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<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_CashAndCashEquivalentsAtCarryingValue" xlink:label="loc_350FKH75322F_us-gaap_CashAndCashEquivalentsAtCarryingValue"/>
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<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_AccountsReceivableNetCurrent" xlink:label="loc_929216F4IJ579I98G136_us-gaap_AccountsReceivableNetCurrent"/>
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<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_572HMJ97544H_us-gaap_AccountsReceivableRelatedPartiesCurrent" xml:lang="en-US">Accounts Receivable, Related Parties, Current</label>
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<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_PrepaidExpenseCurrent" xlink:label="loc_929216F4IJ579I98G136_us-gaap_PrepaidExpenseCurrent"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_141438H6KL791K10I358_us-gaap_PrepaidExpenseCurrent" xml:lang="en-US">Prepaid Expense, Current</label>
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<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/totalLabel" xlink:label="lab_572HMJ97544H_us-gaap_AssetsCurrent" xml:lang="en-US">Total Current Assets</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_350FKH75322F_us-gaap_AssetsCurrent" xlink:to="lab_572HMJ97544H_us-gaap_AssetsCurrent"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_PropertyPlantAndEquipmentNet" xlink:label="loc_929216F4IJ579I98G136_us-gaap_PropertyPlantAndEquipmentNet"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_141438H6KL791K10I358_us-gaap_PropertyPlantAndEquipmentNet" xml:lang="en-US">Property, Plant and Equipment, Net</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_141438H6KL791K10I358_us-gaap_PropertyPlantAndEquipmentNet" xml:lang="en-US">Property and equipment, net</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:label="lab_141438H6KL791K10I358_us-gaap_PropertyPlantAndEquipmentNet" xml:lang="en-US">Property and equipment, net</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_929216F4IJ579I98G136_us-gaap_PropertyPlantAndEquipmentNet" xlink:to="lab_141438H6KL791K10I358_us-gaap_PropertyPlantAndEquipmentNet"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_OtherAssetsAbstract" xlink:label="loc_350FKH75322F_us-gaap_OtherAssetsAbstract"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_572HMJ97544H_us-gaap_OtherAssetsAbstract" xml:lang="en-US">OtherAssetsAbstract</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:label="lab_572HMJ97544H_us-gaap_OtherAssetsAbstract" xml:lang="en-US">Other Assets</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_350FKH75322F_us-gaap_OtherAssetsAbstract" xlink:to="lab_572HMJ97544H_us-gaap_OtherAssetsAbstract"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsNet" xlink:label="loc_929216F4IJ579I98G136_us-gaap_FiniteLivedIntangibleAssetsNet"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_141438H6KL791K10I358_us-gaap_FiniteLivedIntangibleAssetsNet" xml:lang="en-US">Finite-Lived Intangible Assets, Net</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:label="lab_141438H6KL791K10I358_us-gaap_FiniteLivedIntangibleAssetsNet" xml:lang="en-US">Patent rights, net</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/totalLabel" xlink:label="lab_141438H6KL791K10I358_us-gaap_FiniteLivedIntangibleAssetsNet" xml:lang="en-US">Patent rights and intangible assets, net</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_929216F4IJ579I98G136_us-gaap_FiniteLivedIntangibleAssetsNet" xlink:to="lab_141438H6KL791K10I358_us-gaap_FiniteLivedIntangibleAssetsNet"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_CapitalizedComputerSoftwareNet" xlink:label="loc_350FKH75322F_us-gaap_CapitalizedComputerSoftwareNet"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_572HMJ97544H_us-gaap_CapitalizedComputerSoftwareNet" xml:lang="en-US">Capitalized Computer Software, Net</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_572HMJ97544H_us-gaap_CapitalizedComputerSoftwareNet" xml:lang="en-US">Web-based technology, net</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:label="lab_572HMJ97544H_us-gaap_CapitalizedComputerSoftwareNet" xml:lang="en-US">Web development costs, net</label>
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<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_SecurityDeposit" xlink:label="loc_929216F4IJ579I98G136_us-gaap_SecurityDeposit"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_141438H6KL791K10I358_us-gaap_SecurityDeposit" xml:lang="en-US">SecurityDeposit</label>
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<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/totalLabel" xlink:label="lab_572HMJ97544H_us-gaap_OtherAssets" xml:lang="en-US">Total Other Assets</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_350FKH75322F_us-gaap_OtherAssets" xlink:to="lab_572HMJ97544H_us-gaap_OtherAssets"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_Assets" xlink:label="loc_929216F4IJ579I98G136_us-gaap_Assets"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_141438H6KL791K10I358_us-gaap_Assets" xml:lang="en-US">Assets</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/totalLabel" xlink:label="lab_141438H6KL791K10I358_us-gaap_Assets" xml:lang="en-US">TOTAL ASSETS</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_929216F4IJ579I98G136_us-gaap_Assets" xlink:to="lab_141438H6KL791K10I358_us-gaap_Assets"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_LiabilitiesAndStockholdersEquityAbstract" xlink:label="loc_350FKH75322F_us-gaap_LiabilitiesAndStockholdersEquityAbstract"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_572HMJ97544H_us-gaap_LiabilitiesAndStockholdersEquityAbstract" xml:lang="en-US">LiabilitiesAndStockholdersEquityAbstract</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:label="lab_572HMJ97544H_us-gaap_LiabilitiesAndStockholdersEquityAbstract" xml:lang="en-US">LIABILITIES AND STOCKHOLDERS' EQUITY</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_350FKH75322F_us-gaap_LiabilitiesAndStockholdersEquityAbstract" xlink:to="lab_572HMJ97544H_us-gaap_LiabilitiesAndStockholdersEquityAbstract"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_LiabilitiesCurrentAbstract" xlink:label="loc_929216F4IJ579I98G136_us-gaap_LiabilitiesCurrentAbstract"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_141438H6KL791K10I358_us-gaap_LiabilitiesCurrentAbstract" xml:lang="en-US">LiabilitiesCurrentAbstract</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:label="lab_141438H6KL791K10I358_us-gaap_LiabilitiesCurrentAbstract" xml:lang="en-US">Current Liabilities</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_929216F4IJ579I98G136_us-gaap_LiabilitiesCurrentAbstract" xlink:to="lab_141438H6KL791K10I358_us-gaap_LiabilitiesCurrentAbstract"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_AccountsPayableTradeCurrent" xlink:label="loc_350FKH75322F_us-gaap_AccountsPayableTradeCurrent"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_572HMJ97544H_us-gaap_AccountsPayableTradeCurrent" xml:lang="en-US">AccountsPayableTradeCurrent</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:label="lab_572HMJ97544H_us-gaap_AccountsPayableTradeCurrent" xml:lang="en-US">Accounts payable - trade</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_350FKH75322F_us-gaap_AccountsPayableTradeCurrent" xlink:to="lab_572HMJ97544H_us-gaap_AccountsPayableTradeCurrent"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_AccruedLiabilitiesCurrent" xlink:label="loc_929216F4IJ579I98G136_us-gaap_AccruedLiabilitiesCurrent"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_141438H6KL791K10I358_us-gaap_AccruedLiabilitiesCurrent" xml:lang="en-US">Accrued Liabilities, Current</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:label="lab_141438H6KL791K10I358_us-gaap_AccruedLiabilitiesCurrent" xml:lang="en-US">Accrued expenses</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_929216F4IJ579I98G136_us-gaap_AccruedLiabilitiesCurrent" xlink:to="lab_141438H6KL791K10I358_us-gaap_AccruedLiabilitiesCurrent"/>
<loc xlink:type="locator" xlink:href="oprx-20180331.xsd#oprx_RevenueSharePayableCurrent" xlink:label="loc_350FKH75322F_oprx_RevenueSharePayableCurrent"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_572HMJ97544H_oprx_RevenueSharePayableCurrent" xml:lang="en-US">Revenue Share Payable Current</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:label="lab_572HMJ97544H_oprx_RevenueSharePayableCurrent" xml:lang="en-US">Revenue share payable</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:label="lab_572HMJ97544H_oprx_RevenueSharePayableCurrent" xml:lang="en-US">Aggregate carrying value as of the balance sheet date of the liabilities for revenue share payable within one year (or the normal operating cycle, if longer).</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_350FKH75322F_oprx_RevenueSharePayableCurrent" xlink:to="lab_572HMJ97544H_oprx_RevenueSharePayableCurrent"/>
<loc xlink:type="locator" xlink:href="oprx-20180331.xsd#oprx_RevenueSharesPayableRelatedParty" xlink:label="loc_929216F4IJ579I98G136_oprx_RevenueSharesPayableRelatedParty"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_141438H6KL791K10I358_oprx_RevenueSharesPayableRelatedParty" xml:lang="en-US">Revenue Shares Payable - Related Party</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_141438H6KL791K10I358_oprx_RevenueSharesPayableRelatedParty" xml:lang="en-US">Revenue share payable - related party</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:label="lab_141438H6KL791K10I358_oprx_RevenueSharesPayableRelatedParty" xml:lang="en-US">Revenue shares payable, related parties.</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_929216F4IJ579I98G136_oprx_RevenueSharesPayableRelatedParty" xlink:to="lab_141438H6KL791K10I358_oprx_RevenueSharesPayableRelatedParty"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_DeferredRevenueCurrent" xlink:label="loc_350FKH75322F_us-gaap_DeferredRevenueCurrent"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_572HMJ97544H_us-gaap_DeferredRevenueCurrent" xml:lang="en-US">Deferred Revenue, Current</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_572HMJ97544H_us-gaap_DeferredRevenueCurrent" xml:lang="en-US">Deferred revenue</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:label="lab_572HMJ97544H_us-gaap_DeferredRevenueCurrent" xml:lang="en-US">Deferred revenue</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_350FKH75322F_us-gaap_DeferredRevenueCurrent" xlink:to="lab_572HMJ97544H_us-gaap_DeferredRevenueCurrent"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_LiabilitiesCurrent" xlink:label="loc_929216F4IJ579I98G136_us-gaap_LiabilitiesCurrent"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_141438H6KL791K10I358_us-gaap_LiabilitiesCurrent" xml:lang="en-US">Liabilities, Current</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/totalLabel" xlink:label="lab_141438H6KL791K10I358_us-gaap_LiabilitiesCurrent" xml:lang="en-US">Total Liabilities</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_929216F4IJ579I98G136_us-gaap_LiabilitiesCurrent" xlink:to="lab_141438H6KL791K10I358_us-gaap_LiabilitiesCurrent"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_StockholdersEquityAbstract" xlink:label="loc_350FKH75322F_us-gaap_StockholdersEquityAbstract"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_572HMJ97544H_us-gaap_StockholdersEquityAbstract" xml:lang="en-US">StockholdersEquityAbstract</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:label="lab_572HMJ97544H_us-gaap_StockholdersEquityAbstract" xml:lang="en-US">Stockholders' Equity</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_350FKH75322F_us-gaap_StockholdersEquityAbstract" xlink:to="lab_572HMJ97544H_us-gaap_StockholdersEquityAbstract"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_PreferredStockValue" xlink:label="loc_929216F4IJ579I98G136_us-gaap_PreferredStockValue"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_141438H6KL791K10I358_us-gaap_PreferredStockValue" xml:lang="en-US">Preferred Stock, Value, Issued</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_141438H6KL791K10I358_us-gaap_PreferredStockValue" xml:lang="en-US">Preferred stock, $0.001 par value, 10,000,000 shares authorized, no issued and outstanding at March 31, 2018 or December 31, 2017</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:label="lab_141438H6KL791K10I358_us-gaap_PreferredStockValue" xml:lang="en-US">Preferred stock, $.001 par value, 10,000,000 shares authorized, 0 and 65 shares issued and outstanding, respectively</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_929216F4IJ579I98G136_us-gaap_PreferredStockValue" xlink:to="lab_141438H6KL791K10I358_us-gaap_PreferredStockValue"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_CommonStockValue" xlink:label="loc_350FKH75322F_us-gaap_CommonStockValue"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_572HMJ97544H_us-gaap_CommonStockValue" xml:lang="en-US">Common Stock, Value, Issued</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_572HMJ97544H_us-gaap_CommonStockValue" xml:lang="en-US">Preferred stock</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:label="lab_572HMJ97544H_us-gaap_CommonStockValue" xml:lang="en-US">Common stock, $0.001 par value, 500,000,000 shares authorized, 9,878,944 and 9,772,694 shares issued and outstanding at March 31, 2018 and December 31, 2017, respectively</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/definitionGuidance" xlink:label="lab_572HMJ97544H_us-gaap_CommonStockValue" xml:lang="en-US">Common stock valued</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/disclosureGuidance" xlink:label="lab_572HMJ97544H_us-gaap_CommonStockValue" xml:lang="en-US">Common stock value, issued</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_350FKH75322F_us-gaap_CommonStockValue" xlink:to="lab_572HMJ97544H_us-gaap_CommonStockValue"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_WarrantsAndRightsOutstanding" xlink:label="loc_929216F4IJ579I98G136_us-gaap_WarrantsAndRightsOutstanding"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_141438H6KL791K10I358_us-gaap_WarrantsAndRightsOutstanding" xml:lang="en-US">WarrantsAndRightsOutstanding</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:label="lab_141438H6KL791K10I358_us-gaap_WarrantsAndRightsOutstanding" xml:lang="en-US">Stock warrants</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_929216F4IJ579I98G136_us-gaap_WarrantsAndRightsOutstanding" xlink:to="lab_141438H6KL791K10I358_us-gaap_WarrantsAndRightsOutstanding"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_AdditionalPaidInCapital" xlink:label="loc_350FKH75322F_us-gaap_AdditionalPaidInCapital"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_572HMJ97544H_us-gaap_AdditionalPaidInCapital" xml:lang="en-US">AdditionalPaidInCapital</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:label="lab_572HMJ97544H_us-gaap_AdditionalPaidInCapital" xml:lang="en-US">Additional paid-in-capital</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_350FKH75322F_us-gaap_AdditionalPaidInCapital" xlink:to="lab_572HMJ97544H_us-gaap_AdditionalPaidInCapital"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_RetainedEarningsAccumulatedDeficit" xlink:label="loc_929216F4IJ579I98G136_us-gaap_RetainedEarningsAccumulatedDeficit"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_141438H6KL791K10I358_us-gaap_RetainedEarningsAccumulatedDeficit" xml:lang="en-US">RetainedEarningsAccumulatedDeficit</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:label="lab_141438H6KL791K10I358_us-gaap_RetainedEarningsAccumulatedDeficit" xml:lang="en-US">Accumulated deficit</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2009/role/negatedLabel" xlink:label="lab_141438H6KL791K10I358_us-gaap_RetainedEarningsAccumulatedDeficit" xml:lang="en-US">Accumulated deficit</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_929216F4IJ579I98G136_us-gaap_RetainedEarningsAccumulatedDeficit" xlink:to="lab_141438H6KL791K10I358_us-gaap_RetainedEarningsAccumulatedDeficit"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_StockholdersEquity" xlink:label="loc_350FKH75322F_us-gaap_StockholdersEquity"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_572HMJ97544H_us-gaap_StockholdersEquity" xml:lang="en-US">Stockholders' Equity Attributable to Parent</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/totalLabel" xlink:label="lab_572HMJ97544H_us-gaap_StockholdersEquity" xml:lang="en-US">Total Stockholders' Equity</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/periodStartLabel" xlink:label="lab_572HMJ97544H_us-gaap_StockholdersEquity" xml:lang="en-US">Balance</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/periodEndLabel" xlink:label="lab_572HMJ97544H_us-gaap_StockholdersEquity" xml:lang="en-US">Balance</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_350FKH75322F_us-gaap_StockholdersEquity" xlink:to="lab_572HMJ97544H_us-gaap_StockholdersEquity"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_LiabilitiesAndStockholdersEquity" xlink:label="loc_929216F4IJ579I98G136_us-gaap_LiabilitiesAndStockholdersEquity"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_141438H6KL791K10I358_us-gaap_LiabilitiesAndStockholdersEquity" xml:lang="en-US">Liabilities and Equity</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/totalLabel" xlink:label="lab_141438H6KL791K10I358_us-gaap_LiabilitiesAndStockholdersEquity" xml:lang="en-US">TOTAL LIABILITIES AND STOCKHOLDERS' EQUITY</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_929216F4IJ579I98G136_us-gaap_LiabilitiesAndStockholdersEquity" xlink:to="lab_141438H6KL791K10I358_us-gaap_LiabilitiesAndStockholdersEquity"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_PreferredStockParOrStatedValuePerShare" xlink:label="loc_350FKH75322F_us-gaap_PreferredStockParOrStatedValuePerShare"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_572HMJ97544H_us-gaap_PreferredStockParOrStatedValuePerShare" xml:lang="en-US">Preferred Stock, Par or Stated Value Per Share</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_572HMJ97544H_us-gaap_PreferredStockParOrStatedValuePerShare" xml:lang="en-US">Preferred Stock, par value</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:label="lab_572HMJ97544H_us-gaap_PreferredStockParOrStatedValuePerShare" xml:lang="en-US">Preferred stock, par value</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_350FKH75322F_us-gaap_PreferredStockParOrStatedValuePerShare" xlink:to="lab_572HMJ97544H_us-gaap_PreferredStockParOrStatedValuePerShare"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_PreferredStockSharesAuthorized" xlink:label="loc_929216F4IJ579I98G136_us-gaap_PreferredStockSharesAuthorized"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_141438H6KL791K10I358_us-gaap_PreferredStockSharesAuthorized" xml:lang="en-US">Preferred Stock, Shares Authorized</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_141438H6KL791K10I358_us-gaap_PreferredStockSharesAuthorized" xml:lang="en-US">Preferred stock, shares authorized</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:label="lab_141438H6KL791K10I358_us-gaap_PreferredStockSharesAuthorized" xml:lang="en-US">Preferred stock, shares authorized</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_929216F4IJ579I98G136_us-gaap_PreferredStockSharesAuthorized" xlink:to="lab_141438H6KL791K10I358_us-gaap_PreferredStockSharesAuthorized"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_PreferredStockSharesIssued" xlink:label="loc_350FKH75322F_us-gaap_PreferredStockSharesIssued"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_572HMJ97544H_us-gaap_PreferredStockSharesIssued" xml:lang="en-US">PreferredStockSharesIssued</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:label="lab_572HMJ97544H_us-gaap_PreferredStockSharesIssued" xml:lang="en-US">Preferred stock, shares issued</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_350FKH75322F_us-gaap_PreferredStockSharesIssued" xlink:to="lab_572HMJ97544H_us-gaap_PreferredStockSharesIssued"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_PreferredStockSharesOutstanding" xlink:label="loc_929216F4IJ579I98G136_us-gaap_PreferredStockSharesOutstanding"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_141438H6KL791K10I358_us-gaap_PreferredStockSharesOutstanding" xml:lang="en-US">Preferred stock, shares outstanding</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_929216F4IJ579I98G136_us-gaap_PreferredStockSharesOutstanding" xlink:to="lab_141438H6KL791K10I358_us-gaap_PreferredStockSharesOutstanding"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_CommonStockParOrStatedValuePerShare" xlink:label="loc_350FKH75322F_us-gaap_CommonStockParOrStatedValuePerShare"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_572HMJ97544H_us-gaap_CommonStockParOrStatedValuePerShare" xml:lang="en-US">Common Stock, Par or Stated Value Per Share</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:label="lab_572HMJ97544H_us-gaap_CommonStockParOrStatedValuePerShare" xml:lang="en-US">Common stock, par value</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_350FKH75322F_us-gaap_CommonStockParOrStatedValuePerShare" xlink:to="lab_572HMJ97544H_us-gaap_CommonStockParOrStatedValuePerShare"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_CommonStockSharesAuthorized" xlink:label="loc_929216F4IJ579I98G136_us-gaap_CommonStockSharesAuthorized"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_141438H6KL791K10I358_us-gaap_CommonStockSharesAuthorized" xml:lang="en-US">Common Stock, Shares Authorized</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:label="lab_141438H6KL791K10I358_us-gaap_CommonStockSharesAuthorized" xml:lang="en-US">Common stock, shares authorized</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_929216F4IJ579I98G136_us-gaap_CommonStockSharesAuthorized" xlink:to="lab_141438H6KL791K10I358_us-gaap_CommonStockSharesAuthorized"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_CommonStockSharesIssued" xlink:label="loc_350FKH75322F_us-gaap_CommonStockSharesIssued"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_572HMJ97544H_us-gaap_CommonStockSharesIssued" xml:lang="en-US">Common Stock, Shares, Issued</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_572HMJ97544H_us-gaap_CommonStockSharesIssued" xml:lang="en-US">Common stock reflected</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:label="lab_572HMJ97544H_us-gaap_CommonStockSharesIssued" xml:lang="en-US">Common stock, shares issued</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_350FKH75322F_us-gaap_CommonStockSharesIssued" xlink:to="lab_572HMJ97544H_us-gaap_CommonStockSharesIssued"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_CommonStockSharesOutstanding" xlink:label="loc_929216F4IJ579I98G136_us-gaap_CommonStockSharesOutstanding"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_141438H6KL791K10I358_us-gaap_CommonStockSharesOutstanding" xml:lang="en-US">Common Stock, Shares, Outstanding</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:label="lab_141438H6KL791K10I358_us-gaap_CommonStockSharesOutstanding" xml:lang="en-US">Common stock, shares outstanding</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_929216F4IJ579I98G136_us-gaap_CommonStockSharesOutstanding" xlink:to="lab_141438H6KL791K10I358_us-gaap_CommonStockSharesOutstanding"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_IncomeStatementAbstract" xlink:label="loc_350FKH75322F_us-gaap_IncomeStatementAbstract"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_572HMJ97544H_us-gaap_IncomeStatementAbstract" xml:lang="en-US">Income Statement [Abstract]</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_572HMJ97544H_us-gaap_IncomeStatementAbstract" xml:lang="en-US">NET REVENUE</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_350FKH75322F_us-gaap_IncomeStatementAbstract" xlink:to="lab_572HMJ97544H_us-gaap_IncomeStatementAbstract"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_RevenuesAbstract" xlink:label="loc_929216F4IJ579I98G136_us-gaap_RevenuesAbstract"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_141438H6KL791K10I358_us-gaap_RevenuesAbstract" xml:lang="en-US">Revenues [Abstract]</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_141438H6KL791K10I358_us-gaap_RevenuesAbstract" xml:lang="en-US">NET REVENUE</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_929216F4IJ579I98G136_us-gaap_RevenuesAbstract" xlink:to="lab_141438H6KL791K10I358_us-gaap_RevenuesAbstract"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_SalesRevenueNet" xlink:label="loc_350FKH75322F_us-gaap_SalesRevenueNet"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_572HMJ97544H_us-gaap_SalesRevenueNet" xml:lang="en-US">Revenue, Net</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_572HMJ97544H_us-gaap_SalesRevenueNet" xml:lang="en-US">Revenue</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_350FKH75322F_us-gaap_SalesRevenueNet" xlink:to="lab_572HMJ97544H_us-gaap_SalesRevenueNet"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_RevenueFromRelatedParties" xlink:label="loc_929216F4IJ579I98G136_us-gaap_RevenueFromRelatedParties"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_141438H6KL791K10I358_us-gaap_RevenueFromRelatedParties" xml:lang="en-US">Revenue from Related Parties</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_141438H6KL791K10I358_us-gaap_RevenueFromRelatedParties" xml:lang="en-US">Revenue - Related Party</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_929216F4IJ579I98G136_us-gaap_RevenueFromRelatedParties" xlink:to="lab_141438H6KL791K10I358_us-gaap_RevenueFromRelatedParties"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_Revenues" xlink:label="loc_350FKH75322F_us-gaap_Revenues"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_572HMJ97544H_us-gaap_Revenues" xml:lang="en-US">Revenues</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:label="lab_572HMJ97544H_us-gaap_Revenues" xml:lang="en-US">NET REVENUE</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/totalLabel" xlink:label="lab_572HMJ97544H_us-gaap_Revenues" xml:lang="en-US">TOTAL NET REVENUE</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_350FKH75322F_us-gaap_Revenues" xlink:to="lab_572HMJ97544H_us-gaap_Revenues"/>
<loc xlink:type="locator" xlink:href="oprx-20180331.xsd#oprx_RevenueShareExpense" xlink:label="loc_929216F4IJ579I98G136_oprx_RevenueShareExpense"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_141438H6KL791K10I358_oprx_RevenueShareExpense" xml:lang="en-US">Revenue Share Expense</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_141438H6KL791K10I358_oprx_RevenueShareExpense" xml:lang="en-US">REVENUE SHARE EXPENSE</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:label="lab_141438H6KL791K10I358_oprx_RevenueShareExpense" xml:lang="en-US">Revenue share expense</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_929216F4IJ579I98G136_oprx_RevenueShareExpense" xlink:to="lab_141438H6KL791K10I358_oprx_RevenueShareExpense"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_GrossProfit" xlink:label="loc_350FKH75322F_us-gaap_GrossProfit"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_572HMJ97544H_us-gaap_GrossProfit" xml:lang="en-US">GrossProfit</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:label="lab_572HMJ97544H_us-gaap_GrossProfit" xml:lang="en-US">GROSS MARGIN</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/totalLabel" xlink:label="lab_572HMJ97544H_us-gaap_GrossProfit" xml:lang="en-US">GROSS MARGIN</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_350FKH75322F_us-gaap_GrossProfit" xlink:to="lab_572HMJ97544H_us-gaap_GrossProfit"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_OperatingCostsAndExpensesAbstract" xlink:label="loc_929216F4IJ579I98G136_us-gaap_OperatingCostsAndExpensesAbstract"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_141438H6KL791K10I358_us-gaap_OperatingCostsAndExpensesAbstract" xml:lang="en-US">Operating Costs and Expenses [Abstract]</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_141438H6KL791K10I358_us-gaap_OperatingCostsAndExpensesAbstract" xml:lang="en-US">Operating expenses</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_929216F4IJ579I98G136_us-gaap_OperatingCostsAndExpensesAbstract" xlink:to="lab_141438H6KL791K10I358_us-gaap_OperatingCostsAndExpensesAbstract"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_AllocatedShareBasedCompensationExpense" xlink:label="loc_350FKH75322F_us-gaap_AllocatedShareBasedCompensationExpense"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_572HMJ97544H_us-gaap_AllocatedShareBasedCompensationExpense" xml:lang="en-US">Allocated Share-based Compensation Expense</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_572HMJ97544H_us-gaap_AllocatedShareBasedCompensationExpense" xml:lang="en-US">Stock-based compensation</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_350FKH75322F_us-gaap_AllocatedShareBasedCompensationExpense" xlink:to="lab_572HMJ97544H_us-gaap_AllocatedShareBasedCompensationExpense"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_DepreciationAndAmortization" xlink:label="loc_929216F4IJ579I98G136_us-gaap_DepreciationAndAmortization"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_141438H6KL791K10I358_us-gaap_DepreciationAndAmortization" xml:lang="en-US">Depreciation, Depletion and Amortization, Nonproduction</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:label="lab_141438H6KL791K10I358_us-gaap_DepreciationAndAmortization" xml:lang="en-US">Depreciation and amortization</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/disclosureGuidance" xlink:label="lab_141438H6KL791K10I358_us-gaap_DepreciationAndAmortization" xml:lang="en-US">Depreciation and amortization</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_929216F4IJ579I98G136_us-gaap_DepreciationAndAmortization" xlink:to="lab_141438H6KL791K10I358_us-gaap_DepreciationAndAmortization"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_LitigationSettlementExpense" xlink:label="loc_350FKH75322F_us-gaap_LitigationSettlementExpense"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_572HMJ97544H_us-gaap_LitigationSettlementExpense" xml:lang="en-US">Litigation Settlement, Expense</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_572HMJ97544H_us-gaap_LitigationSettlementExpense" xml:lang="en-US">Lawsuit settlement</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_350FKH75322F_us-gaap_LitigationSettlementExpense" xlink:to="lab_572HMJ97544H_us-gaap_LitigationSettlementExpense"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_OtherGeneralAndAdministrativeExpense" xlink:label="loc_929216F4IJ579I98G136_us-gaap_OtherGeneralAndAdministrativeExpense"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_141438H6KL791K10I358_us-gaap_OtherGeneralAndAdministrativeExpense" xml:lang="en-US">Other General and Administrative Expense</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_141438H6KL791K10I358_us-gaap_OtherGeneralAndAdministrativeExpense" xml:lang="en-US">Other general and administrative expenses</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_929216F4IJ579I98G136_us-gaap_OtherGeneralAndAdministrativeExpense" xlink:to="lab_141438H6KL791K10I358_us-gaap_OtherGeneralAndAdministrativeExpense"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_OperatingExpenses" xlink:label="loc_350FKH75322F_us-gaap_OperatingExpenses"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_572HMJ97544H_us-gaap_OperatingExpenses" xml:lang="en-US">Operating expenses</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_572HMJ97544H_us-gaap_OperatingExpenses" xml:lang="en-US">Operating expenses</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:label="lab_572HMJ97544H_us-gaap_OperatingExpenses" xml:lang="en-US">OPERATING EXPENSES</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/totalLabel" xlink:label="lab_572HMJ97544H_us-gaap_OperatingExpenses" xml:lang="en-US">OPERATING EXPENSES</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2009/role/negatedLabel" xlink:label="lab_572HMJ97544H_us-gaap_OperatingExpenses" xml:lang="en-US">OPERATING EXPENSES</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_350FKH75322F_us-gaap_OperatingExpenses" xlink:to="lab_572HMJ97544H_us-gaap_OperatingExpenses"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_OperatingIncomeLoss" xlink:label="loc_929216F4IJ579I98G136_us-gaap_OperatingIncomeLoss"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_141438H6KL791K10I358_us-gaap_OperatingIncomeLoss" xml:lang="en-US">OperatingIncomeLoss</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_141438H6KL791K10I358_us-gaap_OperatingIncomeLoss" xml:lang="en-US">LOSS FROM OPERATIONS</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:label="lab_141438H6KL791K10I358_us-gaap_OperatingIncomeLoss" xml:lang="en-US">Loss from operations</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/totalLabel" xlink:label="lab_141438H6KL791K10I358_us-gaap_OperatingIncomeLoss" xml:lang="en-US">LOSS FROM OPERATIONS</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_929216F4IJ579I98G136_us-gaap_OperatingIncomeLoss" xlink:to="lab_141438H6KL791K10I358_us-gaap_OperatingIncomeLoss"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_OtherIncomeAndExpensesAbstract" xlink:label="loc_350FKH75322F_us-gaap_OtherIncomeAndExpensesAbstract"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_572HMJ97544H_us-gaap_OtherIncomeAndExpensesAbstract" xml:lang="en-US">OtherIncomeAndExpensesAbstract</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:label="lab_572HMJ97544H_us-gaap_OtherIncomeAndExpensesAbstract" xml:lang="en-US">OTHER INCOME (EXPENSE)</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_350FKH75322F_us-gaap_OtherIncomeAndExpensesAbstract" xlink:to="lab_572HMJ97544H_us-gaap_OtherIncomeAndExpensesAbstract"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_InvestmentIncomeInterest" xlink:label="loc_929216F4IJ579I98G136_us-gaap_InvestmentIncomeInterest"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_141438H6KL791K10I358_us-gaap_InvestmentIncomeInterest" xml:lang="en-US">Investment Income, Interest</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_141438H6KL791K10I358_us-gaap_InvestmentIncomeInterest" xml:lang="en-US">Interest income</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:label="lab_141438H6KL791K10I358_us-gaap_InvestmentIncomeInterest" xml:lang="en-US">Interest Income</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_929216F4IJ579I98G136_us-gaap_InvestmentIncomeInterest" xlink:to="lab_141438H6KL791K10I358_us-gaap_InvestmentIncomeInterest"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_InterestExpense" xlink:label="loc_350FKH75322F_us-gaap_InterestExpense"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_572HMJ97544H_us-gaap_InterestExpense" xml:lang="en-US">Interest Expense</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_572HMJ97544H_us-gaap_InterestExpense" xml:lang="en-US">Interest Expense</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_350FKH75322F_us-gaap_InterestExpense" xlink:to="lab_572HMJ97544H_us-gaap_InterestExpense"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_NonoperatingIncomeExpense" xlink:label="loc_929216F4IJ579I98G136_us-gaap_NonoperatingIncomeExpense"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_141438H6KL791K10I358_us-gaap_NonoperatingIncomeExpense" xml:lang="en-US">Nonoperating Income (Expense)</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/totalLabel" xlink:label="lab_141438H6KL791K10I358_us-gaap_NonoperatingIncomeExpense" xml:lang="en-US">TOTAL OTHER INCOME (EXPENSE)</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2009/role/negatedTotalLabel" xlink:label="lab_141438H6KL791K10I358_us-gaap_NonoperatingIncomeExpense" xml:lang="en-US">TOTAL OTHER INCOME (EXPENSE)</label>
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<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest" xlink:label="loc_350FKH75322F_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_572HMJ97544H_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest" xml:lang="en-US">Income (Loss) from Continuing Operations before Income Taxes, Noncontrolling Interest</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/totalLabel" xlink:label="lab_572HMJ97544H_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest" xml:lang="en-US">LOSS BEFORE PROVISION FOR INCOME TAXES</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_350FKH75322F_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest" xlink:to="lab_572HMJ97544H_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_IncomeTaxExpenseBenefit" xlink:label="loc_929216F4IJ579I98G136_us-gaap_IncomeTaxExpenseBenefit"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_141438H6KL791K10I358_us-gaap_IncomeTaxExpenseBenefit" xml:lang="en-US">Income Tax Expense (Benefit)</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:label="lab_141438H6KL791K10I358_us-gaap_IncomeTaxExpenseBenefit" xml:lang="en-US">PROVISION FOR INCOME TAXES</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_929216F4IJ579I98G136_us-gaap_IncomeTaxExpenseBenefit" xlink:to="lab_141438H6KL791K10I358_us-gaap_IncomeTaxExpenseBenefit"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_NetIncomeLoss" xlink:label="loc_350FKH75322F_us-gaap_NetIncomeLoss"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_572HMJ97544H_us-gaap_NetIncomeLoss" xml:lang="en-US">Net Income (Loss) Attributable to Parent</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_572HMJ97544H_us-gaap_NetIncomeLoss" xml:lang="en-US">Net loss for the period</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:label="lab_572HMJ97544H_us-gaap_NetIncomeLoss" xml:lang="en-US">NET LOSS</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/positiveLabel" xlink:label="lab_572HMJ97544H_us-gaap_NetIncomeLoss" xml:lang="en-US">Net loss</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/totalLabel" xlink:label="lab_572HMJ97544H_us-gaap_NetIncomeLoss" xml:lang="en-US">NET LOSS</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/definitionGuidance" xlink:label="lab_572HMJ97544H_us-gaap_NetIncomeLoss" xml:lang="en-US">Net loss for the year</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_350FKH75322F_us-gaap_NetIncomeLoss" xlink:to="lab_572HMJ97544H_us-gaap_NetIncomeLoss"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_EarningsPerShareBasicAndDilutedOtherDisclosuresAbstract" xlink:label="loc_929216F4IJ579I98G136_us-gaap_EarningsPerShareBasicAndDilutedOtherDisclosuresAbstract"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_141438H6KL791K10I358_us-gaap_EarningsPerShareBasicAndDilutedOtherDisclosuresAbstract" xml:lang="en-US">Earnings Per Share, Basic and Diluted, Other Disclosures [Abstract]</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_141438H6KL791K10I358_us-gaap_EarningsPerShareBasicAndDilutedOtherDisclosuresAbstract" xml:lang="en-US">WEIGHTED AVERAGE SHARES OUTSTANDING</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_929216F4IJ579I98G136_us-gaap_EarningsPerShareBasicAndDilutedOtherDisclosuresAbstract" xlink:to="lab_141438H6KL791K10I358_us-gaap_EarningsPerShareBasicAndDilutedOtherDisclosuresAbstract"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_WeightedAverageNumberOfShareOutstandingBasicAndDiluted" xlink:label="loc_350FKH75322F_us-gaap_WeightedAverageNumberOfShareOutstandingBasicAndDiluted"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_572HMJ97544H_us-gaap_WeightedAverageNumberOfShareOutstandingBasicAndDiluted" xml:lang="en-US">Weighted Average Number of Shares Outstanding, Basic and Diluted</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_572HMJ97544H_us-gaap_WeightedAverageNumberOfShareOutstandingBasicAndDiluted" xml:lang="en-US">BASIC AND DILUTED</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_350FKH75322F_us-gaap_WeightedAverageNumberOfShareOutstandingBasicAndDiluted" xlink:to="lab_572HMJ97544H_us-gaap_WeightedAverageNumberOfShareOutstandingBasicAndDiluted"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_EarningsPerShareAbstract" xlink:label="loc_929216F4IJ579I98G136_us-gaap_EarningsPerShareAbstract"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_141438H6KL791K10I358_us-gaap_EarningsPerShareAbstract" xml:lang="en-US">Earnings Per Share [Abstract]</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_141438H6KL791K10I358_us-gaap_EarningsPerShareAbstract" xml:lang="en-US">NET LOSS PER SHARE</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_929216F4IJ579I98G136_us-gaap_EarningsPerShareAbstract" xlink:to="lab_141438H6KL791K10I358_us-gaap_EarningsPerShareAbstract"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_EarningsPerShareBasicAndDiluted" xlink:label="loc_350FKH75322F_us-gaap_EarningsPerShareBasicAndDiluted"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_572HMJ97544H_us-gaap_EarningsPerShareBasicAndDiluted" xml:lang="en-US">Earnings Per Share, Basic and Diluted</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_572HMJ97544H_us-gaap_EarningsPerShareBasicAndDiluted" xml:lang="en-US">NET LOSS PER SHARE: BASIC &amp; DILUTIVE</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:label="lab_572HMJ97544H_us-gaap_EarningsPerShareBasicAndDiluted" xml:lang="en-US">BASIC AND DILUTED</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_350FKH75322F_us-gaap_EarningsPerShareBasicAndDiluted" xlink:to="lab_572HMJ97544H_us-gaap_EarningsPerShareBasicAndDiluted"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_StatementOfStockholdersEquityAbstract" xlink:label="loc_929216F4IJ579I98G136_us-gaap_StatementOfStockholdersEquityAbstract"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_141438H6KL791K10I358_us-gaap_StatementOfStockholdersEquityAbstract" xml:lang="en-US">Statement of Stockholders' Equity [Abstract]</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_929216F4IJ579I98G136_us-gaap_StatementOfStockholdersEquityAbstract" xlink:to="lab_141438H6KL791K10I358_us-gaap_StatementOfStockholdersEquityAbstract"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_StatementTable" xlink:label="loc_350FKH75322F_us-gaap_StatementTable"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_572HMJ97544H_us-gaap_StatementTable" xml:lang="en-US">Statement [Table]</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_350FKH75322F_us-gaap_StatementTable" xlink:to="lab_572HMJ97544H_us-gaap_StatementTable"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_StatementEquityComponentsAxis" xlink:label="loc_929216F4IJ579I98G136_us-gaap_StatementEquityComponentsAxis"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_141438H6KL791K10I358_us-gaap_StatementEquityComponentsAxis" xml:lang="en-US">Equity Components [Axis]</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_929216F4IJ579I98G136_us-gaap_StatementEquityComponentsAxis" xlink:to="lab_141438H6KL791K10I358_us-gaap_StatementEquityComponentsAxis"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_EquityComponentDomain" xlink:label="loc_350FKH75322F_us-gaap_EquityComponentDomain"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_572HMJ97544H_us-gaap_EquityComponentDomain" xml:lang="en-US">Equity Component [Domain]</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_350FKH75322F_us-gaap_EquityComponentDomain" xlink:to="lab_572HMJ97544H_us-gaap_EquityComponentDomain"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_PreferredStockMember" xlink:label="loc_929216F4IJ579I98G136_us-gaap_PreferredStockMember"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_141438H6KL791K10I358_us-gaap_PreferredStockMember" xml:lang="en-US">Preferred Stock [Member]</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_141438H6KL791K10I358_us-gaap_PreferredStockMember" xml:lang="en-US">Preferred Stock</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_929216F4IJ579I98G136_us-gaap_PreferredStockMember" xlink:to="lab_141438H6KL791K10I358_us-gaap_PreferredStockMember"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_CommonStockMember" xlink:label="loc_350FKH75322F_us-gaap_CommonStockMember"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_572HMJ97544H_us-gaap_CommonStockMember" xml:lang="en-US">Common Stock [Member]</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_572HMJ97544H_us-gaap_CommonStockMember" xml:lang="en-US">Common Stock [Member]</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/disclosureGuidance" xlink:label="lab_572HMJ97544H_us-gaap_CommonStockMember" xml:lang="en-US">Common Stock</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_350FKH75322F_us-gaap_CommonStockMember" xlink:to="lab_572HMJ97544H_us-gaap_CommonStockMember"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_WarrantMember" xlink:label="loc_929216F4IJ579I98G136_us-gaap_WarrantMember"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_141438H6KL791K10I358_us-gaap_WarrantMember" xml:lang="en-US">Warrant [Member]</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_141438H6KL791K10I358_us-gaap_WarrantMember" xml:lang="en-US">Stock Warrants</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:label="lab_141438H6KL791K10I358_us-gaap_WarrantMember" xml:lang="en-US">Warrant [Member]</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_929216F4IJ579I98G136_us-gaap_WarrantMember" xlink:to="lab_141438H6KL791K10I358_us-gaap_WarrantMember"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_AdditionalPaidInCapitalMember" xlink:label="loc_350FKH75322F_us-gaap_AdditionalPaidInCapitalMember"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_572HMJ97544H_us-gaap_AdditionalPaidInCapitalMember" xml:lang="en-US">Additional Paid-in Capital [Member]</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_572HMJ97544H_us-gaap_AdditionalPaidInCapitalMember" xml:lang="en-US">Additional Paid-in Capital</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_350FKH75322F_us-gaap_AdditionalPaidInCapitalMember" xlink:to="lab_572HMJ97544H_us-gaap_AdditionalPaidInCapitalMember"/>
