	</link:roleType>
	<link:roleType roleURI="http://OPRX/role/WebsiteDevelopmentCostsDetailsNarrative" id="WebsiteDevelopmentCostsDetailsNarrative">
	  <link:definition>0041 - Disclosure - WEBSITE DEVELOPMENT COSTS (Details Narrative)</link:definition>
	  <link:usedOn>link:presentationLink</link:usedOn>
	  <link:usedOn>link:calculationLink</link:usedOn>
	  <link:usedOn>link:definitionLink</link:usedOn>
	</link:roleType>
	<link:roleType roleURI="http://OPRX/role/PatentRightsAndIntangibleAssets-PatentRightsAndIntangibleAssetsDetails" id="PatentRightsAndIntangibleAssets-PatentRightsAndIntangibleAssetsDetails">
	  <link:definition>0042 - Disclosure - PATENT RIGHTS AND INTANGIBLE ASSETS - PATENT RIGHTS AND INTANGIBLE ASSETS (Details)</link:definition>
	  <link:usedOn>link:presentationLink</link:usedOn>
	  <link:usedOn>link:calculationLink</link:usedOn>
	  <link:usedOn>link:definitionLink</link:usedOn>
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	<link:roleType roleURI="http://OPRX/role/PatentRightsAndIntangibleAssetsDetailsNarrative" id="PatentRightsAndIntangibleAssetsDetailsNarrative">
	  <link:definition>0043 - Disclosure - PATENT RIGHTS AND INTANGIBLE ASSETS (Details Narrative)</link:definition>
	  <link:usedOn>link:presentationLink</link:usedOn>
	  <link:usedOn>link:calculationLink</link:usedOn>
	  <link:usedOn>link:definitionLink</link:usedOn>
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	<link:roleType roleURI="http://OPRX/role/AccruedExpenses-AccruedExpensesDetails" id="AccruedExpenses-AccruedExpensesDetails">
	  <link:definition>0044 - Disclosure - ACCRUED EXPENSES - ACCRUED EXPENSES (Details)</link:definition>
	  <link:usedOn>link:presentationLink</link:usedOn>
	  <link:usedOn>link:calculationLink</link:usedOn>
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	<link:roleType roleURI="http://OPRX/role/DeferredRevenueDetailsNarrative" id="DeferredRevenueDetailsNarrative">
	  <link:definition>0045 - Disclosure - DEFERRED REVENUE (Details Narrative)</link:definition>
	  <link:usedOn>link:presentationLink</link:usedOn>
	  <link:usedOn>link:calculationLink</link:usedOn>
	  <link:usedOn>link:definitionLink</link:usedOn>
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	<link:roleType roleURI="http://OPRX/role/NotePayableDetailsNarrative" id="NotePayableDetailsNarrative">
	  <link:definition>0046 - Disclosure - NOTE PAYABLE (Details Narrative)</link:definition>
	  <link:usedOn>link:presentationLink</link:usedOn>
	  <link:usedOn>link:calculationLink</link:usedOn>
	  <link:usedOn>link:definitionLink</link:usedOn>
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	<link:roleType roleURI="http://OPRX/role/CommonStockDetailsNarrative" id="CommonStockDetailsNarrative">
	  <link:definition>0047 - Disclosure - COMMON STOCK (Details Narrative)</link:definition>
	  <link:usedOn>link:presentationLink</link:usedOn>
	  <link:usedOn>link:calculationLink</link:usedOn>
	  <link:usedOn>link:definitionLink</link:usedOn>
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	<link:roleType roleURI="http://OPRX/role/PreferredStockDetailsNarrative" id="PreferredStockDetailsNarrative">
	  <link:definition>0048 - Disclosure - PREFERRED STOCK (Details Narrative)</link:definition>
	  <link:usedOn>link:presentationLink</link:usedOn>
	  <link:usedOn>link:calculationLink</link:usedOn>
	  <link:usedOn>link:definitionLink</link:usedOn>
	</link:roleType>
	<link:roleType roleURI="http://OPRX/role/StockOptionsAndWarrantsDetailsNarrative" id="StockOptionsAndWarrantsDetailsNarrative">
	  <link:definition>0049 - Disclosure - STOCK OPTIONS AND WARRANTS (Details Narrative)</link:definition>
	  <link:usedOn>link:presentationLink</link:usedOn>
	  <link:usedOn>link:calculationLink</link:usedOn>
	  <link:usedOn>link:definitionLink</link:usedOn>
	</link:roleType>
	<link:roleType roleURI="http://OPRX/role/OperatingLeases-Details" id="OperatingLeases-Details">
	  <link:definition>0050 - Disclosure - OPERATING LEASES -  (Details)</link:definition>
	  <link:usedOn>link:presentationLink</link:usedOn>
	  <link:usedOn>link:calculationLink</link:usedOn>
	  <link:usedOn>link:definitionLink</link:usedOn>
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	<link:roleType roleURI="http://OPRX/role/OperatingLeasesDetailsNarrative" id="OperatingLeasesDetailsNarrative">
	  <link:definition>0051 - Disclosure - OPERATING LEASES (Details Narrative)</link:definition>
