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<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_LI807J2851021H68IH6I_dei_AmendmentFlag" xml:lang="en-US">Amendment Flag</label>
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<loc xlink:type="locator" xlink:href="http://xbrl.sec.gov/dei/2014/dei-2014-01-31.xsd#dei_EntityFilerCategory" xlink:label="loc_JG685H0639809F46GF4G_dei_EntityFilerCategory" />
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_LI807J2851021H68IH6I_dei_EntityFilerCategory" xml:lang="en-US">Entity Filer Category</label>
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<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_StatementOfFinancialPositionAbstract" xlink:label="loc_JG685H0639809F46GF4G_us-gaap_StatementOfFinancialPositionAbstract" />
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<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_JL86J9H1M69L_us-gaap_AssetsAbstract" xml:lang="en-US">AssetsAbstract</label>
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<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_LI807J2851021H68IH6I_us-gaap_AssetsCurrentAbstract" xml:lang="en-US">AssetsCurrentAbstract</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:label="lab_LI807J2851021H68IH6I_us-gaap_AssetsCurrentAbstract" xml:lang="en-US">Current Assets</label>
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<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_CashAndCashEquivalentsAtCarryingValue" xlink:label="loc_HJ64H7F9K47J_us-gaap_CashAndCashEquivalentsAtCarryingValue" />
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_JL86J9H1M69L_us-gaap_CashAndCashEquivalentsAtCarryingValue" xml:lang="en-US">Cash and Cash Equivalents, at Carrying Value</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:label="lab_JL86J9H1M69L_us-gaap_CashAndCashEquivalentsAtCarryingValue" xml:lang="en-US">Cash and cash equivalents</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/periodStartLabel" xlink:label="lab_JL86J9H1M69L_us-gaap_CashAndCashEquivalentsAtCarryingValue" xml:lang="en-US">CASH AND CASH EQUIVALENTS - BEGINNING OF PERIOD</label>
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<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_AccountsReceivableNetCurrent" xlink:label="loc_JG685H0639809F46GF4G_us-gaap_AccountsReceivableNetCurrent" />
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_LI807J2851021H68IH6I_us-gaap_AccountsReceivableNetCurrent" xml:lang="en-US">Accounts Receivable, Net, Current</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:label="lab_LI807J2851021H68IH6I_us-gaap_AccountsReceivableNetCurrent" xml:lang="en-US">Accounts receivable</label>
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<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_PrepaidExpenseCurrent" xlink:label="loc_HJ64H7F9K47J_us-gaap_PrepaidExpenseCurrent" />
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_JL86J9H1M69L_us-gaap_PrepaidExpenseCurrent" xml:lang="en-US">PrepaidExpenseCurrent</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:label="lab_JL86J9H1M69L_us-gaap_PrepaidExpenseCurrent" xml:lang="en-US">Prepaid expenses</label>
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<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_AssetsCurrent" xlink:label="loc_JG685H0639809F46GF4G_us-gaap_AssetsCurrent" />
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_LI807J2851021H68IH6I_us-gaap_AssetsCurrent" xml:lang="en-US">AssetsCurrent</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/totalLabel" xlink:label="lab_LI807J2851021H68IH6I_us-gaap_AssetsCurrent" xml:lang="en-US">Total Current Assets</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_JG685H0639809F46GF4G_us-gaap_AssetsCurrent" xlink:to="lab_LI807J2851021H68IH6I_us-gaap_AssetsCurrent"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_PropertyPlantAndEquipmentNet" xlink:label="loc_HJ64H7F9K47J_us-gaap_PropertyPlantAndEquipmentNet" />
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_JL86J9H1M69L_us-gaap_PropertyPlantAndEquipmentNet" xml:lang="en-US">PropertyPlantAndEquipmentNet</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:label="lab_JL86J9H1M69L_us-gaap_PropertyPlantAndEquipmentNet" xml:lang="en-US">Property and equipment, net</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_HJ64H7F9K47J_us-gaap_PropertyPlantAndEquipmentNet" xlink:to="lab_JL86J9H1M69L_us-gaap_PropertyPlantAndEquipmentNet"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_OtherAssetsAbstract" xlink:label="loc_JG685H0639809F46GF4G_us-gaap_OtherAssetsAbstract" />