<loc xlink:type="locator" xlink:href="oprx-20180331.xsd#oprx_StockPayableMember" xlink:label="loc_929216F4IJ579I98G136_oprx_StockPayableMember"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_141438H6KL791K10I358_oprx_StockPayableMember" xml:lang="en-US">Stock Payable [Member]</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:label="lab_141438H6KL791K10I358_oprx_StockPayableMember" xml:lang="en-US">Stock Payable</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:label="lab_141438H6KL791K10I358_oprx_StockPayableMember" xml:lang="en-US">Stock payable member.</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_929216F4IJ579I98G136_oprx_StockPayableMember" xlink:to="lab_141438H6KL791K10I358_oprx_StockPayableMember"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_DeferredCompensationShareBasedPaymentsMember" xlink:label="loc_350FKH75322F_us-gaap_DeferredCompensationShareBasedPaymentsMember"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_572HMJ97544H_us-gaap_DeferredCompensationShareBasedPaymentsMember" xml:lang="en-US">Deferred Compensation, Share-based Payments [Member]</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_572HMJ97544H_us-gaap_DeferredCompensationShareBasedPaymentsMember" xml:lang="en-US">Deferred Stock Compensation</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_350FKH75322F_us-gaap_DeferredCompensationShareBasedPaymentsMember" xlink:to="lab_572HMJ97544H_us-gaap_DeferredCompensationShareBasedPaymentsMember"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_RetainedEarningsMember" xlink:label="loc_929216F4IJ579I98G136_us-gaap_RetainedEarningsMember"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_141438H6KL791K10I358_us-gaap_RetainedEarningsMember" xml:lang="en-US">Retained Earnings [Member]</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_141438H6KL791K10I358_us-gaap_RetainedEarningsMember" xml:lang="en-US">Accumulated Deficit</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_929216F4IJ579I98G136_us-gaap_RetainedEarningsMember" xlink:to="lab_141438H6KL791K10I358_us-gaap_RetainedEarningsMember"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_StatementLineItems" xlink:label="loc_350FKH75322F_us-gaap_StatementLineItems"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_572HMJ97544H_us-gaap_StatementLineItems" xml:lang="en-US">Statement [Line Items]</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_350FKH75322F_us-gaap_StatementLineItems" xlink:to="lab_572HMJ97544H_us-gaap_StatementLineItems"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_SharesOutstanding" xlink:label="loc_929216F4IJ579I98G136_us-gaap_SharesOutstanding"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_141438H6KL791K10I358_us-gaap_SharesOutstanding" xml:lang="en-US">Shares, Outstanding</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/periodStartLabel" xlink:label="lab_141438H6KL791K10I358_us-gaap_SharesOutstanding" xml:lang="en-US">Balance, shares</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/periodEndLabel" xlink:label="lab_141438H6KL791K10I358_us-gaap_SharesOutstanding" xml:lang="en-US">Balance, shares</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_929216F4IJ579I98G136_us-gaap_SharesOutstanding" xlink:to="lab_141438H6KL791K10I358_us-gaap_SharesOutstanding"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_StockIssuedDuringPeriodValueEmployeeBenefitPlan" xlink:label="loc_350FKH75322F_us-gaap_StockIssuedDuringPeriodValueEmployeeBenefitPlan"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_572HMJ97544H_us-gaap_StockIssuedDuringPeriodValueEmployeeBenefitPlan" xml:lang="en-US">Stock Issued During Period, Value, Employee Benefit Plan</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_572HMJ97544H_us-gaap_StockIssuedDuringPeriodValueEmployeeBenefitPlan" xml:lang="en-US">Issuance of stock options to employees</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_350FKH75322F_us-gaap_StockIssuedDuringPeriodValueEmployeeBenefitPlan" xlink:to="lab_572HMJ97544H_us-gaap_StockIssuedDuringPeriodValueEmployeeBenefitPlan"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_StockIssuedDuringPeriodValueIssuedForServices" xlink:label="loc_929216F4IJ579I98G136_us-gaap_StockIssuedDuringPeriodValueIssuedForServices"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_141438H6KL791K10I358_us-gaap_StockIssuedDuringPeriodValueIssuedForServices" xml:lang="en-US">Stock Issued During Period, Value, Issued for Services</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_141438H6KL791K10I358_us-gaap_StockIssuedDuringPeriodValueIssuedForServices" xml:lang="en-US">Issuance of common stock: for services</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:label="lab_141438H6KL791K10I358_us-gaap_StockIssuedDuringPeriodValueIssuedForServices" xml:lang="en-US">Issuance of common stock for services</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/definitionGuidance" xlink:label="lab_141438H6KL791K10I358_us-gaap_StockIssuedDuringPeriodValueIssuedForServices" xml:lang="en-US">Gross proceeds</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_929216F4IJ579I98G136_us-gaap_StockIssuedDuringPeriodValueIssuedForServices" xlink:to="lab_141438H6KL791K10I358_us-gaap_StockIssuedDuringPeriodValueIssuedForServices"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_StockIssuedDuringPeriodSharesIssuedForServices" xlink:label="loc_350FKH75322F_us-gaap_StockIssuedDuringPeriodSharesIssuedForServices"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_572HMJ97544H_us-gaap_StockIssuedDuringPeriodSharesIssuedForServices" xml:lang="en-US">Stock Issued During Period, Shares, Issued for Services</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_572HMJ97544H_us-gaap_StockIssuedDuringPeriodSharesIssuedForServices" xml:lang="en-US">Issuance of common stock: for services, shares</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_350FKH75322F_us-gaap_StockIssuedDuringPeriodSharesIssuedForServices" xlink:to="lab_572HMJ97544H_us-gaap_StockIssuedDuringPeriodSharesIssuedForServices"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_StockIssuedDuringPeriodValueNewIssues" xlink:label="loc_929216F4IJ579I98G136_us-gaap_StockIssuedDuringPeriodValueNewIssues"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_141438H6KL791K10I358_us-gaap_StockIssuedDuringPeriodValueNewIssues" xml:lang="en-US">Stock Issued During Period, Value, New Issues</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_141438H6KL791K10I358_us-gaap_StockIssuedDuringPeriodValueNewIssues" xml:lang="en-US">Common stock issued, values</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:label="lab_141438H6KL791K10I358_us-gaap_StockIssuedDuringPeriodValueNewIssues" xml:lang="en-US">Proceeds of common stock</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/zeroVerboseLabel" xlink:label="lab_141438H6KL791K10I358_us-gaap_StockIssuedDuringPeriodValueNewIssues" xml:lang="en-US">Exchange shares of common stock, value</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/disclosureGuidance" xlink:label="lab_141438H6KL791K10I358_us-gaap_StockIssuedDuringPeriodValueNewIssues" xml:lang="en-US">Issuance of common stock: for cash</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_929216F4IJ579I98G136_us-gaap_StockIssuedDuringPeriodValueNewIssues" xlink:to="lab_141438H6KL791K10I358_us-gaap_StockIssuedDuringPeriodValueNewIssues"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_StockIssuedDuringPeriodSharesNewIssues" xlink:label="loc_350FKH75322F_us-gaap_StockIssuedDuringPeriodSharesNewIssues"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_572HMJ97544H_us-gaap_StockIssuedDuringPeriodSharesNewIssues" xml:lang="en-US">Stock Issued During Period, Shares, New Issues</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_572HMJ97544H_us-gaap_StockIssuedDuringPeriodSharesNewIssues" xml:lang="en-US">Common stock issued, Shares</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:label="lab_572HMJ97544H_us-gaap_StockIssuedDuringPeriodSharesNewIssues" xml:lang="en-US">Shares of common stock proceeds to retire a stock payable</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/positiveLabel" xlink:label="lab_572HMJ97544H_us-gaap_StockIssuedDuringPeriodSharesNewIssues" xml:lang="en-US">Common stock issued to an unrelated party</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/zeroTerseLabel" xlink:label="lab_572HMJ97544H_us-gaap_StockIssuedDuringPeriodSharesNewIssues" xml:lang="en-US">Exchange shares of common stock</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/definitionGuidance" xlink:label="lab_572HMJ97544H_us-gaap_StockIssuedDuringPeriodSharesNewIssues" xml:lang="en-US">Issuance of common stock: for cash, shares</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/disclosureGuidance" xlink:label="lab_572HMJ97544H_us-gaap_StockIssuedDuringPeriodSharesNewIssues" xml:lang="en-US">Issuance of common stock: for cash shares</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/presentationGuidance" xlink:label="lab_572HMJ97544H_us-gaap_StockIssuedDuringPeriodSharesNewIssues" xml:lang="en-US">Common stock shares issued to former CEO</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/measurementGuidance" xlink:label="lab_572HMJ97544H_us-gaap_StockIssuedDuringPeriodSharesNewIssues" xml:lang="en-US">Common stock issued, shares</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_350FKH75322F_us-gaap_StockIssuedDuringPeriodSharesNewIssues" xlink:to="lab_572HMJ97544H_us-gaap_StockIssuedDuringPeriodSharesNewIssues"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_StockIssuedDuringPeriodValueStockOptionsExercised" xlink:label="loc_929216F4IJ579I98G136_us-gaap_StockIssuedDuringPeriodValueStockOptionsExercised"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_141438H6KL791K10I358_us-gaap_StockIssuedDuringPeriodValueStockOptionsExercised" xml:lang="en-US">Stock Issued During Period, Value, Stock Options Exercised</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_141438H6KL791K10I358_us-gaap_StockIssuedDuringPeriodValueStockOptionsExercised" xml:lang="en-US">Issuance of common stock: for options</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_929216F4IJ579I98G136_us-gaap_StockIssuedDuringPeriodValueStockOptionsExercised" xlink:to="lab_141438H6KL791K10I358_us-gaap_StockIssuedDuringPeriodValueStockOptionsExercised"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_StockIssuedDuringPeriodSharesStockOptionsExercised" xlink:label="loc_350FKH75322F_us-gaap_StockIssuedDuringPeriodSharesStockOptionsExercised"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_572HMJ97544H_us-gaap_StockIssuedDuringPeriodSharesStockOptionsExercised" xml:lang="en-US">Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercises in Period</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_572HMJ97544H_us-gaap_StockIssuedDuringPeriodSharesStockOptionsExercised" xml:lang="en-US">Issuance of common stock: for options, shares</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:label="lab_572HMJ97544H_us-gaap_StockIssuedDuringPeriodSharesStockOptionsExercised" xml:lang="en-US">Options, exercises in period</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2009/role/negatedLabel" xlink:label="lab_572HMJ97544H_us-gaap_StockIssuedDuringPeriodSharesStockOptionsExercised" xml:lang="en-US">Exercised</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_350FKH75322F_us-gaap_StockIssuedDuringPeriodSharesStockOptionsExercised" xlink:to="lab_572HMJ97544H_us-gaap_StockIssuedDuringPeriodSharesStockOptionsExercised"/>
<loc xlink:type="locator" xlink:href="oprx-20180331.xsd#oprx_StockIssuedDuringPeriodValueForLitigationSettlement" xlink:label="loc_929216F4IJ579I98G136_oprx_StockIssuedDuringPeriodValueForLitigationSettlement"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_141438H6KL791K10I358_oprx_StockIssuedDuringPeriodValueForLitigationSettlement" xml:lang="en-US">Stock Issued During Period Value For Litigation Settlement</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_141438H6KL791K10I358_oprx_StockIssuedDuringPeriodValueForLitigationSettlement" xml:lang="en-US">Issuance of common stock: for litigation settlement</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:label="lab_141438H6KL791K10I358_oprx_StockIssuedDuringPeriodValueForLitigationSettlement" xml:lang="en-US">The value of shares issued for litigation settlement.</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_929216F4IJ579I98G136_oprx_StockIssuedDuringPeriodValueForLitigationSettlement" xlink:to="lab_141438H6KL791K10I358_oprx_StockIssuedDuringPeriodValueForLitigationSettlement"/>
<loc xlink:type="locator" xlink:href="oprx-20180331.xsd#oprx_StockIssuedDuringPeriodSharesForLitigationSettlement" xlink:label="loc_350FKH75322F_oprx_StockIssuedDuringPeriodSharesForLitigationSettlement"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_572HMJ97544H_oprx_StockIssuedDuringPeriodSharesForLitigationSettlement" xml:lang="en-US">Stock Issued During Period Shares For Litigation Settlement</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_572HMJ97544H_oprx_StockIssuedDuringPeriodSharesForLitigationSettlement" xml:lang="en-US">Issuance of common stock: for litigation settlement, shares</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:label="lab_572HMJ97544H_oprx_StockIssuedDuringPeriodSharesForLitigationSettlement" xml:lang="en-US">Number of shares issued for litigation settlement.</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_350FKH75322F_oprx_StockIssuedDuringPeriodSharesForLitigationSettlement" xlink:to="lab_572HMJ97544H_oprx_StockIssuedDuringPeriodSharesForLitigationSettlement"/>
<loc xlink:type="locator" xlink:href="oprx-20180331.xsd#oprx_StockIssuedDuringPeriodValueForStockPayable" xlink:label="loc_929216F4IJ579I98G136_oprx_StockIssuedDuringPeriodValueForStockPayable"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_141438H6KL791K10I358_oprx_StockIssuedDuringPeriodValueForStockPayable" xml:lang="en-US">Stock Issued During Period Value For Stock Payable</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_141438H6KL791K10I358_oprx_StockIssuedDuringPeriodValueForStockPayable" xml:lang="en-US">Issue shares for stock payable</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:label="lab_141438H6KL791K10I358_oprx_StockIssuedDuringPeriodValueForStockPayable" xml:lang="en-US">The value of shares issued for stock payable.</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_929216F4IJ579I98G136_oprx_StockIssuedDuringPeriodValueForStockPayable" xlink:to="lab_141438H6KL791K10I358_oprx_StockIssuedDuringPeriodValueForStockPayable"/>
<loc xlink:type="locator" xlink:href="oprx-20180331.xsd#oprx_StockIssuedDuringPeriodSharesForStockPayable" xlink:label="loc_350FKH75322F_oprx_StockIssuedDuringPeriodSharesForStockPayable"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_572HMJ97544H_oprx_StockIssuedDuringPeriodSharesForStockPayable" xml:lang="en-US">Stock Issued During Period Shares For Stock Payable</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_572HMJ97544H_oprx_StockIssuedDuringPeriodSharesForStockPayable" xml:lang="en-US">Issue shares for stock payable, shares</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:label="lab_572HMJ97544H_oprx_StockIssuedDuringPeriodSharesForStockPayable" xml:lang="en-US">Nmber of shares issued for stock payable.</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_350FKH75322F_oprx_StockIssuedDuringPeriodSharesForStockPayable" xlink:to="lab_572HMJ97544H_oprx_StockIssuedDuringPeriodSharesForStockPayable"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_StockRedeemedOrCalledDuringPeriodValue" xlink:label="loc_929216F4IJ579I98G136_us-gaap_StockRedeemedOrCalledDuringPeriodValue"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_141438H6KL791K10I358_us-gaap_StockRedeemedOrCalledDuringPeriodValue" xml:lang="en-US">Stock Redeemed or Called During Period, Value</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:label="lab_141438H6KL791K10I358_us-gaap_StockRedeemedOrCalledDuringPeriodValue" xml:lang="en-US">Total redeemed share value</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/definitionGuidance" xlink:label="lab_141438H6KL791K10I358_us-gaap_StockRedeemedOrCalledDuringPeriodValue" xml:lang="en-US">Shares payable redeemed for cash</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/disclosureGuidance" xlink:label="lab_141438H6KL791K10I358_us-gaap_StockRedeemedOrCalledDuringPeriodValue" xml:lang="en-US">Shares redeemed for cash</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/presentationGuidance" xlink:label="lab_141438H6KL791K10I358_us-gaap_StockRedeemedOrCalledDuringPeriodValue" xml:lang="en-US">Shares payable redeemed for cash</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_929216F4IJ579I98G136_us-gaap_StockRedeemedOrCalledDuringPeriodValue" xlink:to="lab_141438H6KL791K10I358_us-gaap_StockRedeemedOrCalledDuringPeriodValue"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_StockRedeemedOrCalledDuringPeriodShares" xlink:label="loc_350FKH75322F_us-gaap_StockRedeemedOrCalledDuringPeriodShares"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_572HMJ97544H_us-gaap_StockRedeemedOrCalledDuringPeriodShares" xml:lang="en-US">Stock Redeemed or Called During Period, Shares</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_572HMJ97544H_us-gaap_StockRedeemedOrCalledDuringPeriodShares" xml:lang="en-US">Shares redeemed for cash, shares</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:label="lab_572HMJ97544H_us-gaap_StockRedeemedOrCalledDuringPeriodShares" xml:lang="en-US">Shares redeemed</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/disclosureGuidance" xlink:label="lab_572HMJ97544H_us-gaap_StockRedeemedOrCalledDuringPeriodShares" xml:lang="en-US">Redeem shares for cash, shares</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_350FKH75322F_us-gaap_StockRedeemedOrCalledDuringPeriodShares" xlink:to="lab_572HMJ97544H_us-gaap_StockRedeemedOrCalledDuringPeriodShares"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_AdjustmentsToAdditionalPaidInCapitalWarrantIssued" xlink:label="loc_929216F4IJ579I98G136_us-gaap_AdjustmentsToAdditionalPaidInCapitalWarrantIssued"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_141438H6KL791K10I358_us-gaap_AdjustmentsToAdditionalPaidInCapitalWarrantIssued" xml:lang="en-US">Adjustments to Additional Paid in Capital, Warrant Issued</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_141438H6KL791K10I358_us-gaap_AdjustmentsToAdditionalPaidInCapitalWarrantIssued" xml:lang="en-US">Expiration of Warrants</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_929216F4IJ579I98G136_us-gaap_AdjustmentsToAdditionalPaidInCapitalWarrantIssued" xlink:to="lab_141438H6KL791K10I358_us-gaap_AdjustmentsToAdditionalPaidInCapitalWarrantIssued"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_DeferredCompensationArrangementWithIndividualCompensationExpense" xlink:label="loc_350FKH75322F_us-gaap_DeferredCompensationArrangementWithIndividualCompensationExpense"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_572HMJ97544H_us-gaap_DeferredCompensationArrangementWithIndividualCompensationExpense" xml:lang="en-US">Deferred Compensation Arrangement with Individual, Compensation Expense</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_572HMJ97544H_us-gaap_DeferredCompensationArrangementWithIndividualCompensationExpense" xml:lang="en-US">Expense consulting services</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_350FKH75322F_us-gaap_DeferredCompensationArrangementWithIndividualCompensationExpense" xlink:to="lab_572HMJ97544H_us-gaap_DeferredCompensationArrangementWithIndividualCompensationExpense"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_StatementOfCashFlowsAbstract" xlink:label="loc_929216F4IJ579I98G136_us-gaap_StatementOfCashFlowsAbstract"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_141438H6KL791K10I358_us-gaap_StatementOfCashFlowsAbstract" xml:lang="en-US">Statements of Cash Flows [Abstract]</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_929216F4IJ579I98G136_us-gaap_StatementOfCashFlowsAbstract" xlink:to="lab_141438H6KL791K10I358_us-gaap_StatementOfCashFlowsAbstract"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivitiesAbstract" xlink:label="loc_350FKH75322F_us-gaap_NetCashProvidedByUsedInOperatingActivitiesAbstract"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_572HMJ97544H_us-gaap_NetCashProvidedByUsedInOperatingActivitiesAbstract" xml:lang="en-US">Net Cash Provided by (Used in) Operating Activities [Abstract]</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:label="lab_572HMJ97544H_us-gaap_NetCashProvidedByUsedInOperatingActivitiesAbstract" xml:lang="en-US">CASH FLOWS FROM OPERATING ACTIVITIES:</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_350FKH75322F_us-gaap_NetCashProvidedByUsedInOperatingActivitiesAbstract" xlink:to="lab_572HMJ97544H_us-gaap_NetCashProvidedByUsedInOperatingActivitiesAbstract"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract" xlink:label="loc_929216F4IJ579I98G136_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_141438H6KL791K10I358_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract" xml:lang="en-US">AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_141438H6KL791K10I358_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract" xml:lang="en-US">Adjustments to reconcile net loss to net cash provided by (used in) operating activities:</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:label="lab_141438H6KL791K10I358_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract" xml:lang="en-US">Adjustments to reconcile net loss to net cash used in operating activities:</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_929216F4IJ579I98G136_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract" xlink:to="lab_141438H6KL791K10I358_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_GainLossOnDispositionOfAssets1" xlink:label="loc_350FKH75322F_us-gaap_GainLossOnDispositionOfAssets1"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_572HMJ97544H_us-gaap_GainLossOnDispositionOfAssets1" xml:lang="en-US">Gain (Loss) on Disposition of Assets</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_572HMJ97544H_us-gaap_GainLossOnDispositionOfAssets1" xml:lang="en-US">Loss on disposal of assets</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2009/role/negatedLabel" xlink:label="lab_572HMJ97544H_us-gaap_GainLossOnDispositionOfAssets1" xml:lang="en-US">Loss on disposal of assets</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_350FKH75322F_us-gaap_GainLossOnDispositionOfAssets1" xlink:to="lab_572HMJ97544H_us-gaap_GainLossOnDispositionOfAssets1"/>
<loc xlink:type="locator" xlink:href="oprx-20180331.xsd#oprx_StockOptionsIssuedForServices" xlink:label="loc_929216F4IJ579I98G136_oprx_StockOptionsIssuedForServices"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_141438H6KL791K10I358_oprx_StockOptionsIssuedForServices" xml:lang="en-US">Stock Options Issued For Services</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_141438H6KL791K10I358_oprx_StockOptionsIssuedForServices" xml:lang="en-US">Stock options issued for services</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:label="lab_141438H6KL791K10I358_oprx_StockOptionsIssuedForServices" xml:lang="en-US">Amount of stock options issued for services.</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2009/role/negatedLabel" xlink:label="lab_141438H6KL791K10I358_oprx_StockOptionsIssuedForServices" xml:lang="en-US">Stock and options issued for services</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_929216F4IJ579I98G136_oprx_StockOptionsIssuedForServices" xlink:to="lab_141438H6KL791K10I358_oprx_StockOptionsIssuedForServices"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_ShareBasedCompensation" xlink:label="loc_350FKH75322F_us-gaap_ShareBasedCompensation"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_572HMJ97544H_us-gaap_ShareBasedCompensation" xml:lang="en-US">Share-based Compensation</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_572HMJ97544H_us-gaap_ShareBasedCompensation" xml:lang="en-US">Stock-based compensation</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:label="lab_572HMJ97544H_us-gaap_ShareBasedCompensation" xml:lang="en-US">Compensation expense</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/definitionGuidance" xlink:label="lab_572HMJ97544H_us-gaap_ShareBasedCompensation" xml:lang="en-US">Common stock to be issued as compensation</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_350FKH75322F_us-gaap_ShareBasedCompensation" xlink:to="lab_572HMJ97544H_us-gaap_ShareBasedCompensation"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_IncreaseDecreaseInOperatingCapitalAbstract" xlink:label="loc_929216F4IJ579I98G136_us-gaap_IncreaseDecreaseInOperatingCapitalAbstract"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_141438H6KL791K10I358_us-gaap_IncreaseDecreaseInOperatingCapitalAbstract" xml:lang="en-US">Increase (Decrease) in Operating Capital [Abstract]</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:label="lab_141438H6KL791K10I358_us-gaap_IncreaseDecreaseInOperatingCapitalAbstract" xml:lang="en-US">Changes in:</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_929216F4IJ579I98G136_us-gaap_IncreaseDecreaseInOperatingCapitalAbstract" xlink:to="lab_141438H6KL791K10I358_us-gaap_IncreaseDecreaseInOperatingCapitalAbstract"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_IncreaseDecreaseInAccountsReceivable" xlink:label="loc_350FKH75322F_us-gaap_IncreaseDecreaseInAccountsReceivable"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_572HMJ97544H_us-gaap_IncreaseDecreaseInAccountsReceivable" xml:lang="en-US">IncreaseDecreaseInAccountsReceivable</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_572HMJ97544H_us-gaap_IncreaseDecreaseInAccountsReceivable" xml:lang="en-US">Decrease in accounts receivable</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:label="lab_572HMJ97544H_us-gaap_IncreaseDecreaseInAccountsReceivable" xml:lang="en-US">Accounts receivable</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2009/role/negatedLabel" xlink:label="lab_572HMJ97544H_us-gaap_IncreaseDecreaseInAccountsReceivable" xml:lang="en-US">Accounts receivable</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_350FKH75322F_us-gaap_IncreaseDecreaseInAccountsReceivable" xlink:to="lab_572HMJ97544H_us-gaap_IncreaseDecreaseInAccountsReceivable"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_IncreaseDecreaseInAccountsReceivableRelatedParties" xlink:label="loc_929216F4IJ579I98G136_us-gaap_IncreaseDecreaseInAccountsReceivableRelatedParties"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_141438H6KL791K10I358_us-gaap_IncreaseDecreaseInAccountsReceivableRelatedParties" xml:lang="en-US">Increase (Decrease) in Accounts Receivable, Related Parties</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_141438H6KL791K10I358_us-gaap_IncreaseDecreaseInAccountsReceivableRelatedParties" xml:lang="en-US">Accounts receivable related party</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2009/role/negatedLabel" xlink:label="lab_141438H6KL791K10I358_us-gaap_IncreaseDecreaseInAccountsReceivableRelatedParties" xml:lang="en-US">Accounts receivable related party</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_929216F4IJ579I98G136_us-gaap_IncreaseDecreaseInAccountsReceivableRelatedParties" xlink:to="lab_141438H6KL791K10I358_us-gaap_IncreaseDecreaseInAccountsReceivableRelatedParties"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_IncreaseDecreaseInPrepaidExpense" xlink:label="loc_350FKH75322F_us-gaap_IncreaseDecreaseInPrepaidExpense"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_572HMJ97544H_us-gaap_IncreaseDecreaseInPrepaidExpense" xml:lang="en-US">Increase (Decrease) in Prepaid Expense</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2009/role/negatedLabel" xlink:label="lab_572HMJ97544H_us-gaap_IncreaseDecreaseInPrepaidExpense" xml:lang="en-US">Prepaid expenses</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_350FKH75322F_us-gaap_IncreaseDecreaseInPrepaidExpense" xlink:to="lab_572HMJ97544H_us-gaap_IncreaseDecreaseInPrepaidExpense"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_IncreaseDecreaseInAccountsPayable" xlink:label="loc_929216F4IJ579I98G136_us-gaap_IncreaseDecreaseInAccountsPayable"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_141438H6KL791K10I358_us-gaap_IncreaseDecreaseInAccountsPayable" xml:lang="en-US">IncreaseDecreaseInAccountsPayable</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_141438H6KL791K10I358_us-gaap_IncreaseDecreaseInAccountsPayable" xml:lang="en-US">Decrease in accounts payable</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:label="lab_141438H6KL791K10I358_us-gaap_IncreaseDecreaseInAccountsPayable" xml:lang="en-US">Accounts payable</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_929216F4IJ579I98G136_us-gaap_IncreaseDecreaseInAccountsPayable" xlink:to="lab_141438H6KL791K10I358_us-gaap_IncreaseDecreaseInAccountsPayable"/>
<loc xlink:type="locator" xlink:href="oprx-20180331.xsd#oprx_IncreaseDecreaseInRevenueSharePayable" xlink:label="loc_350FKH75322F_oprx_IncreaseDecreaseInRevenueSharePayable"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_572HMJ97544H_oprx_IncreaseDecreaseInRevenueSharePayable" xml:lang="en-US">Increase Decrease In Revenue Share Payable</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_572HMJ97544H_oprx_IncreaseDecreaseInRevenueSharePayable" xml:lang="en-US">Decrease in revenue share payable</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:label="lab_572HMJ97544H_oprx_IncreaseDecreaseInRevenueSharePayable" xml:lang="en-US">Revenue share payable</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:label="lab_572HMJ97544H_oprx_IncreaseDecreaseInRevenueSharePayable" xml:lang="en-US">The increase (decrease) during the reporting period in revenue share payable.</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2009/role/negatedLabel" xlink:label="lab_572HMJ97544H_oprx_IncreaseDecreaseInRevenueSharePayable" xml:lang="en-US">Revenue share payable</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_350FKH75322F_oprx_IncreaseDecreaseInRevenueSharePayable" xlink:to="lab_572HMJ97544H_oprx_IncreaseDecreaseInRevenueSharePayable"/>
<loc xlink:type="locator" xlink:href="oprx-20180331.xsd#oprx_IncreaseDecreaseInRevenueSharePayableRelatedParty" xlink:label="loc_929216F4IJ579I98G136_oprx_IncreaseDecreaseInRevenueSharePayableRelatedParty"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_141438H6KL791K10I358_oprx_IncreaseDecreaseInRevenueSharePayableRelatedParty" xml:lang="en-US">Increase Decrease In Revenue Share Payable Related Party</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_141438H6KL791K10I358_oprx_IncreaseDecreaseInRevenueSharePayableRelatedParty" xml:lang="en-US">Revenue share payable - related party</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:label="lab_141438H6KL791K10I358_oprx_IncreaseDecreaseInRevenueSharePayableRelatedParty" xml:lang="en-US">Increase Decrease In Revenue Share Payable Related Party.</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2009/role/negatedLabel" xlink:label="lab_141438H6KL791K10I358_oprx_IncreaseDecreaseInRevenueSharePayableRelatedParty" xml:lang="en-US">Revenue share payable - related party</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_929216F4IJ579I98G136_oprx_IncreaseDecreaseInRevenueSharePayableRelatedParty" xlink:to="lab_141438H6KL791K10I358_oprx_IncreaseDecreaseInRevenueSharePayableRelatedParty"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_IncreaseDecreaseInAccruedLiabilities" xlink:label="loc_350FKH75322F_us-gaap_IncreaseDecreaseInAccruedLiabilities"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_572HMJ97544H_us-gaap_IncreaseDecreaseInAccruedLiabilities" xml:lang="en-US">IncreaseDecreaseInAccruedLiabilities</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:label="lab_572HMJ97544H_us-gaap_IncreaseDecreaseInAccruedLiabilities" xml:lang="en-US">Accrued expenses</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_350FKH75322F_us-gaap_IncreaseDecreaseInAccruedLiabilities" xlink:to="lab_572HMJ97544H_us-gaap_IncreaseDecreaseInAccruedLiabilities"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_IncreaseDecreaseInDeferredRevenue" xlink:label="loc_929216F4IJ579I98G136_us-gaap_IncreaseDecreaseInDeferredRevenue"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_141438H6KL791K10I358_us-gaap_IncreaseDecreaseInDeferredRevenue" xml:lang="en-US">Increase in deferred revenue</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_141438H6KL791K10I358_us-gaap_IncreaseDecreaseInDeferredRevenue" xml:lang="en-US">Increase in deferred revenue</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:label="lab_141438H6KL791K10I358_us-gaap_IncreaseDecreaseInDeferredRevenue" xml:lang="en-US">Deferred revenue</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/definitionGuidance" xlink:label="lab_141438H6KL791K10I358_us-gaap_IncreaseDecreaseInDeferredRevenue" xml:lang="en-US">Decrease in deferred revenue</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_929216F4IJ579I98G136_us-gaap_IncreaseDecreaseInDeferredRevenue" xlink:to="lab_141438H6KL791K10I358_us-gaap_IncreaseDecreaseInDeferredRevenue"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivities" xlink:label="loc_350FKH75322F_us-gaap_NetCashProvidedByUsedInOperatingActivities"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_572HMJ97544H_us-gaap_NetCashProvidedByUsedInOperatingActivities" xml:lang="en-US">Net Cash Provided by (Used in) Operating Activities</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/totalLabel" xlink:label="lab_572HMJ97544H_us-gaap_NetCashProvidedByUsedInOperatingActivities" xml:lang="en-US">NET CASH USED IN OPERATING ACTIVITIES</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_350FKH75322F_us-gaap_NetCashProvidedByUsedInOperatingActivities" xlink:to="lab_572HMJ97544H_us-gaap_NetCashProvidedByUsedInOperatingActivities"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract" xlink:label="loc_929216F4IJ579I98G136_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_141438H6KL791K10I358_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract" xml:lang="en-US">Net Cash Provided by (Used in) Investing Activities [Abstract]</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:label="lab_141438H6KL791K10I358_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract" xml:lang="en-US">CASH FLOWS FROM INVESTING ACTIVITIES:</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_929216F4IJ579I98G136_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract" xlink:to="lab_141438H6KL791K10I358_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_PaymentsToAcquirePropertyPlantAndEquipment" xlink:label="loc_350FKH75322F_us-gaap_PaymentsToAcquirePropertyPlantAndEquipment"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_572HMJ97544H_us-gaap_PaymentsToAcquirePropertyPlantAndEquipment" xml:lang="en-US">Payments to Acquire Property, Plant, and Equipment</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_572HMJ97544H_us-gaap_PaymentsToAcquirePropertyPlantAndEquipment" xml:lang="en-US">Purchase of property and equipment</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2009/role/negatedLabel" xlink:label="lab_572HMJ97544H_us-gaap_PaymentsToAcquirePropertyPlantAndEquipment" xml:lang="en-US">Equipment</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_350FKH75322F_us-gaap_PaymentsToAcquirePropertyPlantAndEquipment" xlink:to="lab_572HMJ97544H_us-gaap_PaymentsToAcquirePropertyPlantAndEquipment"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_PaymentsForProceedsFromRemovalCosts" xlink:label="loc_929216F4IJ579I98G136_us-gaap_PaymentsForProceedsFromRemovalCosts"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_141438H6KL791K10I358_us-gaap_PaymentsForProceedsFromRemovalCosts" xml:lang="en-US">Payments for (Proceeds from) Removal Costs</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_141438H6KL791K10I358_us-gaap_PaymentsForProceedsFromRemovalCosts" xml:lang="en-US">Development costs</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2009/role/negatedLabel" xlink:label="lab_141438H6KL791K10I358_us-gaap_PaymentsForProceedsFromRemovalCosts" xml:lang="en-US">Development costs</label>