	  <link:usedOn>link:presentationLink</link:usedOn>
	  <link:usedOn>link:calculationLink</link:usedOn>
	  <link:usedOn>link:definitionLink</link:usedOn>
	</link:roleType>
	<link:roleType roleURI="http://OPRX/role/RelatedPartyTransactionsDetailsNarrative" id="RelatedPartyTransactionsDetailsNarrative">
	  <link:definition>0052 - Disclosure - RELATED PARTY TRANSACTIONS (Details Narrative)</link:definition>
	  <link:usedOn>link:presentationLink</link:usedOn>
	  <link:usedOn>link:calculationLink</link:usedOn>
	  <link:usedOn>link:definitionLink</link:usedOn>
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	<link:roleType roleURI="http://OPRX/role/MajorCustomersDetailsNarrative" id="MajorCustomersDetailsNarrative">
	  <link:definition>0053 - Disclosure - MAJOR CUSTOMERS (Details Narrative)</link:definition>
	  <link:usedOn>link:presentationLink</link:usedOn>
	  <link:usedOn>link:calculationLink</link:usedOn>
	  <link:usedOn>link:definitionLink</link:usedOn>
	</link:roleType>
	<link:roleType roleURI="http://OPRX/role/IncomeTaxes-FederalIncomeTaxDetails" id="IncomeTaxes-FederalIncomeTaxDetails">
	  <link:definition>0054 - Disclosure - INCOME TAXES - FEDERAL INCOME TAX (Details)</link:definition>
	  <link:usedOn>link:presentationLink</link:usedOn>
	  <link:usedOn>link:calculationLink</link:usedOn>
	  <link:usedOn>link:definitionLink</link:usedOn>
	</link:roleType>
	<link:roleType roleURI="http://OPRX/role/IncomeTaxes-DeferredTaxAssetDetails" id="IncomeTaxes-DeferredTaxAssetDetails">
	  <link:definition>0055 - Disclosure - INCOME TAXES - DEFERRED TAX ASSET (Details)</link:definition>
	  <link:usedOn>link:presentationLink</link:usedOn>
	  <link:usedOn>link:calculationLink</link:usedOn>
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	<link:roleType roleURI="http://OPRX/role/IncomeTaxesDetailsNarrative" id="IncomeTaxesDetailsNarrative">
	  <link:definition>0056 - Disclosure - INCOME TAXES (Details Narrative)</link:definition>
	  <link:usedOn>link:presentationLink</link:usedOn>
	  <link:usedOn>link:calculationLink</link:usedOn>
	  <link:usedOn>link:definitionLink</link:usedOn>
	</link:roleType>
	<link:roleType roleURI="http://OPRX/role/OperatingExpenses-OperatingExpensesDetails" id="OperatingExpenses-OperatingExpensesDetails">
	  <link:definition>0057 - Disclosure - OPERATING EXPENSES - OPERATING EXPENSES (Details)</link:definition>
	  <link:usedOn>link:presentationLink</link:usedOn>
	  <link:usedOn>link:calculationLink</link:usedOn>
	  <link:usedOn>link:definitionLink</link:usedOn>
	</link:roleType>
	<link:roleType roleURI="http://OPRX/role/Restatement-RestatedFinancialsDetails" id="Restatement-RestatedFinancialsDetails">
	  <link:definition>0058 - Disclosure - RESTATEMENT - RESTATED FINANCIALS (Details)</link:definition>
	  <link:usedOn>link:presentationLink</link:usedOn>
	  <link:usedOn>link:calculationLink</link:usedOn>
	  <link:usedOn>link:definitionLink</link:usedOn>
	</link:roleType>
	<link:linkbaseRef xlink:type="simple" xlink:href="oprx-20120930_pre.xml" xlink:role="http://www.xbrl.org/2003/role/presentationLinkbaseRef" xlink:arcrole="http://www.w3.org/1999/xlink/properties/linkbase" xlink:title="Presentation Links" />
	<link:linkbaseRef xlink:type="simple" xlink:href="oprx-20120930_lab.xml" xlink:role="http://www.xbrl.org/2003/role/labelLinkbaseRef" xlink:arcrole="http://www.w3.org/1999/xlink/properties/linkbase" xlink:title="Label Links" />
	<link:linkbaseRef xlink:type="simple" xlink:href="oprx-20120930_cal.xml" xlink:role="http://www.xbrl.org/2003/role/calculationLinkbaseRef" xlink:arcrole="http://www.w3.org/1999/xlink/properties/linkbase" xlink:title="Calculation Links" />
	<link:linkbaseRef xlink:type="simple" xlink:href="oprx-20120930_def.xml" xlink:role="http://www.xbrl.org/2003/role/definitionLinkbaseRef" xlink:arcrole="http://www.w3.org/1999/xlink/properties/linkbase" xlink:title="Definition Links" />
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    </annotation>
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    <import namespace="http://www.xbrl.org/2003/linkbase" schemaLocation="http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd" />
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    <element id="OPRX_NotesPayableTextBlock" name="NotesPayableTextBlock" nillable="true" xbrli:periodType="duration" type="nonnum:textBlockItemType" substitutionGroup="xbrli:item" />