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_LI807J2851021H68IH6I_us-gaap_OtherAssetsAbstract" xml:lang="en-US">OtherAssetsAbstract</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:label="lab_LI807J2851021H68IH6I_us-gaap_OtherAssetsAbstract" xml:lang="en-US">Other Assets</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_JG685H0639809F46GF4G_us-gaap_OtherAssetsAbstract" xlink:to="lab_LI807J2851021H68IH6I_us-gaap_OtherAssetsAbstract"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsNet" xlink:label="loc_HJ64H7F9K47J_us-gaap_FiniteLivedIntangibleAssetsNet" />
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_JL86J9H1M69L_us-gaap_FiniteLivedIntangibleAssetsNet" xml:lang="en-US">Finite-Lived Intangible Assets, Net</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:label="lab_JL86J9H1M69L_us-gaap_FiniteLivedIntangibleAssetsNet" xml:lang="en-US">Patent rights, net</label>
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<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_CapitalizedComputerSoftwareNet" xlink:label="loc_JG685H0639809F46GF4G_us-gaap_CapitalizedComputerSoftwareNet" />
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<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:label="lab_LI807J2851021H68IH6I_us-gaap_CapitalizedComputerSoftwareNet" xml:lang="en-US">Web development costs, net</label>
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<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_SecurityDeposit" xlink:label="loc_HJ64H7F9K47J_us-gaap_SecurityDeposit" />
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<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:label="lab_JL86J9H1M69L_us-gaap_SecurityDeposit" xml:lang="en-US">Security deposit</label>
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<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/totalLabel" xlink:label="lab_LI807J2851021H68IH6I_us-gaap_OtherAssets" xml:lang="en-US">Total Other Assets</label>
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<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_JL86J9H1M69L_us-gaap_Assets" xml:lang="en-US">Assets</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/totalLabel" xlink:label="lab_JL86J9H1M69L_us-gaap_Assets" xml:lang="en-US">TOTAL ASSETS</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_HJ64H7F9K47J_us-gaap_Assets" xlink:to="lab_JL86J9H1M69L_us-gaap_Assets"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_LiabilitiesAndStockholdersEquityAbstract" xlink:label="loc_JG685H0639809F46GF4G_us-gaap_LiabilitiesAndStockholdersEquityAbstract" />
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_LI807J2851021H68IH6I_us-gaap_LiabilitiesAndStockholdersEquityAbstract" xml:lang="en-US">LiabilitiesAndStockholdersEquityAbstract</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:label="lab_LI807J2851021H68IH6I_us-gaap_LiabilitiesAndStockholdersEquityAbstract" xml:lang="en-US">LIABILITIES AND STOCKHOLDERS' EQUITY</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_JG685H0639809F46GF4G_us-gaap_LiabilitiesAndStockholdersEquityAbstract" xlink:to="lab_LI807J2851021H68IH6I_us-gaap_LiabilitiesAndStockholdersEquityAbstract"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_LiabilitiesCurrentAbstract" xlink:label="loc_HJ64H7F9K47J_us-gaap_LiabilitiesCurrentAbstract" />
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_JL86J9H1M69L_us-gaap_LiabilitiesCurrentAbstract" xml:lang="en-US">LiabilitiesCurrentAbstract</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:label="lab_JL86J9H1M69L_us-gaap_LiabilitiesCurrentAbstract" xml:lang="en-US">Current Liabilities</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_HJ64H7F9K47J_us-gaap_LiabilitiesCurrentAbstract" xlink:to="lab_JL86J9H1M69L_us-gaap_LiabilitiesCurrentAbstract"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_AccountsPayableTradeCurrent" xlink:label="loc_JG685H0639809F46GF4G_us-gaap_AccountsPayableTradeCurrent" />
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_LI807J2851021H68IH6I_us-gaap_AccountsPayableTradeCurrent" xml:lang="en-US">AccountsPayableTradeCurrent</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:label="lab_LI807J2851021H68IH6I_us-gaap_AccountsPayableTradeCurrent" xml:lang="en-US">Accounts payable - trade</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_JG685H0639809F46GF4G_us-gaap_AccountsPayableTradeCurrent" xlink:to="lab_LI807J2851021H68IH6I_us-gaap_AccountsPayableTradeCurrent"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_AccountsPayableRelatedPartiesCurrent" xlink:label="loc_HJ64H7F9K47J_us-gaap_AccountsPayableRelatedPartiesCurrent" />
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_JL86J9H1M69L_us-gaap_AccountsPayableRelatedPartiesCurrent" xml:lang="en-US">Accounts Payable, Related Parties, Current</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:label="lab_JL86J9H1M69L_us-gaap_AccountsPayableRelatedPartiesCurrent" xml:lang="en-US">Accounts payable - related party</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_HJ64H7F9K47J_us-gaap_AccountsPayableRelatedPartiesCurrent" xlink:to="lab_JL86J9H1M69L_us-gaap_AccountsPayableRelatedPartiesCurrent"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_AccruedLiabilitiesCurrent" xlink:label="loc_JG685H0639809F46GF4G_us-gaap_AccruedLiabilitiesCurrent" />