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<loc xlink:type="locator" xlink:href="oprx-20180331.xsd#oprx_PaymentsToAcquirePatientRights" xlink:label="loc_350FKH75322F_oprx_PaymentsToAcquirePatientRights"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_572HMJ97544H_oprx_PaymentsToAcquirePatientRights" xml:lang="en-US">Payments To Acquire Patient Rights</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:label="lab_572HMJ97544H_oprx_PaymentsToAcquirePatientRights" xml:lang="en-US">The cash outflow associated with the acquisition of patient rights.</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2009/role/negatedLabel" xlink:label="lab_572HMJ97544H_oprx_PaymentsToAcquirePatientRights" xml:lang="en-US">Patent rights</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_350FKH75322F_oprx_PaymentsToAcquirePatientRights" xlink:to="lab_572HMJ97544H_oprx_PaymentsToAcquirePatientRights"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_PaymentsToAcquireIntangibleAssets" xlink:label="loc_929216F4IJ579I98G136_us-gaap_PaymentsToAcquireIntangibleAssets"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_141438H6KL791K10I358_us-gaap_PaymentsToAcquireIntangibleAssets" xml:lang="en-US">Payments to Acquire Intangible Assets</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2009/role/negatedLabel" xlink:label="lab_141438H6KL791K10I358_us-gaap_PaymentsToAcquireIntangibleAssets" xml:lang="en-US">Intangible Assets</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_929216F4IJ579I98G136_us-gaap_PaymentsToAcquireIntangibleAssets" xlink:to="lab_141438H6KL791K10I358_us-gaap_PaymentsToAcquireIntangibleAssets"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivities" xlink:label="loc_350FKH75322F_us-gaap_NetCashProvidedByUsedInInvestingActivities"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_572HMJ97544H_us-gaap_NetCashProvidedByUsedInInvestingActivities" xml:lang="en-US">Net Cash Provided by (Used in) Investing Activities</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/totalLabel" xlink:label="lab_572HMJ97544H_us-gaap_NetCashProvidedByUsedInInvestingActivities" xml:lang="en-US">NET CASH USED IN INVESTING ACTIVITIES</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_350FKH75322F_us-gaap_NetCashProvidedByUsedInInvestingActivities" xlink:to="lab_572HMJ97544H_us-gaap_NetCashProvidedByUsedInInvestingActivities"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract" xlink:label="loc_929216F4IJ579I98G136_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_141438H6KL791K10I358_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract" xml:lang="en-US">Net Cash Provided by (Used in) Financing Activities [Abstract]</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:label="lab_141438H6KL791K10I358_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract" xml:lang="en-US">CASH FLOWS FROM FINANCING ACTIVITIES:</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_929216F4IJ579I98G136_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract" xlink:to="lab_141438H6KL791K10I358_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_ProceedsFromIssuanceOfCommonStock" xlink:label="loc_350FKH75322F_us-gaap_ProceedsFromIssuanceOfCommonStock"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_572HMJ97544H_us-gaap_ProceedsFromIssuanceOfCommonStock" xml:lang="en-US">Proceeds from Issuance of Common Stock</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_572HMJ97544H_us-gaap_ProceedsFromIssuanceOfCommonStock" xml:lang="en-US">Issuance of common stock</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:label="lab_572HMJ97544H_us-gaap_ProceedsFromIssuanceOfCommonStock" xml:lang="en-US">Proceeds from issuance of common stock</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/definitionGuidance" xlink:label="lab_572HMJ97544H_us-gaap_ProceedsFromIssuanceOfCommonStock" xml:lang="en-US">Net proceeds of common stock amount</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_350FKH75322F_us-gaap_ProceedsFromIssuanceOfCommonStock" xlink:to="lab_572HMJ97544H_us-gaap_ProceedsFromIssuanceOfCommonStock"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_PaymentsForRepurchaseOfCommonStock" xlink:label="loc_929216F4IJ579I98G136_us-gaap_PaymentsForRepurchaseOfCommonStock"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_141438H6KL791K10I358_us-gaap_PaymentsForRepurchaseOfCommonStock" xml:lang="en-US">Payments for Repurchase of Common Stock</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_141438H6KL791K10I358_us-gaap_PaymentsForRepurchaseOfCommonStock" xml:lang="en-US">Common stock payable amount</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:label="lab_141438H6KL791K10I358_us-gaap_PaymentsForRepurchaseOfCommonStock" xml:lang="en-US">Common stock payable Amount</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/definitionGuidance" xlink:label="lab_141438H6KL791K10I358_us-gaap_PaymentsForRepurchaseOfCommonStock" xml:lang="en-US">Value of common stock</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2009/role/negatedLabel" xlink:label="lab_141438H6KL791K10I358_us-gaap_PaymentsForRepurchaseOfCommonStock" xml:lang="en-US">Redemption of common stock</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_929216F4IJ579I98G136_us-gaap_PaymentsForRepurchaseOfCommonStock" xlink:to="lab_141438H6KL791K10I358_us-gaap_PaymentsForRepurchaseOfCommonStock"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivities" xlink:label="loc_350FKH75322F_us-gaap_NetCashProvidedByUsedInFinancingActivities"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_572HMJ97544H_us-gaap_NetCashProvidedByUsedInFinancingActivities" xml:lang="en-US">Net Cash Provided by (Used in) Financing Activities</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:label="lab_572HMJ97544H_us-gaap_NetCashProvidedByUsedInFinancingActivities" xml:lang="en-US">Net proceeds received</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/totalLabel" xlink:label="lab_572HMJ97544H_us-gaap_NetCashProvidedByUsedInFinancingActivities" xml:lang="en-US">NET CASH USED IN FINANCING ACTIVITIES</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_350FKH75322F_us-gaap_NetCashProvidedByUsedInFinancingActivities" xlink:to="lab_572HMJ97544H_us-gaap_NetCashProvidedByUsedInFinancingActivities"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_CashAndCashEquivalentsPeriodIncreaseDecrease" xlink:label="loc_929216F4IJ579I98G136_us-gaap_CashAndCashEquivalentsPeriodIncreaseDecrease"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_141438H6KL791K10I358_us-gaap_CashAndCashEquivalentsPeriodIncreaseDecrease" xml:lang="en-US">NET INCREASE (DECREASE) IN CASH AND CASH EQUIVALENTS</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:label="lab_141438H6KL791K10I358_us-gaap_CashAndCashEquivalentsPeriodIncreaseDecrease" xml:lang="en-US">NET INCREASE IN CASH AND CASH EQUIVALENTS</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/totalLabel" xlink:label="lab_141438H6KL791K10I358_us-gaap_CashAndCashEquivalentsPeriodIncreaseDecrease" xml:lang="en-US">NET INCREASE (DECREASE) IN CASH AND CASH EQUIVALENTS</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_929216F4IJ579I98G136_us-gaap_CashAndCashEquivalentsPeriodIncreaseDecrease" xlink:to="lab_141438H6KL791K10I358_us-gaap_CashAndCashEquivalentsPeriodIncreaseDecrease"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_SupplementalCashFlowInformationAbstract" xlink:label="loc_350FKH75322F_us-gaap_SupplementalCashFlowInformationAbstract"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_572HMJ97544H_us-gaap_SupplementalCashFlowInformationAbstract" xml:lang="en-US">SupplementalCashFlowInformationAbstract</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:label="lab_572HMJ97544H_us-gaap_SupplementalCashFlowInformationAbstract" xml:lang="en-US">SUPPLEMENTAL CASH FLOW INFORMATION:</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_350FKH75322F_us-gaap_SupplementalCashFlowInformationAbstract" xlink:to="lab_572HMJ97544H_us-gaap_SupplementalCashFlowInformationAbstract"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_InterestPaidNet" xlink:label="loc_929216F4IJ579I98G136_us-gaap_InterestPaidNet"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_141438H6KL791K10I358_us-gaap_InterestPaidNet" xml:lang="en-US">Interest Paid, Net</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:label="lab_141438H6KL791K10I358_us-gaap_InterestPaidNet" xml:lang="en-US">Cash paid for interest</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_929216F4IJ579I98G136_us-gaap_InterestPaidNet" xlink:to="lab_141438H6KL791K10I358_us-gaap_InterestPaidNet"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_IncomeTaxesPaid" xlink:label="loc_350FKH75322F_us-gaap_IncomeTaxesPaid"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_572HMJ97544H_us-gaap_IncomeTaxesPaid" xml:lang="en-US">IncomeTaxesPaid</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:label="lab_572HMJ97544H_us-gaap_IncomeTaxesPaid" xml:lang="en-US">Cash paid for income taxes</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_350FKH75322F_us-gaap_IncomeTaxesPaid" xlink:to="lab_572HMJ97544H_us-gaap_IncomeTaxesPaid"/>
<loc xlink:type="locator" xlink:href="oprx-20180331.xsd#oprx_NonCashIssuanceOfSharesToWpp" xlink:label="loc_929216F4IJ579I98G136_oprx_NonCashIssuanceOfSharesToWpp"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_141438H6KL791K10I358_oprx_NonCashIssuanceOfSharesToWpp" xml:lang="en-US">Non Cash Issuance Of Shares To Wpp</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_141438H6KL791K10I358_oprx_NonCashIssuanceOfSharesToWpp" xml:lang="en-US">Non-cash issuance of shares to WPP</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:label="lab_141438H6KL791K10I358_oprx_NonCashIssuanceOfSharesToWpp" xml:lang="en-US">Non cash issuance of shares to WPP.</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_929216F4IJ579I98G136_oprx_NonCashIssuanceOfSharesToWpp" xlink:to="lab_141438H6KL791K10I358_oprx_NonCashIssuanceOfSharesToWpp"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract" xlink:label="loc_350FKH75322F_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_572HMJ97544H_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract" xml:lang="en-US">Nature of Business and Basis of Presentation [Abstract]</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_350FKH75322F_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract" xlink:to="lab_572HMJ97544H_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsDisclosureTextBlock" xlink:label="loc_929216F4IJ579I98G136_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsDisclosureTextBlock"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_141438H6KL791K10I358_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsDisclosureTextBlock" xml:lang="en-US">Organization, Consolidation and Presentation of Financial Statements Disclosure [Text Block]</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_141438H6KL791K10I358_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsDisclosureTextBlock" xml:lang="en-US">NATURE OF BUSINESS AND BASIS OF PRESENTATION</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_929216F4IJ579I98G136_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsDisclosureTextBlock" xlink:to="lab_141438H6KL791K10I358_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsDisclosureTextBlock"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_AccountingChangesAndErrorCorrectionsAbstract" xlink:label="loc_350FKH75322F_us-gaap_AccountingChangesAndErrorCorrectionsAbstract"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_572HMJ97544H_us-gaap_AccountingChangesAndErrorCorrectionsAbstract" xml:lang="en-US">New Financial Accounting Standards [Abstract]</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_350FKH75322F_us-gaap_AccountingChangesAndErrorCorrectionsAbstract" xlink:to="lab_572HMJ97544H_us-gaap_AccountingChangesAndErrorCorrectionsAbstract"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_NewAccountingPronouncementsAndChangesInAccountingPrinciplesTextBlock" xlink:label="loc_929216F4IJ579I98G136_us-gaap_NewAccountingPronouncementsAndChangesInAccountingPrinciplesTextBlock"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_141438H6KL791K10I358_us-gaap_NewAccountingPronouncementsAndChangesInAccountingPrinciplesTextBlock" xml:lang="en-US">New Accounting Pronouncements and Changes in Accounting Principles [Text Block]</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_141438H6KL791K10I358_us-gaap_NewAccountingPronouncementsAndChangesInAccountingPrinciplesTextBlock" xml:lang="en-US">NEW FINANCIAL ACCOUNTING STANDARDS</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_929216F4IJ579I98G136_us-gaap_NewAccountingPronouncementsAndChangesInAccountingPrinciplesTextBlock" xlink:to="lab_141438H6KL791K10I358_us-gaap_NewAccountingPronouncementsAndChangesInAccountingPrinciplesTextBlock"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_EquityAbstract" xlink:label="loc_350FKH75322F_us-gaap_EquityAbstract"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_572HMJ97544H_us-gaap_EquityAbstract" xml:lang="en-US">Stockholders' Equity [Abstract]</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_350FKH75322F_us-gaap_EquityAbstract" xlink:to="lab_572HMJ97544H_us-gaap_EquityAbstract"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_StockholdersEquityNoteDisclosureTextBlock" xlink:label="loc_929216F4IJ579I98G136_us-gaap_StockholdersEquityNoteDisclosureTextBlock"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_141438H6KL791K10I358_us-gaap_StockholdersEquityNoteDisclosureTextBlock" xml:lang="en-US">Stockholders' Equity Note Disclosure [Text Block]</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_141438H6KL791K10I358_us-gaap_StockholdersEquityNoteDisclosureTextBlock" xml:lang="en-US">STOCKHOLDERS' EQUITY</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_929216F4IJ579I98G136_us-gaap_StockholdersEquityNoteDisclosureTextBlock" xlink:to="lab_141438H6KL791K10I358_us-gaap_StockholdersEquityNoteDisclosureTextBlock"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_DisclosureOfCompensationRelatedCostsSharebasedPaymentsAbstract" xlink:label="loc_350FKH75322F_us-gaap_DisclosureOfCompensationRelatedCostsSharebasedPaymentsAbstract"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_572HMJ97544H_us-gaap_DisclosureOfCompensationRelatedCostsSharebasedPaymentsAbstract" xml:lang="en-US">Share Based Payments - Options [Abstract]</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_350FKH75322F_us-gaap_DisclosureOfCompensationRelatedCostsSharebasedPaymentsAbstract" xlink:to="lab_572HMJ97544H_us-gaap_DisclosureOfCompensationRelatedCostsSharebasedPaymentsAbstract"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_DisclosureOfCompensationRelatedCostsShareBasedPaymentsTextBlock" xlink:label="loc_929216F4IJ579I98G136_us-gaap_DisclosureOfCompensationRelatedCostsShareBasedPaymentsTextBlock"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_141438H6KL791K10I358_us-gaap_DisclosureOfCompensationRelatedCostsShareBasedPaymentsTextBlock" xml:lang="en-US">Disclosure of Compensation Related Costs, Share-based Payments [Text Block]</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_141438H6KL791K10I358_us-gaap_DisclosureOfCompensationRelatedCostsShareBasedPaymentsTextBlock" xml:lang="en-US">SHARE BASED PAYMENTS - OPTIONS</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_929216F4IJ579I98G136_us-gaap_DisclosureOfCompensationRelatedCostsShareBasedPaymentsTextBlock" xlink:to="lab_141438H6KL791K10I358_us-gaap_DisclosureOfCompensationRelatedCostsShareBasedPaymentsTextBlock"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_RelatedPartyTransactionsAbstract" xlink:label="loc_350FKH75322F_us-gaap_RelatedPartyTransactionsAbstract"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_572HMJ97544H_us-gaap_RelatedPartyTransactionsAbstract" xml:lang="en-US">Related Party Transactions [Abstract]</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_350FKH75322F_us-gaap_RelatedPartyTransactionsAbstract" xlink:to="lab_572HMJ97544H_us-gaap_RelatedPartyTransactionsAbstract"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_RelatedPartyTransactionsDisclosureTextBlock" xlink:label="loc_929216F4IJ579I98G136_us-gaap_RelatedPartyTransactionsDisclosureTextBlock"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_141438H6KL791K10I358_us-gaap_RelatedPartyTransactionsDisclosureTextBlock" xml:lang="en-US">Related Party Transactions Disclosure [Text Block]</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_141438H6KL791K10I358_us-gaap_RelatedPartyTransactionsDisclosureTextBlock" xml:lang="en-US">RELATED PARTY TRANSACTIONS</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_929216F4IJ579I98G136_us-gaap_RelatedPartyTransactionsDisclosureTextBlock" xlink:to="lab_141438H6KL791K10I358_us-gaap_RelatedPartyTransactionsDisclosureTextBlock"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_CommitmentsAndContingenciesDisclosureAbstract" xlink:label="loc_350FKH75322F_us-gaap_CommitmentsAndContingenciesDisclosureAbstract"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_572HMJ97544H_us-gaap_CommitmentsAndContingenciesDisclosureAbstract" xml:lang="en-US">Contingencies [Abstract]</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_350FKH75322F_us-gaap_CommitmentsAndContingenciesDisclosureAbstract" xlink:to="lab_572HMJ97544H_us-gaap_CommitmentsAndContingenciesDisclosureAbstract"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_CommitmentsAndContingenciesDisclosureTextBlock" xlink:label="loc_929216F4IJ579I98G136_us-gaap_CommitmentsAndContingenciesDisclosureTextBlock"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_141438H6KL791K10I358_us-gaap_CommitmentsAndContingenciesDisclosureTextBlock" xml:lang="en-US">CONTINGENCIES</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_141438H6KL791K10I358_us-gaap_CommitmentsAndContingenciesDisclosureTextBlock" xml:lang="en-US">CONTINGENCIES</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_929216F4IJ579I98G136_us-gaap_CommitmentsAndContingenciesDisclosureTextBlock" xlink:to="lab_141438H6KL791K10I358_us-gaap_CommitmentsAndContingenciesDisclosureTextBlock"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_AccountingPoliciesAbstract" xlink:label="loc_350FKH75322F_us-gaap_AccountingPoliciesAbstract"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_572HMJ97544H_us-gaap_AccountingPoliciesAbstract" xml:lang="en-US">Summary of Significant Accounting Policies [Abstract]</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_572HMJ97544H_us-gaap_AccountingPoliciesAbstract" xml:lang="en-US">Summary of Significant Accounting Policies [Abstract]</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_350FKH75322F_us-gaap_AccountingPoliciesAbstract" xlink:to="lab_572HMJ97544H_us-gaap_AccountingPoliciesAbstract"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_SignificantAccountingPoliciesTextBlock" xlink:label="loc_929216F4IJ579I98G136_us-gaap_SignificantAccountingPoliciesTextBlock"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_141438H6KL791K10I358_us-gaap_SignificantAccountingPoliciesTextBlock" xml:lang="en-US">Significant Accounting Policies [Text Block]</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:label="lab_141438H6KL791K10I358_us-gaap_SignificantAccountingPoliciesTextBlock" xml:lang="en-US">SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_929216F4IJ579I98G136_us-gaap_SignificantAccountingPoliciesTextBlock" xlink:to="lab_141438H6KL791K10I358_us-gaap_SignificantAccountingPoliciesTextBlock"/>
<loc xlink:type="locator" xlink:href="oprx-20180331.xsd#oprx_PrepaidExpensesAbstract" xlink:label="loc_350FKH75322F_oprx_PrepaidExpensesAbstract"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_572HMJ97544H_oprx_PrepaidExpensesAbstract" xml:lang="en-US">Prepaid Expenses [Abstract]</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_350FKH75322F_oprx_PrepaidExpensesAbstract" xlink:to="lab_572HMJ97544H_oprx_PrepaidExpensesAbstract"/>
<loc xlink:type="locator" xlink:href="oprx-20180331.xsd#oprx_PrepaidExpensesTextBlock" xlink:label="loc_929216F4IJ579I98G136_oprx_PrepaidExpensesTextBlock"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_141438H6KL791K10I358_oprx_PrepaidExpensesTextBlock" xml:lang="en-US">Prepaid Expenses [Text Block]</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:label="lab_141438H6KL791K10I358_oprx_PrepaidExpensesTextBlock" xml:lang="en-US">PREPAID EXPENSES</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:label="lab_141438H6KL791K10I358_oprx_PrepaidExpensesTextBlock" xml:lang="en-US">The entire disclosure for prepaid expenses.</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_929216F4IJ579I98G136_oprx_PrepaidExpensesTextBlock" xlink:to="lab_141438H6KL791K10I358_oprx_PrepaidExpensesTextBlock"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_PropertyPlantAndEquipmentAbstract" xlink:label="loc_350FKH75322F_us-gaap_PropertyPlantAndEquipmentAbstract"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_572HMJ97544H_us-gaap_PropertyPlantAndEquipmentAbstract" xml:lang="en-US">Property and Equipment [Abstract]</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_572HMJ97544H_us-gaap_PropertyPlantAndEquipmentAbstract" xml:lang="en-US">Property and Equipment [Abstract]</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_350FKH75322F_us-gaap_PropertyPlantAndEquipmentAbstract" xlink:to="lab_572HMJ97544H_us-gaap_PropertyPlantAndEquipmentAbstract"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_PropertyPlantAndEquipmentDisclosureTextBlock" xlink:label="loc_929216F4IJ579I98G136_us-gaap_PropertyPlantAndEquipmentDisclosureTextBlock"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_141438H6KL791K10I358_us-gaap_PropertyPlantAndEquipmentDisclosureTextBlock" xml:lang="en-US">Property, Plant and Equipment Disclosure [Text Block]</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:label="lab_141438H6KL791K10I358_us-gaap_PropertyPlantAndEquipmentDisclosureTextBlock" xml:lang="en-US">PROPERTY AND EQUIPMENT</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_929216F4IJ579I98G136_us-gaap_PropertyPlantAndEquipmentDisclosureTextBlock" xlink:to="lab_141438H6KL791K10I358_us-gaap_PropertyPlantAndEquipmentDisclosureTextBlock"/>
<loc xlink:type="locator" xlink:href="oprx-20180331.xsd#oprx_WebBasedTechnologyAbstract" xlink:label="loc_350FKH75322F_oprx_WebBasedTechnologyAbstract"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_572HMJ97544H_oprx_WebBasedTechnologyAbstract" xml:lang="en-US">Web-Based Technology [Abstract]</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_572HMJ97544H_oprx_WebBasedTechnologyAbstract" xml:lang="en-US">Web-Based Technology</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_350FKH75322F_oprx_WebBasedTechnologyAbstract" xlink:to="lab_572HMJ97544H_oprx_WebBasedTechnologyAbstract"/>
<loc xlink:type="locator" xlink:href="oprx-20180331.xsd#oprx_WebBasedTechnologyTextBlock" xlink:label="loc_929216F4IJ579I98G136_oprx_WebBasedTechnologyTextBlock"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_141438H6KL791K10I358_oprx_WebBasedTechnologyTextBlock" xml:lang="en-US">Web Based Technology [Text Block]</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_141438H6KL791K10I358_oprx_WebBasedTechnologyTextBlock" xml:lang="en-US">WEB-BASED TECHNOLOGY</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:label="lab_141438H6KL791K10I358_oprx_WebBasedTechnologyTextBlock" xml:lang="en-US">The entire disclosure for web based technology.</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_929216F4IJ579I98G136_oprx_WebBasedTechnologyTextBlock" xlink:to="lab_141438H6KL791K10I358_oprx_WebBasedTechnologyTextBlock"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_GoodwillAndIntangibleAssetsDisclosureAbstract" xlink:label="loc_350FKH75322F_us-gaap_GoodwillAndIntangibleAssetsDisclosureAbstract"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_572HMJ97544H_us-gaap_GoodwillAndIntangibleAssetsDisclosureAbstract" xml:lang="en-US">Patent and Trademarks [Abstract]</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_350FKH75322F_us-gaap_GoodwillAndIntangibleAssetsDisclosureAbstract" xlink:to="lab_572HMJ97544H_us-gaap_GoodwillAndIntangibleAssetsDisclosureAbstract"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_IntangibleAssetsDisclosureTextBlock" xlink:label="loc_929216F4IJ579I98G136_us-gaap_IntangibleAssetsDisclosureTextBlock"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_141438H6KL791K10I358_us-gaap_IntangibleAssetsDisclosureTextBlock" xml:lang="en-US">Intangible Assets Disclosure [Text Block]</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_141438H6KL791K10I358_us-gaap_IntangibleAssetsDisclosureTextBlock" xml:lang="en-US">PATENT AND TRADEMARKS</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_929216F4IJ579I98G136_us-gaap_IntangibleAssetsDisclosureTextBlock" xlink:to="lab_141438H6KL791K10I358_us-gaap_IntangibleAssetsDisclosureTextBlock"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_RevenueRecognitionAbstract" xlink:label="loc_350FKH75322F_us-gaap_RevenueRecognitionAbstract"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_572HMJ97544H_us-gaap_RevenueRecognitionAbstract" xml:lang="en-US">Deferred Revenue [Abstract]</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_350FKH75322F_us-gaap_RevenueRecognitionAbstract" xlink:to="lab_572HMJ97544H_us-gaap_RevenueRecognitionAbstract"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_DeferredRevenueDisclosureTextBlock" xlink:label="loc_929216F4IJ579I98G136_us-gaap_DeferredRevenueDisclosureTextBlock"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_141438H6KL791K10I358_us-gaap_DeferredRevenueDisclosureTextBlock" xml:lang="en-US">Deferred Revenue Disclosure [Text Block]</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:label="lab_141438H6KL791K10I358_us-gaap_DeferredRevenueDisclosureTextBlock" xml:lang="en-US">DEFERRED REVENUE</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_929216F4IJ579I98G136_us-gaap_DeferredRevenueDisclosureTextBlock" xlink:to="lab_141438H6KL791K10I358_us-gaap_DeferredRevenueDisclosureTextBlock"/>
<loc xlink:type="locator" xlink:href="oprx-20180331.xsd#oprx_PreferredStockAbstract" xlink:label="loc_350FKH75322F_oprx_PreferredStockAbstract"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_572HMJ97544H_oprx_PreferredStockAbstract" xml:lang="en-US">Preferred Stock [Abstract]</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_350FKH75322F_oprx_PreferredStockAbstract" xlink:to="lab_572HMJ97544H_oprx_PreferredStockAbstract"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_PreferredStockTextBlock" xlink:label="loc_929216F4IJ579I98G136_us-gaap_PreferredStockTextBlock"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_141438H6KL791K10I358_us-gaap_PreferredStockTextBlock" xml:lang="en-US">Preferred Stock [Text Block]</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_141438H6KL791K10I358_us-gaap_PreferredStockTextBlock" xml:lang="en-US">PREFERRED STOCK</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_929216F4IJ579I98G136_us-gaap_PreferredStockTextBlock" xlink:to="lab_141438H6KL791K10I358_us-gaap_PreferredStockTextBlock"/>
<loc xlink:type="locator" xlink:href="oprx-20180331.xsd#oprx_CommonStockAbstract" xlink:label="loc_350FKH75322F_oprx_CommonStockAbstract"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_572HMJ97544H_oprx_CommonStockAbstract" xml:lang="en-US">Common Stock [Abstract]</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_350FKH75322F_oprx_CommonStockAbstract" xlink:to="lab_572HMJ97544H_oprx_CommonStockAbstract"/>
<loc xlink:type="locator" xlink:href="oprx-20180331.xsd#oprx_CommonStockTextBlock" xlink:label="loc_929216F4IJ579I98G136_oprx_CommonStockTextBlock"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_141438H6KL791K10I358_oprx_CommonStockTextBlock" xml:lang="en-US">Common Stock [Text Block]</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_141438H6KL791K10I358_oprx_CommonStockTextBlock" xml:lang="en-US">COMMON STOCK</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:label="lab_141438H6KL791K10I358_oprx_CommonStockTextBlock" xml:lang="en-US">The entire disclosure for common stock.</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_929216F4IJ579I98G136_oprx_CommonStockTextBlock" xlink:to="lab_141438H6KL791K10I358_oprx_CommonStockTextBlock"/>
<loc xlink:type="locator" xlink:href="oprx-20180331.xsd#oprx_WarrantsAbstract" xlink:label="loc_350FKH75322F_oprx_WarrantsAbstract"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_572HMJ97544H_oprx_WarrantsAbstract" xml:lang="en-US">Warrants [Abstract]</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_350FKH75322F_oprx_WarrantsAbstract" xlink:to="lab_572HMJ97544H_oprx_WarrantsAbstract"/>
<loc xlink:type="locator" xlink:href="oprx-20180331.xsd#oprx_WarrantsTextBlock" xlink:label="loc_929216F4IJ579I98G136_oprx_WarrantsTextBlock"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_141438H6KL791K10I358_oprx_WarrantsTextBlock" xml:lang="en-US">Warrants [Text Block]</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_141438H6KL791K10I358_oprx_WarrantsTextBlock" xml:lang="en-US">WARRANTS</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:label="lab_141438H6KL791K10I358_oprx_WarrantsTextBlock" xml:lang="en-US">The entire disclosure for warrants.</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_929216F4IJ579I98G136_oprx_WarrantsTextBlock" xlink:to="lab_141438H6KL791K10I358_oprx_WarrantsTextBlock"/>
<loc xlink:type="locator" xlink:href="oprx-20180331.xsd#oprx_MajorCustomersAbstract" xlink:label="loc_350FKH75322F_oprx_MajorCustomersAbstract"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_572HMJ97544H_oprx_MajorCustomersAbstract" xml:lang="en-US">Major Customers [Abstract]</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_350FKH75322F_oprx_MajorCustomersAbstract" xlink:to="lab_572HMJ97544H_oprx_MajorCustomersAbstract"/>
<loc xlink:type="locator" xlink:href="oprx-20180331.xsd#oprx_MajorCustomersTextBlock" xlink:label="loc_929216F4IJ579I98G136_oprx_MajorCustomersTextBlock"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_141438H6KL791K10I358_oprx_MajorCustomersTextBlock" xml:lang="en-US">Major Customers [Text Block]</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_141438H6KL791K10I358_oprx_MajorCustomersTextBlock" xml:lang="en-US">MAJOR CUSTOMERS</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:label="lab_141438H6KL791K10I358_oprx_MajorCustomersTextBlock" xml:lang="en-US">The entire disclosure for Major customers.</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_929216F4IJ579I98G136_oprx_MajorCustomersTextBlock" xlink:to="lab_141438H6KL791K10I358_oprx_MajorCustomersTextBlock"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_IncomeTaxDisclosureAbstract" xlink:label="loc_350FKH75322F_us-gaap_IncomeTaxDisclosureAbstract"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_572HMJ97544H_us-gaap_IncomeTaxDisclosureAbstract" xml:lang="en-US">Income Taxes [Abstract]</label>
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<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_CompensationAndRetirementDisclosureAbstract" xlink:label="loc_350FKH75322F_us-gaap_CompensationAndRetirementDisclosureAbstract"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_572HMJ97544H_us-gaap_CompensationAndRetirementDisclosureAbstract" xml:lang="en-US">Retirement Plan [Abstract]</label>
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<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_PensionAndOtherPostretirementBenefitsDisclosureTextBlock" xlink:label="loc_929216F4IJ579I98G136_us-gaap_PensionAndOtherPostretirementBenefitsDisclosureTextBlock"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_141438H6KL791K10I358_us-gaap_PensionAndOtherPostretirementBenefitsDisclosureTextBlock" xml:lang="en-US">Pension and Other Postretirement Benefits Disclosure [Text Block]</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_141438H6KL791K10I358_us-gaap_PensionAndOtherPostretirementBenefitsDisclosureTextBlock" xml:lang="en-US">RETIREMENT PLAN</label>
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<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_SubsequentEventsAbstract" xlink:label="loc_350FKH75322F_us-gaap_SubsequentEventsAbstract"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_572HMJ97544H_us-gaap_SubsequentEventsAbstract" xml:lang="en-US">Subsequent Events [Abstract]</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_350FKH75322F_us-gaap_SubsequentEventsAbstract" xlink:to="lab_572HMJ97544H_us-gaap_SubsequentEventsAbstract"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_SubsequentEventsTextBlock" xlink:label="loc_929216F4IJ579I98G136_us-gaap_SubsequentEventsTextBlock"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_141438H6KL791K10I358_us-gaap_SubsequentEventsTextBlock" xml:lang="en-US">Subsequent Events [Text Block]</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_141438H6KL791K10I358_us-gaap_SubsequentEventsTextBlock" xml:lang="en-US">SUBSEQUENT EVENTS</label>
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<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_BasisOfAccountingPolicyPolicyTextBlock" xlink:label="loc_350FKH75322F_us-gaap_BasisOfAccountingPolicyPolicyTextBlock"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_572HMJ97544H_us-gaap_BasisOfAccountingPolicyPolicyTextBlock" xml:lang="en-US">Basis of Accounting, Policy [Policy Text Block]</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_572HMJ97544H_us-gaap_BasisOfAccountingPolicyPolicyTextBlock" xml:lang="en-US">Basis of Presentation</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:label="lab_572HMJ97544H_us-gaap_BasisOfAccountingPolicyPolicyTextBlock" xml:lang="en-US">Principles of Consolidation</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_350FKH75322F_us-gaap_BasisOfAccountingPolicyPolicyTextBlock" xlink:to="lab_572HMJ97544H_us-gaap_BasisOfAccountingPolicyPolicyTextBlock"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_ConsolidationPolicyTextBlock" xlink:label="loc_929216F4IJ579I98G136_us-gaap_ConsolidationPolicyTextBlock"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_141438H6KL791K10I358_us-gaap_ConsolidationPolicyTextBlock" xml:lang="en-US">Consolidation, Policy [Policy Text Block]</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_141438H6KL791K10I358_us-gaap_ConsolidationPolicyTextBlock" xml:lang="en-US">Principles of Consolidation</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_929216F4IJ579I98G136_us-gaap_ConsolidationPolicyTextBlock" xlink:to="lab_141438H6KL791K10I358_us-gaap_ConsolidationPolicyTextBlock"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_CashAndCashEquivalentsPolicyTextBlock" xlink:label="loc_350FKH75322F_us-gaap_CashAndCashEquivalentsPolicyTextBlock"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_572HMJ97544H_us-gaap_CashAndCashEquivalentsPolicyTextBlock" xml:lang="en-US">Cash and Cash Equivalents, Policy [Policy Text Block]</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:label="lab_572HMJ97544H_us-gaap_CashAndCashEquivalentsPolicyTextBlock" xml:lang="en-US">Cash and Cash Equivalents</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_350FKH75322F_us-gaap_CashAndCashEquivalentsPolicyTextBlock" xlink:to="lab_572HMJ97544H_us-gaap_CashAndCashEquivalentsPolicyTextBlock"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_FairValueOfFinancialInstrumentsPolicy" xlink:label="loc_929216F4IJ579I98G136_us-gaap_FairValueOfFinancialInstrumentsPolicy"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_141438H6KL791K10I358_us-gaap_FairValueOfFinancialInstrumentsPolicy" xml:lang="en-US">Fair Value of Financial Instruments, Policy [Policy Text Block]</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:label="lab_141438H6KL791K10I358_us-gaap_FairValueOfFinancialInstrumentsPolicy" xml:lang="en-US">Fair Value of Financial Instruments</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_929216F4IJ579I98G136_us-gaap_FairValueOfFinancialInstrumentsPolicy" xlink:to="lab_141438H6KL791K10I358_us-gaap_FairValueOfFinancialInstrumentsPolicy"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_ReceivablesTradeAndOtherAccountsReceivableAllowanceForDoubtfulAccountsPolicy" xlink:label="loc_350FKH75322F_us-gaap_ReceivablesTradeAndOtherAccountsReceivableAllowanceForDoubtfulAccountsPolicy"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_572HMJ97544H_us-gaap_ReceivablesTradeAndOtherAccountsReceivableAllowanceForDoubtfulAccountsPolicy" xml:lang="en-US">Receivables, Trade and Other Accounts Receivable, Allowance for Doubtful Accounts, Policy [Policy Text Block]</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:label="lab_572HMJ97544H_us-gaap_ReceivablesTradeAndOtherAccountsReceivableAllowanceForDoubtfulAccountsPolicy" xml:lang="en-US">Accounts Receivable and Allowance for Doubtful Accounts</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_350FKH75322F_us-gaap_ReceivablesTradeAndOtherAccountsReceivableAllowanceForDoubtfulAccountsPolicy" xlink:to="lab_572HMJ97544H_us-gaap_ReceivablesTradeAndOtherAccountsReceivableAllowanceForDoubtfulAccountsPolicy"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_PropertyPlantAndEquipmentPolicyTextBlock" xlink:label="loc_929216F4IJ579I98G136_us-gaap_PropertyPlantAndEquipmentPolicyTextBlock"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_141438H6KL791K10I358_us-gaap_PropertyPlantAndEquipmentPolicyTextBlock" xml:lang="en-US">Property, Plant and Equipment, Policy [Policy Text Block]</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:label="lab_141438H6KL791K10I358_us-gaap_PropertyPlantAndEquipmentPolicyTextBlock" xml:lang="en-US">Property and Equipment</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_929216F4IJ579I98G136_us-gaap_PropertyPlantAndEquipmentPolicyTextBlock" xlink:to="lab_141438H6KL791K10I358_us-gaap_PropertyPlantAndEquipmentPolicyTextBlock"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_GoodwillAndIntangibleAssetsPolicyTextBlock" xlink:label="loc_350FKH75322F_us-gaap_GoodwillAndIntangibleAssetsPolicyTextBlock"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_572HMJ97544H_us-gaap_GoodwillAndIntangibleAssetsPolicyTextBlock" xml:lang="en-US">Goodwill and Intangible Assets, Policy [Policy Text Block]</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_572HMJ97544H_us-gaap_GoodwillAndIntangibleAssetsPolicyTextBlock" xml:lang="en-US">Intangible Assets</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_350FKH75322F_us-gaap_GoodwillAndIntangibleAssetsPolicyTextBlock" xlink:to="lab_572HMJ97544H_us-gaap_GoodwillAndIntangibleAssetsPolicyTextBlock"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_RevenueRecognitionPolicyTextBlock" xlink:label="loc_929216F4IJ579I98G136_us-gaap_RevenueRecognitionPolicyTextBlock"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_141438H6KL791K10I358_us-gaap_RevenueRecognitionPolicyTextBlock" xml:lang="en-US">Revenue Recognition, Policy [Policy Text Block]</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:label="lab_141438H6KL791K10I358_us-gaap_RevenueRecognitionPolicyTextBlock" xml:lang="en-US">Revenue Recognition and Revenue Share Expense</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_929216F4IJ579I98G136_us-gaap_RevenueRecognitionPolicyTextBlock" xlink:to="lab_141438H6KL791K10I358_us-gaap_RevenueRecognitionPolicyTextBlock"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_IncomeTaxPolicyTextBlock" xlink:label="loc_350FKH75322F_us-gaap_IncomeTaxPolicyTextBlock"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_572HMJ97544H_us-gaap_IncomeTaxPolicyTextBlock" xml:lang="en-US">Income Tax, Policy [Policy Text Block]</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_572HMJ97544H_us-gaap_IncomeTaxPolicyTextBlock" xml:lang="en-US">Income Taxes</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_350FKH75322F_us-gaap_IncomeTaxPolicyTextBlock" xlink:to="lab_572HMJ97544H_us-gaap_IncomeTaxPolicyTextBlock"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_UseOfEstimates" xlink:label="loc_929216F4IJ579I98G136_us-gaap_UseOfEstimates"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_141438H6KL791K10I358_us-gaap_UseOfEstimates" xml:lang="en-US">Use of Estimates, Policy [Policy Text Block]</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_141438H6KL791K10I358_us-gaap_UseOfEstimates" xml:lang="en-US">Use of Estimates</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_929216F4IJ579I98G136_us-gaap_UseOfEstimates" xlink:to="lab_141438H6KL791K10I358_us-gaap_UseOfEstimates"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_ConcentrationRiskCreditRisk" xlink:label="loc_350FKH75322F_us-gaap_ConcentrationRiskCreditRisk"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_572HMJ97544H_us-gaap_ConcentrationRiskCreditRisk" xml:lang="en-US">Concentration Risk, Credit Risk, Policy [Policy Text Block]</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:label="lab_572HMJ97544H_us-gaap_ConcentrationRiskCreditRisk" xml:lang="en-US">Concentration of Credit Risks</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_350FKH75322F_us-gaap_ConcentrationRiskCreditRisk" xlink:to="lab_572HMJ97544H_us-gaap_ConcentrationRiskCreditRisk"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_ResearchAndDevelopmentExpensePolicy" xlink:label="loc_929216F4IJ579I98G136_us-gaap_ResearchAndDevelopmentExpensePolicy"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_141438H6KL791K10I358_us-gaap_ResearchAndDevelopmentExpensePolicy" xml:lang="en-US">Research and Development Expense, Policy [Policy Text Block]</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_141438H6KL791K10I358_us-gaap_ResearchAndDevelopmentExpensePolicy" xml:lang="en-US">Research and Development</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_929216F4IJ579I98G136_us-gaap_ResearchAndDevelopmentExpensePolicy" xlink:to="lab_141438H6KL791K10I358_us-gaap_ResearchAndDevelopmentExpensePolicy"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_ShareBasedCompensationOptionAndIncentivePlansPolicy" xlink:label="loc_350FKH75322F_us-gaap_ShareBasedCompensationOptionAndIncentivePlansPolicy"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_572HMJ97544H_us-gaap_ShareBasedCompensationOptionAndIncentivePlansPolicy" xml:lang="en-US">Share-based Compensation, Option and Incentive Plans Policy [Policy Text Block]</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:label="lab_572HMJ97544H_us-gaap_ShareBasedCompensationOptionAndIncentivePlansPolicy" xml:lang="en-US">Share-based Payments</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_350FKH75322F_us-gaap_ShareBasedCompensationOptionAndIncentivePlansPolicy" xlink:to="lab_572HMJ97544H_us-gaap_ShareBasedCompensationOptionAndIncentivePlansPolicy"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_EarningsPerSharePolicyTextBlock" xlink:label="loc_929216F4IJ579I98G136_us-gaap_EarningsPerSharePolicyTextBlock"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_141438H6KL791K10I358_us-gaap_EarningsPerSharePolicyTextBlock" xml:lang="en-US">Earnings Per Share, Policy [Policy Text Block]</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:label="lab_141438H6KL791K10I358_us-gaap_EarningsPerSharePolicyTextBlock" xml:lang="en-US">Loss Per Common and Common Equivalent Share</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_929216F4IJ579I98G136_us-gaap_EarningsPerSharePolicyTextBlock" xlink:to="lab_141438H6KL791K10I358_us-gaap_EarningsPerSharePolicyTextBlock"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_ImpairmentOrDisposalOfLongLivedAssetsPolicyTextBlock" xlink:label="loc_350FKH75322F_us-gaap_ImpairmentOrDisposalOfLongLivedAssetsPolicyTextBlock"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_572HMJ97544H_us-gaap_ImpairmentOrDisposalOfLongLivedAssetsPolicyTextBlock" xml:lang="en-US">Impairment or Disposal of Long-Lived Assets, Policy [Policy Text Block]</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:label="lab_572HMJ97544H_us-gaap_ImpairmentOrDisposalOfLongLivedAssetsPolicyTextBlock" xml:lang="en-US">Impairment of Long-Lived Assets</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_350FKH75322F_us-gaap_ImpairmentOrDisposalOfLongLivedAssetsPolicyTextBlock" xlink:to="lab_572HMJ97544H_us-gaap_ImpairmentOrDisposalOfLongLivedAssetsPolicyTextBlock"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_NewAccountingPronouncementsPolicyPolicyTextBlock" xlink:label="loc_929216F4IJ579I98G136_us-gaap_NewAccountingPronouncementsPolicyPolicyTextBlock"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_141438H6KL791K10I358_us-gaap_NewAccountingPronouncementsPolicyPolicyTextBlock" xml:lang="en-US">New Accounting Pronouncements, Policy [Policy Text Block]</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:label="lab_141438H6KL791K10I358_us-gaap_NewAccountingPronouncementsPolicyPolicyTextBlock" xml:lang="en-US">Recently Issued Accounting Guidance</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_929216F4IJ579I98G136_us-gaap_NewAccountingPronouncementsPolicyPolicyTextBlock" xlink:to="lab_141438H6KL791K10I358_us-gaap_NewAccountingPronouncementsPolicyPolicyTextBlock"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_DisclosureOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTextBlock" xlink:label="loc_350FKH75322F_us-gaap_DisclosureOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTextBlock"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_572HMJ97544H_us-gaap_DisclosureOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTextBlock" xml:lang="en-US">Disclosure of Share-based Compensation Arrangements by Share-based Payment Award [Table Text Block]</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_572HMJ97544H_us-gaap_DisclosureOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTextBlock" xml:lang="en-US">Schedule of fair value method to account for stock-based compensation</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_350FKH75322F_us-gaap_DisclosureOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTextBlock" xlink:to="lab_572HMJ97544H_us-gaap_DisclosureOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTextBlock"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_ScheduleOfShareBasedCompensationStockOptionsActivityTableTextBlock" xlink:label="loc_929216F4IJ579I98G136_us-gaap_ScheduleOfShareBasedCompensationStockOptionsActivityTableTextBlock"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_141438H6KL791K10I358_us-gaap_ScheduleOfShareBasedCompensationStockOptionsActivityTableTextBlock" xml:lang="en-US">Share-based Compensation, Stock Options, Activity [Table Text Block]</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_141438H6KL791K10I358_us-gaap_ScheduleOfShareBasedCompensationStockOptionsActivityTableTextBlock" xml:lang="en-US">Summary of options and warrants outstanding</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_929216F4IJ579I98G136_us-gaap_ScheduleOfShareBasedCompensationStockOptionsActivityTableTextBlock" xlink:to="lab_141438H6KL791K10I358_us-gaap_ScheduleOfShareBasedCompensationStockOptionsActivityTableTextBlock"/>