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    <element id="OPRX_StockOptionsWarrantsTextBlock" name="StockOptionsWarrantsTextBlock" nillable="true" xbrli:periodType="duration" type="nonnum:textBlockItemType" substitutionGroup="xbrli:item" />
    <element id="OPRX_MajorCustomersTextBlock" name="MajorCustomersTextBlock" nillable="true" xbrli:periodType="duration" type="nonnum:textBlockItemType" substitutionGroup="xbrli:item" />
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    <element id="OPRX_ScheduleOfPropertyEquipmentTextBlock" name="ScheduleOfPropertyEquipmentTextBlock" nillable="true" xbrli:periodType="duration" type="nonnum:textBlockItemType" substitutionGroup="xbrli:item" />
    <element id="OPRX_ScheduleOfWebsiteDevelopmentCostsTableTextBlock" name="ScheduleOfWebsiteDevelopmentCostsTableTextBlock" nillable="true" xbrli:periodType="duration" type="nonnum:textBlockItemType" substitutionGroup="xbrli:item" />
    <element id="OPRX_ScheduleOfAccruedExpensesTableTextBlock" name="ScheduleOfAccruedExpensesTableTextBlock" nillable="true" xbrli:periodType="duration" type="nonnum:textBlockItemType" substitutionGroup="xbrli:item" />
    <element id="OPRX_ScheduleOfOperatingCostAndExpenseByComponentTextBlock" name="ScheduleOfOperatingCostAndExpenseByComponentTextBlock" nillable="true" xbrli:periodType="duration" type="nonnum:textBlockItemType" substitutionGroup="xbrli:item" />
    <element id="OPRX_ScheduleOfRestatedFinancialsForSixMonthsEndedTableTextBlock" name="ScheduleOfRestatedFinancialsForSixMonthsEndedTableTextBlock" nillable="true" xbrli:periodType="duration" type="nonnum:textBlockItemType" substitutionGroup="xbrli:item" />
    <element id="OPRX_ScheduleOfRestatedFinancialsForThreeMonthsEndedTableTextBlock" name="ScheduleOfRestatedFinancialsForThreeMonthsEndedTableTextBlock" nillable="true" xbrli:periodType="duration" type="nonnum:textBlockItemType" substitutionGroup="xbrli:item" />
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    <element id="OPRX_SubtotalofWebsiteDevelopmentCosts" name="SubtotalofWebsiteDevelopmentCosts" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
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    <element id="OPRX_EmployeesShareBasedCompensationExpense2" name="EmployeesShareBasedCompensationExpense2" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="OPRX_EmployeesStockOptionVestingPeriod2" name="EmployeesStockOptionVestingPeriod2" nillable="true" xbrli:periodType="duration" type="us-types:durationStringItemType" substitutionGroup="xbrli:item" />
    <element id="OPRX_MinimumAnnualLeaseAmountDue" name="MinimumAnnualLeaseAmountDue" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="OPRX_TotalLeaseCommitmentDue" name="TotalLeaseCommitmentDue" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="OPRX_MonthlyRentDue" name="MonthlyRentDue" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="OPRX_TermOfLease" name="TermOfLease" nillable="true" xbrli:periodType="duration" type="us-types:durationStringItemType" substitutionGroup="xbrli:item" />
    <element id="OPRX_CommonStockIssuedForPurchaseOfPatent" name="CommonStockIssuedForPurchaseOfPatent" nillable="true" xbrli:periodType="instant" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" />
    <element id="OPRX_ShareBasedCompensationArrangementofStockOptionsIssued" name="ShareBasedCompensationArrangementofStockOptionsIssued" nillable="true" xbrli:periodType="instant" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" />
    <element id="OPRX_ShareBasedCompensationArrangementofStockOptionsValue" name="ShareBasedCompensationArrangementofStockOptionsValue" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="OPRX_CommonStockValueOnGrantDate" name="CommonStockValueOnGrantDate" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="OPRX_MajorCustomers" name="MajorCustomers" nillable="true" xbrli:periodType="duration" type="num:percentItemType" substitutionGroup="xbrli:item" />
    <element id="OPRX_NetFederalIncomeTax" name="NetFederalIncomeTax" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="OPRX_Consulting" name="Consulting" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="OPRX_IncreaseDecreaseInPayrollTax" name="IncreaseDecreaseInPayrollTax" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
</schema>
</XBRL>