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_LI807J2851021H68IH6I_us-gaap_AccruedLiabilitiesCurrent" xml:lang="en-US">Accrued Liabilities, Current</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:label="lab_LI807J2851021H68IH6I_us-gaap_AccruedLiabilitiesCurrent" xml:lang="en-US">Accrued expenses</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_JG685H0639809F46GF4G_us-gaap_AccruedLiabilitiesCurrent" xlink:to="lab_LI807J2851021H68IH6I_us-gaap_AccruedLiabilitiesCurrent"/>
<loc xlink:type="locator" xlink:href="oprx-20150331.xsd#oprx_RevenueSharePayableCurrent" xlink:label="loc_HJ64H7F9K47J_oprx_RevenueSharePayableCurrent" />
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_JL86J9H1M69L_oprx_RevenueSharePayableCurrent" xml:lang="en-US">Revenue Share Payable Current</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:label="lab_JL86J9H1M69L_oprx_RevenueSharePayableCurrent" xml:lang="en-US">Revenue share payable</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:label="lab_JL86J9H1M69L_oprx_RevenueSharePayableCurrent" xml:lang="en-US">Aggregate carrying value as of the balance sheet date of the liabilities for revenue share payable within one year (or the normal operating cycle, if longer).</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_HJ64H7F9K47J_oprx_RevenueSharePayableCurrent" xlink:to="lab_JL86J9H1M69L_oprx_RevenueSharePayableCurrent"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DeferredRevenueCurrent" xlink:label="loc_JG685H0639809F46GF4G_us-gaap_DeferredRevenueCurrent" />
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_LI807J2851021H68IH6I_us-gaap_DeferredRevenueCurrent" xml:lang="en-US">Deferred Revenue, Current</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:label="lab_LI807J2851021H68IH6I_us-gaap_DeferredRevenueCurrent" xml:lang="en-US">Deferred revenue</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_JG685H0639809F46GF4G_us-gaap_DeferredRevenueCurrent" xlink:to="lab_LI807J2851021H68IH6I_us-gaap_DeferredRevenueCurrent"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_LiabilitiesCurrent" xlink:label="loc_HJ64H7F9K47J_us-gaap_LiabilitiesCurrent" />
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_JL86J9H1M69L_us-gaap_LiabilitiesCurrent" xml:lang="en-US">Liabilities, Current</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/totalLabel" xlink:label="lab_JL86J9H1M69L_us-gaap_LiabilitiesCurrent" xml:lang="en-US">Total Liabilities</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_HJ64H7F9K47J_us-gaap_LiabilitiesCurrent" xlink:to="lab_JL86J9H1M69L_us-gaap_LiabilitiesCurrent"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_StockholdersEquityAbstract" xlink:label="loc_JG685H0639809F46GF4G_us-gaap_StockholdersEquityAbstract" />
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_LI807J2851021H68IH6I_us-gaap_StockholdersEquityAbstract" xml:lang="en-US">StockholdersEquityAbstract</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:label="lab_LI807J2851021H68IH6I_us-gaap_StockholdersEquityAbstract" xml:lang="en-US">Stockholders' Equity</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_JG685H0639809F46GF4G_us-gaap_StockholdersEquityAbstract" xlink:to="lab_LI807J2851021H68IH6I_us-gaap_StockholdersEquityAbstract"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_CommonStockValue" xlink:label="loc_HJ64H7F9K47J_us-gaap_CommonStockValue" />
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_JL86J9H1M69L_us-gaap_CommonStockValue" xml:lang="en-US">Common Stock, Value, Issued</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_JL86J9H1M69L_us-gaap_CommonStockValue" xml:lang="en-US">Preferred stock</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:label="lab_JL86J9H1M69L_us-gaap_CommonStockValue" xml:lang="en-US">Common stock, $.001 par value, 500,000,000 shares authorized, 22,924,819 and 22,867,319 shares issued and outstanding, respectively</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_HJ64H7F9K47J_us-gaap_CommonStockValue" xlink:to="lab_JL86J9H1M69L_us-gaap_CommonStockValue"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_PreferredStockValue" xlink:label="loc_JG685H0639809F46GF4G_us-gaap_PreferredStockValue" />
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_LI807J2851021H68IH6I_us-gaap_PreferredStockValue" xml:lang="en-US">Preferred Stock, Value, Issued</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:label="lab_LI807J2851021H68IH6I_us-gaap_PreferredStockValue" xml:lang="en-US">Preferred stock, $.001 par value, 10,000,000 shares authorized, 0 and 65 shares issued and outstanding, respectively</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_JG685H0639809F46GF4G_us-gaap_PreferredStockValue" xlink:to="lab_LI807J2851021H68IH6I_us-gaap_PreferredStockValue"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_WarrantsAndRightsOutstanding" xlink:label="loc_HJ64H7F9K47J_us-gaap_WarrantsAndRightsOutstanding" />