<loc xlink:type="locator" xlink:href="oprx-20180331.xsd#oprx_PrepaidExpensesTableTextBlock" xlink:label="loc_350FKH75322F_oprx_PrepaidExpensesTableTextBlock"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_572HMJ97544H_oprx_PrepaidExpensesTableTextBlock" xml:lang="en-US">Prepaid Expenses [Table Text Block]</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_572HMJ97544H_oprx_PrepaidExpensesTableTextBlock" xml:lang="en-US">Schedule of prepaid expenses</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:label="lab_572HMJ97544H_oprx_PrepaidExpensesTableTextBlock" xml:lang="en-US">Tabular disclosure of prepaid expenses.</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_350FKH75322F_oprx_PrepaidExpensesTableTextBlock" xlink:to="lab_572HMJ97544H_oprx_PrepaidExpensesTableTextBlock"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_PropertyPlantAndEquipmentTextBlock" xlink:label="loc_929216F4IJ579I98G136_us-gaap_PropertyPlantAndEquipmentTextBlock"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_141438H6KL791K10I358_us-gaap_PropertyPlantAndEquipmentTextBlock" xml:lang="en-US">Property, Plant and Equipment [Table Text Block]</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:label="lab_141438H6KL791K10I358_us-gaap_PropertyPlantAndEquipmentTextBlock" xml:lang="en-US">Schedule of property and equipment</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_929216F4IJ579I98G136_us-gaap_PropertyPlantAndEquipmentTextBlock" xlink:to="lab_141438H6KL791K10I358_us-gaap_PropertyPlantAndEquipmentTextBlock"/>
<loc xlink:type="locator" xlink:href="oprx-20180331.xsd#oprx_ScheduleOfCapitalizedCostsInDevelopingWebBasedTechnologyTableTextBlock" xlink:label="loc_350FKH75322F_oprx_ScheduleOfCapitalizedCostsInDevelopingWebBasedTechnologyTableTextBlock"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_572HMJ97544H_oprx_ScheduleOfCapitalizedCostsInDevelopingWebBasedTechnologyTableTextBlock" xml:lang="en-US">Schedule Of Capitalized Costs In Developing Web Based Technology [Table Text Block]</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:label="lab_572HMJ97544H_oprx_ScheduleOfCapitalizedCostsInDevelopingWebBasedTechnologyTableTextBlock" xml:lang="en-US">Schedule of capitalized costs in developing web-based technology</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:label="lab_572HMJ97544H_oprx_ScheduleOfCapitalizedCostsInDevelopingWebBasedTechnologyTableTextBlock" xml:lang="en-US">Tabular disclosure of capitalized costs in developing web-based technology.</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_350FKH75322F_oprx_ScheduleOfCapitalizedCostsInDevelopingWebBasedTechnologyTableTextBlock" xlink:to="lab_572HMJ97544H_oprx_ScheduleOfCapitalizedCostsInDevelopingWebBasedTechnologyTableTextBlock"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_ScheduleOfIntangibleAssetsAndGoodwillTableTextBlock" xlink:label="loc_929216F4IJ579I98G136_us-gaap_ScheduleOfIntangibleAssetsAndGoodwillTableTextBlock"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_141438H6KL791K10I358_us-gaap_ScheduleOfIntangibleAssetsAndGoodwillTableTextBlock" xml:lang="en-US">Schedule of Intangible Assets and Goodwill [Table Text Block]</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_141438H6KL791K10I358_us-gaap_ScheduleOfIntangibleAssetsAndGoodwillTableTextBlock" xml:lang="en-US">Schedule of patent and trademarks</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_929216F4IJ579I98G136_us-gaap_ScheduleOfIntangibleAssetsAndGoodwillTableTextBlock" xlink:to="lab_141438H6KL791K10I358_us-gaap_ScheduleOfIntangibleAssetsAndGoodwillTableTextBlock"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_ScheduleOfRelatedPartyTransactionsTableTextBlock" xlink:label="loc_350FKH75322F_us-gaap_ScheduleOfRelatedPartyTransactionsTableTextBlock"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_572HMJ97544H_us-gaap_ScheduleOfRelatedPartyTransactionsTableTextBlock" xml:lang="en-US">Schedule of Related Party Transactions [Table Text Block]</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:label="lab_572HMJ97544H_us-gaap_ScheduleOfRelatedPartyTransactionsTableTextBlock" xml:lang="en-US">Schedule of sets forth the activity between the Company and WPP</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_350FKH75322F_us-gaap_ScheduleOfRelatedPartyTransactionsTableTextBlock" xlink:to="lab_572HMJ97544H_us-gaap_ScheduleOfRelatedPartyTransactionsTableTextBlock"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_ScheduleOfShareBasedCompensationActivityTableTextBlock" xlink:label="loc_929216F4IJ579I98G136_us-gaap_ScheduleOfShareBasedCompensationActivityTableTextBlock"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_141438H6KL791K10I358_us-gaap_ScheduleOfShareBasedCompensationActivityTableTextBlock" xml:lang="en-US">Share-based Compensation, Activity [Table Text Block]</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_141438H6KL791K10I358_us-gaap_ScheduleOfShareBasedCompensationActivityTableTextBlock" xml:lang="en-US">Schedule of option activity</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_929216F4IJ579I98G136_us-gaap_ScheduleOfShareBasedCompensationActivityTableTextBlock" xlink:to="lab_141438H6KL791K10I358_us-gaap_ScheduleOfShareBasedCompensationActivityTableTextBlock"/>
<loc xlink:type="locator" xlink:href="oprx-20180331.xsd#oprx_ScheduleOfOptionsOutstandingTableTextBlock" xlink:label="loc_350FKH75322F_oprx_ScheduleOfOptionsOutstandingTableTextBlock"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_572HMJ97544H_oprx_ScheduleOfOptionsOutstandingTableTextBlock" xml:lang="en-US">Schedule Of Options Outstanding [Table Text Block]</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_572HMJ97544H_oprx_ScheduleOfOptionsOutstandingTableTextBlock" xml:lang="en-US">Schedule of expiration date and exercise price of the options outstanding</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:label="lab_572HMJ97544H_oprx_ScheduleOfOptionsOutstandingTableTextBlock" xml:lang="en-US">Tabular disclosure for options outstanding, exercise price and expiration date.</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_350FKH75322F_oprx_ScheduleOfOptionsOutstandingTableTextBlock" xlink:to="lab_572HMJ97544H_oprx_ScheduleOfOptionsOutstandingTableTextBlock"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_ScheduleOfStockholdersEquityNoteWarrantsOrRightsTextBlock" xlink:label="loc_929216F4IJ579I98G136_us-gaap_ScheduleOfStockholdersEquityNoteWarrantsOrRightsTextBlock"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_141438H6KL791K10I358_us-gaap_ScheduleOfStockholdersEquityNoteWarrantsOrRightsTextBlock" xml:lang="en-US">Schedule of Stockholders' Equity Note, Warrants or Rights [Table Text Block]</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_141438H6KL791K10I358_us-gaap_ScheduleOfStockholdersEquityNoteWarrantsOrRightsTextBlock" xml:lang="en-US">Schedule of warrants outstanding</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_929216F4IJ579I98G136_us-gaap_ScheduleOfStockholdersEquityNoteWarrantsOrRightsTextBlock" xlink:to="lab_141438H6KL791K10I358_us-gaap_ScheduleOfStockholdersEquityNoteWarrantsOrRightsTextBlock"/>
<loc xlink:type="locator" xlink:href="oprx-20180331.xsd#oprx_ScheduleOfShareBasedCompensationWarrantActivityTableTextBlock" xlink:label="loc_350FKH75322F_oprx_ScheduleOfShareBasedCompensationWarrantActivityTableTextBlock"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_572HMJ97544H_oprx_ScheduleOfShareBasedCompensationWarrantActivityTableTextBlock" xml:lang="en-US">Schedule Of Share Based Compensation Warrant Activity [Table Text Block]</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:label="lab_572HMJ97544H_oprx_ScheduleOfShareBasedCompensationWarrantActivityTableTextBlock" xml:lang="en-US">Schedule of warrant activity</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:label="lab_572HMJ97544H_oprx_ScheduleOfShareBasedCompensationWarrantActivityTableTextBlock" xml:lang="en-US">Schedule Of Share Based Compensation Warrant Activity.</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_350FKH75322F_oprx_ScheduleOfShareBasedCompensationWarrantActivityTableTextBlock" xlink:to="lab_572HMJ97544H_oprx_ScheduleOfShareBasedCompensationWarrantActivityTableTextBlock"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_ScheduleOfEffectiveIncomeTaxRateReconciliationTableTextBlock" xlink:label="loc_929216F4IJ579I98G136_us-gaap_ScheduleOfEffectiveIncomeTaxRateReconciliationTableTextBlock"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_141438H6KL791K10I358_us-gaap_ScheduleOfEffectiveIncomeTaxRateReconciliationTableTextBlock" xml:lang="en-US">Schedule of Effective Income Tax Rate Reconciliation [Table Text Block]</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_141438H6KL791K10I358_us-gaap_ScheduleOfEffectiveIncomeTaxRateReconciliationTableTextBlock" xml:lang="en-US">Schedule of federal income tax benefit</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_929216F4IJ579I98G136_us-gaap_ScheduleOfEffectiveIncomeTaxRateReconciliationTableTextBlock" xlink:to="lab_141438H6KL791K10I358_us-gaap_ScheduleOfEffectiveIncomeTaxRateReconciliationTableTextBlock"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_ScheduleOfDeferredTaxAssetsAndLiabilitiesTableTextBlock" xlink:label="loc_350FKH75322F_us-gaap_ScheduleOfDeferredTaxAssetsAndLiabilitiesTableTextBlock"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_572HMJ97544H_us-gaap_ScheduleOfDeferredTaxAssetsAndLiabilitiesTableTextBlock" xml:lang="en-US">Schedule of Deferred Tax Assets and Liabilities [Table Text Block]</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_572HMJ97544H_us-gaap_ScheduleOfDeferredTaxAssetsAndLiabilitiesTableTextBlock" xml:lang="en-US">Schedule of deferred tax assets</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_350FKH75322F_us-gaap_ScheduleOfDeferredTaxAssetsAndLiabilitiesTableTextBlock" xlink:to="lab_572HMJ97544H_us-gaap_ScheduleOfDeferredTaxAssetsAndLiabilitiesTableTextBlock"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_ScheduleOfFutureMinimumRentalPaymentsForOperatingLeasesTableTextBlock" xlink:label="loc_929216F4IJ579I98G136_us-gaap_ScheduleOfFutureMinimumRentalPaymentsForOperatingLeasesTableTextBlock"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_141438H6KL791K10I358_us-gaap_ScheduleOfFutureMinimumRentalPaymentsForOperatingLeasesTableTextBlock" xml:lang="en-US">Schedule of Future Minimum Rental Payments for Operating Leases [Table Text Block]</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_141438H6KL791K10I358_us-gaap_ScheduleOfFutureMinimumRentalPaymentsForOperatingLeasesTableTextBlock" xml:lang="en-US">Schedule of minimum annual rent payments</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_929216F4IJ579I98G136_us-gaap_ScheduleOfFutureMinimumRentalPaymentsForOperatingLeasesTableTextBlock" xlink:to="lab_141438H6KL791K10I358_us-gaap_ScheduleOfFutureMinimumRentalPaymentsForOperatingLeasesTableTextBlock"/>
<loc xlink:type="locator" xlink:href="oprx-20180331.xsd#oprx_NatureOfBusinessAndBasisOfPresentationTextualAbstract" xlink:label="loc_350FKH75322F_oprx_NatureOfBusinessAndBasisOfPresentationTextualAbstract"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_572HMJ97544H_oprx_NatureOfBusinessAndBasisOfPresentationTextualAbstract" xml:lang="en-US">Nature Of Business And Basis Of Presentation Textual [Abstract]</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:label="lab_572HMJ97544H_oprx_NatureOfBusinessAndBasisOfPresentationTextualAbstract" xml:lang="en-US">Nature of Business and Basis of Presentation (Textual)</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:label="lab_572HMJ97544H_oprx_NatureOfBusinessAndBasisOfPresentationTextualAbstract" xml:lang="en-US">Nature of Business and Basis of Presentation</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_350FKH75322F_oprx_NatureOfBusinessAndBasisOfPresentationTextualAbstract" xlink:to="lab_572HMJ97544H_oprx_NatureOfBusinessAndBasisOfPresentationTextualAbstract"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_BusinessAcquisitionEquityInterestsIssuedOrIssuableNumberOfSharesIssued" xlink:label="loc_929216F4IJ579I98G136_us-gaap_BusinessAcquisitionEquityInterestsIssuedOrIssuableNumberOfSharesIssued"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_141438H6KL791K10I358_us-gaap_BusinessAcquisitionEquityInterestsIssuedOrIssuableNumberOfSharesIssued" xml:lang="en-US">Business Acquisition, Equity Interest Issued or Issuable, Number of Shares</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_141438H6KL791K10I358_us-gaap_BusinessAcquisitionEquityInterestsIssuedOrIssuableNumberOfSharesIssued" xml:lang="en-US">Shares issued by RFID, Ltd. pursuant to a share exchange agreement</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_929216F4IJ579I98G136_us-gaap_BusinessAcquisitionEquityInterestsIssuedOrIssuableNumberOfSharesIssued" xlink:to="lab_141438H6KL791K10I358_us-gaap_BusinessAcquisitionEquityInterestsIssuedOrIssuableNumberOfSharesIssued"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_EquityMethodInvestmentOwnershipPercentage" xlink:label="loc_350FKH75322F_us-gaap_EquityMethodInvestmentOwnershipPercentage"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_572HMJ97544H_us-gaap_EquityMethodInvestmentOwnershipPercentage" xml:lang="en-US">Equity Method Investment, Ownership Percentage</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_572HMJ97544H_us-gaap_EquityMethodInvestmentOwnershipPercentage" xml:lang="en-US">Percentage of stock of owned by RFID</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:label="lab_572HMJ97544H_us-gaap_EquityMethodInvestmentOwnershipPercentage" xml:lang="en-US">Percentage of ownership</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_350FKH75322F_us-gaap_EquityMethodInvestmentOwnershipPercentage" xlink:to="lab_572HMJ97544H_us-gaap_EquityMethodInvestmentOwnershipPercentage"/>
<loc xlink:type="locator" xlink:href="oprx-20180331.xsd#oprx_NewFinancialAccountingStandardsTextualAbstract" xlink:label="loc_929216F4IJ579I98G136_oprx_NewFinancialAccountingStandardsTextualAbstract"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_141438H6KL791K10I358_oprx_NewFinancialAccountingStandardsTextualAbstract" xml:lang="en-US">New Financial Accounting Standards Textual [Abstract]</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_141438H6KL791K10I358_oprx_NewFinancialAccountingStandardsTextualAbstract" xml:lang="en-US">New Financial Accounting Standards (Textual)</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_929216F4IJ579I98G136_oprx_NewFinancialAccountingStandardsTextualAbstract" xlink:to="lab_141438H6KL791K10I358_oprx_NewFinancialAccountingStandardsTextualAbstract"/>
<loc xlink:type="locator" xlink:href="oprx-20180331.xsd#oprx_NewRevenueStandardIncreaseDeferredRevenue" xlink:label="loc_350FKH75322F_oprx_NewRevenueStandardIncreaseDeferredRevenue"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_572HMJ97544H_oprx_NewRevenueStandardIncreaseDeferredRevenue" xml:lang="en-US">New Revenue Standard Increase Deferred Revenue</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_572HMJ97544H_oprx_NewRevenueStandardIncreaseDeferredRevenue" xml:lang="en-US">Increase in deferred revenue</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:label="lab_572HMJ97544H_oprx_NewRevenueStandardIncreaseDeferredRevenue" xml:lang="en-US">New revenue standard increase deferred revenue.</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_350FKH75322F_oprx_NewRevenueStandardIncreaseDeferredRevenue" xlink:to="lab_572HMJ97544H_oprx_NewRevenueStandardIncreaseDeferredRevenue"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_NewAccountingPronouncementOrChangeInAccountingPrincipleDescription" xlink:label="loc_929216F4IJ579I98G136_us-gaap_NewAccountingPronouncementOrChangeInAccountingPrincipleDescription"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_141438H6KL791K10I358_us-gaap_NewAccountingPronouncementOrChangeInAccountingPrincipleDescription" xml:lang="en-US">New Accounting Pronouncement or Change in Accounting Principle, Description</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_141438H6KL791K10I358_us-gaap_NewAccountingPronouncementOrChangeInAccountingPrincipleDescription" xml:lang="en-US">New revenue accounting standard, description</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_929216F4IJ579I98G136_us-gaap_NewAccountingPronouncementOrChangeInAccountingPrincipleDescription" xlink:to="lab_141438H6KL791K10I358_us-gaap_NewAccountingPronouncementOrChangeInAccountingPrincipleDescription"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_ScheduleOfStockByClassTable" xlink:label="loc_350FKH75322F_us-gaap_ScheduleOfStockByClassTable"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_572HMJ97544H_us-gaap_ScheduleOfStockByClassTable" xml:lang="en-US">Schedule of Stock by Class [Table]</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_350FKH75322F_us-gaap_ScheduleOfStockByClassTable" xlink:to="lab_572HMJ97544H_us-gaap_ScheduleOfStockByClassTable"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_TitleOfIndividualAxis" xlink:label="loc_929216F4IJ579I98G136_us-gaap_TitleOfIndividualAxis"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_141438H6KL791K10I358_us-gaap_TitleOfIndividualAxis" xml:lang="en-US">Title of Individual [Axis]</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_929216F4IJ579I98G136_us-gaap_TitleOfIndividualAxis" xlink:to="lab_141438H6KL791K10I358_us-gaap_TitleOfIndividualAxis"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_TitleOfIndividualWithRelationshipToEntityDomain" xlink:label="loc_350FKH75322F_us-gaap_TitleOfIndividualWithRelationshipToEntityDomain"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_572HMJ97544H_us-gaap_TitleOfIndividualWithRelationshipToEntityDomain" xml:lang="en-US">Relationship to Entity [Domain]</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_350FKH75322F_us-gaap_TitleOfIndividualWithRelationshipToEntityDomain" xlink:to="lab_572HMJ97544H_us-gaap_TitleOfIndividualWithRelationshipToEntityDomain"/>
<loc xlink:type="locator" xlink:href="oprx-20180331.xsd#oprx_IndependentDirectorsMember" xlink:label="loc_929216F4IJ579I98G136_oprx_IndependentDirectorsMember"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_141438H6KL791K10I358_oprx_IndependentDirectorsMember" xml:lang="en-US">Independent Directors [Member]</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_929216F4IJ579I98G136_oprx_IndependentDirectorsMember" xlink:to="lab_141438H6KL791K10I358_oprx_IndependentDirectorsMember"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_ClassOfStockLineItems" xlink:label="loc_350FKH75322F_us-gaap_ClassOfStockLineItems"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_572HMJ97544H_us-gaap_ClassOfStockLineItems" xml:lang="en-US">Class of Stock [Line Items]</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_350FKH75322F_us-gaap_ClassOfStockLineItems" xlink:to="lab_572HMJ97544H_us-gaap_ClassOfStockLineItems"/>
<loc xlink:type="locator" xlink:href="oprx-20180331.xsd#oprx_StockholdersEquityTextualAbstract" xlink:label="loc_929216F4IJ579I98G136_oprx_StockholdersEquityTextualAbstract"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_141438H6KL791K10I358_oprx_StockholdersEquityTextualAbstract" xml:lang="en-US">Stockholders Equity Textual [Abstract]</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_141438H6KL791K10I358_oprx_StockholdersEquityTextualAbstract" xml:lang="en-US">Stockholders' Equity (Textual)</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_929216F4IJ579I98G136_oprx_StockholdersEquityTextualAbstract" xlink:to="lab_141438H6KL791K10I358_oprx_StockholdersEquityTextualAbstract"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_SharesIssued" xlink:label="loc_350FKH75322F_us-gaap_SharesIssued"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_572HMJ97544H_us-gaap_SharesIssued" xml:lang="en-US">Shares, Issued</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_572HMJ97544H_us-gaap_SharesIssued" xml:lang="en-US">Additional shares issued</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:label="lab_572HMJ97544H_us-gaap_SharesIssued" xml:lang="en-US">Additional shares issued</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_350FKH75322F_us-gaap_SharesIssued" xlink:to="lab_572HMJ97544H_us-gaap_SharesIssued"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_StockIssuedDuringPeriodSharesOther" xlink:label="loc_929216F4IJ579I98G136_us-gaap_StockIssuedDuringPeriodSharesOther"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_141438H6KL791K10I358_us-gaap_StockIssuedDuringPeriodSharesOther" xml:lang="en-US">Stock Issued During Period, Shares, Other</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:label="lab_141438H6KL791K10I358_us-gaap_StockIssuedDuringPeriodSharesOther" xml:lang="en-US">Compensation plan issuance of shares</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_929216F4IJ579I98G136_us-gaap_StockIssuedDuringPeriodSharesOther" xlink:to="lab_141438H6KL791K10I358_us-gaap_StockIssuedDuringPeriodSharesOther"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_StockIssuedDuringPeriodValueOther" xlink:label="loc_350FKH75322F_us-gaap_StockIssuedDuringPeriodValueOther"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_572HMJ97544H_us-gaap_StockIssuedDuringPeriodValueOther" xml:lang="en-US">Stock Issued During Period, Value, Other</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_572HMJ97544H_us-gaap_StockIssuedDuringPeriodValueOther" xml:lang="en-US">Compensation plan issuance, value</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_350FKH75322F_us-gaap_StockIssuedDuringPeriodValueOther" xlink:to="lab_572HMJ97544H_us-gaap_StockIssuedDuringPeriodValueOther"/>
<loc xlink:type="locator" xlink:href="oprx-20180331.xsd#oprx_DilutedLossPerCommonShare" xlink:label="loc_929216F4IJ579I98G136_oprx_DilutedLossPerCommonShare"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_141438H6KL791K10I358_oprx_DilutedLossPerCommonShare" xml:lang="en-US">Diluted Loss Per Common Share</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_141438H6KL791K10I358_oprx_DilutedLossPerCommonShare" xml:lang="en-US">Diluted loss per common share</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:label="lab_141438H6KL791K10I358_oprx_DilutedLossPerCommonShare" xml:lang="en-US">diluted loss per common share.</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_929216F4IJ579I98G136_oprx_DilutedLossPerCommonShare" xlink:to="lab_141438H6KL791K10I358_oprx_DilutedLossPerCommonShare"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable" xlink:label="loc_350FKH75322F_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_572HMJ97544H_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable" xml:lang="en-US">Schedule of Share-based Compensation Arrangements by Share-based Payment Award [Table]</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_350FKH75322F_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable" xlink:to="lab_572HMJ97544H_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_AwardTypeAxis" xlink:label="loc_929216F4IJ579I98G136_us-gaap_AwardTypeAxis"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_141438H6KL791K10I358_us-gaap_AwardTypeAxis" xml:lang="en-US">Award Type [Axis]</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_929216F4IJ579I98G136_us-gaap_AwardTypeAxis" xlink:to="lab_141438H6KL791K10I358_us-gaap_AwardTypeAxis"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain" xlink:label="loc_350FKH75322F_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_572HMJ97544H_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain" xml:lang="en-US">Equity Award [Domain]</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_350FKH75322F_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain" xlink:to="lab_572HMJ97544H_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain"/>
<loc xlink:type="locator" xlink:href="oprx-20180331.xsd#oprx_StockOptionsMember" xlink:label="loc_929216F4IJ579I98G136_oprx_StockOptionsMember"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_141438H6KL791K10I358_oprx_StockOptionsMember" xml:lang="en-US">Stock Options [Member]</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_141438H6KL791K10I358_oprx_StockOptionsMember" xml:lang="en-US">Stock Options [Member]</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:label="lab_141438H6KL791K10I358_oprx_StockOptionsMember" xml:lang="en-US">Stock Options</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_929216F4IJ579I98G136_oprx_StockOptionsMember" xlink:to="lab_141438H6KL791K10I358_oprx_StockOptionsMember"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems" xlink:label="loc_350FKH75322F_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_572HMJ97544H_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems" xml:lang="en-US">Share-based Compensation Arrangement by Share-based Payment Award [Line Items]</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_350FKH75322F_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems" xlink:to="lab_572HMJ97544H_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingRollForward" xlink:label="loc_929216F4IJ579I98G136_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingRollForward"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_141438H6KL791K10I358_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingRollForward" xml:lang="en-US">Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding [Roll Forward]</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_141438H6KL791K10I358_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingRollForward" xml:lang="en-US">Number of Options</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_929216F4IJ579I98G136_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingRollForward" xlink:to="lab_141438H6KL791K10I358_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingRollForward"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingNumber" xlink:label="loc_350FKH75322F_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingNumber"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_572HMJ97544H_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingNumber" xml:lang="en-US">Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Number</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:label="lab_572HMJ97544H_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingNumber" xml:lang="en-US">Options</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/periodStartLabel" xlink:label="lab_572HMJ97544H_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingNumber" xml:lang="en-US">Begining balance, Outstanding</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/periodEndLabel" xlink:label="lab_572HMJ97544H_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingNumber" xml:lang="en-US">Ending balance, Outstanding</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_350FKH75322F_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingNumber" xlink:to="lab_572HMJ97544H_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingNumber"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodGross" xlink:label="loc_929216F4IJ579I98G136_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodGross"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_141438H6KL791K10I358_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodGross" xml:lang="en-US">Share-based Compensation Arrangement by Share-based Payment Award, Options, Grants in Period, Gross</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_141438H6KL791K10I358_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodGross" xml:lang="en-US">Total common granted stock</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:label="lab_141438H6KL791K10I358_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodGross" xml:lang="en-US">Granted</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/definitionGuidance" xlink:label="lab_141438H6KL791K10I358_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodGross" xml:lang="en-US">Shares granted</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_929216F4IJ579I98G136_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodGross" xlink:to="lab_141438H6KL791K10I358_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodGross"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExpirationsInPeriod" xlink:label="loc_350FKH75322F_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExpirationsInPeriod"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_572HMJ97544H_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExpirationsInPeriod" xml:lang="en-US">Share-based Compensation Arrangement by Share-based Payment Award, Options, Expirations in Period</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_572HMJ97544H_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExpirationsInPeriod" xml:lang="en-US">Expired</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2009/role/negatedLabel" xlink:label="lab_572HMJ97544H_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExpirationsInPeriod" xml:lang="en-US">Expired</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_350FKH75322F_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExpirationsInPeriod" xlink:to="lab_572HMJ97544H_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExpirationsInPeriod"/>
<loc xlink:type="locator" xlink:href="oprx-20180331.xsd#oprx_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisable" xlink:label="loc_929216F4IJ579I98G136_oprx_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisable"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_141438H6KL791K10I358_oprx_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisable" xml:lang="en-US">Share Based Compensation Arrangement By Share Based Payment Award Options Exercisable</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_141438H6KL791K10I358_oprx_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisable" xml:lang="en-US">Exercisable</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:label="lab_141438H6KL791K10I358_oprx_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisable" xml:lang="en-US">Options exercisable</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:label="lab_141438H6KL791K10I358_oprx_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisable" xml:lang="en-US">Number of share options (or share units) exercisable during the current period.</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_929216F4IJ579I98G136_oprx_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisable" xlink:to="lab_141438H6KL791K10I358_oprx_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisable"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePriceRollforward" xlink:label="loc_350FKH75322F_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePriceRollforward"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_572HMJ97544H_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePriceRollforward" xml:lang="en-US">Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Weighted Average Exercise Price [Abstract]</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_572HMJ97544H_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePriceRollforward" xml:lang="en-US">Weighted average exercise price</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_350FKH75322F_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePriceRollforward" xlink:to="lab_572HMJ97544H_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePriceRollforward"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePrice" xlink:label="loc_929216F4IJ579I98G136_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePrice"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_141438H6KL791K10I358_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePrice" xml:lang="en-US">Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Weighted Average Exercise Price</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:label="lab_141438H6KL791K10I358_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePrice" xml:lang="en-US">Weighted average exercise price</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/periodStartLabel" xlink:label="lab_141438H6KL791K10I358_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePrice" xml:lang="en-US">Beginning balance, Outstanding</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/periodEndLabel" xlink:label="lab_141438H6KL791K10I358_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePrice" xml:lang="en-US">Ending balance, Outstanding</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2009/role/negatedPeriodEndLabel" xlink:label="lab_141438H6KL791K10I358_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePrice" xml:lang="en-US">Ending balance, Outstanding</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_929216F4IJ579I98G136_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePrice" xlink:to="lab_141438H6KL791K10I358_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePrice"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsGrantsInPeriodWeightedAverageExercisePrice" xlink:label="loc_350FKH75322F_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsGrantsInPeriodWeightedAverageExercisePrice"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_572HMJ97544H_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsGrantsInPeriodWeightedAverageExercisePrice" xml:lang="en-US">Share-based Compensation Arrangements by Share-based Payment Award, Options, Grants in Period, Weighted Average Exercise Price</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_572HMJ97544H_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsGrantsInPeriodWeightedAverageExercisePrice" xml:lang="en-US">Granted</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_350FKH75322F_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsGrantsInPeriodWeightedAverageExercisePrice" xlink:to="lab_572HMJ97544H_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsGrantsInPeriodWeightedAverageExercisePrice"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsExercisesInPeriodWeightedAverageExercisePrice" xlink:label="loc_929216F4IJ579I98G136_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsExercisesInPeriodWeightedAverageExercisePrice"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_141438H6KL791K10I358_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsExercisesInPeriodWeightedAverageExercisePrice" xml:lang="en-US">Share-based Compensation Arrangements by Share-based Payment Award, Options, Exercises in Period, Weighted Average Exercise Price</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_141438H6KL791K10I358_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsExercisesInPeriodWeightedAverageExercisePrice" xml:lang="en-US">Exercised</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_929216F4IJ579I98G136_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsExercisesInPeriodWeightedAverageExercisePrice" xlink:to="lab_141438H6KL791K10I358_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsExercisesInPeriodWeightedAverageExercisePrice"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsExpirationsInPeriodWeightedAverageExercisePrice" xlink:label="loc_350FKH75322F_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsExpirationsInPeriodWeightedAverageExercisePrice"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_572HMJ97544H_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsExpirationsInPeriodWeightedAverageExercisePrice" xml:lang="en-US">Share-based Compensation Arrangements by Share-based Payment Award, Options, Expirations in Period, Weighted Average Exercise Price</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_572HMJ97544H_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsExpirationsInPeriodWeightedAverageExercisePrice" xml:lang="en-US">Expired</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_350FKH75322F_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsExpirationsInPeriodWeightedAverageExercisePrice" xlink:to="lab_572HMJ97544H_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsExpirationsInPeriodWeightedAverageExercisePrice"/>
<loc xlink:type="locator" xlink:href="oprx-20180331.xsd#oprx_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsExercisableInPeriodWeightedAverageExercisePrice" xlink:label="loc_929216F4IJ579I98G136_oprx_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsExercisableInPeriodWeightedAverageExercisePrice"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_141438H6KL791K10I358_oprx_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsExercisableInPeriodWeightedAverageExercisePrice" xml:lang="en-US">Share Based Compensation Arrangements By Share Based Payment Award Options Exercisable In Period Weighted Average Exercise Price</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_141438H6KL791K10I358_oprx_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsExercisableInPeriodWeightedAverageExercisePrice" xml:lang="en-US">Exercisable</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:label="lab_141438H6KL791K10I358_oprx_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsExercisableInPeriodWeightedAverageExercisePrice" xml:lang="en-US">Weighted average per share amount that are exercisable.</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_929216F4IJ579I98G136_oprx_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsExercisableInPeriodWeightedAverageExercisePrice" xlink:to="lab_141438H6KL791K10I358_oprx_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsExercisableInPeriodWeightedAverageExercisePrice"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_SharebasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeOutstandingOptionsWeightedAverageRemainingContractualTerm2" xlink:label="loc_350FKH75322F_us-gaap_SharebasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeOutstandingOptionsWeightedAverageRemainingContractualTerm2"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_572HMJ97544H_us-gaap_SharebasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeOutstandingOptionsWeightedAverageRemainingContractualTerm2" xml:lang="en-US">Share-based Compensation, Shares Authorized under Stock Option Plans, Exercise Price Range, Outstanding Options, Weighted Average Remaining Contractual Term</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_572HMJ97544H_us-gaap_SharebasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeOutstandingOptionsWeightedAverageRemainingContractualTerm2" xml:lang="en-US">Outstanding, Weighted average remaining contractual life (years)</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_350FKH75322F_us-gaap_SharebasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeOutstandingOptionsWeightedAverageRemainingContractualTerm2" xlink:to="lab_572HMJ97544H_us-gaap_SharebasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeOutstandingOptionsWeightedAverageRemainingContractualTerm2"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsExercisableWeightedAverageRemainingContractualTerm1" xlink:label="loc_929216F4IJ579I98G136_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsExercisableWeightedAverageRemainingContractualTerm1"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_141438H6KL791K10I358_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsExercisableWeightedAverageRemainingContractualTerm1" xml:lang="en-US">Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercisable, Weighted Average Remaining Contractual Term</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_141438H6KL791K10I358_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsExercisableWeightedAverageRemainingContractualTerm1" xml:lang="en-US">Exercisable, Weighted average remaining contractual life (years)</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:label="lab_141438H6KL791K10I358_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsExercisableWeightedAverageRemainingContractualTerm1" xml:lang="en-US">Weighted average contractual life</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_929216F4IJ579I98G136_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsExercisableWeightedAverageRemainingContractualTerm1" xlink:to="lab_141438H6KL791K10I358_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsExercisableWeightedAverageRemainingContractualTerm1"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingIntrinsicValue" xlink:label="loc_350FKH75322F_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingIntrinsicValue"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_572HMJ97544H_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingIntrinsicValue" xml:lang="en-US">Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Intrinsic Value</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_572HMJ97544H_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingIntrinsicValue" xml:lang="en-US">Outstanding, Aggregate intrinsic value</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_350FKH75322F_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingIntrinsicValue" xlink:to="lab_572HMJ97544H_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingIntrinsicValue"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsExercisableIntrinsicValue1" xlink:label="loc_929216F4IJ579I98G136_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsExercisableIntrinsicValue1"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_141438H6KL791K10I358_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsExercisableIntrinsicValue1" xml:lang="en-US">Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercisable, Intrinsic Value</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_141438H6KL791K10I358_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsExercisableIntrinsicValue1" xml:lang="en-US">Exercisable, Aggregate intrinsic value</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_929216F4IJ579I98G136_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsExercisableIntrinsicValue1" xlink:to="lab_141438H6KL791K10I358_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsExercisableIntrinsicValue1"/>
