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      <link:loc xlink:type="locator" xlink:href="oprx-20111231.xsd#OPRX_CancellationOfStockWarrants" xlink:label="loc_OPRXCancellationOfStockWarrants_80" />
      <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_OPRXStatementLineItems" xlink:to="loc_OPRXCancellationOfStockWarrants_80" xlink:type="arc" order="30" />
      <link:loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2011/elts/us-gaap-2011-01-31.xsd#us-gaap_NetIncomeLoss" xlink:label="loc_OPRXNetIncomeLoss_80" />
      <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_OPRXStatementLineItems" xlink:to="loc_OPRXNetIncomeLoss_80" xlink:type="arc" order="31" />
    </link:definitionLink>
    <link:definitionLink xlink:type="extended" xlink:role="http://OPRX/role/StatementsOfCashFlows" xlink:title="0006 - Statement - Statements of Cash Flows" />
    <link:definitionLink xlink:type="extended" xlink:role="http://OPRX/role/NatureOfBusiness" xlink:title="0007 - Disclosure - NATURE OF BUSINESS" />
    <link:definitionLink xlink:type="extended" xlink:role="http://OPRX/role/SummaryOfSignifcantAccountingPolicies" xlink:title="0008 - Disclosure - SUMMARY OF SIGNIFCANT ACCOUNTING POLICIES" />
    <link:definitionLink xlink:type="extended" xlink:role="http://OPRX/role/PrepaidExpenses" xlink:title="0009 - Disclosure - PREPAID EXPENSES" />
    <link:definitionLink xlink:type="extended" xlink:role="http://OPRX/role/PropertyAndEquipment" xlink:title="0010 - Disclosure - PROPERTY AND EQUIPMENT" />
    <link:definitionLink xlink:type="extended" xlink:role="http://OPRX/role/WebsiteDevelopmentCosts" xlink:title="0011 - Disclosure - WEBSITE DEVELOPMENT COSTS" />
    <link:definitionLink xlink:type="extended" xlink:role="http://OPRX/role/PatentRightsAndIntangibleAssets" xlink:title="0012 - Disclosure - PATENT RIGHTS AND INTANGIBLE ASSETS" />
    <link:definitionLink xlink:type="extended" xlink:role="http://OPRX/role/AccruedExpenses" xlink:title="0013 - Disclosure - ACCRUED EXPENSES" />
    <link:definitionLink xlink:type="extended" xlink:role="http://OPRX/role/DeferredRevenue" xlink:title="0014 - Disclosure - DEFERRED REVENUE" />
    <link:definitionLink xlink:type="extended" xlink:role="http://OPRX/role/NotePayable" xlink:title="0015 - Disclosure - NOTE PAYABLE" />
    <link:definitionLink xlink:type="extended" xlink:role="http://OPRX/role/CommonStock" xlink:title="0016 - Disclosure - COMMON STOCK" />
    <link:definitionLink xlink:type="extended" xlink:role="http://OPRX/role/PreferredStock" xlink:title="0017 - Disclosure - PREFERRED STOCK" />
    <link:definitionLink xlink:type="extended" xlink:role="http://OPRX/role/StockOptionsAndWarrants" xlink:title="0018 - Disclosure - STOCK OPTIONS AND WARRANTS" />
    <link:definitionLink xlink:type="extended" xlink:role="http://OPRX/role/OperatingLeases" xlink:title="0019 - Disclosure - OPERATING LEASES" />
    <link:definitionLink xlink:type="extended" xlink:role="http://OPRX/role/RelatedPartyTransactions" xlink:title="0020 - Disclosure - RELATED PARTY TRANSACTIONS" />
    <link:definitionLink xlink:type="extended" xlink:role="http://OPRX/role/MajorCustomers" xlink:title="0021 - Disclosure - MAJOR CUSTOMERS" />
    <link:definitionLink xlink:type="extended" xlink:role="http://OPRX/role/IncomeTaxes" xlink:title="0022 - Disclosure - INCOME TAXES" />
    <link:definitionLink xlink:type="extended" xlink:role="http://OPRX/role/OperatingExpenses" xlink:title="0023 - Disclosure - OPERATING EXPENSES" />
    <link:definitionLink xlink:type="extended" xlink:role="http://OPRX/role/OtherIncome" xlink:title="0024 - Disclosure - OTHER INCOME" />
    <link:definitionLink xlink:type="extended" xlink:role="http://OPRX/role/GoingConcern" xlink:title="0025 - Disclosure - GOING CONCERN" />
    <link:definitionLink xlink:type="extended" xlink:role="http://OPRX/role/SubsequentEvents" xlink:title="0026 - Disclosure - SUBSEQUENT EVENTS" />
</link:linkbase>
</XBRL>