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_JL86J9H1M69L_us-gaap_WarrantsAndRightsOutstanding" xml:lang="en-US">WarrantsAndRightsOutstanding</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:label="lab_JL86J9H1M69L_us-gaap_WarrantsAndRightsOutstanding" xml:lang="en-US">Stock warrants</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_HJ64H7F9K47J_us-gaap_WarrantsAndRightsOutstanding" xlink:to="lab_JL86J9H1M69L_us-gaap_WarrantsAndRightsOutstanding"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_AdditionalPaidInCapital" xlink:label="loc_JG685H0639809F46GF4G_us-gaap_AdditionalPaidInCapital" />
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_LI807J2851021H68IH6I_us-gaap_AdditionalPaidInCapital" xml:lang="en-US">AdditionalPaidInCapital</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:label="lab_LI807J2851021H68IH6I_us-gaap_AdditionalPaidInCapital" xml:lang="en-US">Additional paid-in-capital</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_JG685H0639809F46GF4G_us-gaap_AdditionalPaidInCapital" xlink:to="lab_LI807J2851021H68IH6I_us-gaap_AdditionalPaidInCapital"/>
<loc xlink:type="locator" xlink:href="oprx-20150331.xsd#oprx_StockPayable" xlink:label="loc_HJ64H7F9K47J_oprx_StockPayable" />
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_JL86J9H1M69L_oprx_StockPayable" xml:lang="en-US">Stock Payable</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_JL86J9H1M69L_oprx_StockPayable" xml:lang="en-US">Stock payable</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:label="lab_JL86J9H1M69L_oprx_StockPayable" xml:lang="en-US">Stock payable.</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_HJ64H7F9K47J_oprx_StockPayable" xlink:to="lab_JL86J9H1M69L_oprx_StockPayable"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DeferredCompensationEquity" xlink:label="loc_JG685H0639809F46GF4G_us-gaap_DeferredCompensationEquity" />
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_LI807J2851021H68IH6I_us-gaap_DeferredCompensationEquity" xml:lang="en-US">Deferred Compensation Equity</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:label="lab_LI807J2851021H68IH6I_us-gaap_DeferredCompensationEquity" xml:lang="en-US">Deferred stock compensation</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2009/role/negatedLabel" xlink:label="lab_LI807J2851021H68IH6I_us-gaap_DeferredCompensationEquity" xml:lang="en-US">Deferred stock compensation</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_JG685H0639809F46GF4G_us-gaap_DeferredCompensationEquity" xlink:to="lab_LI807J2851021H68IH6I_us-gaap_DeferredCompensationEquity"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_RetainedEarningsAccumulatedDeficit" xlink:label="loc_HJ64H7F9K47J_us-gaap_RetainedEarningsAccumulatedDeficit" />
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_JL86J9H1M69L_us-gaap_RetainedEarningsAccumulatedDeficit" xml:lang="en-US">RetainedEarningsAccumulatedDeficit</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:label="lab_JL86J9H1M69L_us-gaap_RetainedEarningsAccumulatedDeficit" xml:lang="en-US">Accumulated deficit</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2009/role/negatedLabel" xlink:label="lab_JL86J9H1M69L_us-gaap_RetainedEarningsAccumulatedDeficit" xml:lang="en-US">Accumulated deficit</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_HJ64H7F9K47J_us-gaap_RetainedEarningsAccumulatedDeficit" xlink:to="lab_JL86J9H1M69L_us-gaap_RetainedEarningsAccumulatedDeficit"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_StockholdersEquity" xlink:label="loc_JG685H0639809F46GF4G_us-gaap_StockholdersEquity" />
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_LI807J2851021H68IH6I_us-gaap_StockholdersEquity" xml:lang="en-US">Stockholders' Equity Attributable to Parent</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/totalLabel" xlink:label="lab_LI807J2851021H68IH6I_us-gaap_StockholdersEquity" xml:lang="en-US">Total Stockholders' Equity</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_JG685H0639809F46GF4G_us-gaap_StockholdersEquity" xlink:to="lab_LI807J2851021H68IH6I_us-gaap_StockholdersEquity"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_LiabilitiesAndStockholdersEquity" xlink:label="loc_HJ64H7F9K47J_us-gaap_LiabilitiesAndStockholdersEquity" />
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_JL86J9H1M69L_us-gaap_LiabilitiesAndStockholdersEquity" xml:lang="en-US">Liabilities and Equity</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/totalLabel" xlink:label="lab_JL86J9H1M69L_us-gaap_LiabilitiesAndStockholdersEquity" xml:lang="en-US">TOTAL LIABILITIES AND STOCKHOLDERS' EQUITY</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_HJ64H7F9K47J_us-gaap_LiabilitiesAndStockholdersEquity" xlink:to="lab_JL86J9H1M69L_us-gaap_LiabilitiesAndStockholdersEquity"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_CommonStockParOrStatedValuePerShare" xlink:label="loc_JG685H0639809F46GF4G_us-gaap_CommonStockParOrStatedValuePerShare" />