<loc xlink:type="locator" xlink:href="oprx-20180331.xsd#oprx_OptionsOneMember" xlink:label="loc_350FKH75322F_oprx_OptionsOneMember"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_572HMJ97544H_oprx_OptionsOneMember" xml:lang="en-US">Options One [Member]</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_572HMJ97544H_oprx_OptionsOneMember" xml:lang="en-US">Options One [Member]</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:label="lab_572HMJ97544H_oprx_OptionsOneMember" xml:lang="en-US">Options One</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_350FKH75322F_oprx_OptionsOneMember" xlink:to="lab_572HMJ97544H_oprx_OptionsOneMember"/>
<loc xlink:type="locator" xlink:href="oprx-20180331.xsd#oprx_OptionsTwoMember" xlink:label="loc_929216F4IJ579I98G136_oprx_OptionsTwoMember"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_141438H6KL791K10I358_oprx_OptionsTwoMember" xml:lang="en-US">Options Two [Member]</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_141438H6KL791K10I358_oprx_OptionsTwoMember" xml:lang="en-US">Options Two [Member]</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:label="lab_141438H6KL791K10I358_oprx_OptionsTwoMember" xml:lang="en-US">Options Two</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_929216F4IJ579I98G136_oprx_OptionsTwoMember" xlink:to="lab_141438H6KL791K10I358_oprx_OptionsTwoMember"/>
<loc xlink:type="locator" xlink:href="oprx-20180331.xsd#oprx_OptionsThreeMember" xlink:label="loc_350FKH75322F_oprx_OptionsThreeMember"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_572HMJ97544H_oprx_OptionsThreeMember" xml:lang="en-US">Options Three [Member]</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_572HMJ97544H_oprx_OptionsThreeMember" xml:lang="en-US">Options Three [Member]</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:label="lab_572HMJ97544H_oprx_OptionsThreeMember" xml:lang="en-US">Options Three</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_350FKH75322F_oprx_OptionsThreeMember" xlink:to="lab_572HMJ97544H_oprx_OptionsThreeMember"/>
<loc xlink:type="locator" xlink:href="oprx-20180331.xsd#oprx_OptionsFourMember" xlink:label="loc_929216F4IJ579I98G136_oprx_OptionsFourMember"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_141438H6KL791K10I358_oprx_OptionsFourMember" xml:lang="en-US">Options Four [Member]</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_141438H6KL791K10I358_oprx_OptionsFourMember" xml:lang="en-US">Options Four [Member]</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:label="lab_141438H6KL791K10I358_oprx_OptionsFourMember" xml:lang="en-US">Options Four</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_929216F4IJ579I98G136_oprx_OptionsFourMember" xlink:to="lab_141438H6KL791K10I358_oprx_OptionsFourMember"/>
<loc xlink:type="locator" xlink:href="oprx-20180331.xsd#oprx_OptionsFiveMember" xlink:label="loc_350FKH75322F_oprx_OptionsFiveMember"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_572HMJ97544H_oprx_OptionsFiveMember" xml:lang="en-US">Options Five [Member]</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_572HMJ97544H_oprx_OptionsFiveMember" xml:lang="en-US">Options Five [Member]</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:label="lab_572HMJ97544H_oprx_OptionsFiveMember" xml:lang="en-US">Options Five</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_350FKH75322F_oprx_OptionsFiveMember" xlink:to="lab_572HMJ97544H_oprx_OptionsFiveMember"/>
<loc xlink:type="locator" xlink:href="oprx-20180331.xsd#oprx_OptionsSixMember" xlink:label="loc_929216F4IJ579I98G136_oprx_OptionsSixMember"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_141438H6KL791K10I358_oprx_OptionsSixMember" xml:lang="en-US">Options Six [Member]</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_141438H6KL791K10I358_oprx_OptionsSixMember" xml:lang="en-US">Options Six [Member]</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:label="lab_141438H6KL791K10I358_oprx_OptionsSixMember" xml:lang="en-US">Options Six</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_929216F4IJ579I98G136_oprx_OptionsSixMember" xlink:to="lab_141438H6KL791K10I358_oprx_OptionsSixMember"/>
<loc xlink:type="locator" xlink:href="oprx-20180331.xsd#oprx_OptionsSevenMember" xlink:label="loc_350FKH75322F_oprx_OptionsSevenMember"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_572HMJ97544H_oprx_OptionsSevenMember" xml:lang="en-US">Options Seven [Member]</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_572HMJ97544H_oprx_OptionsSevenMember" xml:lang="en-US">Options Seven [Member]</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:label="lab_572HMJ97544H_oprx_OptionsSevenMember" xml:lang="en-US">Options Seven</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_350FKH75322F_oprx_OptionsSevenMember" xlink:to="lab_572HMJ97544H_oprx_OptionsSevenMember"/>
<loc xlink:type="locator" xlink:href="oprx-20180331.xsd#oprx_OptionsEightMember" xlink:label="loc_929216F4IJ579I98G136_oprx_OptionsEightMember"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_141438H6KL791K10I358_oprx_OptionsEightMember" xml:lang="en-US">Options Eight [Member]</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_141438H6KL791K10I358_oprx_OptionsEightMember" xml:lang="en-US">Options Eight [Member]</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:label="lab_141438H6KL791K10I358_oprx_OptionsEightMember" xml:lang="en-US">Options Eight</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_929216F4IJ579I98G136_oprx_OptionsEightMember" xlink:to="lab_141438H6KL791K10I358_oprx_OptionsEightMember"/>
<loc xlink:type="locator" xlink:href="oprx-20180331.xsd#oprx_OptionsNineMember" xlink:label="loc_350FKH75322F_oprx_OptionsNineMember"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_572HMJ97544H_oprx_OptionsNineMember" xml:lang="en-US">Options Nine [Member]</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_572HMJ97544H_oprx_OptionsNineMember" xml:lang="en-US">Options Nine [Member]</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:label="lab_572HMJ97544H_oprx_OptionsNineMember" xml:lang="en-US">Options Nine</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_350FKH75322F_oprx_OptionsNineMember" xlink:to="lab_572HMJ97544H_oprx_OptionsNineMember"/>
<loc xlink:type="locator" xlink:href="oprx-20180331.xsd#oprx_OptionsOutstanding" xlink:label="loc_929216F4IJ579I98G136_oprx_OptionsOutstanding"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_141438H6KL791K10I358_oprx_OptionsOutstanding" xml:lang="en-US">Options Outstanding</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_141438H6KL791K10I358_oprx_OptionsOutstanding" xml:lang="en-US">Number of Options</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:label="lab_141438H6KL791K10I358_oprx_OptionsOutstanding" xml:lang="en-US">The number of option outstanding.</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_929216F4IJ579I98G136_oprx_OptionsOutstanding" xlink:to="lab_141438H6KL791K10I358_oprx_OptionsOutstanding"/>
<loc xlink:type="locator" xlink:href="http://xbrl.sec.gov/invest/2013/invest-2013-01-31.xsd#invest_InvestmentOptionsExercisePrice" xlink:label="loc_350FKH75322F_invest_InvestmentOptionsExercisePrice"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_572HMJ97544H_invest_InvestmentOptionsExercisePrice" xml:lang="en-US">Investment Options, Exercise Price</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_572HMJ97544H_invest_InvestmentOptionsExercisePrice" xml:lang="en-US">Exercise Price</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_350FKH75322F_invest_InvestmentOptionsExercisePrice" xlink:to="lab_572HMJ97544H_invest_InvestmentOptionsExercisePrice"/>
<loc xlink:type="locator" xlink:href="http://xbrl.sec.gov/invest/2013/invest-2013-01-31.xsd#invest_InvestmentOptionsExpirationDate" xlink:label="loc_929216F4IJ579I98G136_invest_InvestmentOptionsExpirationDate"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_141438H6KL791K10I358_invest_InvestmentOptionsExpirationDate" xml:lang="en-US">Investment Options, Expiration Date</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_141438H6KL791K10I358_invest_InvestmentOptionsExpirationDate" xml:lang="en-US">Expiration Date</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:label="lab_141438H6KL791K10I358_invest_InvestmentOptionsExpirationDate" xml:lang="en-US">Options expired</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_929216F4IJ579I98G136_invest_InvestmentOptionsExpirationDate" xlink:to="lab_141438H6KL791K10I358_invest_InvestmentOptionsExpirationDate"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_StockCompensationPlanMember" xlink:label="loc_350FKH75322F_us-gaap_StockCompensationPlanMember"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_572HMJ97544H_us-gaap_StockCompensationPlanMember" xml:lang="en-US">Stock Compensation Plan [Member]</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_572HMJ97544H_us-gaap_StockCompensationPlanMember" xml:lang="en-US">2013 Equity Compensation Plan [Member]</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_350FKH75322F_us-gaap_StockCompensationPlanMember" xlink:to="lab_572HMJ97544H_us-gaap_StockCompensationPlanMember"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_DerivativeInstrumentRiskAxis" xlink:label="loc_929216F4IJ579I98G136_us-gaap_DerivativeInstrumentRiskAxis"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_141438H6KL791K10I358_us-gaap_DerivativeInstrumentRiskAxis" xml:lang="en-US">Derivative Instrument [Axis]</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_929216F4IJ579I98G136_us-gaap_DerivativeInstrumentRiskAxis" xlink:to="lab_141438H6KL791K10I358_us-gaap_DerivativeInstrumentRiskAxis"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_DerivativeContractTypeDomain" xlink:label="loc_350FKH75322F_us-gaap_DerivativeContractTypeDomain"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_572HMJ97544H_us-gaap_DerivativeContractTypeDomain" xml:lang="en-US">Derivative Contract [Domain]</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_350FKH75322F_us-gaap_DerivativeContractTypeDomain" xlink:to="lab_572HMJ97544H_us-gaap_DerivativeContractTypeDomain"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_StockOptionMember" xlink:label="loc_929216F4IJ579I98G136_us-gaap_StockOptionMember"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_141438H6KL791K10I358_us-gaap_StockOptionMember" xml:lang="en-US">Equity Option [Member]</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_141438H6KL791K10I358_us-gaap_StockOptionMember" xml:lang="en-US">Stock Option [Member]</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_929216F4IJ579I98G136_us-gaap_StockOptionMember" xlink:to="lab_141438H6KL791K10I358_us-gaap_StockOptionMember"/>
<loc xlink:type="locator" xlink:href="oprx-20180331.xsd#oprx_StockOptionsTextualAbstract" xlink:label="loc_350FKH75322F_oprx_StockOptionsTextualAbstract"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_572HMJ97544H_oprx_StockOptionsTextualAbstract" xml:lang="en-US">Stock Options Textual [Abstract]</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_572HMJ97544H_oprx_StockOptionsTextualAbstract" xml:lang="en-US">Share Based Payments - Options (Textual)</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_350FKH75322F_oprx_StockOptionsTextualAbstract" xlink:to="lab_572HMJ97544H_oprx_StockOptionsTextualAbstract"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_DeferredCompensationArrangementWithIndividualCommonStockReservedForFutureIssuance" xlink:label="loc_929216F4IJ579I98G136_us-gaap_DeferredCompensationArrangementWithIndividualCommonStockReservedForFutureIssuance"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_141438H6KL791K10I358_us-gaap_DeferredCompensationArrangementWithIndividualCommonStockReservedForFutureIssuance" xml:lang="en-US">Deferred Compensation Arrangement with Individual, Common Stock Reserved for Future Issuance</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_141438H6KL791K10I358_us-gaap_DeferredCompensationArrangementWithIndividualCommonStockReservedForFutureIssuance" xml:lang="en-US">Shares reserved for issuance</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_929216F4IJ579I98G136_us-gaap_DeferredCompensationArrangementWithIndividualCommonStockReservedForFutureIssuance" xlink:to="lab_141438H6KL791K10I358_us-gaap_DeferredCompensationArrangementWithIndividualCommonStockReservedForFutureIssuance"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardPlanModificationDescriptionAndTerms" xlink:label="loc_350FKH75322F_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardPlanModificationDescriptionAndTerms"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_572HMJ97544H_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardPlanModificationDescriptionAndTerms" xml:lang="en-US">Share-based Compensation Arrangement by Share-based Payment Award, Plan Modification, Description and Terms</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_572HMJ97544H_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardPlanModificationDescriptionAndTerms" xml:lang="en-US">Share-based compensation plan, description</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_350FKH75322F_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardPlanModificationDescriptionAndTerms" xlink:to="lab_572HMJ97544H_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardPlanModificationDescriptionAndTerms"/>
<loc xlink:type="locator" xlink:href="oprx-20180331.xsd#oprx_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodGrossOne" xlink:label="loc_929216F4IJ579I98G136_oprx_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodGrossOne"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_141438H6KL791K10I358_oprx_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodGrossOne" xml:lang="en-US">Share Based Compensation Arrangement By Share Based Payment Award Options Grants In Period Gross One</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_141438H6KL791K10I358_oprx_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodGrossOne" xml:lang="en-US">Options outstanding</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:label="lab_141438H6KL791K10I358_oprx_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodGrossOne" xml:lang="en-US">Gross number of share options (or share units) granted during the period.</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_929216F4IJ579I98G136_oprx_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodGrossOne" xlink:to="lab_141438H6KL791K10I358_oprx_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodGrossOne"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_StockIssuedDuringPeriodSharesRestrictedStockAwardGross" xlink:label="loc_350FKH75322F_us-gaap_StockIssuedDuringPeriodSharesRestrictedStockAwardGross"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_572HMJ97544H_us-gaap_StockIssuedDuringPeriodSharesRestrictedStockAwardGross" xml:lang="en-US">Stock Issued During Period, Shares, Restricted Stock Award, Gross</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_572HMJ97544H_us-gaap_StockIssuedDuringPeriodSharesRestrictedStockAwardGross" xml:lang="en-US">Restricted shares</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_350FKH75322F_us-gaap_StockIssuedDuringPeriodSharesRestrictedStockAwardGross" xlink:to="lab_572HMJ97544H_us-gaap_StockIssuedDuringPeriodSharesRestrictedStockAwardGross"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardCompensationCost1" xlink:label="loc_929216F4IJ579I98G136_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardCompensationCost1"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_141438H6KL791K10I358_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardCompensationCost1" xml:lang="en-US">Share-based Compensation Arrangement by Share-based Payment Award, Compensation Cost</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_141438H6KL791K10I358_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardCompensationCost1" xml:lang="en-US">Compensation cost</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_929216F4IJ579I98G136_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardCompensationCost1" xlink:to="lab_141438H6KL791K10I358_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardCompensationCost1"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsNonvestedNumberOfShares" xlink:label="loc_350FKH75322F_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsNonvestedNumberOfShares"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_572HMJ97544H_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsNonvestedNumberOfShares" xml:lang="en-US">Share-based Compensation Arrangement by Share-based Payment Award, Options, Nonvested, Number of Shares</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:label="lab_572HMJ97544H_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsNonvestedNumberOfShares" xml:lang="en-US">Non-vested shares</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_350FKH75322F_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsNonvestedNumberOfShares" xlink:to="lab_572HMJ97544H_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsNonvestedNumberOfShares"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_ExcessStockSharesAuthorized" xlink:label="loc_929216F4IJ579I98G136_us-gaap_ExcessStockSharesAuthorized"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_141438H6KL791K10I358_us-gaap_ExcessStockSharesAuthorized" xml:lang="en-US">Excess Stock, Shares Authorized</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_141438H6KL791K10I358_us-gaap_ExcessStockSharesAuthorized" xml:lang="en-US">Increased shares of common stock authorized</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_929216F4IJ579I98G136_us-gaap_ExcessStockSharesAuthorized" xlink:to="lab_141438H6KL791K10I358_us-gaap_ExcessStockSharesAuthorized"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_ScheduleOfRelatedPartyTransactionsByRelatedPartyTable" xlink:label="loc_350FKH75322F_us-gaap_ScheduleOfRelatedPartyTransactionsByRelatedPartyTable"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_572HMJ97544H_us-gaap_ScheduleOfRelatedPartyTransactionsByRelatedPartyTable" xml:lang="en-US">Schedule of Related Party Transactions, by Related Party [Table]</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_350FKH75322F_us-gaap_ScheduleOfRelatedPartyTransactionsByRelatedPartyTable" xlink:to="lab_572HMJ97544H_us-gaap_ScheduleOfRelatedPartyTransactionsByRelatedPartyTable"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_RelatedPartyTransactionAxis" xlink:label="loc_929216F4IJ579I98G136_us-gaap_RelatedPartyTransactionAxis"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_141438H6KL791K10I358_us-gaap_RelatedPartyTransactionAxis" xml:lang="en-US">Related Party Transaction [Axis]</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_929216F4IJ579I98G136_us-gaap_RelatedPartyTransactionAxis" xlink:to="lab_141438H6KL791K10I358_us-gaap_RelatedPartyTransactionAxis"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_RelatedPartyTransactionDomain" xlink:label="loc_350FKH75322F_us-gaap_RelatedPartyTransactionDomain"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_572HMJ97544H_us-gaap_RelatedPartyTransactionDomain" xml:lang="en-US">Related Party Transaction [Domain]</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_350FKH75322F_us-gaap_RelatedPartyTransactionDomain" xlink:to="lab_572HMJ97544H_us-gaap_RelatedPartyTransactionDomain"/>
<loc xlink:type="locator" xlink:href="oprx-20180331.xsd#oprx_BillingsToRelatedPartiesMember" xlink:label="loc_929216F4IJ579I98G136_oprx_BillingsToRelatedPartiesMember"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_141438H6KL791K10I358_oprx_BillingsToRelatedPartiesMember" xml:lang="en-US">Billings To Related Parties [Member]</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:label="lab_141438H6KL791K10I358_oprx_BillingsToRelatedPartiesMember" xml:lang="en-US">Total billings to WPP Agencies [Member]</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_929216F4IJ579I98G136_oprx_BillingsToRelatedPartiesMember" xlink:to="lab_141438H6KL791K10I358_oprx_BillingsToRelatedPartiesMember"/>
<loc xlink:type="locator" xlink:href="oprx-20180331.xsd#oprx_RevenueRecognizedFromRelatedPartyMember" xlink:label="loc_350FKH75322F_oprx_RevenueRecognizedFromRelatedPartyMember"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_572HMJ97544H_oprx_RevenueRecognizedFromRelatedPartyMember" xml:lang="en-US">Revenue Recognized From Related Party [Member]</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:label="lab_572HMJ97544H_oprx_RevenueRecognizedFromRelatedPartyMember" xml:lang="en-US">Revenue recognized from WPP Agencies [Member]</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_350FKH75322F_oprx_RevenueRecognizedFromRelatedPartyMember" xlink:to="lab_572HMJ97544H_oprx_RevenueRecognizedFromRelatedPartyMember"/>
<loc xlink:type="locator" xlink:href="oprx-20180331.xsd#oprx_AccountsReceivableFromRelatedPartyMember" xlink:label="loc_929216F4IJ579I98G136_oprx_AccountsReceivableFromRelatedPartyMember"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_141438H6KL791K10I358_oprx_AccountsReceivableFromRelatedPartyMember" xml:lang="en-US">Accounts Receivable From Related Party [Member]</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:label="lab_141438H6KL791K10I358_oprx_AccountsReceivableFromRelatedPartyMember" xml:lang="en-US">Accounts receivable from WPP Agencies [Member]</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_929216F4IJ579I98G136_oprx_AccountsReceivableFromRelatedPartyMember" xlink:to="lab_141438H6KL791K10I358_oprx_AccountsReceivableFromRelatedPartyMember"/>
<loc xlink:type="locator" xlink:href="oprx-20180331.xsd#oprx_RebatesGivenToRelatedPartyMember" xlink:label="loc_350FKH75322F_oprx_RebatesGivenToRelatedPartyMember"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_572HMJ97544H_oprx_RebatesGivenToRelatedPartyMember" xml:lang="en-US">Rebates Given To Related Party [Member]</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:label="lab_572HMJ97544H_oprx_RebatesGivenToRelatedPartyMember" xml:lang="en-US">Rebates given to WPP Agencies [Member]</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_350FKH75322F_oprx_RebatesGivenToRelatedPartyMember" xlink:to="lab_572HMJ97544H_oprx_RebatesGivenToRelatedPartyMember"/>
<loc xlink:type="locator" xlink:href="oprx-20180331.xsd#oprx_MarketingServicesPurchasedFromRelatedPartyMember" xlink:label="loc_929216F4IJ579I98G136_oprx_MarketingServicesPurchasedFromRelatedPartyMember"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_141438H6KL791K10I358_oprx_MarketingServicesPurchasedFromRelatedPartyMember" xml:lang="en-US">Marketing Services Purchased From Related Party [Member]</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:label="lab_141438H6KL791K10I358_oprx_MarketingServicesPurchasedFromRelatedPartyMember" xml:lang="en-US">Marketing services purchased from WPP Agencies [Member]</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_929216F4IJ579I98G136_oprx_MarketingServicesPurchasedFromRelatedPartyMember" xlink:to="lab_141438H6KL791K10I358_oprx_MarketingServicesPurchasedFromRelatedPartyMember"/>
<loc xlink:type="locator" xlink:href="oprx-20180331.xsd#oprx_AccountsPayableToRelatedPartyMember" xlink:label="loc_350FKH75322F_oprx_AccountsPayableToRelatedPartyMember"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_572HMJ97544H_oprx_AccountsPayableToRelatedPartyMember" xml:lang="en-US">Accounts Payable To Related Party [Member]</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:label="lab_572HMJ97544H_oprx_AccountsPayableToRelatedPartyMember" xml:lang="en-US">Accounts payable to WPP Agencies [Member]</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_350FKH75322F_oprx_AccountsPayableToRelatedPartyMember" xlink:to="lab_572HMJ97544H_oprx_AccountsPayableToRelatedPartyMember"/>
<loc xlink:type="locator" xlink:href="oprx-20180331.xsd#oprx_RevenueShareExpenseRecordedToRelatedPartyMember" xlink:label="loc_929216F4IJ579I98G136_oprx_RevenueShareExpenseRecordedToRelatedPartyMember"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_141438H6KL791K10I358_oprx_RevenueShareExpenseRecordedToRelatedPartyMember" xml:lang="en-US">Revenue Share Expense Recorded To Related Party [Member]</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:label="lab_141438H6KL791K10I358_oprx_RevenueShareExpenseRecordedToRelatedPartyMember" xml:lang="en-US">Revenue share expense recorded to WPP Agencies</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_929216F4IJ579I98G136_oprx_RevenueShareExpenseRecordedToRelatedPartyMember" xlink:to="lab_141438H6KL791K10I358_oprx_RevenueShareExpenseRecordedToRelatedPartyMember"/>
<loc xlink:type="locator" xlink:href="oprx-20180331.xsd#oprx_RevenueShareExpensesOwedToRelatedPartyMember" xlink:label="loc_350FKH75322F_oprx_RevenueShareExpensesOwedToRelatedPartyMember"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_572HMJ97544H_oprx_RevenueShareExpensesOwedToRelatedPartyMember" xml:lang="en-US">Revenue Share Expenses Owed To Related Party [Member]</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_572HMJ97544H_oprx_RevenueShareExpensesOwedToRelatedPartyMember" xml:lang="en-US">Revenue share expenses owed to WPP Agencies [Member]</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_350FKH75322F_oprx_RevenueShareExpensesOwedToRelatedPartyMember" xlink:to="lab_572HMJ97544H_oprx_RevenueShareExpensesOwedToRelatedPartyMember"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_RelatedPartyTransactionLineItems" xlink:label="loc_929216F4IJ579I98G136_us-gaap_RelatedPartyTransactionLineItems"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_141438H6KL791K10I358_us-gaap_RelatedPartyTransactionLineItems" xml:lang="en-US">Related Party Transaction [Line Items]</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_929216F4IJ579I98G136_us-gaap_RelatedPartyTransactionLineItems" xlink:to="lab_141438H6KL791K10I358_us-gaap_RelatedPartyTransactionLineItems"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_RelatedPartyTransactionAmountsOfTransaction" xlink:label="loc_350FKH75322F_us-gaap_RelatedPartyTransactionAmountsOfTransaction"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_572HMJ97544H_us-gaap_RelatedPartyTransactionAmountsOfTransaction" xml:lang="en-US">Related Party Transaction, Amounts of Transaction</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_572HMJ97544H_us-gaap_RelatedPartyTransactionAmountsOfTransaction" xml:lang="en-US">Lieu of common stock issued</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:label="lab_572HMJ97544H_us-gaap_RelatedPartyTransactionAmountsOfTransaction" xml:lang="en-US">Related party transactions</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_350FKH75322F_us-gaap_RelatedPartyTransactionAmountsOfTransaction" xlink:to="lab_572HMJ97544H_us-gaap_RelatedPartyTransactionAmountsOfTransaction"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_RelatedPartyTransactionsByRelatedPartyAxis" xlink:label="loc_929216F4IJ579I98G136_us-gaap_RelatedPartyTransactionsByRelatedPartyAxis"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_141438H6KL791K10I358_us-gaap_RelatedPartyTransactionsByRelatedPartyAxis" xml:lang="en-US">Related Party [Axis]</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_929216F4IJ579I98G136_us-gaap_RelatedPartyTransactionsByRelatedPartyAxis" xlink:to="lab_141438H6KL791K10I358_us-gaap_RelatedPartyTransactionsByRelatedPartyAxis"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_RelatedPartyDomain" xlink:label="loc_350FKH75322F_us-gaap_RelatedPartyDomain"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_572HMJ97544H_us-gaap_RelatedPartyDomain" xml:lang="en-US">Related Party [Domain]</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_350FKH75322F_us-gaap_RelatedPartyDomain" xlink:to="lab_572HMJ97544H_us-gaap_RelatedPartyDomain"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_ChiefExecutiveOfficerMember" xlink:label="loc_929216F4IJ579I98G136_us-gaap_ChiefExecutiveOfficerMember"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_141438H6KL791K10I358_us-gaap_ChiefExecutiveOfficerMember" xml:lang="en-US">Chief Executive Officer [Member]</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_141438H6KL791K10I358_us-gaap_ChiefExecutiveOfficerMember" xml:lang="en-US">CEO, Shadron Stastney [Member]</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:label="lab_141438H6KL791K10I358_us-gaap_ChiefExecutiveOfficerMember" xml:lang="en-US">CEO [Member]</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_929216F4IJ579I98G136_us-gaap_ChiefExecutiveOfficerMember" xlink:to="lab_141438H6KL791K10I358_us-gaap_ChiefExecutiveOfficerMember"/>
<loc xlink:type="locator" xlink:href="oprx-20180331.xsd#oprx_RelatedPartyTransactionsTextualAbstract" xlink:label="loc_350FKH75322F_oprx_RelatedPartyTransactionsTextualAbstract"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_572HMJ97544H_oprx_RelatedPartyTransactionsTextualAbstract" xml:lang="en-US">Related Party Transactions Textual [Abstract]</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_572HMJ97544H_oprx_RelatedPartyTransactionsTextualAbstract" xml:lang="en-US">Related Party Transactions (Textual)</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_350FKH75322F_oprx_RelatedPartyTransactionsTextualAbstract" xlink:to="lab_572HMJ97544H_oprx_RelatedPartyTransactionsTextualAbstract"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_StockIssuedDuringPeriodSharesPurchaseOfAssets" xlink:label="loc_929216F4IJ579I98G136_us-gaap_StockIssuedDuringPeriodSharesPurchaseOfAssets"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_141438H6KL791K10I358_us-gaap_StockIssuedDuringPeriodSharesPurchaseOfAssets" xml:lang="en-US">Stock Issued During Period, Shares, Purchase of Assets</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:label="lab_141438H6KL791K10I358_us-gaap_StockIssuedDuringPeriodSharesPurchaseOfAssets" xml:lang="en-US">Shares issued for in connection with purchase of a patent</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_929216F4IJ579I98G136_us-gaap_StockIssuedDuringPeriodSharesPurchaseOfAssets" xlink:to="lab_141438H6KL791K10I358_us-gaap_StockIssuedDuringPeriodSharesPurchaseOfAssets"/>
<loc xlink:type="locator" xlink:href="oprx-20180331.xsd#oprx_OptionsGrantedToAcquireExclusivePatentRightsShares" xlink:label="loc_350FKH75322F_oprx_OptionsGrantedToAcquireExclusivePatentRightsShares"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_572HMJ97544H_oprx_OptionsGrantedToAcquireExclusivePatentRightsShares" xml:lang="en-US">Options Granted To Acquire Exclusive Patent Rights Shares</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_572HMJ97544H_oprx_OptionsGrantedToAcquireExclusivePatentRightsShares" xml:lang="en-US">Stock options</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:label="lab_572HMJ97544H_oprx_OptionsGrantedToAcquireExclusivePatentRightsShares" xml:lang="en-US">Options granted to acquire exclusive patent rights shares.</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/disclosureGuidance" xlink:label="lab_572HMJ97544H_oprx_OptionsGrantedToAcquireExclusivePatentRightsShares" xml:lang="en-US">Stock options</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_350FKH75322F_oprx_OptionsGrantedToAcquireExclusivePatentRightsShares" xlink:to="lab_572HMJ97544H_oprx_OptionsGrantedToAcquireExclusivePatentRightsShares"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_SaleOfStockTransactionDate" xlink:label="loc_929216F4IJ579I98G136_us-gaap_SaleOfStockTransactionDate"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_141438H6KL791K10I358_us-gaap_SaleOfStockTransactionDate" xml:lang="en-US">Sale of Stock, Transaction Date</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_141438H6KL791K10I358_us-gaap_SaleOfStockTransactionDate" xml:lang="en-US">Expire date</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_929216F4IJ579I98G136_us-gaap_SaleOfStockTransactionDate" xlink:to="lab_141438H6KL791K10I358_us-gaap_SaleOfStockTransactionDate"/>
<loc xlink:type="locator" xlink:href="oprx-20180331.xsd#oprx_OptionsGrantedToAcquireExclusivePatentRightsValue" xlink:label="loc_350FKH75322F_oprx_OptionsGrantedToAcquireExclusivePatentRightsValue"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_572HMJ97544H_oprx_OptionsGrantedToAcquireExclusivePatentRightsValue" xml:lang="en-US">Options Granted To Acquire Exclusive Patent Rights Value</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_572HMJ97544H_oprx_OptionsGrantedToAcquireExclusivePatentRightsValue" xml:lang="en-US">Shares values</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:label="lab_572HMJ97544H_oprx_OptionsGrantedToAcquireExclusivePatentRightsValue" xml:lang="en-US">Shares values</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:label="lab_572HMJ97544H_oprx_OptionsGrantedToAcquireExclusivePatentRightsValue" xml:lang="en-US">Options granted to acquire exclusive patent rights value.</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_350FKH75322F_oprx_OptionsGrantedToAcquireExclusivePatentRightsValue" xlink:to="lab_572HMJ97544H_oprx_OptionsGrantedToAcquireExclusivePatentRightsValue"/>
<loc xlink:type="locator" xlink:href="oprx-20180331.xsd#oprx_AdjustmentToDebtObligationPaymentToRelatedParty" xlink:label="loc_929216F4IJ579I98G136_oprx_AdjustmentToDebtObligationPaymentToRelatedParty"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_141438H6KL791K10I358_oprx_AdjustmentToDebtObligationPaymentToRelatedParty" xml:lang="en-US">Adjustment To Debt Obligation Payment To Related Party</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_141438H6KL791K10I358_oprx_AdjustmentToDebtObligationPaymentToRelatedParty" xml:lang="en-US">Payment of cash to related party</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:label="lab_141438H6KL791K10I358_oprx_AdjustmentToDebtObligationPaymentToRelatedParty" xml:lang="en-US">Payment of cash to related party</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:label="lab_141438H6KL791K10I358_oprx_AdjustmentToDebtObligationPaymentToRelatedParty" xml:lang="en-US">The adjustment needed to reconcile previously recorded amounts to the actual aggregate amount paid, whether in cash or other consideration, to obligation for payment or issue of shares to related party.</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_929216F4IJ579I98G136_oprx_AdjustmentToDebtObligationPaymentToRelatedParty" xlink:to="lab_141438H6KL791K10I358_oprx_AdjustmentToDebtObligationPaymentToRelatedParty"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_AccountsPayableRelatedPartiesCurrent" xlink:label="loc_350FKH75322F_us-gaap_AccountsPayableRelatedPartiesCurrent"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_572HMJ97544H_us-gaap_AccountsPayableRelatedPartiesCurrent" xml:lang="en-US">Accounts Payable, Related Parties, Current</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_572HMJ97544H_us-gaap_AccountsPayableRelatedPartiesCurrent" xml:lang="en-US">Accounts payable - related party</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:label="lab_572HMJ97544H_us-gaap_AccountsPayableRelatedPartiesCurrent" xml:lang="en-US">Payable to the related party</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_350FKH75322F_us-gaap_AccountsPayableRelatedPartiesCurrent" xlink:to="lab_572HMJ97544H_us-gaap_AccountsPayableRelatedPartiesCurrent"/>
<loc xlink:type="locator" xlink:href="oprx-20180331.xsd#oprx_YearEndedDecemberThirtyFirstAbstract" xlink:label="loc_929216F4IJ579I98G136_oprx_YearEndedDecemberThirtyFirstAbstract"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_141438H6KL791K10I358_oprx_YearEndedDecemberThirtyFirstAbstract" xml:lang="en-US">Year Ended December Thirty First [Abstract]</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_141438H6KL791K10I358_oprx_YearEndedDecemberThirtyFirstAbstract" xml:lang="en-US">Year ended December 31:</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_929216F4IJ579I98G136_oprx_YearEndedDecemberThirtyFirstAbstract" xlink:to="lab_141438H6KL791K10I358_oprx_YearEndedDecemberThirtyFirstAbstract"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_OperatingLeasesFutureMinimumPaymentsDueCurrent" xlink:label="loc_350FKH75322F_us-gaap_OperatingLeasesFutureMinimumPaymentsDueCurrent"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_572HMJ97544H_us-gaap_OperatingLeasesFutureMinimumPaymentsDueCurrent" xml:lang="en-US">Operating Leases, Future Minimum Payments Due, Next Twelve Months</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_572HMJ97544H_us-gaap_OperatingLeasesFutureMinimumPaymentsDueCurrent" xml:lang="en-US">2018</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_350FKH75322F_us-gaap_OperatingLeasesFutureMinimumPaymentsDueCurrent" xlink:to="lab_572HMJ97544H_us-gaap_OperatingLeasesFutureMinimumPaymentsDueCurrent"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_OperatingLeasesFutureMinimumPaymentsDueInTwoYears" xlink:label="loc_929216F4IJ579I98G136_us-gaap_OperatingLeasesFutureMinimumPaymentsDueInTwoYears"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_141438H6KL791K10I358_us-gaap_OperatingLeasesFutureMinimumPaymentsDueInTwoYears" xml:lang="en-US">Operating Leases, Future Minimum Payments, Due in Two Years</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:label="lab_141438H6KL791K10I358_us-gaap_OperatingLeasesFutureMinimumPaymentsDueInTwoYears" xml:lang="en-US">2019</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_929216F4IJ579I98G136_us-gaap_OperatingLeasesFutureMinimumPaymentsDueInTwoYears" xlink:to="lab_141438H6KL791K10I358_us-gaap_OperatingLeasesFutureMinimumPaymentsDueInTwoYears"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_OperatingLeasesFutureMinimumPaymentsDue" xlink:label="loc_350FKH75322F_us-gaap_OperatingLeasesFutureMinimumPaymentsDue"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_572HMJ97544H_us-gaap_OperatingLeasesFutureMinimumPaymentsDue" xml:lang="en-US">Operating Leases, Future Minimum Payments Due</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/totalLabel" xlink:label="lab_572HMJ97544H_us-gaap_OperatingLeasesFutureMinimumPaymentsDue" xml:lang="en-US">Total lease commitment</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_350FKH75322F_us-gaap_OperatingLeasesFutureMinimumPaymentsDue" xlink:to="lab_572HMJ97544H_us-gaap_OperatingLeasesFutureMinimumPaymentsDue"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_LossContingenciesTable" xlink:label="loc_929216F4IJ579I98G136_us-gaap_LossContingenciesTable"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_141438H6KL791K10I358_us-gaap_LossContingenciesTable" xml:lang="en-US">Loss Contingencies [Table]</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_929216F4IJ579I98G136_us-gaap_LossContingenciesTable" xlink:to="lab_141438H6KL791K10I358_us-gaap_LossContingenciesTable"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_LitigationStatusAxis" xlink:label="loc_350FKH75322F_us-gaap_LitigationStatusAxis"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_572HMJ97544H_us-gaap_LitigationStatusAxis" xml:lang="en-US">Litigation Status [Axis]</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_350FKH75322F_us-gaap_LitigationStatusAxis" xlink:to="lab_572HMJ97544H_us-gaap_LitigationStatusAxis"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_LitigationStatusDomain" xlink:label="loc_929216F4IJ579I98G136_us-gaap_LitigationStatusDomain"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_141438H6KL791K10I358_us-gaap_LitigationStatusDomain" xml:lang="en-US">Litigation Status [Domain]</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_929216F4IJ579I98G136_us-gaap_LitigationStatusDomain" xlink:to="lab_141438H6KL791K10I358_us-gaap_LitigationStatusDomain"/>
<loc xlink:type="locator" xlink:href="oprx-20180331.xsd#oprx_LdmGroupMember" xlink:label="loc_350FKH75322F_oprx_LdmGroupMember"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_572HMJ97544H_oprx_LdmGroupMember" xml:lang="en-US">Ldm Group [Member]</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_572HMJ97544H_oprx_LdmGroupMember" xml:lang="en-US">LDM Group [Member]</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:label="lab_572HMJ97544H_oprx_LdmGroupMember" xml:lang="en-US">Ldm group member.</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_350FKH75322F_oprx_LdmGroupMember" xlink:to="lab_572HMJ97544H_oprx_LdmGroupMember"/>
<loc xlink:type="locator" xlink:href="oprx-20180331.xsd#oprx_PdrNetworkMember" xlink:label="loc_929216F4IJ579I98G136_oprx_PdrNetworkMember"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_141438H6KL791K10I358_oprx_PdrNetworkMember" xml:lang="en-US">Pdr Network [Member]</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:label="lab_141438H6KL791K10I358_oprx_PdrNetworkMember" xml:lang="en-US">PDR Network [Member]</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:label="lab_141438H6KL791K10I358_oprx_PdrNetworkMember" xml:lang="en-US">Pdr network member.</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_929216F4IJ579I98G136_oprx_PdrNetworkMember" xlink:to="lab_141438H6KL791K10I358_oprx_PdrNetworkMember"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_StatementScenarioAxis" xlink:label="loc_350FKH75322F_us-gaap_StatementScenarioAxis"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_572HMJ97544H_us-gaap_StatementScenarioAxis" xml:lang="en-US">Scenario [Axis]</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_350FKH75322F_us-gaap_StatementScenarioAxis" xlink:to="lab_572HMJ97544H_us-gaap_StatementScenarioAxis"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_ScenarioUnspecifiedDomain" xlink:label="loc_929216F4IJ579I98G136_us-gaap_ScenarioUnspecifiedDomain"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_141438H6KL791K10I358_us-gaap_ScenarioUnspecifiedDomain" xml:lang="en-US">Scenario, Unspecified [Domain]</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_929216F4IJ579I98G136_us-gaap_ScenarioUnspecifiedDomain" xlink:to="lab_141438H6KL791K10I358_us-gaap_ScenarioUnspecifiedDomain"/>
<loc xlink:type="locator" xlink:href="oprx-20180331.xsd#oprx_InstallmentOneMember" xlink:label="loc_350FKH75322F_oprx_InstallmentOneMember"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_572HMJ97544H_oprx_InstallmentOneMember" xml:lang="en-US">Installment One [Member]</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_572HMJ97544H_oprx_InstallmentOneMember" xml:lang="en-US">Installment 1 [Member]</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:label="lab_572HMJ97544H_oprx_InstallmentOneMember" xml:lang="en-US">Installments one member.</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_350FKH75322F_oprx_InstallmentOneMember" xlink:to="lab_572HMJ97544H_oprx_InstallmentOneMember"/>
<loc xlink:type="locator" xlink:href="oprx-20180331.xsd#oprx_InstallmentTwoMember" xlink:label="loc_929216F4IJ579I98G136_oprx_InstallmentTwoMember"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_141438H6KL791K10I358_oprx_InstallmentTwoMember" xml:lang="en-US">Installment Two [Member]</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_141438H6KL791K10I358_oprx_InstallmentTwoMember" xml:lang="en-US">Installment 2 [Member]</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:label="lab_141438H6KL791K10I358_oprx_InstallmentTwoMember" xml:lang="en-US">Installments two member.</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_929216F4IJ579I98G136_oprx_InstallmentTwoMember" xlink:to="lab_141438H6KL791K10I358_oprx_InstallmentTwoMember"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_LossContingenciesLineItems" xlink:label="loc_350FKH75322F_us-gaap_LossContingenciesLineItems"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_572HMJ97544H_us-gaap_LossContingenciesLineItems" xml:lang="en-US">Loss Contingencies [Line Items]</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_350FKH75322F_us-gaap_LossContingenciesLineItems" xlink:to="lab_572HMJ97544H_us-gaap_LossContingenciesLineItems"/>
<loc xlink:type="locator" xlink:href="oprx-20180331.xsd#oprx_CommitmentsAndContingentLiabilitiesTextualAbstract" xlink:label="loc_929216F4IJ579I98G136_oprx_CommitmentsAndContingentLiabilitiesTextualAbstract"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_141438H6KL791K10I358_oprx_CommitmentsAndContingentLiabilitiesTextualAbstract" xml:lang="en-US">Commitments And Contingent Liabilities Textual [Abstract]</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_141438H6KL791K10I358_oprx_CommitmentsAndContingentLiabilitiesTextualAbstract" xml:lang="en-US">Contingencies (Textual)</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_929216F4IJ579I98G136_oprx_CommitmentsAndContingentLiabilitiesTextualAbstract" xlink:to="lab_141438H6KL791K10I358_oprx_CommitmentsAndContingentLiabilitiesTextualAbstract"/>
<loc xlink:type="locator" xlink:href="oprx-20180331.xsd#oprx_ContigentLiabilitiesRelatedToAuditFeesInPercentage" xlink:label="loc_350FKH75322F_oprx_ContigentLiabilitiesRelatedToAuditFeesInPercentage"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_572HMJ97544H_oprx_ContigentLiabilitiesRelatedToAuditFeesInPercentage" xml:lang="en-US">Contigent Liabilities Related To Audit Fees In Percentage</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_572HMJ97544H_oprx_ContigentLiabilitiesRelatedToAuditFeesInPercentage" xml:lang="en-US">Contingent liabilities related to audit fees in percentage</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:label="lab_572HMJ97544H_oprx_ContigentLiabilitiesRelatedToAuditFeesInPercentage" xml:lang="en-US">Contigent liabilities related to audit fees in percentage.</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_350FKH75322F_oprx_ContigentLiabilitiesRelatedToAuditFeesInPercentage" xlink:to="lab_572HMJ97544H_oprx_ContigentLiabilitiesRelatedToAuditFeesInPercentage"/>
<loc xlink:type="locator" xlink:href="oprx-20180331.xsd#oprx_InstallmentsPaymentsAgreement" xlink:label="loc_929216F4IJ579I98G136_oprx_InstallmentsPaymentsAgreement"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_141438H6KL791K10I358_oprx_InstallmentsPaymentsAgreement" xml:lang="en-US">Installments Payments Agreement</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_141438H6KL791K10I358_oprx_InstallmentsPaymentsAgreement" xml:lang="en-US">Allscripts agreement payment</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:label="lab_141438H6KL791K10I358_oprx_InstallmentsPaymentsAgreement" xml:lang="en-US">Installments payments agreement.</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_929216F4IJ579I98G136_oprx_InstallmentsPaymentsAgreement" xlink:to="lab_141438H6KL791K10I358_oprx_InstallmentsPaymentsAgreement"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_DescriptionOfLesseeLeasingArrangementsOperatingLeases" xlink:label="loc_350FKH75322F_us-gaap_DescriptionOfLesseeLeasingArrangementsOperatingLeases"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_572HMJ97544H_us-gaap_DescriptionOfLesseeLeasingArrangementsOperatingLeases" xml:lang="en-US">Description of Lessee Leasing Arrangements, Operating Leases</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_572HMJ97544H_us-gaap_DescriptionOfLesseeLeasingArrangementsOperatingLeases" xml:lang="en-US">Description of new leasing arrangements</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_350FKH75322F_us-gaap_DescriptionOfLesseeLeasingArrangementsOperatingLeases" xlink:to="lab_572HMJ97544H_us-gaap_DescriptionOfLesseeLeasingArrangementsOperatingLeases"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_LeaseExpirationDate1" xlink:label="loc_929216F4IJ579I98G136_us-gaap_LeaseExpirationDate1"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_141438H6KL791K10I358_us-gaap_LeaseExpirationDate1" xml:lang="en-US">Lease Expiration Date</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:label="lab_141438H6KL791K10I358_us-gaap_LeaseExpirationDate1" xml:lang="en-US">Lease expiration date</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_929216F4IJ579I98G136_us-gaap_LeaseExpirationDate1" xlink:to="lab_141438H6KL791K10I358_us-gaap_LeaseExpirationDate1"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_LeaseAndRentalExpense" xlink:label="loc_350FKH75322F_us-gaap_LeaseAndRentalExpense"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_572HMJ97544H_us-gaap_LeaseAndRentalExpense" xml:lang="en-US">Operating Leases, Rent Expense</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_572HMJ97544H_us-gaap_LeaseAndRentalExpense" xml:lang="en-US">Operating lease payable</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_350FKH75322F_us-gaap_LeaseAndRentalExpense" xlink:to="lab_572HMJ97544H_us-gaap_LeaseAndRentalExpense"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_OperatingLeasesRentExpenseNet" xlink:label="loc_929216F4IJ579I98G136_us-gaap_OperatingLeasesRentExpenseNet"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_141438H6KL791K10I358_us-gaap_OperatingLeasesRentExpenseNet" xml:lang="en-US">Operating Leases, Rent Expense, Net</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_141438H6KL791K10I358_us-gaap_OperatingLeasesRentExpenseNet" xml:lang="en-US">Operating leases rent expense</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_929216F4IJ579I98G136_us-gaap_OperatingLeasesRentExpenseNet" xlink:to="lab_141438H6KL791K10I358_us-gaap_OperatingLeasesRentExpenseNet"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsRemainderOfFiscalYear" xlink:label="loc_350FKH75322F_us-gaap_LesseeOperatingLeaseLiabilityPaymentsRemainderOfFiscalYear"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_572HMJ97544H_us-gaap_LesseeOperatingLeaseLiabilityPaymentsRemainderOfFiscalYear" xml:lang="en-US">Lessee, Operating Lease, Liability, Payments, Remainder of Fiscal Year</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_572HMJ97544H_us-gaap_LesseeOperatingLeaseLiabilityPaymentsRemainderOfFiscalYear" xml:lang="en-US">Allscripts payment of remaining amount</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_350FKH75322F_us-gaap_LesseeOperatingLeaseLiabilityPaymentsRemainderOfFiscalYear" xlink:to="lab_572HMJ97544H_us-gaap_LesseeOperatingLeaseLiabilityPaymentsRemainderOfFiscalYear"/>
<loc xlink:type="locator" xlink:href="oprx-20180331.xsd#oprx_AdditionalPaymentOnContractTermination" xlink:label="loc_929216F4IJ579I98G136_oprx_AdditionalPaymentOnContractTermination"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_141438H6KL791K10I358_oprx_AdditionalPaymentOnContractTermination" xml:lang="en-US">Additional Payment On Contract Termination</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_141438H6KL791K10I358_oprx_AdditionalPaymentOnContractTermination" xml:lang="en-US">Additional payment of termination</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:label="lab_141438H6KL791K10I358_oprx_AdditionalPaymentOnContractTermination" xml:lang="en-US">Additional payment on contract termination.</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_929216F4IJ579I98G136_oprx_AdditionalPaymentOnContractTermination" xlink:to="lab_141438H6KL791K10I358_oprx_AdditionalPaymentOnContractTermination"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_ResearchDevelopmentAndComputerSoftwareActivityDescription" xlink:label="loc_350FKH75322F_us-gaap_ResearchDevelopmentAndComputerSoftwareActivityDescription"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_572HMJ97544H_us-gaap_ResearchDevelopmentAndComputerSoftwareActivityDescription" xml:lang="en-US">Research, Development and Computer Software, Activity Description</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_572HMJ97544H_us-gaap_ResearchDevelopmentAndComputerSoftwareActivityDescription" xml:lang="en-US">Description of administer and software</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_350FKH75322F_us-gaap_ResearchDevelopmentAndComputerSoftwareActivityDescription" xlink:to="lab_572HMJ97544H_us-gaap_ResearchDevelopmentAndComputerSoftwareActivityDescription"/>
<loc xlink:type="locator" xlink:href="oprx-20180331.xsd#oprx_SummaryOfSignificantAccountingPoliciesTable" xlink:label="loc_929216F4IJ579I98G136_oprx_SummaryOfSignificantAccountingPoliciesTable"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_141438H6KL791K10I358_oprx_SummaryOfSignificantAccountingPoliciesTable" xml:lang="en-US">Summary Of Significant Accounting Policies [Table]</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_929216F4IJ579I98G136_oprx_SummaryOfSignificantAccountingPoliciesTable" xlink:to="lab_141438H6KL791K10I358_oprx_SummaryOfSignificantAccountingPoliciesTable"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_RangeAxis" xlink:label="loc_350FKH75322F_us-gaap_RangeAxis"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_572HMJ97544H_us-gaap_RangeAxis" xml:lang="en-US">Range [Axis]</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_350FKH75322F_us-gaap_RangeAxis" xlink:to="lab_572HMJ97544H_us-gaap_RangeAxis"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_RangeMember" xlink:label="loc_929216F4IJ579I98G136_us-gaap_RangeMember"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_141438H6KL791K10I358_us-gaap_RangeMember" xml:lang="en-US">Range [Domain]</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_929216F4IJ579I98G136_us-gaap_RangeMember" xlink:to="lab_141438H6KL791K10I358_us-gaap_RangeMember"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_MinimumMember" xlink:label="loc_350FKH75322F_us-gaap_MinimumMember"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_572HMJ97544H_us-gaap_MinimumMember" xml:lang="en-US">Minimum [Member]</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_572HMJ97544H_us-gaap_MinimumMember" xml:lang="en-US">Minimum [Member]</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_350FKH75322F_us-gaap_MinimumMember" xlink:to="lab_572HMJ97544H_us-gaap_MinimumMember"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_MaximumMember" xlink:label="loc_929216F4IJ579I98G136_us-gaap_MaximumMember"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_141438H6KL791K10I358_us-gaap_MaximumMember" xml:lang="en-US">Maximum [Member]</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_141438H6KL791K10I358_us-gaap_MaximumMember" xml:lang="en-US">Maximum [Member]</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_929216F4IJ579I98G136_us-gaap_MaximumMember" xlink:to="lab_141438H6KL791K10I358_us-gaap_MaximumMember"/>
<loc xlink:type="locator" xlink:href="oprx-20180331.xsd#oprx_SummaryOfSignificantAccountingPoliciesLineItems" xlink:label="loc_350FKH75322F_oprx_SummaryOfSignificantAccountingPoliciesLineItems"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_572HMJ97544H_oprx_SummaryOfSignificantAccountingPoliciesLineItems" xml:lang="en-US">Summary Of Significant Accounting Policies [Line Items]</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_350FKH75322F_oprx_SummaryOfSignificantAccountingPoliciesLineItems" xlink:to="lab_572HMJ97544H_oprx_SummaryOfSignificantAccountingPoliciesLineItems"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsAndMethodologyAbstract" xlink:label="loc_929216F4IJ579I98G136_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsAndMethodologyAbstract"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_141438H6KL791K10I358_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsAndMethodologyAbstract" xml:lang="en-US">Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions and Methodology [Abstract]</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_141438H6KL791K10I358_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsAndMethodologyAbstract" xml:lang="en-US">Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions and Methodology</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_929216F4IJ579I98G136_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsAndMethodologyAbstract" xlink:to="lab_141438H6KL791K10I358_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsAndMethodologyAbstract"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedDividendRate" xlink:label="loc_350FKH75322F_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedDividendRate"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_572HMJ97544H_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedDividendRate" xml:lang="en-US">Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions, Expected Dividend Rate</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_572HMJ97544H_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedDividendRate" xml:lang="en-US">Expected dividend yield</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:label="lab_572HMJ97544H_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedDividendRate" xml:lang="en-US">Expected dividend yield</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_350FKH75322F_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedDividendRate" xlink:to="lab_572HMJ97544H_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedDividendRate"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsRiskFreeInterestRateMinimum" xlink:label="loc_929216F4IJ579I98G136_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsRiskFreeInterestRateMinimum"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_141438H6KL791K10I358_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsRiskFreeInterestRateMinimum" xml:lang="en-US">Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions, Risk Free Interest Rate, Minimum</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_141438H6KL791K10I358_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsRiskFreeInterestRateMinimum" xml:lang="en-US">Risk free interest rate minimum</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_929216F4IJ579I98G136_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsRiskFreeInterestRateMinimum" xlink:to="lab_141438H6KL791K10I358_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsRiskFreeInterestRateMinimum"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsRiskFreeInterestRateMaximum" xlink:label="loc_350FKH75322F_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsRiskFreeInterestRateMaximum"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_572HMJ97544H_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsRiskFreeInterestRateMaximum" xml:lang="en-US">Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions, Risk Free Interest Rate, Maximum</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_572HMJ97544H_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsRiskFreeInterestRateMaximum" xml:lang="en-US">Risk free interest rate maximum</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_350FKH75322F_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsRiskFreeInterestRateMaximum" xlink:to="lab_572HMJ97544H_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsRiskFreeInterestRateMaximum"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardFairValueAssumptionsExpectedTerm1" xlink:label="loc_929216F4IJ579I98G136_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardFairValueAssumptionsExpectedTerm1"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_141438H6KL791K10I358_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardFairValueAssumptionsExpectedTerm1" xml:lang="en-US">Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions, Expected Term</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_141438H6KL791K10I358_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardFairValueAssumptionsExpectedTerm1" xml:lang="en-US">Expected option term</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:label="lab_141438H6KL791K10I358_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardFairValueAssumptionsExpectedTerm1" xml:lang="en-US">Expected option term</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_929216F4IJ579I98G136_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardFairValueAssumptionsExpectedTerm1" xlink:to="lab_141438H6KL791K10I358_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardFairValueAssumptionsExpectedTerm1"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedVolatilityRate" xlink:label="loc_350FKH75322F_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedVolatilityRate"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_572HMJ97544H_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedVolatilityRate" xml:lang="en-US">Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions, Expected Volatility Rate</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_572HMJ97544H_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedVolatilityRate" xml:lang="en-US">Expected volatility</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:label="lab_572HMJ97544H_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedVolatilityRate" xml:lang="en-US">Turnover/forfeiture rate</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_350FKH75322F_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedVolatilityRate" xlink:to="lab_572HMJ97544H_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedVolatilityRate"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedVolatilityRateMinimum" xlink:label="loc_929216F4IJ579I98G136_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedVolatilityRateMinimum"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_141438H6KL791K10I358_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedVolatilityRateMinimum" xml:lang="en-US">Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions, Expected Volatility Rate, Minimum</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_141438H6KL791K10I358_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedVolatilityRateMinimum" xml:lang="en-US">Expected volatility minimum</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_929216F4IJ579I98G136_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedVolatilityRateMinimum" xlink:to="lab_141438H6KL791K10I358_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedVolatilityRateMinimum"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedVolatilityRateMaximum" xlink:label="loc_350FKH75322F_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedVolatilityRateMaximum"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_572HMJ97544H_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedVolatilityRateMaximum" xml:lang="en-US">Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions, Expected Volatility Rate, Maximum</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_572HMJ97544H_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedVolatilityRateMaximum" xml:lang="en-US">Expected volatility maximum</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_350FKH75322F_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedVolatilityRateMaximum" xlink:to="lab_572HMJ97544H_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedVolatilityRateMaximum"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_ClassOfWarrantOrRightOutstanding" xlink:label="loc_929216F4IJ579I98G136_us-gaap_ClassOfWarrantOrRightOutstanding"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_141438H6KL791K10I358_us-gaap_ClassOfWarrantOrRightOutstanding" xml:lang="en-US">Class of Warrant or Right, Outstanding</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:label="lab_141438H6KL791K10I358_us-gaap_ClassOfWarrantOrRightOutstanding" xml:lang="en-US">Warrants</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_929216F4IJ579I98G136_us-gaap_ClassOfWarrantOrRightOutstanding" xlink:to="lab_141438H6KL791K10I358_us-gaap_ClassOfWarrantOrRightOutstanding"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_PropertyPlantAndEquipmentByTypeAxis" xlink:label="loc_350FKH75322F_us-gaap_PropertyPlantAndEquipmentByTypeAxis"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_572HMJ97544H_us-gaap_PropertyPlantAndEquipmentByTypeAxis" xml:lang="en-US">Property, Plant and Equipment, Type [Axis]</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_350FKH75322F_us-gaap_PropertyPlantAndEquipmentByTypeAxis" xlink:to="lab_572HMJ97544H_us-gaap_PropertyPlantAndEquipmentByTypeAxis"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_PropertyPlantAndEquipmentTypeDomain" xlink:label="loc_929216F4IJ579I98G136_us-gaap_PropertyPlantAndEquipmentTypeDomain"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_141438H6KL791K10I358_us-gaap_PropertyPlantAndEquipmentTypeDomain" xml:lang="en-US">Property, Plant and Equipment, Type [Domain]</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_929216F4IJ579I98G136_us-gaap_PropertyPlantAndEquipmentTypeDomain" xlink:to="lab_141438H6KL791K10I358_us-gaap_PropertyPlantAndEquipmentTypeDomain"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_OfficeEquipmentMember" xlink:label="loc_350FKH75322F_us-gaap_OfficeEquipmentMember"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_572HMJ97544H_us-gaap_OfficeEquipmentMember" xml:lang="en-US">Office Equipment [Member]</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_350FKH75322F_us-gaap_OfficeEquipmentMember" xlink:to="lab_572HMJ97544H_us-gaap_OfficeEquipmentMember"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_ComputerEquipmentMember" xlink:label="loc_929216F4IJ579I98G136_us-gaap_ComputerEquipmentMember"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_141438H6KL791K10I358_us-gaap_ComputerEquipmentMember" xml:lang="en-US">Computer Equipment [Member]</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_141438H6KL791K10I358_us-gaap_ComputerEquipmentMember" xml:lang="en-US">Computer equipment [Member]</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_929216F4IJ579I98G136_us-gaap_ComputerEquipmentMember" xlink:to="lab_141438H6KL791K10I358_us-gaap_ComputerEquipmentMember"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis" xlink:label="loc_350FKH75322F_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_572HMJ97544H_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis" xml:lang="en-US">Finite-Lived Intangible Assets by Major Class [Axis]</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_350FKH75322F_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis" xlink:to="lab_572HMJ97544H_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain" xlink:label="loc_929216F4IJ579I98G136_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_141438H6KL791K10I358_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain" xml:lang="en-US">Finite-Lived Intangible Assets, Major Class Name [Domain]</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_929216F4IJ579I98G136_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain" xlink:to="lab_141438H6KL791K10I358_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_PatentsMember" xlink:label="loc_350FKH75322F_us-gaap_PatentsMember"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_572HMJ97544H_us-gaap_PatentsMember" xml:lang="en-US">Patents [Member]</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_572HMJ97544H_us-gaap_PatentsMember" xml:lang="en-US">SampleMD Patent [Member]</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:label="lab_572HMJ97544H_us-gaap_PatentsMember" xml:lang="en-US">Key Patent [Member]</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_350FKH75322F_us-gaap_PatentsMember" xlink:to="lab_572HMJ97544H_us-gaap_PatentsMember"/>
<loc xlink:type="locator" xlink:href="oprx-20180331.xsd#oprx_SoftwareAndWebsitesMember" xlink:label="loc_929216F4IJ579I98G136_oprx_SoftwareAndWebsitesMember"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_141438H6KL791K10I358_oprx_SoftwareAndWebsitesMember" xml:lang="en-US">Software and Websites [Member]</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_929216F4IJ579I98G136_oprx_SoftwareAndWebsitesMember" xlink:to="lab_141438H6KL791K10I358_oprx_SoftwareAndWebsitesMember"/>
<loc xlink:type="locator" xlink:href="oprx-20180331.xsd#oprx_SummaryOfSignificantAccountingPoliciesTextualAbstract" xlink:label="loc_350FKH75322F_oprx_SummaryOfSignificantAccountingPoliciesTextualAbstract"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_572HMJ97544H_oprx_SummaryOfSignificantAccountingPoliciesTextualAbstract" xml:lang="en-US">Summary Of Significant Accounting Policies Textual [Abstract]</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:label="lab_572HMJ97544H_oprx_SummaryOfSignificantAccountingPoliciesTextualAbstract" xml:lang="en-US">Summary of Significant Accounting Policies (Textual)</label>
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<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_PropertyPlantAndEquipmentUsefulLife" xlink:label="loc_929216F4IJ579I98G136_us-gaap_PropertyPlantAndEquipmentUsefulLife"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_141438H6KL791K10I358_us-gaap_PropertyPlantAndEquipmentUsefulLife" xml:lang="en-US">Property, Plant and Equipment, Useful Life</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_141438H6KL791K10I358_us-gaap_PropertyPlantAndEquipmentUsefulLife" xml:lang="en-US">Property and equipment, estimated useful lives</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_929216F4IJ579I98G136_us-gaap_PropertyPlantAndEquipmentUsefulLife" xlink:to="lab_141438H6KL791K10I358_us-gaap_PropertyPlantAndEquipmentUsefulLife"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_ProvisionForDoubtfulAccounts" xlink:label="loc_350FKH75322F_us-gaap_ProvisionForDoubtfulAccounts"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_572HMJ97544H_us-gaap_ProvisionForDoubtfulAccounts" xml:lang="en-US">Provision for Doubtful Accounts</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_572HMJ97544H_us-gaap_ProvisionForDoubtfulAccounts" xml:lang="en-US">Bad debt expense</label>
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<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_AllowanceForDoubtfulAccountsReceivableCurrent" xlink:label="loc_929216F4IJ579I98G136_us-gaap_AllowanceForDoubtfulAccountsReceivableCurrent"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_141438H6KL791K10I358_us-gaap_AllowanceForDoubtfulAccountsReceivableCurrent" xml:lang="en-US">Allowance for Doubtful Accounts Receivable, Current</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:label="lab_141438H6KL791K10I358_us-gaap_AllowanceForDoubtfulAccountsReceivableCurrent" xml:lang="en-US">Allowance for doubtful accounts</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_929216F4IJ579I98G136_us-gaap_AllowanceForDoubtfulAccountsReceivableCurrent" xlink:to="lab_141438H6KL791K10I358_us-gaap_AllowanceForDoubtfulAccountsReceivableCurrent"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_RevenueRecognitionNewAccountingPronouncementMaterialEffectDescription" xlink:label="loc_350FKH75322F_us-gaap_RevenueRecognitionNewAccountingPronouncementMaterialEffectDescription"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_572HMJ97544H_us-gaap_RevenueRecognitionNewAccountingPronouncementMaterialEffectDescription" xml:lang="en-US">Revenue Recognition, New Accounting Pronouncement, Material Effect, Description</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:label="lab_572HMJ97544H_us-gaap_RevenueRecognitionNewAccountingPronouncementMaterialEffectDescription" xml:lang="en-US">Revenue recognition and revenue shares, Description</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_350FKH75322F_us-gaap_RevenueRecognitionNewAccountingPronouncementMaterialEffectDescription" xlink:to="lab_572HMJ97544H_us-gaap_RevenueRecognitionNewAccountingPronouncementMaterialEffectDescription"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareAmount" xlink:label="loc_929216F4IJ579I98G136_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareAmount"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_141438H6KL791K10I358_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareAmount" xml:lang="en-US">Antidilutive Securities Excluded from Computation of Earnings Per Share, Amount</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:label="lab_141438H6KL791K10I358_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareAmount" xml:lang="en-US">Number of common shares potentially issuable upon the exercise of certain options and warrants</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_929216F4IJ579I98G136_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareAmount" xlink:to="lab_141438H6KL791K10I358_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareAmount"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_AcquiredFiniteLivedIntangibleAssetsWeightedAverageUsefulLife" xlink:label="loc_350FKH75322F_us-gaap_AcquiredFiniteLivedIntangibleAssetsWeightedAverageUsefulLife"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_572HMJ97544H_us-gaap_AcquiredFiniteLivedIntangibleAssetsWeightedAverageUsefulLife" xml:lang="en-US">Acquired Finite-lived Intangible Assets, Weighted Average Useful Life</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_572HMJ97544H_us-gaap_AcquiredFiniteLivedIntangibleAssetsWeightedAverageUsefulLife" xml:lang="en-US">Intangible assets amortized over their estimated useful lives</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_350FKH75322F_us-gaap_AcquiredFiniteLivedIntangibleAssetsWeightedAverageUsefulLife" xlink:to="lab_572HMJ97544H_us-gaap_AcquiredFiniteLivedIntangibleAssetsWeightedAverageUsefulLife"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_PrepaidInsurance" xlink:label="loc_929216F4IJ579I98G136_us-gaap_PrepaidInsurance"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_141438H6KL791K10I358_us-gaap_PrepaidInsurance" xml:lang="en-US">Prepaid Insurance</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_141438H6KL791K10I358_us-gaap_PrepaidInsurance" xml:lang="en-US">Insurance</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_929216F4IJ579I98G136_us-gaap_PrepaidInsurance" xlink:to="lab_141438H6KL791K10I358_us-gaap_PrepaidInsurance"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_PrepaidRent" xlink:label="loc_350FKH75322F_us-gaap_PrepaidRent"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_572HMJ97544H_us-gaap_PrepaidRent" xml:lang="en-US">Prepaid Rent</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_572HMJ97544H_us-gaap_PrepaidRent" xml:lang="en-US">Rent</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_350FKH75322F_us-gaap_PrepaidRent" xlink:to="lab_572HMJ97544H_us-gaap_PrepaidRent"/>
<loc xlink:type="locator" xlink:href="oprx-20180331.xsd#oprx_PrepaidExpensesFees" xlink:label="loc_929216F4IJ579I98G136_oprx_PrepaidExpensesFees"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_141438H6KL791K10I358_oprx_PrepaidExpensesFees" xml:lang="en-US">Prepaid Expenses Fees</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_141438H6KL791K10I358_oprx_PrepaidExpensesFees" xml:lang="en-US">EHR access fees</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:label="lab_141438H6KL791K10I358_oprx_PrepaidExpensesFees" xml:lang="en-US">Its represented prepaid fees.</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_929216F4IJ579I98G136_oprx_PrepaidExpensesFees" xlink:to="lab_141438H6KL791K10I358_oprx_PrepaidExpensesFees"/>
<loc xlink:type="locator" xlink:href="oprx-20180331.xsd#oprx_PrepaidLegalFees" xlink:label="loc_350FKH75322F_oprx_PrepaidLegalFees"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_572HMJ97544H_oprx_PrepaidLegalFees" xml:lang="en-US">Prepaid Legal Fees</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_572HMJ97544H_oprx_PrepaidLegalFees" xml:lang="en-US">Legal</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:label="lab_572HMJ97544H_oprx_PrepaidLegalFees" xml:lang="en-US">Amount of asset related to consideration paid in advance for legal fees that provides economic benefits within a future period of one year or the normal operating cycle, if longer.</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_350FKH75322F_oprx_PrepaidLegalFees" xlink:to="lab_572HMJ97544H_oprx_PrepaidLegalFees"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_ScheduleOfPropertyPlantAndEquipmentTable" xlink:label="loc_929216F4IJ579I98G136_us-gaap_ScheduleOfPropertyPlantAndEquipmentTable"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_141438H6KL791K10I358_us-gaap_ScheduleOfPropertyPlantAndEquipmentTable" xml:lang="en-US">Property, Plant and Equipment [Table]</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_929216F4IJ579I98G136_us-gaap_ScheduleOfPropertyPlantAndEquipmentTable" xlink:to="lab_141438H6KL791K10I358_us-gaap_ScheduleOfPropertyPlantAndEquipmentTable"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_FurnitureAndFixturesMember" xlink:label="loc_350FKH75322F_us-gaap_FurnitureAndFixturesMember"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_572HMJ97544H_us-gaap_FurnitureAndFixturesMember" xml:lang="en-US">Furniture and Fixtures [Member]</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_572HMJ97544H_us-gaap_FurnitureAndFixturesMember" xml:lang="en-US">Furniture and fixtures [Member]</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_350FKH75322F_us-gaap_FurnitureAndFixturesMember" xlink:to="lab_572HMJ97544H_us-gaap_FurnitureAndFixturesMember"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_PropertyPlantAndEquipmentLineItems" xlink:label="loc_929216F4IJ579I98G136_us-gaap_PropertyPlantAndEquipmentLineItems"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_141438H6KL791K10I358_us-gaap_PropertyPlantAndEquipmentLineItems" xml:lang="en-US">Property, Plant and Equipment [Line Items]</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_929216F4IJ579I98G136_us-gaap_PropertyPlantAndEquipmentLineItems" xlink:to="lab_141438H6KL791K10I358_us-gaap_PropertyPlantAndEquipmentLineItems"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_PropertyPlantAndEquipmentGross" xlink:label="loc_350FKH75322F_us-gaap_PropertyPlantAndEquipmentGross"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_572HMJ97544H_us-gaap_PropertyPlantAndEquipmentGross" xml:lang="en-US">Property, Plant and Equipment, Gross</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_572HMJ97544H_us-gaap_PropertyPlantAndEquipmentGross" xml:lang="en-US">Property and equipment, Subtotal</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_350FKH75322F_us-gaap_PropertyPlantAndEquipmentGross" xlink:to="lab_572HMJ97544H_us-gaap_PropertyPlantAndEquipmentGross"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment" xlink:label="loc_929216F4IJ579I98G136_us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_141438H6KL791K10I358_us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment" xml:lang="en-US">Accumulated Depreciation, Depletion and Amortization, Property, Plant, and Equipment</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_141438H6KL791K10I358_us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment" xml:lang="en-US">Accumulated depreciation</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2009/role/negatedLabel" xlink:label="lab_141438H6KL791K10I358_us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment" xml:lang="en-US">Accumulated depreciation</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_929216F4IJ579I98G136_us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment" xlink:to="lab_141438H6KL791K10I358_us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment"/>
<loc xlink:type="locator" xlink:href="oprx-20180331.xsd#oprx_PropertyAndEquipmentTextualAbstract" xlink:label="loc_350FKH75322F_oprx_PropertyAndEquipmentTextualAbstract"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_572HMJ97544H_oprx_PropertyAndEquipmentTextualAbstract" xml:lang="en-US">Property And Equipment Textual [Abstract]</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:label="lab_572HMJ97544H_oprx_PropertyAndEquipmentTextualAbstract" xml:lang="en-US">Property and Equipment (Textual)</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_350FKH75322F_oprx_PropertyAndEquipmentTextualAbstract" xlink:to="lab_572HMJ97544H_oprx_PropertyAndEquipmentTextualAbstract"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_Depreciation" xlink:label="loc_929216F4IJ579I98G136_us-gaap_Depreciation"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_141438H6KL791K10I358_us-gaap_Depreciation" xml:lang="en-US">Depreciation</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:label="lab_141438H6KL791K10I358_us-gaap_Depreciation" xml:lang="en-US">Depreciation expense</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_929216F4IJ579I98G136_us-gaap_Depreciation" xlink:to="lab_141438H6KL791K10I358_us-gaap_Depreciation"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_ScheduleOfFiniteLivedIntangibleAssetsTable" xlink:label="loc_350FKH75322F_us-gaap_ScheduleOfFiniteLivedIntangibleAssetsTable"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_572HMJ97544H_us-gaap_ScheduleOfFiniteLivedIntangibleAssetsTable" xml:lang="en-US">Schedule of Finite-Lived Intangible Assets [Table]</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_350FKH75322F_us-gaap_ScheduleOfFiniteLivedIntangibleAssetsTable" xlink:to="lab_572HMJ97544H_us-gaap_ScheduleOfFiniteLivedIntangibleAssetsTable"/>
<loc xlink:type="locator" xlink:href="oprx-20180331.xsd#oprx_WebbasedTechnologyMember" xlink:label="loc_929216F4IJ579I98G136_oprx_WebbasedTechnologyMember"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_141438H6KL791K10I358_oprx_WebbasedTechnologyMember" xml:lang="en-US">Webbased Technology [Member]</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_141438H6KL791K10I358_oprx_WebbasedTechnologyMember" xml:lang="en-US">OptimizeRx consumer web-based technology [Member]</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:label="lab_141438H6KL791K10I358_oprx_WebbasedTechnologyMember" xml:lang="en-US">OptimizeRx consumer web-based technology [Member]</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_929216F4IJ579I98G136_oprx_WebbasedTechnologyMember" xlink:to="lab_141438H6KL791K10I358_oprx_WebbasedTechnologyMember"/>
<loc xlink:type="locator" xlink:href="oprx-20180331.xsd#oprx_OptimizerxEhrIntegratedTechnologyMember" xlink:label="loc_350FKH75322F_oprx_OptimizerxEhrIntegratedTechnologyMember"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_572HMJ97544H_oprx_OptimizerxEhrIntegratedTechnologyMember" xml:lang="en-US">Optimizerx Ehr Integrated Technology [Member]</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_572HMJ97544H_oprx_OptimizerxEhrIntegratedTechnologyMember" xml:lang="en-US">OptimizeRx EHR integrated technology [Member]</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:label="lab_572HMJ97544H_oprx_OptimizerxEhrIntegratedTechnologyMember" xml:lang="en-US">OptimizeRx EHR integrated technology [Member]</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_350FKH75322F_oprx_OptimizerxEhrIntegratedTechnologyMember" xlink:to="lab_572HMJ97544H_oprx_OptimizerxEhrIntegratedTechnologyMember"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsLineItems" xlink:label="loc_929216F4IJ579I98G136_us-gaap_FiniteLivedIntangibleAssetsLineItems"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_141438H6KL791K10I358_us-gaap_FiniteLivedIntangibleAssetsLineItems" xml:lang="en-US">Finite-Lived Intangible Assets [Line Items]</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_929216F4IJ579I98G136_us-gaap_FiniteLivedIntangibleAssetsLineItems" xlink:to="lab_141438H6KL791K10I358_us-gaap_FiniteLivedIntangibleAssetsLineItems"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_CapitalizedComputerSoftwareGross" xlink:label="loc_350FKH75322F_us-gaap_CapitalizedComputerSoftwareGross"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_572HMJ97544H_us-gaap_CapitalizedComputerSoftwareGross" xml:lang="en-US">Capitalized Computer Software, Gross</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_572HMJ97544H_us-gaap_CapitalizedComputerSoftwareGross" xml:lang="en-US">Web-based technology, Subtotal</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_350FKH75322F_us-gaap_CapitalizedComputerSoftwareGross" xlink:to="lab_572HMJ97544H_us-gaap_CapitalizedComputerSoftwareGross"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_CapitalizedComputerSoftwareAccumulatedAmortization" xlink:label="loc_929216F4IJ579I98G136_us-gaap_CapitalizedComputerSoftwareAccumulatedAmortization"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_141438H6KL791K10I358_us-gaap_CapitalizedComputerSoftwareAccumulatedAmortization" xml:lang="en-US">Capitalized Computer Software, Accumulated Amortization</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_141438H6KL791K10I358_us-gaap_CapitalizedComputerSoftwareAccumulatedAmortization" xml:lang="en-US">Accumulated amortization</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2009/role/negatedLabel" xlink:label="lab_141438H6KL791K10I358_us-gaap_CapitalizedComputerSoftwareAccumulatedAmortization" xml:lang="en-US">Accumulated amortization</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_929216F4IJ579I98G136_us-gaap_CapitalizedComputerSoftwareAccumulatedAmortization" xlink:to="lab_141438H6KL791K10I358_us-gaap_CapitalizedComputerSoftwareAccumulatedAmortization"/>