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_LI807J2851021H68IH6I_us-gaap_CommonStockParOrStatedValuePerShare" xml:lang="en-US">CommonStockParOrStatedValuePerShare</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:label="lab_LI807J2851021H68IH6I_us-gaap_CommonStockParOrStatedValuePerShare" xml:lang="en-US">Common stock par value</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_JG685H0639809F46GF4G_us-gaap_CommonStockParOrStatedValuePerShare" xlink:to="lab_LI807J2851021H68IH6I_us-gaap_CommonStockParOrStatedValuePerShare"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_CommonStockSharesAuthorized" xlink:label="loc_HJ64H7F9K47J_us-gaap_CommonStockSharesAuthorized" />
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_JL86J9H1M69L_us-gaap_CommonStockSharesAuthorized" xml:lang="en-US">CommonStockSharesAuthorized</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:label="lab_JL86J9H1M69L_us-gaap_CommonStockSharesAuthorized" xml:lang="en-US">Common stock, shares authorized</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_HJ64H7F9K47J_us-gaap_CommonStockSharesAuthorized" xlink:to="lab_JL86J9H1M69L_us-gaap_CommonStockSharesAuthorized"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_CommonStockSharesIssued" xlink:label="loc_JG685H0639809F46GF4G_us-gaap_CommonStockSharesIssued" />
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_LI807J2851021H68IH6I_us-gaap_CommonStockSharesIssued" xml:lang="en-US">Common Stock, Shares, Issued</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:label="lab_LI807J2851021H68IH6I_us-gaap_CommonStockSharesIssued" xml:lang="en-US">Common stock, shares issued</label>
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<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_LI807J2851021H68IH6I_us-gaap_PreferredStockParOrStatedValuePerShare" xml:lang="en-US">PreferredStockParOrStatedValuePerShare</label>
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<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_JL86J9H1M69L_us-gaap_PreferredStockSharesAuthorized" xml:lang="en-US">PreferredStockSharesAuthorized</label>
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<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_LI807J2851021H68IH6I_us-gaap_PreferredStockSharesIssued" xml:lang="en-US">PreferredStockSharesIssued</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:label="lab_LI807J2851021H68IH6I_us-gaap_PreferredStockSharesIssued" xml:lang="en-US">Preferred stock, shares issued</label>
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<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_PreferredStockSharesOutstanding" xlink:label="loc_HJ64H7F9K47J_us-gaap_PreferredStockSharesOutstanding" />
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_JL86J9H1M69L_us-gaap_PreferredStockSharesOutstanding" xml:lang="en-US">Preferred stock, shares outstanding</label>
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<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_IncomeStatementAbstract" xlink:label="loc_JG685H0639809F46GF4G_us-gaap_IncomeStatementAbstract" />
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_LI807J2851021H68IH6I_us-gaap_IncomeStatementAbstract" xml:lang="en-US">Income Statement [Abstract]</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_JG685H0639809F46GF4G_us-gaap_IncomeStatementAbstract" xlink:to="lab_LI807J2851021H68IH6I_us-gaap_IncomeStatementAbstract"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_Revenues" xlink:label="loc_HJ64H7F9K47J_us-gaap_Revenues" />
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_JL86J9H1M69L_us-gaap_Revenues" xml:lang="en-US">Revenues</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:label="lab_JL86J9H1M69L_us-gaap_Revenues" xml:lang="en-US">NET REVENUE</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_HJ64H7F9K47J_us-gaap_Revenues" xlink:to="lab_JL86J9H1M69L_us-gaap_Revenues"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_CostOfGoodsSold" xlink:label="loc_JG685H0639809F46GF4G_us-gaap_CostOfGoodsSold" />
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_LI807J2851021H68IH6I_us-gaap_CostOfGoodsSold" xml:lang="en-US">Cost of Goods Sold</label>
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<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_GrossProfit" xlink:label="loc_HJ64H7F9K47J_us-gaap_GrossProfit" />