<loc xlink:type="locator" xlink:href="oprx-20180331.xsd#oprx_WebBasedTechnologyTextualAbstract" xlink:label="loc_350FKH75322F_oprx_WebBasedTechnologyTextualAbstract"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_572HMJ97544H_oprx_WebBasedTechnologyTextualAbstract" xml:lang="en-US">Web Based Technology Textual [Abstract]</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_572HMJ97544H_oprx_WebBasedTechnologyTextualAbstract" xml:lang="en-US">Web-Based Technology (Textual)</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_350FKH75322F_oprx_WebBasedTechnologyTextualAbstract" xlink:to="lab_572HMJ97544H_oprx_WebBasedTechnologyTextualAbstract"/>
<loc xlink:type="locator" xlink:href="oprx-20180331.xsd#oprx_CapitalizedComputerSoftwareAmortizationPeriodDescription" xlink:label="loc_929216F4IJ579I98G136_oprx_CapitalizedComputerSoftwareAmortizationPeriodDescription"/>
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<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_PresentValueOfFutureInsuranceProfitsAmortizationExpense1" xlink:label="loc_929216F4IJ579I98G136_us-gaap_PresentValueOfFutureInsuranceProfitsAmortizationExpense1"/>
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<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseNextTwelveMonths" xlink:label="loc_350FKH75322F_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseNextTwelveMonths"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_572HMJ97544H_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseNextTwelveMonths" xml:lang="en-US">Finite-Lived Intangible Assets, Amortization Expense, Next Twelve Months</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:label="lab_572HMJ97544H_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseNextTwelveMonths" xml:lang="en-US">Amortization expense 2018</label>
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<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearTwo" xlink:label="loc_929216F4IJ579I98G136_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearTwo"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_141438H6KL791K10I358_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearTwo" xml:lang="en-US">Finite-Lived Intangible Assets, Amortization Expense, Year Two</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:label="lab_141438H6KL791K10I358_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearTwo" xml:lang="en-US">Amortization expense for 2019</label>
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<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetOffMarketLeaseFavorableGross" xlink:label="loc_350FKH75322F_us-gaap_FiniteLivedIntangibleAssetOffMarketLeaseFavorableGross"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_572HMJ97544H_us-gaap_FiniteLivedIntangibleAssetOffMarketLeaseFavorableGross" xml:lang="en-US">Finite-Lived Intangible Asset, Off-market Lease, Favorable, Gross</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_572HMJ97544H_us-gaap_FiniteLivedIntangibleAssetOffMarketLeaseFavorableGross" xml:lang="en-US">Patent rights and intangible assets</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_350FKH75322F_us-gaap_FiniteLivedIntangibleAssetOffMarketLeaseFavorableGross" xlink:to="lab_572HMJ97544H_us-gaap_FiniteLivedIntangibleAssetOffMarketLeaseFavorableGross"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_FiniteLivedPatentsGross" xlink:label="loc_929216F4IJ579I98G136_us-gaap_FiniteLivedPatentsGross"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_141438H6KL791K10I358_us-gaap_FiniteLivedPatentsGross" xml:lang="en-US">Finite-Lived Patents, Gross</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_141438H6KL791K10I358_us-gaap_FiniteLivedPatentsGross" xml:lang="en-US">Patent defense costs</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_929216F4IJ579I98G136_us-gaap_FiniteLivedPatentsGross" xlink:to="lab_141438H6KL791K10I358_us-gaap_FiniteLivedPatentsGross"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_OtherFiniteLivedIntangibleAssetsGross" xlink:label="loc_350FKH75322F_us-gaap_OtherFiniteLivedIntangibleAssetsGross"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_572HMJ97544H_us-gaap_OtherFiniteLivedIntangibleAssetsGross" xml:lang="en-US">Other Finite-Lived Intangible Assets, Gross</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_572HMJ97544H_us-gaap_OtherFiniteLivedIntangibleAssetsGross" xml:lang="en-US">New patents and trademarks</label>
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<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsGross" xlink:label="loc_929216F4IJ579I98G136_us-gaap_FiniteLivedIntangibleAssetsGross"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_141438H6KL791K10I358_us-gaap_FiniteLivedIntangibleAssetsGross" xml:lang="en-US">Finite-Lived Intangible Assets, Gross</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_141438H6KL791K10I358_us-gaap_FiniteLivedIntangibleAssetsGross" xml:lang="en-US">Patent rights and intangible assets</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/totalLabel" xlink:label="lab_141438H6KL791K10I358_us-gaap_FiniteLivedIntangibleAssetsGross" xml:lang="en-US">Subtotal</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_929216F4IJ579I98G136_us-gaap_FiniteLivedIntangibleAssetsGross" xlink:to="lab_141438H6KL791K10I358_us-gaap_FiniteLivedIntangibleAssetsGross"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization" xlink:label="loc_350FKH75322F_us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_572HMJ97544H_us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization" xml:lang="en-US">Finite-Lived Intangible Assets, Accumulated Amortization</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_572HMJ97544H_us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization" xml:lang="en-US">Accumulated amortization</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2009/role/negatedLabel" xlink:label="lab_572HMJ97544H_us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization" xml:lang="en-US">Accumulated amortization</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_350FKH75322F_us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization" xlink:to="lab_572HMJ97544H_us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization"/>
<loc xlink:type="locator" xlink:href="oprx-20180331.xsd#oprx_PatentAndTrademarksTextualAbstract" xlink:label="loc_929216F4IJ579I98G136_oprx_PatentAndTrademarksTextualAbstract"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_141438H6KL791K10I358_oprx_PatentAndTrademarksTextualAbstract" xml:lang="en-US">Patent And Trademarks Textual [Abstract]</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_141438H6KL791K10I358_oprx_PatentAndTrademarksTextualAbstract" xml:lang="en-US">Patent and Trademarks (Textual)</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_929216F4IJ579I98G136_oprx_PatentAndTrademarksTextualAbstract" xlink:to="lab_141438H6KL791K10I358_oprx_PatentAndTrademarksTextualAbstract"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_AccountsPayableRelatedPartiesCurrentAndNoncurrent" xlink:label="loc_350FKH75322F_us-gaap_AccountsPayableRelatedPartiesCurrentAndNoncurrent"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_572HMJ97544H_us-gaap_AccountsPayableRelatedPartiesCurrentAndNoncurrent" xml:lang="en-US">Accounts Payable, Related Parties</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_572HMJ97544H_us-gaap_AccountsPayableRelatedPartiesCurrentAndNoncurrent" xml:lang="en-US">Accounts payable - related party</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:label="lab_572HMJ97544H_us-gaap_AccountsPayableRelatedPartiesCurrentAndNoncurrent" xml:lang="en-US">Services of accounts payable- related parties</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_350FKH75322F_us-gaap_AccountsPayableRelatedPartiesCurrentAndNoncurrent" xlink:to="lab_572HMJ97544H_us-gaap_AccountsPayableRelatedPartiesCurrentAndNoncurrent"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsAmortizationMethod" xlink:label="loc_929216F4IJ579I98G136_us-gaap_FiniteLivedIntangibleAssetsAmortizationMethod"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_141438H6KL791K10I358_us-gaap_FiniteLivedIntangibleAssetsAmortizationMethod" xml:lang="en-US">Finite-Lived Intangible Assets, Amortization Method</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_141438H6KL791K10I358_us-gaap_FiniteLivedIntangibleAssetsAmortizationMethod" xml:lang="en-US">Amortizing patent, Description</label>
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<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetUsefulLife" xlink:label="loc_350FKH75322F_us-gaap_FiniteLivedIntangibleAssetUsefulLife"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_572HMJ97544H_us-gaap_FiniteLivedIntangibleAssetUsefulLife" xml:lang="en-US">Finite-Lived Intangible Asset, Useful Life</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_572HMJ97544H_us-gaap_FiniteLivedIntangibleAssetUsefulLife" xml:lang="en-US">Useful life</label>
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<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseNextRollingTwelveMonths" xlink:label="loc_929216F4IJ579I98G136_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseNextRollingTwelveMonths"/>
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<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_141438H6KL791K10I358_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseNextRollingTwelveMonths" xml:lang="en-US">Amortization expense</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:label="lab_141438H6KL791K10I358_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseNextRollingTwelveMonths" xml:lang="en-US">Amortization expense 2018</label>
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<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_572HMJ97544H_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseRollingYearTwo" xml:lang="en-US">Amortization expense related to patents 2019</label>
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<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_572HMJ97544H_us-gaap_AuctionMarketPreferredSecuritiesStockSeriesTitleDomain" xml:lang="en-US">Auction Market Preferred Securities, Stock Series, Title [Domain]</label>
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<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_SeriesAMember" xlink:label="loc_929216F4IJ579I98G136_us-gaap_SeriesAMember"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_141438H6KL791K10I358_us-gaap_SeriesAMember" xml:lang="en-US">Series A [Member]</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_141438H6KL791K10I358_us-gaap_SeriesAMember" xml:lang="en-US">Series A [Member]</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_929216F4IJ579I98G136_us-gaap_SeriesAMember" xlink:to="lab_141438H6KL791K10I358_us-gaap_SeriesAMember"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_SeriesBMember" xlink:label="loc_350FKH75322F_us-gaap_SeriesBMember"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_572HMJ97544H_us-gaap_SeriesBMember" xml:lang="en-US">Series B [Member]</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_572HMJ97544H_us-gaap_SeriesBMember" xml:lang="en-US">Series B [Member]</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_350FKH75322F_us-gaap_SeriesBMember" xlink:to="lab_572HMJ97544H_us-gaap_SeriesBMember"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_AuctionMarketPreferredSecuritiesStockSeriesLineItems" xlink:label="loc_929216F4IJ579I98G136_us-gaap_AuctionMarketPreferredSecuritiesStockSeriesLineItems"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_141438H6KL791K10I358_us-gaap_AuctionMarketPreferredSecuritiesStockSeriesLineItems" xml:lang="en-US">Auction Market Preferred Securities, Stock Series [Line Items]</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_929216F4IJ579I98G136_us-gaap_AuctionMarketPreferredSecuritiesStockSeriesLineItems" xlink:to="lab_141438H6KL791K10I358_us-gaap_AuctionMarketPreferredSecuritiesStockSeriesLineItems"/>
<loc xlink:type="locator" xlink:href="oprx-20180331.xsd#oprx_PreferredStockTextualAbstract" xlink:label="loc_350FKH75322F_oprx_PreferredStockTextualAbstract"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_572HMJ97544H_oprx_PreferredStockTextualAbstract" xml:lang="en-US">Preferred Stock Textual [Abstract]</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_572HMJ97544H_oprx_PreferredStockTextualAbstract" xml:lang="en-US">Preferred Stock (Textual)</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_350FKH75322F_oprx_PreferredStockTextualAbstract" xlink:to="lab_572HMJ97544H_oprx_PreferredStockTextualAbstract"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_PreferredStockDividendRatePercentage" xlink:label="loc_929216F4IJ579I98G136_us-gaap_PreferredStockDividendRatePercentage"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_141438H6KL791K10I358_us-gaap_PreferredStockDividendRatePercentage" xml:lang="en-US">Preferred Stock, Dividend Rate, Percentage</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_141438H6KL791K10I358_us-gaap_PreferredStockDividendRatePercentage" xml:lang="en-US">Percentage of dividends rate</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_929216F4IJ579I98G136_us-gaap_PreferredStockDividendRatePercentage" xlink:to="lab_141438H6KL791K10I358_us-gaap_PreferredStockDividendRatePercentage"/>
<loc xlink:type="locator" xlink:href="oprx-20180331.xsd#oprx_PlacementAgentsMember" xlink:label="loc_350FKH75322F_oprx_PlacementAgentsMember"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_572HMJ97544H_oprx_PlacementAgentsMember" xml:lang="en-US">Placement Agents [Member]</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_572HMJ97544H_oprx_PlacementAgentsMember" xml:lang="en-US">Placement agents [Member]</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_350FKH75322F_oprx_PlacementAgentsMember" xlink:to="lab_572HMJ97544H_oprx_PlacementAgentsMember"/>
<loc xlink:type="locator" xlink:href="oprx-20180331.xsd#oprx_ThreeOfficersMember" xlink:label="loc_929216F4IJ579I98G136_oprx_ThreeOfficersMember"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_141438H6KL791K10I358_oprx_ThreeOfficersMember" xml:lang="en-US">Three Officers [Member]</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_141438H6KL791K10I358_oprx_ThreeOfficersMember" xml:lang="en-US">Three executive officers [Member]</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_929216F4IJ579I98G136_oprx_ThreeOfficersMember" xlink:to="lab_141438H6KL791K10I358_oprx_ThreeOfficersMember"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_OfficerMember" xlink:label="loc_350FKH75322F_us-gaap_OfficerMember"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_572HMJ97544H_us-gaap_OfficerMember" xml:lang="en-US">Officer [Member]</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_350FKH75322F_us-gaap_OfficerMember" xlink:to="lab_572HMJ97544H_us-gaap_OfficerMember"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_DirectorMember" xlink:label="loc_929216F4IJ579I98G136_us-gaap_DirectorMember"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_141438H6KL791K10I358_us-gaap_DirectorMember" xml:lang="en-US">Directors [Member]</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:label="lab_141438H6KL791K10I358_us-gaap_DirectorMember" xml:lang="en-US">Director [Member]</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/disclosureGuidance" xlink:label="lab_141438H6KL791K10I358_us-gaap_DirectorMember" xml:lang="en-US">Directors [Member]</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_929216F4IJ579I98G136_us-gaap_DirectorMember" xlink:to="lab_141438H6KL791K10I358_us-gaap_DirectorMember"/>
<loc xlink:type="locator" xlink:href="oprx-20180331.xsd#oprx_TwoOfficersMember" xlink:label="loc_350FKH75322F_oprx_TwoOfficersMember"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_572HMJ97544H_oprx_TwoOfficersMember" xml:lang="en-US">Two Officers [Member]</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_572HMJ97544H_oprx_TwoOfficersMember" xml:lang="en-US">Two executive officers [Member]</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_350FKH75322F_oprx_TwoOfficersMember" xlink:to="lab_572HMJ97544H_oprx_TwoOfficersMember"/>
<loc xlink:type="locator" xlink:href="oprx-20180331.xsd#oprx_UnrelatedPartyMember" xlink:label="loc_929216F4IJ579I98G136_oprx_UnrelatedPartyMember"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_141438H6KL791K10I358_oprx_UnrelatedPartyMember" xml:lang="en-US">Unrelated Party [Member]</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_141438H6KL791K10I358_oprx_UnrelatedPartyMember" xml:lang="en-US">Unrelated party [Member]</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_929216F4IJ579I98G136_oprx_UnrelatedPartyMember" xlink:to="lab_141438H6KL791K10I358_oprx_UnrelatedPartyMember"/>
<loc xlink:type="locator" xlink:href="oprx-20180331.xsd#oprx_ShadronStastneyMember" xlink:label="loc_350FKH75322F_oprx_ShadronStastneyMember"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_572HMJ97544H_oprx_ShadronStastneyMember" xml:lang="en-US">Shadron Stastney [Member]</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_350FKH75322F_oprx_ShadronStastneyMember" xlink:to="lab_572HMJ97544H_oprx_ShadronStastneyMember"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_FinancialInstrumentAxis" xlink:label="loc_929216F4IJ579I98G136_us-gaap_FinancialInstrumentAxis"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_141438H6KL791K10I358_us-gaap_FinancialInstrumentAxis" xml:lang="en-US">Financial Instrument [Axis]</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_929216F4IJ579I98G136_us-gaap_FinancialInstrumentAxis" xlink:to="lab_141438H6KL791K10I358_us-gaap_FinancialInstrumentAxis"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain" xlink:label="loc_350FKH75322F_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_572HMJ97544H_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain" xml:lang="en-US">Financial Instruments [Domain]</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_350FKH75322F_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain" xlink:to="lab_572HMJ97544H_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain"/>
<loc xlink:type="locator" xlink:href="oprx-20180331.xsd#oprx_ConsultingAgreementMember" xlink:label="loc_929216F4IJ579I98G136_oprx_ConsultingAgreementMember"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_141438H6KL791K10I358_oprx_ConsultingAgreementMember" xml:lang="en-US">Consulting Agreement [Member]</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_929216F4IJ579I98G136_oprx_ConsultingAgreementMember" xlink:to="lab_141438H6KL791K10I358_oprx_ConsultingAgreementMember"/>
<loc xlink:type="locator" xlink:href="oprx-20180331.xsd#oprx_CapitalMarketsAdvisoryAgreementMember" xlink:label="loc_350FKH75322F_oprx_CapitalMarketsAdvisoryAgreementMember"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_572HMJ97544H_oprx_CapitalMarketsAdvisoryAgreementMember" xml:lang="en-US">Capital Markets Advisory Agreement [Member]</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_350FKH75322F_oprx_CapitalMarketsAdvisoryAgreementMember" xlink:to="lab_572HMJ97544H_oprx_CapitalMarketsAdvisoryAgreementMember"/>
<loc xlink:type="locator" xlink:href="oprx-20180331.xsd#oprx_SecuritiesPurchaseAgreementMember" xlink:label="loc_929216F4IJ579I98G136_oprx_SecuritiesPurchaseAgreementMember"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_141438H6KL791K10I358_oprx_SecuritiesPurchaseAgreementMember" xml:lang="en-US">Securities Purchase Agreement [Member]</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_929216F4IJ579I98G136_oprx_SecuritiesPurchaseAgreementMember" xlink:to="lab_141438H6KL791K10I358_oprx_SecuritiesPurchaseAgreementMember"/>
<loc xlink:type="locator" xlink:href="oprx-20180331.xsd#oprx_CapitalSupportAgreementOneMember" xlink:label="loc_350FKH75322F_oprx_CapitalSupportAgreementOneMember"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_572HMJ97544H_oprx_CapitalSupportAgreementOneMember" xml:lang="en-US">Capital Support Agreement One [Member]</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_350FKH75322F_oprx_CapitalSupportAgreementOneMember" xlink:to="lab_572HMJ97544H_oprx_CapitalSupportAgreementOneMember"/>
<loc xlink:type="locator" xlink:href="oprx-20180331.xsd#oprx_NewCapitalMarketsAdvisoryAgreementSharesIssuedFirstMember" xlink:label="loc_929216F4IJ579I98G136_oprx_NewCapitalMarketsAdvisoryAgreementSharesIssuedFirstMember"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_141438H6KL791K10I358_oprx_NewCapitalMarketsAdvisoryAgreementSharesIssuedFirstMember" xml:lang="en-US">New Capital Markets Advisory Agreement Shares Issued First [Member]</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_929216F4IJ579I98G136_oprx_NewCapitalMarketsAdvisoryAgreementSharesIssuedFirstMember" xlink:to="lab_141438H6KL791K10I358_oprx_NewCapitalMarketsAdvisoryAgreementSharesIssuedFirstMember"/>
<loc xlink:type="locator" xlink:href="oprx-20180331.xsd#oprx_FormerExecutiveOfficerMember" xlink:label="loc_350FKH75322F_oprx_FormerExecutiveOfficerMember"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_572HMJ97544H_oprx_FormerExecutiveOfficerMember" xml:lang="en-US">Former Executive Officer [Member]</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_350FKH75322F_oprx_FormerExecutiveOfficerMember" xlink:to="lab_572HMJ97544H_oprx_FormerExecutiveOfficerMember"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_OptionIndexedToIssuersEquityTypeAxis" xlink:label="loc_929216F4IJ579I98G136_us-gaap_OptionIndexedToIssuersEquityTypeAxis"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_141438H6KL791K10I358_us-gaap_OptionIndexedToIssuersEquityTypeAxis" xml:lang="en-US">Option Indexed to Issuer's Equity, Type [Axis]</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_929216F4IJ579I98G136_us-gaap_OptionIndexedToIssuersEquityTypeAxis" xlink:to="lab_141438H6KL791K10I358_us-gaap_OptionIndexedToIssuersEquityTypeAxis"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_OptionIndexedToIssuersEquityTypeDomain" xlink:label="loc_350FKH75322F_us-gaap_OptionIndexedToIssuersEquityTypeDomain"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_572HMJ97544H_us-gaap_OptionIndexedToIssuersEquityTypeDomain" xml:lang="en-US">Option Indexed to Issuer's Equity, Type [Domain]</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_350FKH75322F_us-gaap_OptionIndexedToIssuersEquityTypeDomain" xlink:to="lab_572HMJ97544H_us-gaap_OptionIndexedToIssuersEquityTypeDomain"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_EmployeeStockOptionMember" xlink:label="loc_929216F4IJ579I98G136_us-gaap_EmployeeStockOptionMember"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_141438H6KL791K10I358_us-gaap_EmployeeStockOptionMember" xml:lang="en-US">Employee Stock Option [Member]</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_141438H6KL791K10I358_us-gaap_EmployeeStockOptionMember" xml:lang="en-US">Employee stock options [Member]</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_929216F4IJ579I98G136_us-gaap_EmployeeStockOptionMember" xlink:to="lab_141438H6KL791K10I358_us-gaap_EmployeeStockOptionMember"/>
<loc xlink:type="locator" xlink:href="oprx-20180331.xsd#oprx_CommonStockTextualAbstract" xlink:label="loc_350FKH75322F_oprx_CommonStockTextualAbstract"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_572HMJ97544H_oprx_CommonStockTextualAbstract" xml:lang="en-US">Common Stock Textual [Abstract]</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_572HMJ97544H_oprx_CommonStockTextualAbstract" xml:lang="en-US">Stockholders' Equity (Textual)</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:label="lab_572HMJ97544H_oprx_CommonStockTextualAbstract" xml:lang="en-US">Common Stock (Textual)</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_350FKH75322F_oprx_CommonStockTextualAbstract" xlink:to="lab_572HMJ97544H_oprx_CommonStockTextualAbstract"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_SharesIssuedPricePerShare" xlink:label="loc_929216F4IJ579I98G136_us-gaap_SharesIssuedPricePerShare"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_141438H6KL791K10I358_us-gaap_SharesIssuedPricePerShare" xml:lang="en-US">Shares Issued, Price Per Share</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_141438H6KL791K10I358_us-gaap_SharesIssuedPricePerShare" xml:lang="en-US">Average price per share</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/definitionGuidance" xlink:label="lab_141438H6KL791K10I358_us-gaap_SharesIssuedPricePerShare" xml:lang="en-US">Common stock price per share</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_929216F4IJ579I98G136_us-gaap_SharesIssuedPricePerShare" xlink:to="lab_141438H6KL791K10I358_us-gaap_SharesIssuedPricePerShare"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_DeferredCompensationEquity" xlink:label="loc_350FKH75322F_us-gaap_DeferredCompensationEquity"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_572HMJ97544H_us-gaap_DeferredCompensationEquity" xml:lang="en-US">Deferred Compensation Equity</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_572HMJ97544H_us-gaap_DeferredCompensationEquity" xml:lang="en-US">Deferred stock compensation</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:label="lab_572HMJ97544H_us-gaap_DeferredCompensationEquity" xml:lang="en-US">Deferred stock compensation</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_350FKH75322F_us-gaap_DeferredCompensationEquity" xlink:to="lab_572HMJ97544H_us-gaap_DeferredCompensationEquity"/>
<loc xlink:type="locator" xlink:href="oprx-20180331.xsd#oprx_WarrantExercisePricePeriod" xlink:label="loc_929216F4IJ579I98G136_oprx_WarrantExercisePricePeriod"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_141438H6KL791K10I358_oprx_WarrantExercisePricePeriod" xml:lang="en-US">Warrant Exercise Price Period</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:label="lab_141438H6KL791K10I358_oprx_WarrantExercisePricePeriod" xml:lang="en-US">Warrant exercise price period</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:label="lab_141438H6KL791K10I358_oprx_WarrantExercisePricePeriod" xml:lang="en-US">Warrant exercise price period.</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_929216F4IJ579I98G136_oprx_WarrantExercisePricePeriod" xlink:to="lab_141438H6KL791K10I358_oprx_WarrantExercisePricePeriod"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_SaleOfStockPricePerShare" xlink:label="loc_350FKH75322F_us-gaap_SaleOfStockPricePerShare"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_572HMJ97544H_us-gaap_SaleOfStockPricePerShare" xml:lang="en-US">Sale of Stock, Price Per Share</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_572HMJ97544H_us-gaap_SaleOfStockPricePerShare" xml:lang="en-US">Sale of stock price per share</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_350FKH75322F_us-gaap_SaleOfStockPricePerShare" xlink:to="lab_572HMJ97544H_us-gaap_SaleOfStockPricePerShare"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_SaleOfStockConsiderationReceivedOnTransaction" xlink:label="loc_929216F4IJ579I98G136_us-gaap_SaleOfStockConsiderationReceivedOnTransaction"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_141438H6KL791K10I358_us-gaap_SaleOfStockConsiderationReceivedOnTransaction" xml:lang="en-US">Sale of Stock, Consideration Received on Transaction</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_141438H6KL791K10I358_us-gaap_SaleOfStockConsiderationReceivedOnTransaction" xml:lang="en-US">Sale of common stock value</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_929216F4IJ579I98G136_us-gaap_SaleOfStockConsiderationReceivedOnTransaction" xlink:to="lab_141438H6KL791K10I358_us-gaap_SaleOfStockConsiderationReceivedOnTransaction"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_SaleOfStockNumberOfSharesIssuedInTransaction" xlink:label="loc_350FKH75322F_us-gaap_SaleOfStockNumberOfSharesIssuedInTransaction"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_572HMJ97544H_us-gaap_SaleOfStockNumberOfSharesIssuedInTransaction" xml:lang="en-US">Sale of Stock, Number of Shares Issued in Transaction</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_572HMJ97544H_us-gaap_SaleOfStockNumberOfSharesIssuedInTransaction" xml:lang="en-US">Sale of common stock shares</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_350FKH75322F_us-gaap_SaleOfStockNumberOfSharesIssuedInTransaction" xlink:to="lab_572HMJ97544H_us-gaap_SaleOfStockNumberOfSharesIssuedInTransaction"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_AccruedSalesCommissionCurrent" xlink:label="loc_929216F4IJ579I98G136_us-gaap_AccruedSalesCommissionCurrent"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_141438H6KL791K10I358_us-gaap_AccruedSalesCommissionCurrent" xml:lang="en-US">Accrued Sales Commission, Current</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_141438H6KL791K10I358_us-gaap_AccruedSalesCommissionCurrent" xml:lang="en-US">Commissions and expenses</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_929216F4IJ579I98G136_us-gaap_AccruedSalesCommissionCurrent" xlink:to="lab_141438H6KL791K10I358_us-gaap_AccruedSalesCommissionCurrent"/>
<loc xlink:type="locator" xlink:href="oprx-20180331.xsd#oprx_PurchaseOfWarrants" xlink:label="loc_350FKH75322F_oprx_PurchaseOfWarrants"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_572HMJ97544H_oprx_PurchaseOfWarrants" xml:lang="en-US">Purchase Of Warrants</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_572HMJ97544H_oprx_PurchaseOfWarrants" xml:lang="en-US">Purchase of warrants</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:label="lab_572HMJ97544H_oprx_PurchaseOfWarrants" xml:lang="en-US">Purchase of warrants.</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_350FKH75322F_oprx_PurchaseOfWarrants" xlink:to="lab_572HMJ97544H_oprx_PurchaseOfWarrants"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_EmployeeRelatedLiabilitiesCurrent" xlink:label="loc_929216F4IJ579I98G136_us-gaap_EmployeeRelatedLiabilitiesCurrent"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_141438H6KL791K10I358_us-gaap_EmployeeRelatedLiabilitiesCurrent" xml:lang="en-US">Employee-related Liabilities, Current</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_141438H6KL791K10I358_us-gaap_EmployeeRelatedLiabilitiesCurrent" xml:lang="en-US">Employee Bonus</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_929216F4IJ579I98G136_us-gaap_EmployeeRelatedLiabilitiesCurrent" xlink:to="lab_141438H6KL791K10I358_us-gaap_EmployeeRelatedLiabilitiesCurrent"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_PaymentsOfStockIssuanceCosts" xlink:label="loc_350FKH75322F_us-gaap_PaymentsOfStockIssuanceCosts"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_572HMJ97544H_us-gaap_PaymentsOfStockIssuanceCosts" xml:lang="en-US">Payments of Stock Issuance Costs</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_572HMJ97544H_us-gaap_PaymentsOfStockIssuanceCosts" xml:lang="en-US">Common stock issued for equity issuance costs</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_350FKH75322F_us-gaap_PaymentsOfStockIssuanceCosts" xlink:to="lab_572HMJ97544H_us-gaap_PaymentsOfStockIssuanceCosts"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_StockAndWarrantsIssuedDuringPeriodValuePreferredStockAndWarrants" xlink:label="loc_929216F4IJ579I98G136_us-gaap_StockAndWarrantsIssuedDuringPeriodValuePreferredStockAndWarrants"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_141438H6KL791K10I358_us-gaap_StockAndWarrantsIssuedDuringPeriodValuePreferredStockAndWarrants" xml:lang="en-US">Stock and Warrants Issued During Period, Value, Preferred Stock and Warrants</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_141438H6KL791K10I358_us-gaap_StockAndWarrantsIssuedDuringPeriodValuePreferredStockAndWarrants" xml:lang="en-US">Warrants, value</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_929216F4IJ579I98G136_us-gaap_StockAndWarrantsIssuedDuringPeriodValuePreferredStockAndWarrants" xlink:to="lab_141438H6KL791K10I358_us-gaap_StockAndWarrantsIssuedDuringPeriodValuePreferredStockAndWarrants"/>
<loc xlink:type="locator" xlink:href="oprx-20180331.xsd#oprx_CommissionsPercentage" xlink:label="loc_350FKH75322F_oprx_CommissionsPercentage"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_572HMJ97544H_oprx_CommissionsPercentage" xml:lang="en-US">Commissions Percentage</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_572HMJ97544H_oprx_CommissionsPercentage" xml:lang="en-US">Commissions percentage</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:label="lab_572HMJ97544H_oprx_CommissionsPercentage" xml:lang="en-US">commissions percentage.</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_350FKH75322F_oprx_CommissionsPercentage" xlink:to="lab_572HMJ97544H_oprx_CommissionsPercentage"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_StockIssuedDuringPeriodValueShareBasedCompensationGross" xlink:label="loc_929216F4IJ579I98G136_us-gaap_StockIssuedDuringPeriodValueShareBasedCompensationGross"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_141438H6KL791K10I358_us-gaap_StockIssuedDuringPeriodValueShareBasedCompensationGross" xml:lang="en-US">Stock Issued During Period, Value, Share-based Compensation, Gross</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_141438H6KL791K10I358_us-gaap_StockIssuedDuringPeriodValueShareBasedCompensationGross" xml:lang="en-US">Employee bonus, value</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_929216F4IJ579I98G136_us-gaap_StockIssuedDuringPeriodValueShareBasedCompensationGross" xlink:to="lab_141438H6KL791K10I358_us-gaap_StockIssuedDuringPeriodValueShareBasedCompensationGross"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_StockIssuedDuringPeriodSharesShareBasedCompensationGross" xlink:label="loc_350FKH75322F_us-gaap_StockIssuedDuringPeriodSharesShareBasedCompensationGross"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_572HMJ97544H_us-gaap_StockIssuedDuringPeriodSharesShareBasedCompensationGross" xml:lang="en-US">Stock Issued During Period, Shares, Share-based Compensation, Gross</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_572HMJ97544H_us-gaap_StockIssuedDuringPeriodSharesShareBasedCompensationGross" xml:lang="en-US">Employee bonus, share</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_350FKH75322F_us-gaap_StockIssuedDuringPeriodSharesShareBasedCompensationGross" xlink:to="lab_572HMJ97544H_us-gaap_StockIssuedDuringPeriodSharesShareBasedCompensationGross"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_StockGrantedDuringPeriodValueSharebasedCompensationGross" xlink:label="loc_929216F4IJ579I98G136_us-gaap_StockGrantedDuringPeriodValueSharebasedCompensationGross"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_141438H6KL791K10I358_us-gaap_StockGrantedDuringPeriodValueSharebasedCompensationGross" xml:lang="en-US">Stock Granted, Value, Share-based Compensation, Gross</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_141438H6KL791K10I358_us-gaap_StockGrantedDuringPeriodValueSharebasedCompensationGross" xml:lang="en-US">Granted value</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_929216F4IJ579I98G136_us-gaap_StockGrantedDuringPeriodValueSharebasedCompensationGross" xlink:to="lab_141438H6KL791K10I358_us-gaap_StockGrantedDuringPeriodValueSharebasedCompensationGross"/>
<loc xlink:type="locator" xlink:href="oprx-20180331.xsd#oprx_StockIssuedDuringPeroidSharesCacelled" xlink:label="loc_350FKH75322F_oprx_StockIssuedDuringPeroidSharesCacelled"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_572HMJ97544H_oprx_StockIssuedDuringPeroidSharesCacelled" xml:lang="en-US">Stock Issued During Peroid Shares Cacelled</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_572HMJ97544H_oprx_StockIssuedDuringPeroidSharesCacelled" xml:lang="en-US">Number of shares not issued</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:label="lab_572HMJ97544H_oprx_StockIssuedDuringPeroidSharesCacelled" xml:lang="en-US">Represnts number of shares terminated or cancelled.</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_350FKH75322F_oprx_StockIssuedDuringPeroidSharesCacelled" xlink:to="lab_572HMJ97544H_oprx_StockIssuedDuringPeroidSharesCacelled"/>
<loc xlink:type="locator" xlink:href="oprx-20180331.xsd#oprx_StockRedeemedDuringPeriodValueOne" xlink:label="loc_929216F4IJ579I98G136_oprx_StockRedeemedDuringPeriodValueOne"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_141438H6KL791K10I358_oprx_StockRedeemedDuringPeriodValueOne" xml:lang="en-US">Stock Redeemed During Period Value One</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_141438H6KL791K10I358_oprx_StockRedeemedDuringPeriodValueOne" xml:lang="en-US">Cash payments of redeemed shares</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:label="lab_141438H6KL791K10I358_oprx_StockRedeemedDuringPeriodValueOne" xml:lang="en-US">Equity impact of the value of stock bought back by the entity at the exercise price or redemption price.</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_929216F4IJ579I98G136_oprx_StockRedeemedDuringPeriodValueOne" xlink:to="lab_141438H6KL791K10I358_oprx_StockRedeemedDuringPeriodValueOne"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsForfeituresInPeriod" xlink:label="loc_350FKH75322F_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsForfeituresInPeriod"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_572HMJ97544H_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsForfeituresInPeriod" xml:lang="en-US">Share-based Compensation Arrangement by Share-based Payment Award, Options, Forfeitures in Period</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_572HMJ97544H_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsForfeituresInPeriod" xml:lang="en-US">Purchased and cancelled shares</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_350FKH75322F_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsForfeituresInPeriod" xlink:to="lab_572HMJ97544H_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsForfeituresInPeriod"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_StockIssuedDuringPeriodValueShareBasedCompensationForfeited" xlink:label="loc_929216F4IJ579I98G136_us-gaap_StockIssuedDuringPeriodValueShareBasedCompensationForfeited"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_141438H6KL791K10I358_us-gaap_StockIssuedDuringPeriodValueShareBasedCompensationForfeited" xml:lang="en-US">Stock Issued During Period, Value, Share-based Compensation, Forfeited</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_141438H6KL791K10I358_us-gaap_StockIssuedDuringPeriodValueShareBasedCompensationForfeited" xml:lang="en-US">Total payment</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:label="lab_141438H6KL791K10I358_us-gaap_StockIssuedDuringPeriodValueShareBasedCompensationForfeited" xml:lang="en-US">Restricted common stock to officers</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_929216F4IJ579I98G136_us-gaap_StockIssuedDuringPeriodValueShareBasedCompensationForfeited" xlink:to="lab_141438H6KL791K10I358_us-gaap_StockIssuedDuringPeriodValueShareBasedCompensationForfeited"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_SharePrice" xlink:label="loc_350FKH75322F_us-gaap_SharePrice"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_572HMJ97544H_us-gaap_SharePrice" xml:lang="en-US">Share Price</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:label="lab_572HMJ97544H_us-gaap_SharePrice" xml:lang="en-US">Per share price</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_350FKH75322F_us-gaap_SharePrice" xlink:to="lab_572HMJ97544H_us-gaap_SharePrice"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_ClassOfWarrantOrRightExercisePriceOfWarrantsOrRights1" xlink:label="loc_929216F4IJ579I98G136_us-gaap_ClassOfWarrantOrRightExercisePriceOfWarrantsOrRights1"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_141438H6KL791K10I358_us-gaap_ClassOfWarrantOrRightExercisePriceOfWarrantsOrRights1" xml:lang="en-US">Class of Warrant or Right, Exercise Price of Warrants or Rights</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_141438H6KL791K10I358_us-gaap_ClassOfWarrantOrRightExercisePriceOfWarrantsOrRights1" xml:lang="en-US">Exercise price per share of warrants</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_929216F4IJ579I98G136_us-gaap_ClassOfWarrantOrRightExercisePriceOfWarrantsOrRights1" xlink:to="lab_141438H6KL791K10I358_us-gaap_ClassOfWarrantOrRightExercisePriceOfWarrantsOrRights1"/>
<loc xlink:type="locator" xlink:href="oprx-20180331.xsd#oprx_WarrantOneMember" xlink:label="loc_350FKH75322F_oprx_WarrantOneMember"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_572HMJ97544H_oprx_WarrantOneMember" xml:lang="en-US">Warrant One [Member]</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_572HMJ97544H_oprx_WarrantOneMember" xml:lang="en-US">Warrant [Member]</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_350FKH75322F_oprx_WarrantOneMember" xlink:to="lab_572HMJ97544H_oprx_WarrantOneMember"/>