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_JL86J9H1M69L_us-gaap_GrossProfit" xml:lang="en-US">GrossProfit</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:label="lab_JL86J9H1M69L_us-gaap_GrossProfit" xml:lang="en-US">GROSS MARGIN</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/totalLabel" xlink:label="lab_JL86J9H1M69L_us-gaap_GrossProfit" xml:lang="en-US">GROSS MARGIN</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_HJ64H7F9K47J_us-gaap_GrossProfit" xlink:to="lab_JL86J9H1M69L_us-gaap_GrossProfit"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_OperatingExpenses" xlink:label="loc_JG685H0639809F46GF4G_us-gaap_OperatingExpenses" />
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_LI807J2851021H68IH6I_us-gaap_OperatingExpenses" xml:lang="en-US">Operating expenses</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_LI807J2851021H68IH6I_us-gaap_OperatingExpenses" xml:lang="en-US">Operating expenses</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:label="lab_LI807J2851021H68IH6I_us-gaap_OperatingExpenses" xml:lang="en-US">OPERATING EXPENSES</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2009/role/negatedLabel" xlink:label="lab_LI807J2851021H68IH6I_us-gaap_OperatingExpenses" xml:lang="en-US">OPERATING EXPENSES</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_JG685H0639809F46GF4G_us-gaap_OperatingExpenses" xlink:to="lab_LI807J2851021H68IH6I_us-gaap_OperatingExpenses"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_OperatingIncomeLoss" xlink:label="loc_HJ64H7F9K47J_us-gaap_OperatingIncomeLoss" />
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_JL86J9H1M69L_us-gaap_OperatingIncomeLoss" xml:lang="en-US">OperatingIncomeLoss</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_JL86J9H1M69L_us-gaap_OperatingIncomeLoss" xml:lang="en-US">LOSS FROM OPERATIONS</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:label="lab_JL86J9H1M69L_us-gaap_OperatingIncomeLoss" xml:lang="en-US">Loss from operations</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/totalLabel" xlink:label="lab_JL86J9H1M69L_us-gaap_OperatingIncomeLoss" xml:lang="en-US">LOSS FROM OPERATIONS</label>
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<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_OtherIncomeAndExpensesAbstract" xlink:label="loc_JG685H0639809F46GF4G_us-gaap_OtherIncomeAndExpensesAbstract" />
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_LI807J2851021H68IH6I_us-gaap_OtherIncomeAndExpensesAbstract" xml:lang="en-US">OtherIncomeAndExpensesAbstract</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:label="lab_LI807J2851021H68IH6I_us-gaap_OtherIncomeAndExpensesAbstract" xml:lang="en-US">OTHER INCOME (EXPENSE)</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_JG685H0639809F46GF4G_us-gaap_OtherIncomeAndExpensesAbstract" xlink:to="lab_LI807J2851021H68IH6I_us-gaap_OtherIncomeAndExpensesAbstract"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_InterestAndOtherIncome" xlink:label="loc_HJ64H7F9K47J_us-gaap_InterestAndOtherIncome" />
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_JL86J9H1M69L_us-gaap_InterestAndOtherIncome" xml:lang="en-US">Interest and Other Income</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_JL86J9H1M69L_us-gaap_InterestAndOtherIncome" xml:lang="en-US">Interest income</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2009/role/negatedLabel" xlink:label="lab_JL86J9H1M69L_us-gaap_InterestAndOtherIncome" xml:lang="en-US">Interest income</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_HJ64H7F9K47J_us-gaap_InterestAndOtherIncome" xlink:to="lab_JL86J9H1M69L_us-gaap_InterestAndOtherIncome"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_NonoperatingIncomeExpense" xlink:label="loc_JG685H0639809F46GF4G_us-gaap_NonoperatingIncomeExpense" />
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_LI807J2851021H68IH6I_us-gaap_NonoperatingIncomeExpense" xml:lang="en-US">Nonoperating Income (Expense)</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/totalLabel" xlink:label="lab_LI807J2851021H68IH6I_us-gaap_NonoperatingIncomeExpense" xml:lang="en-US">TOTAL OTHER INCOME (EXPENSE)</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2009/role/negatedTotalLabel" xlink:label="lab_LI807J2851021H68IH6I_us-gaap_NonoperatingIncomeExpense" xml:lang="en-US">TOTAL OTHER INCOME (EXPENSE)</label>
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<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesMinorityInterestAndIncomeLossFromEquityMethodInvestments" xlink:label="loc_HJ64H7F9K47J_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesMinorityInterestAndIncomeLossFromEquityMethodInvestments" />
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_JL86J9H1M69L_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesMinorityInterestAndIncomeLossFromEquityMethodInvestments" xml:lang="en-US">Income (Loss) from Continuing Operations before Equity Method Investments, Income Taxes, Extraordinary Items, Noncontrolling Interest</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_JL86J9H1M69L_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesMinorityInterestAndIncomeLossFromEquityMethodInvestments" xml:lang="en-US">Loss before income taxes</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/totalLabel" xlink:label="lab_JL86J9H1M69L_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesMinorityInterestAndIncomeLossFromEquityMethodInvestments" xml:lang="en-US">LOSS BEFORE PROVISION FOR INCOME TAXES</label>
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<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_IncomeTaxExpenseBenefit" xlink:label="loc_JG685H0639809F46GF4G_us-gaap_IncomeTaxExpenseBenefit" />
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<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:label="lab_LI807J2851021H68IH6I_us-gaap_IncomeTaxExpenseBenefit" xml:lang="en-US">PROVISION FOR INCOME TAXES</label>
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<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_JL86J9H1M69L_us-gaap_NetIncomeLoss" xml:lang="en-US">Net Income (Loss) Attributable to Parent</label>
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<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:label="lab_JL86J9H1M69L_us-gaap_NetIncomeLoss" xml:lang="en-US">NET LOSS</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/positiveLabel" xlink:label="lab_JL86J9H1M69L_us-gaap_NetIncomeLoss" xml:lang="en-US">Net loss</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/totalLabel" xlink:label="lab_JL86J9H1M69L_us-gaap_NetIncomeLoss" xml:lang="en-US">NET LOSS</label>
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<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_EarningsPerShareBasicAndDilutedOtherDisclosuresAbstract" xlink:label="loc_JG685H0639809F46GF4G_us-gaap_EarningsPerShareBasicAndDilutedOtherDisclosuresAbstract" />
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_LI807J2851021H68IH6I_us-gaap_EarningsPerShareBasicAndDilutedOtherDisclosuresAbstract" xml:lang="en-US">Earnings Per Share, Basic and Diluted, Other Disclosures [Abstract]</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:label="lab_LI807J2851021H68IH6I_us-gaap_EarningsPerShareBasicAndDilutedOtherDisclosuresAbstract" xml:lang="en-US">WEIGHTED AVERAGE SHARES OUTSTANDING</label>
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<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_JL86J9H1M69L_us-gaap_WeightedAverageNumberOfShareOutstandingBasicAndDiluted" xml:lang="en-US">Weighted Average Number of Shares Outstanding, Basic and Diluted</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:label="lab_JL86J9H1M69L_us-gaap_WeightedAverageNumberOfShareOutstandingBasicAndDiluted" xml:lang="en-US">BASIC AND DILUTED</label>
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<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_EarningsPerShareAbstract" xlink:label="loc_JG685H0639809F46GF4G_us-gaap_EarningsPerShareAbstract" />
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_LI807J2851021H68IH6I_us-gaap_EarningsPerShareAbstract" xml:lang="en-US">Earnings Per Share [Abstract]</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:label="lab_LI807J2851021H68IH6I_us-gaap_EarningsPerShareAbstract" xml:lang="en-US">NET LOSS PER SHARE</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_JG685H0639809F46GF4G_us-gaap_EarningsPerShareAbstract" xlink:to="lab_LI807J2851021H68IH6I_us-gaap_EarningsPerShareAbstract"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_EarningsPerShareBasicAndDiluted" xlink:label="loc_HJ64H7F9K47J_us-gaap_EarningsPerShareBasicAndDiluted" />
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_JL86J9H1M69L_us-gaap_EarningsPerShareBasicAndDiluted" xml:lang="en-US">Earnings Per Share, Basic and Diluted</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_JL86J9H1M69L_us-gaap_EarningsPerShareBasicAndDiluted" xml:lang="en-US">BASIC AND DILUTED</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_HJ64H7F9K47J_us-gaap_EarningsPerShareBasicAndDiluted" xlink:to="lab_JL86J9H1M69L_us-gaap_EarningsPerShareBasicAndDiluted"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_StatementOfCashFlowsAbstract" xlink:label="loc_JG685H0639809F46GF4G_us-gaap_StatementOfCashFlowsAbstract" />
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_LI807J2851021H68IH6I_us-gaap_StatementOfCashFlowsAbstract" xml:lang="en-US">Statements of Cash Flows [Abstract]</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_JG685H0639809F46GF4G_us-gaap_StatementOfCashFlowsAbstract" xlink:to="lab_LI807J2851021H68IH6I_us-gaap_StatementOfCashFlowsAbstract"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivitiesAbstract" xlink:label="loc_HJ64H7F9K47J_us-gaap_NetCashProvidedByUsedInOperatingActivitiesAbstract" />