<loc xlink:type="locator" xlink:href="oprx-20180331.xsd#oprx_WarrantTwoMember" xlink:label="loc_929216F4IJ579I98G136_oprx_WarrantTwoMember"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_141438H6KL791K10I358_oprx_WarrantTwoMember" xml:lang="en-US">Warrant Two [Member]</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_929216F4IJ579I98G136_oprx_WarrantTwoMember" xlink:to="lab_141438H6KL791K10I358_oprx_WarrantTwoMember"/>
<loc xlink:type="locator" xlink:href="oprx-20180331.xsd#oprx_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingShares" xlink:label="loc_350FKH75322F_oprx_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingShares"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_572HMJ97544H_oprx_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingShares" xml:lang="en-US">Share Based Compensation Arrangement By Share Based Payment Award Options Outstanding Shares</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:label="lab_572HMJ97544H_oprx_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingShares" xml:lang="en-US">Number of Shares Underlying Warrants</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:label="lab_572HMJ97544H_oprx_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingShares" xml:lang="en-US">Stock exceeds the exercise price of options outstanding.</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_350FKH75322F_oprx_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingShares" xlink:to="lab_572HMJ97544H_oprx_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingShares"/>
<loc xlink:type="locator" xlink:href="http://xbrl.sec.gov/invest/2013/invest-2013-01-31.xsd#invest_InvestmentWarrantsExercisePrice" xlink:label="loc_929216F4IJ579I98G136_invest_InvestmentWarrantsExercisePrice"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_141438H6KL791K10I358_invest_InvestmentWarrantsExercisePrice" xml:lang="en-US">Investment Warrants, Exercise Price</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_141438H6KL791K10I358_invest_InvestmentWarrantsExercisePrice" xml:lang="en-US">Exercise price</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_929216F4IJ579I98G136_invest_InvestmentWarrantsExercisePrice" xlink:to="lab_141438H6KL791K10I358_invest_InvestmentWarrantsExercisePrice"/>
<loc xlink:type="locator" xlink:href="oprx-20180331.xsd#oprx_ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionEquityInstrumentExpirationDate" xlink:label="loc_350FKH75322F_oprx_ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionEquityInstrumentExpirationDate"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_572HMJ97544H_oprx_ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionEquityInstrumentExpirationDate" xml:lang="en-US">Share Based Compensation Arrangement By Share Based Payment Award Non Option Equity Instrument Expiration Date</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_572HMJ97544H_oprx_ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionEquityInstrumentExpirationDate" xml:lang="en-US">Expiration date</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:label="lab_572HMJ97544H_oprx_ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionEquityInstrumentExpirationDate" xml:lang="en-US">Share based compensation arrangement by share based payment award non option equity instrument expiration date.</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_350FKH75322F_oprx_ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionEquityInstrumentExpirationDate" xlink:to="lab_572HMJ97544H_oprx_ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionEquityInstrumentExpirationDate"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionEquityInstrumentsOutstandingRollForward" xlink:label="loc_929216F4IJ579I98G136_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionEquityInstrumentsOutstandingRollForward"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_141438H6KL791K10I358_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionEquityInstrumentsOutstandingRollForward" xml:lang="en-US">Share-based Compensation Arrangement by Share-based Payment Award, Non-Option Equity Instruments, Outstanding [Roll Forward]</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_141438H6KL791K10I358_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionEquityInstrumentsOutstandingRollForward" xml:lang="en-US">Number of Shares Underlying Warrants</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_929216F4IJ579I98G136_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionEquityInstrumentsOutstandingRollForward" xlink:to="lab_141438H6KL791K10I358_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionEquityInstrumentsOutstandingRollForward"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionEquityInstrumentsOutstandingNumber" xlink:label="loc_350FKH75322F_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionEquityInstrumentsOutstandingNumber"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_572HMJ97544H_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionEquityInstrumentsOutstandingNumber" xml:lang="en-US">Share-based Compensation Arrangement by Share-based Payment Award, Non-Option Equity Instruments, Outstanding, Number</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_572HMJ97544H_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionEquityInstrumentsOutstandingNumber" xml:lang="en-US">Number of Shares Underlying Warrants</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/periodStartLabel" xlink:label="lab_572HMJ97544H_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionEquityInstrumentsOutstandingNumber" xml:lang="en-US">Beginning balance</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/periodEndLabel" xlink:label="lab_572HMJ97544H_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionEquityInstrumentsOutstandingNumber" xml:lang="en-US">Ending balance</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_350FKH75322F_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionEquityInstrumentsOutstandingNumber" xlink:to="lab_572HMJ97544H_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionEquityInstrumentsOutstandingNumber"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionEquityInstrumentsGranted" xlink:label="loc_929216F4IJ579I98G136_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionEquityInstrumentsGranted"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_141438H6KL791K10I358_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionEquityInstrumentsGranted" xml:lang="en-US">Share-based Compensation Arrangement by Share-based Payment Award, Non-Option Equity Instruments, Granted</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_141438H6KL791K10I358_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionEquityInstrumentsGranted" xml:lang="en-US">Granted</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:label="lab_141438H6KL791K10I358_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionEquityInstrumentsGranted" xml:lang="en-US">Issued warrants to purchase</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_929216F4IJ579I98G136_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionEquityInstrumentsGranted" xlink:to="lab_141438H6KL791K10I358_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionEquityInstrumentsGranted"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionEquityInstrumentsExpirations" xlink:label="loc_350FKH75322F_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionEquityInstrumentsExpirations"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_572HMJ97544H_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionEquityInstrumentsExpirations" xml:lang="en-US">Share-based Compensation Arrangement by Share-based Payment Award, Non-Option Equity Instruments, Expirations</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_572HMJ97544H_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionEquityInstrumentsExpirations" xml:lang="en-US">Expired</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2009/role/negatedLabel" xlink:label="lab_572HMJ97544H_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionEquityInstrumentsExpirations" xml:lang="en-US">Expired</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_350FKH75322F_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionEquityInstrumentsExpirations" xlink:to="lab_572HMJ97544H_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionEquityInstrumentsExpirations"/>
<loc xlink:type="locator" xlink:href="oprx-20180331.xsd#oprx_ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionEquityInstrumentWeightedAverageOutstandingAbstract" xlink:label="loc_929216F4IJ579I98G136_oprx_ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionEquityInstrumentWeightedAverageOutstandingAbstract"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_141438H6KL791K10I358_oprx_ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionEquityInstrumentWeightedAverageOutstandingAbstract" xml:lang="en-US">Share Based Compensation Arrangement By Share Based Payment Award Non Option Equity Instrument Weighted Average Outstanding [Abstract]</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_141438H6KL791K10I358_oprx_ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionEquityInstrumentWeightedAverageOutstandingAbstract" xml:lang="en-US">Weighted average exercise price</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_929216F4IJ579I98G136_oprx_ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionEquityInstrumentWeightedAverageOutstandingAbstract" xlink:to="lab_141438H6KL791K10I358_oprx_ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionEquityInstrumentWeightedAverageOutstandingAbstract"/>
<loc xlink:type="locator" xlink:href="oprx-20180331.xsd#oprx_ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionEquityInstrumentOutstandingWeightedAverage" xlink:label="loc_350FKH75322F_oprx_ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionEquityInstrumentOutstandingWeightedAverage"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_572HMJ97544H_oprx_ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionEquityInstrumentOutstandingWeightedAverage" xml:lang="en-US">Share Based Compensation Arrangement By Share Based Payment Award Non Option Equity Instrument Outstanding Weighted Average</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/periodStartLabel" xlink:label="lab_572HMJ97544H_oprx_ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionEquityInstrumentOutstandingWeightedAverage" xml:lang="en-US">Beginning Balance</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/periodEndLabel" xlink:label="lab_572HMJ97544H_oprx_ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionEquityInstrumentOutstandingWeightedAverage" xml:lang="en-US">Ending Balance</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:label="lab_572HMJ97544H_oprx_ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionEquityInstrumentOutstandingWeightedAverage" xml:lang="en-US">Share based compensation arrangement by share based payment award non option equity instrument outstanding weighted average.</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_350FKH75322F_oprx_ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionEquityInstrumentOutstandingWeightedAverage" xlink:to="lab_572HMJ97544H_oprx_ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionEquityInstrumentOutstandingWeightedAverage"/>
<loc xlink:type="locator" xlink:href="oprx-20180331.xsd#oprx_ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionEquityInstrumentWeightedAverageGranted" xlink:label="loc_929216F4IJ579I98G136_oprx_ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionEquityInstrumentWeightedAverageGranted"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_141438H6KL791K10I358_oprx_ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionEquityInstrumentWeightedAverageGranted" xml:lang="en-US">Share Based Compensation Arrangement By Share Based Payment Award Non Option Equity Instrument Weighted Average Granted</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_141438H6KL791K10I358_oprx_ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionEquityInstrumentWeightedAverageGranted" xml:lang="en-US">Granted, weighted average</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:label="lab_141438H6KL791K10I358_oprx_ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionEquityInstrumentWeightedAverageGranted" xml:lang="en-US">Granted</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:label="lab_141438H6KL791K10I358_oprx_ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionEquityInstrumentWeightedAverageGranted" xml:lang="en-US">Share based compensation arrangement by share based payment award non option equity instrument weighted average, grantedPayment Award Non Option Equity Instrument Weighted Average, Granted.</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_929216F4IJ579I98G136_oprx_ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionEquityInstrumentWeightedAverageGranted" xlink:to="lab_141438H6KL791K10I358_oprx_ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionEquityInstrumentWeightedAverageGranted"/>
<loc xlink:type="locator" xlink:href="oprx-20180331.xsd#oprx_ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionEquityInstrumentWeightedAverageExpiration" xlink:label="loc_350FKH75322F_oprx_ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionEquityInstrumentWeightedAverageExpiration"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_572HMJ97544H_oprx_ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionEquityInstrumentWeightedAverageExpiration" xml:lang="en-US">Share Based Compensation Arrangement By Share Based Payment Award Non Option Equity Instrument Weighted Average Expiration</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_572HMJ97544H_oprx_ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionEquityInstrumentWeightedAverageExpiration" xml:lang="en-US">Expired</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:label="lab_572HMJ97544H_oprx_ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionEquityInstrumentWeightedAverageExpiration" xml:lang="en-US">Share based compensation arrangement by share based payment award non option equity instrument weighted average, expiration.</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_350FKH75322F_oprx_ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionEquityInstrumentWeightedAverageExpiration" xlink:to="lab_572HMJ97544H_oprx_ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionEquityInstrumentWeightedAverageExpiration"/>
<loc xlink:type="locator" xlink:href="oprx-20180331.xsd#oprx_WarrantsTextualsAbstract" xlink:label="loc_929216F4IJ579I98G136_oprx_WarrantsTextualsAbstract"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_141438H6KL791K10I358_oprx_WarrantsTextualsAbstract" xml:lang="en-US">Warrants Textuals [Abstract]</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_141438H6KL791K10I358_oprx_WarrantsTextualsAbstract" xml:lang="en-US">Warrants (Textual)</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_929216F4IJ579I98G136_oprx_WarrantsTextualsAbstract" xlink:to="lab_141438H6KL791K10I358_oprx_WarrantsTextualsAbstract"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardEquityInstrumentsOtherThanOptionsAggregateIntrinsicValueOutstanding" xlink:label="loc_350FKH75322F_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardEquityInstrumentsOtherThanOptionsAggregateIntrinsicValueOutstanding"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_572HMJ97544H_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardEquityInstrumentsOtherThanOptionsAggregateIntrinsicValueOutstanding" xml:lang="en-US">Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Aggregate Intrinsic Value, Outstanding</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_572HMJ97544H_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardEquityInstrumentsOtherThanOptionsAggregateIntrinsicValueOutstanding" xml:lang="en-US">Warrants intrinsic value of outstanding</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_350FKH75322F_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardEquityInstrumentsOtherThanOptionsAggregateIntrinsicValueOutstanding" xlink:to="lab_572HMJ97544H_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardEquityInstrumentsOtherThanOptionsAggregateIntrinsicValueOutstanding"/>
<loc xlink:type="locator" xlink:href="oprx-20180331.xsd#oprx_MajorCustomerAbstract" xlink:label="loc_929216F4IJ579I98G136_oprx_MajorCustomerAbstract"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_141438H6KL791K10I358_oprx_MajorCustomerAbstract" xml:lang="en-US">Major Customer [Abstract]</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_929216F4IJ579I98G136_oprx_MajorCustomerAbstract" xlink:to="lab_141438H6KL791K10I358_oprx_MajorCustomerAbstract"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_ScheduleOfEntityWideRevenueByMajorCustomersByReportingSegmentsTable" xlink:label="loc_350FKH75322F_us-gaap_ScheduleOfEntityWideRevenueByMajorCustomersByReportingSegmentsTable"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_572HMJ97544H_us-gaap_ScheduleOfEntityWideRevenueByMajorCustomersByReportingSegmentsTable" xml:lang="en-US">Schedule of Revenue by Major Customers, by Reporting Segments [Table]</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_350FKH75322F_us-gaap_ScheduleOfEntityWideRevenueByMajorCustomersByReportingSegmentsTable" xlink:to="lab_572HMJ97544H_us-gaap_ScheduleOfEntityWideRevenueByMajorCustomersByReportingSegmentsTable"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_MajorCustomersAxis" xlink:label="loc_929216F4IJ579I98G136_us-gaap_MajorCustomersAxis"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_141438H6KL791K10I358_us-gaap_MajorCustomersAxis" xml:lang="en-US">Customer [Axis]</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_929216F4IJ579I98G136_us-gaap_MajorCustomersAxis" xlink:to="lab_141438H6KL791K10I358_us-gaap_MajorCustomersAxis"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_NameOfMajorCustomerDomain" xlink:label="loc_350FKH75322F_us-gaap_NameOfMajorCustomerDomain"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_572HMJ97544H_us-gaap_NameOfMajorCustomerDomain" xml:lang="en-US">Customer [Domain]</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_350FKH75322F_us-gaap_NameOfMajorCustomerDomain" xlink:to="lab_572HMJ97544H_us-gaap_NameOfMajorCustomerDomain"/>
<loc xlink:type="locator" xlink:href="oprx-20180331.xsd#oprx_CustomerOneMember" xlink:label="loc_929216F4IJ579I98G136_oprx_CustomerOneMember"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_141438H6KL791K10I358_oprx_CustomerOneMember" xml:lang="en-US">Customer One [Member]</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_141438H6KL791K10I358_oprx_CustomerOneMember" xml:lang="en-US">Customer [Member]</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_929216F4IJ579I98G136_oprx_CustomerOneMember" xlink:to="lab_141438H6KL791K10I358_oprx_CustomerOneMember"/>
<loc xlink:type="locator" xlink:href="oprx-20180331.xsd#oprx_CustomerTwoMember" xlink:label="loc_350FKH75322F_oprx_CustomerTwoMember"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_572HMJ97544H_oprx_CustomerTwoMember" xml:lang="en-US">Customer Two [Member]</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_572HMJ97544H_oprx_CustomerTwoMember" xml:lang="en-US">Different customer [Member]</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_350FKH75322F_oprx_CustomerTwoMember" xlink:to="lab_572HMJ97544H_oprx_CustomerTwoMember"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_EntityWideRevenueMajorCustomerLineItems" xlink:label="loc_929216F4IJ579I98G136_us-gaap_EntityWideRevenueMajorCustomerLineItems"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_141438H6KL791K10I358_us-gaap_EntityWideRevenueMajorCustomerLineItems" xml:lang="en-US">Revenue, Major Customer [Line Items]</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_929216F4IJ579I98G136_us-gaap_EntityWideRevenueMajorCustomerLineItems" xlink:to="lab_141438H6KL791K10I358_us-gaap_EntityWideRevenueMajorCustomerLineItems"/>
<loc xlink:type="locator" xlink:href="oprx-20180331.xsd#oprx_MajorCustomersTextualAbstract" xlink:label="loc_350FKH75322F_oprx_MajorCustomersTextualAbstract"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_572HMJ97544H_oprx_MajorCustomersTextualAbstract" xml:lang="en-US">Major Customers Textual [Abstract]</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_572HMJ97544H_oprx_MajorCustomersTextualAbstract" xml:lang="en-US">Major Customers (Textual)</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_350FKH75322F_oprx_MajorCustomersTextualAbstract" xlink:to="lab_572HMJ97544H_oprx_MajorCustomersTextualAbstract"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_ConcentrationRiskPercentage1" xlink:label="loc_929216F4IJ579I98G136_us-gaap_ConcentrationRiskPercentage1"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_141438H6KL791K10I358_us-gaap_ConcentrationRiskPercentage1" xml:lang="en-US">Concentration Risk, Percentage</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_141438H6KL791K10I358_us-gaap_ConcentrationRiskPercentage1" xml:lang="en-US">Revenues Percentage</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_929216F4IJ579I98G136_us-gaap_ConcentrationRiskPercentage1" xlink:to="lab_141438H6KL791K10I358_us-gaap_ConcentrationRiskPercentage1"/>
<loc xlink:type="locator" xlink:href="oprx-20180331.xsd#oprx_ConcentrationRiskPercentageTotal" xlink:label="loc_350FKH75322F_oprx_ConcentrationRiskPercentageTotal"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_572HMJ97544H_oprx_ConcentrationRiskPercentageTotal" xml:lang="en-US">Concentration Risk Percentage Total</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:label="lab_572HMJ97544H_oprx_ConcentrationRiskPercentageTotal" xml:lang="en-US">For entity that discloses a concentration risk in relation to quantitative amount, total percentage division</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_350FKH75322F_oprx_ConcentrationRiskPercentageTotal" xlink:to="lab_572HMJ97544H_oprx_ConcentrationRiskPercentageTotal"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_FederalIncomeTaxExpenseBenefitContinuingOperationsAbstract" xlink:label="loc_929216F4IJ579I98G136_us-gaap_FederalIncomeTaxExpenseBenefitContinuingOperationsAbstract"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_141438H6KL791K10I358_us-gaap_FederalIncomeTaxExpenseBenefitContinuingOperationsAbstract" xml:lang="en-US">Federal Income Tax Expense (Benefit), Continuing Operations [Abstract]</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_141438H6KL791K10I358_us-gaap_FederalIncomeTaxExpenseBenefitContinuingOperationsAbstract" xml:lang="en-US">Federal income tax benefit attributable to:</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_929216F4IJ579I98G136_us-gaap_FederalIncomeTaxExpenseBenefitContinuingOperationsAbstract" xlink:to="lab_141438H6KL791K10I358_us-gaap_FederalIncomeTaxExpenseBenefitContinuingOperationsAbstract"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_CurrentFederalTaxExpenseBenefit" xlink:label="loc_350FKH75322F_us-gaap_CurrentFederalTaxExpenseBenefit"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_572HMJ97544H_us-gaap_CurrentFederalTaxExpenseBenefit" xml:lang="en-US">Current Federal Tax Expense (Benefit)</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_572HMJ97544H_us-gaap_CurrentFederalTaxExpenseBenefit" xml:lang="en-US">Current operations</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2009/role/negatedLabel" xlink:label="lab_572HMJ97544H_us-gaap_CurrentFederalTaxExpenseBenefit" xml:lang="en-US">Current operations</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_350FKH75322F_us-gaap_CurrentFederalTaxExpenseBenefit" xlink:to="lab_572HMJ97544H_us-gaap_CurrentFederalTaxExpenseBenefit"/>
<loc xlink:type="locator" xlink:href="oprx-20180331.xsd#oprx_FederalIncomeTaxExpensesBenefitPermanentAndTimingDifferences" xlink:label="loc_929216F4IJ579I98G136_oprx_FederalIncomeTaxExpensesBenefitPermanentAndTimingDifferences"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_141438H6KL791K10I358_oprx_FederalIncomeTaxExpensesBenefitPermanentAndTimingDifferences" xml:lang="en-US">Federal Income Tax Expenses Benefit Permanent And Timing Differences</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_141438H6KL791K10I358_oprx_FederalIncomeTaxExpensesBenefitPermanentAndTimingDifferences" xml:lang="en-US">Permanent and timing differences (net)</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:label="lab_141438H6KL791K10I358_oprx_FederalIncomeTaxExpensesBenefitPermanentAndTimingDifferences" xml:lang="en-US">Federal income tax expenses benefit permanent and timing differences.</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_929216F4IJ579I98G136_oprx_FederalIncomeTaxExpensesBenefitPermanentAndTimingDifferences" xlink:to="lab_141438H6KL791K10I358_oprx_FederalIncomeTaxExpensesBenefitPermanentAndTimingDifferences"/>
<loc xlink:type="locator" xlink:href="oprx-20180331.xsd#oprx_FederalTaxRateChange" xlink:label="loc_350FKH75322F_oprx_FederalTaxRateChange"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_572HMJ97544H_oprx_FederalTaxRateChange" xml:lang="en-US">Federal Tax Rate Change</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_572HMJ97544H_oprx_FederalTaxRateChange" xml:lang="en-US">Tax rate change</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:label="lab_572HMJ97544H_oprx_FederalTaxRateChange" xml:lang="en-US">The amount of difference in tax rate.</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_350FKH75322F_oprx_FederalTaxRateChange" xlink:to="lab_572HMJ97544H_oprx_FederalTaxRateChange"/>
<loc xlink:type="locator" xlink:href="oprx-20180331.xsd#oprx_FederalIncomeTaxExpensesBenefitValueAllowance" xlink:label="loc_929216F4IJ579I98G136_oprx_FederalIncomeTaxExpensesBenefitValueAllowance"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_141438H6KL791K10I358_oprx_FederalIncomeTaxExpensesBenefitValueAllowance" xml:lang="en-US">Federal Income Tax Expenses Benefit Value Allowance</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_141438H6KL791K10I358_oprx_FederalIncomeTaxExpensesBenefitValueAllowance" xml:lang="en-US">Valuation allowance</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:label="lab_141438H6KL791K10I358_oprx_FederalIncomeTaxExpensesBenefitValueAllowance" xml:lang="en-US">Federal income tax expenses benefit value allowance.</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_929216F4IJ579I98G136_oprx_FederalIncomeTaxExpensesBenefitValueAllowance" xlink:to="lab_141438H6KL791K10I358_oprx_FederalIncomeTaxExpensesBenefitValueAllowance"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_FederalIncomeTaxExpenseBenefitContinuingOperations" xlink:label="loc_350FKH75322F_us-gaap_FederalIncomeTaxExpenseBenefitContinuingOperations"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_572HMJ97544H_us-gaap_FederalIncomeTaxExpenseBenefitContinuingOperations" xml:lang="en-US">Federal Income Tax Expense (Benefit), Continuing Operations</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_572HMJ97544H_us-gaap_FederalIncomeTaxExpenseBenefitContinuingOperations" xml:lang="en-US">Net provision for federal income tax</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/totalLabel" xlink:label="lab_572HMJ97544H_us-gaap_FederalIncomeTaxExpenseBenefitContinuingOperations" xml:lang="en-US">Net provision for federal income tax</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_350FKH75322F_us-gaap_FederalIncomeTaxExpenseBenefitContinuingOperations" xlink:to="lab_572HMJ97544H_us-gaap_FederalIncomeTaxExpenseBenefitContinuingOperations"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_ComponentsOfDeferredTaxAssetsAbstract" xlink:label="loc_929216F4IJ579I98G136_us-gaap_ComponentsOfDeferredTaxAssetsAbstract"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_141438H6KL791K10I358_us-gaap_ComponentsOfDeferredTaxAssetsAbstract" xml:lang="en-US">Components of Deferred Tax Assets [Abstract]</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_141438H6KL791K10I358_us-gaap_ComponentsOfDeferredTaxAssetsAbstract" xml:lang="en-US">Deferred tax asset attributable to:</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_929216F4IJ579I98G136_us-gaap_ComponentsOfDeferredTaxAssetsAbstract" xlink:to="lab_141438H6KL791K10I358_us-gaap_ComponentsOfDeferredTaxAssetsAbstract"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_DeferredTaxAssetsOperatingLossCarryforwards" xlink:label="loc_350FKH75322F_us-gaap_DeferredTaxAssetsOperatingLossCarryforwards"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_572HMJ97544H_us-gaap_DeferredTaxAssetsOperatingLossCarryforwards" xml:lang="en-US">Deferred Tax Assets, Operating Loss Carryforwards</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_572HMJ97544H_us-gaap_DeferredTaxAssetsOperatingLossCarryforwards" xml:lang="en-US">Net operating loss carryover</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_350FKH75322F_us-gaap_DeferredTaxAssetsOperatingLossCarryforwards" xlink:to="lab_572HMJ97544H_us-gaap_DeferredTaxAssetsOperatingLossCarryforwards"/>
<loc xlink:type="locator" xlink:href="oprx-20180331.xsd#oprx_DeferredTaxAssetsTaxDeferredDepreciationAndAmortization" xlink:label="loc_929216F4IJ579I98G136_oprx_DeferredTaxAssetsTaxDeferredDepreciationAndAmortization"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_141438H6KL791K10I358_oprx_DeferredTaxAssetsTaxDeferredDepreciationAndAmortization" xml:lang="en-US">Deferred Tax Assets Tax Deferred Depreciation And Amortization</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_141438H6KL791K10I358_oprx_DeferredTaxAssetsTaxDeferredDepreciationAndAmortization" xml:lang="en-US">Depreciation and amortization</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:label="lab_141438H6KL791K10I358_oprx_DeferredTaxAssetsTaxDeferredDepreciationAndAmortization" xml:lang="en-US">Amount of deferred tax assets for depreciation and amortization.</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_929216F4IJ579I98G136_oprx_DeferredTaxAssetsTaxDeferredDepreciationAndAmortization" xlink:to="lab_141438H6KL791K10I358_oprx_DeferredTaxAssetsTaxDeferredDepreciationAndAmortization"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_DeferredTaxAssetsTaxDeferredExpenseCompensationAndBenefitsShareBasedCompensationCost" xlink:label="loc_350FKH75322F_us-gaap_DeferredTaxAssetsTaxDeferredExpenseCompensationAndBenefitsShareBasedCompensationCost"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_572HMJ97544H_us-gaap_DeferredTaxAssetsTaxDeferredExpenseCompensationAndBenefitsShareBasedCompensationCost" xml:lang="en-US">Deferred Tax Assets, Tax Deferred Expense, Compensation and Benefits, Share-based Compensation Cost</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_572HMJ97544H_us-gaap_DeferredTaxAssetsTaxDeferredExpenseCompensationAndBenefitsShareBasedCompensationCost" xml:lang="en-US">Stock compensation</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_350FKH75322F_us-gaap_DeferredTaxAssetsTaxDeferredExpenseCompensationAndBenefitsShareBasedCompensationCost" xlink:to="lab_572HMJ97544H_us-gaap_DeferredTaxAssetsTaxDeferredExpenseCompensationAndBenefitsShareBasedCompensationCost"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_DeferredTaxAssetsOther" xlink:label="loc_929216F4IJ579I98G136_us-gaap_DeferredTaxAssetsOther"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_141438H6KL791K10I358_us-gaap_DeferredTaxAssetsOther" xml:lang="en-US">Deferred Tax Assets, Other</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_141438H6KL791K10I358_us-gaap_DeferredTaxAssetsOther" xml:lang="en-US">Other</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_929216F4IJ579I98G136_us-gaap_DeferredTaxAssetsOther" xlink:to="lab_141438H6KL791K10I358_us-gaap_DeferredTaxAssetsOther"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_DeferredTaxAssetsValuationAllowance" xlink:label="loc_350FKH75322F_us-gaap_DeferredTaxAssetsValuationAllowance"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_572HMJ97544H_us-gaap_DeferredTaxAssetsValuationAllowance" xml:lang="en-US">Deferred Tax Assets, Valuation Allowance</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_572HMJ97544H_us-gaap_DeferredTaxAssetsValuationAllowance" xml:lang="en-US">Valuation allowance</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2009/role/negatedLabel" xlink:label="lab_572HMJ97544H_us-gaap_DeferredTaxAssetsValuationAllowance" xml:lang="en-US">Valuation allowance</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_350FKH75322F_us-gaap_DeferredTaxAssetsValuationAllowance" xlink:to="lab_572HMJ97544H_us-gaap_DeferredTaxAssetsValuationAllowance"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_DeferredTaxAssetsNet" xlink:label="loc_929216F4IJ579I98G136_us-gaap_DeferredTaxAssetsNet"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_141438H6KL791K10I358_us-gaap_DeferredTaxAssetsNet" xml:lang="en-US">Deferred Tax Assets, Net of Valuation Allowance</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_141438H6KL791K10I358_us-gaap_DeferredTaxAssetsNet" xml:lang="en-US">Net deferred tax asset</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/totalLabel" xlink:label="lab_141438H6KL791K10I358_us-gaap_DeferredTaxAssetsNet" xml:lang="en-US">Net deferred tax asset</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_929216F4IJ579I98G136_us-gaap_DeferredTaxAssetsNet" xlink:to="lab_141438H6KL791K10I358_us-gaap_DeferredTaxAssetsNet"/>
<loc xlink:type="locator" xlink:href="oprx-20180331.xsd#oprx_IncomeTaxesTextualAbstract" xlink:label="loc_350FKH75322F_oprx_IncomeTaxesTextualAbstract"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_572HMJ97544H_oprx_IncomeTaxesTextualAbstract" xml:lang="en-US">Income Taxes Textual [Abstract]</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_572HMJ97544H_oprx_IncomeTaxesTextualAbstract" xml:lang="en-US">Income Taxes (Textual)</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_350FKH75322F_oprx_IncomeTaxesTextualAbstract" xlink:to="lab_572HMJ97544H_oprx_IncomeTaxesTextualAbstract"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_OperatingLossCarryforwards" xlink:label="loc_929216F4IJ579I98G136_us-gaap_OperatingLossCarryforwards"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_141438H6KL791K10I358_us-gaap_OperatingLossCarryforwards" xml:lang="en-US">Operating Loss Carryforwards</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_141438H6KL791K10I358_us-gaap_OperatingLossCarryforwards" xml:lang="en-US">Net operating loss carryforwards</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_929216F4IJ579I98G136_us-gaap_OperatingLossCarryforwards" xlink:to="lab_141438H6KL791K10I358_us-gaap_OperatingLossCarryforwards"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_OperatingLossCarryforwardsLimitationsOnUse" xlink:label="loc_350FKH75322F_us-gaap_OperatingLossCarryforwardsLimitationsOnUse"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_572HMJ97544H_us-gaap_OperatingLossCarryforwardsLimitationsOnUse" xml:lang="en-US">Operating Loss Carryforwards, Limitations on Use</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_572HMJ97544H_us-gaap_OperatingLossCarryforwardsLimitationsOnUse" xml:lang="en-US">Net operating loss expire, description</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_350FKH75322F_us-gaap_OperatingLossCarryforwardsLimitationsOnUse" xlink:to="lab_572HMJ97544H_us-gaap_OperatingLossCarryforwardsLimitationsOnUse"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_EffectiveIncomeTaxRateContinuingOperations" xlink:label="loc_929216F4IJ579I98G136_us-gaap_EffectiveIncomeTaxRateContinuingOperations"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_141438H6KL791K10I358_us-gaap_EffectiveIncomeTaxRateContinuingOperations" xml:lang="en-US">Effective Income Tax Rate Reconciliation, Percent</label>
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<loc xlink:type="locator" xlink:href="oprx-20180331.xsd#oprx_RetirementPlanTextualAbstract" xlink:label="loc_350FKH75322F_oprx_RetirementPlanTextualAbstract"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_572HMJ97544H_oprx_RetirementPlanTextualAbstract" xml:lang="en-US">Retirement Plan Textual [Abstract]</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_572HMJ97544H_oprx_RetirementPlanTextualAbstract" xml:lang="en-US">Retirement Plan (Textual)</label>
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<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_DefinedBenefitPlansGeneralInformation" xlink:label="loc_929216F4IJ579I98G136_us-gaap_DefinedBenefitPlansGeneralInformation"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_141438H6KL791K10I358_us-gaap_DefinedBenefitPlansGeneralInformation" xml:lang="en-US">Defined Benefit Plan, Description</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_141438H6KL791K10I358_us-gaap_DefinedBenefitPlansGeneralInformation" xml:lang="en-US">Defined benefit plan, description</label>
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<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_DefinedContributionPlanAdministrativeExpenses" xlink:label="loc_350FKH75322F_us-gaap_DefinedContributionPlanAdministrativeExpenses"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_572HMJ97544H_us-gaap_DefinedContributionPlanAdministrativeExpenses" xml:lang="en-US">Defined Contribution Plan, Administrative Expense</label>
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<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_141438H6KL791K10I358_us-gaap_SubsequentEventTable" xml:lang="en-US">Subsequent Event [Table]</label>
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<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_SubsequentEventTypeDomain" xlink:label="loc_929216F4IJ579I98G136_us-gaap_SubsequentEventTypeDomain"/>
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<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_572HMJ97544H_us-gaap_SubsequentEventMember" xml:lang="en-US">Subsequent Event [Member]</label>
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<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_SubsequentEventLineItems" xlink:label="loc_929216F4IJ579I98G136_us-gaap_SubsequentEventLineItems"/>
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<loc xlink:type="locator" xlink:href="oprx-20180331.xsd#oprx_SubsequentEventsTextualAbstract" xlink:label="loc_350FKH75322F_oprx_SubsequentEventsTextualAbstract"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_572HMJ97544H_oprx_SubsequentEventsTextualAbstract" xml:lang="en-US">Subsequent Events Textual [Abstract]</label>
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<loc xlink:type="locator" xlink:href="oprx-20180331.xsd#oprx_NumberOfSharesAuthorizedIncreased" xlink:label="loc_929216F4IJ579I98G136_oprx_NumberOfSharesAuthorizedIncreased"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_141438H6KL791K10I358_oprx_NumberOfSharesAuthorizedIncreased" xml:lang="en-US">Number Of Shares Authorized Increased</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_141438H6KL791K10I358_oprx_NumberOfSharesAuthorizedIncreased" xml:lang="en-US">Number of shares authorized increased</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:label="lab_141438H6KL791K10I358_oprx_NumberOfSharesAuthorizedIncreased" xml:lang="en-US">Number of shares authorized increased.</label>
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<loc xlink:type="locator" xlink:href="oprx-20180331.xsd#oprx_OptionsToPurchase" xlink:label="loc_350FKH75322F_oprx_OptionsToPurchase"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_572HMJ97544H_oprx_OptionsToPurchase" xml:lang="en-US">Options To Purchase</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_572HMJ97544H_oprx_OptionsToPurchase" xml:lang="en-US">Options to purchase of common stock</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:label="lab_572HMJ97544H_oprx_OptionsToPurchase" xml:lang="en-US">Options to purchase.</label>
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<loc xlink:type="locator" xlink:href="oprx-20180331.xsd#oprx_OptionsToPurchaseExercisePrice" xlink:label="loc_929216F4IJ579I98G136_oprx_OptionsToPurchaseExercisePrice"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_141438H6KL791K10I358_oprx_OptionsToPurchaseExercisePrice" xml:lang="en-US">Options to purchase, exercise price</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_141438H6KL791K10I358_oprx_OptionsToPurchaseExercisePrice" xml:lang="en-US">Options to purchase of common stock , exercise price</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:label="lab_141438H6KL791K10I358_oprx_OptionsToPurchaseExercisePrice" xml:lang="en-US">Options to purchase Eeercise price.</label>
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<loc xlink:type="locator" xlink:href="oprx-20180331.xsd#oprx_ExistingOptionsThatPreviouslyVested" xlink:label="loc_350FKH75322F_oprx_ExistingOptionsThatPreviouslyVested"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_572HMJ97544H_oprx_ExistingOptionsThatPreviouslyVested" xml:lang="en-US">Existing Options That Previously Vested</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_572HMJ97544H_oprx_ExistingOptionsThatPreviouslyVested" xml:lang="en-US">Existing options that previously vested, description</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:label="lab_572HMJ97544H_oprx_ExistingOptionsThatPreviouslyVested" xml:lang="en-US">Existing Options That Previously Vested.</label>
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<loc xlink:type="locator" xlink:href="oprx-20180331.xsd#oprx_GrossProceedsOfCommonStockAmount" xlink:label="loc_929216F4IJ579I98G136_oprx_GrossProceedsOfCommonStockAmount"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_141438H6KL791K10I358_oprx_GrossProceedsOfCommonStockAmount" xml:lang="en-US">Gross Proceeds Of Common Stock Amount</label>
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<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:label="lab_141438H6KL791K10I358_oprx_GrossProceedsOfCommonStockAmount" xml:lang="en-US">The cash inflow from the additional capital contribution to the entity.</label>
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<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_StockholdersEquityNoteStockSplit" xlink:label="loc_350FKH75322F_us-gaap_StockholdersEquityNoteStockSplit"/>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_572HMJ97544H_us-gaap_StockholdersEquityNoteStockSplit" xml:lang="en-US">Stockholders' Equity Note, Stock Split</label>
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