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_JL86J9H1M69L_us-gaap_NetCashProvidedByUsedInOperatingActivitiesAbstract" xml:lang="en-US">NetCashProvidedByUsedInOperatingActivitiesAbstract</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:label="lab_JL86J9H1M69L_us-gaap_NetCashProvidedByUsedInOperatingActivitiesAbstract" xml:lang="en-US">CASH FLOWS FROM OPERATING ACTIVITIES:</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_HJ64H7F9K47J_us-gaap_NetCashProvidedByUsedInOperatingActivitiesAbstract" xlink:to="lab_JL86J9H1M69L_us-gaap_NetCashProvidedByUsedInOperatingActivitiesAbstract"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract" xlink:label="loc_JG685H0639809F46GF4G_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract" />
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_LI807J2851021H68IH6I_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract" xml:lang="en-US">AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:label="lab_LI807J2851021H68IH6I_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract" xml:lang="en-US">Adjustments to reconcile net loss to net cash provided by (used in) operating activities:</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_JG685H0639809F46GF4G_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract" xlink:to="lab_LI807J2851021H68IH6I_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DepreciationAndAmortization" xlink:label="loc_HJ64H7F9K47J_us-gaap_DepreciationAndAmortization" />
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_JL86J9H1M69L_us-gaap_DepreciationAndAmortization" xml:lang="en-US">DepreciationAndAmortization</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:label="lab_JL86J9H1M69L_us-gaap_DepreciationAndAmortization" xml:lang="en-US">Depreciation and amortization</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_HJ64H7F9K47J_us-gaap_DepreciationAndAmortization" xlink:to="lab_JL86J9H1M69L_us-gaap_DepreciationAndAmortization"/>
<loc xlink:type="locator" xlink:href="oprx-20150331.xsd#oprx_StockOptionsIssuedForServices" xlink:label="loc_JG685H0639809F46GF4G_oprx_StockOptionsIssuedForServices" />
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_LI807J2851021H68IH6I_oprx_StockOptionsIssuedForServices" xml:lang="en-US">Stock options issued for services</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:label="lab_LI807J2851021H68IH6I_oprx_StockOptionsIssuedForServices" xml:lang="en-US">Stock options issued for services</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2009/role/negatedLabel" xlink:label="lab_LI807J2851021H68IH6I_oprx_StockOptionsIssuedForServices" xml:lang="en-US">Stock and options issued for services</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_JG685H0639809F46GF4G_oprx_StockOptionsIssuedForServices" xlink:to="lab_LI807J2851021H68IH6I_oprx_StockOptionsIssuedForServices"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_IncreaseDecreaseInOtherOperatingAssetsAndLiabilitiesNetAbstract" xlink:label="loc_HJ64H7F9K47J_us-gaap_IncreaseDecreaseInOtherOperatingAssetsAndLiabilitiesNetAbstract" />
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_JL86J9H1M69L_us-gaap_IncreaseDecreaseInOtherOperatingAssetsAndLiabilitiesNetAbstract" xml:lang="en-US">IncreaseDecreaseInOtherOperatingAssetsAndLiabilitiesNetAbstract</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:label="lab_JL86J9H1M69L_us-gaap_IncreaseDecreaseInOtherOperatingAssetsAndLiabilitiesNetAbstract" xml:lang="en-US">Changes in:</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_HJ64H7F9K47J_us-gaap_IncreaseDecreaseInOtherOperatingAssetsAndLiabilitiesNetAbstract" xlink:to="lab_JL86J9H1M69L_us-gaap_IncreaseDecreaseInOtherOperatingAssetsAndLiabilitiesNetAbstract"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_IncreaseDecreaseInAccountsReceivable" xlink:label="loc_JG685H0639809F46GF4G_us-gaap_IncreaseDecreaseInAccountsReceivable" />
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_LI807J2851021H68IH6I_us-gaap_IncreaseDecreaseInAccountsReceivable" xml:lang="en-US">IncreaseDecreaseInAccountsReceivable</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_LI807J2851021H68IH6I_us-gaap_IncreaseDecreaseInAccountsReceivable" xml:lang="en-US">Decrease in accounts receivable</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:label="lab_LI807J2851021H68IH6I_us-gaap_IncreaseDecreaseInAccountsReceivable" xml:lang="en-US">Accounts receivable</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2009/role/negatedLabel" xlink:label="lab_LI807J2851021H68IH6I_us-gaap_IncreaseDecreaseInAccountsReceivable" xml:lang="en-US">Accounts receivable</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_JG685H0639809F46GF4G_us-gaap_IncreaseDecreaseInAccountsReceivable" xlink:to="lab_LI807J2851021H68IH6I_us-gaap_IncreaseDecreaseInAccountsReceivable"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_IncreaseDecreaseInPrepaidExpense" xlink:label="loc_HJ64H7F9K47J_us-gaap_IncreaseDecreaseInPrepaidExpense" />
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_JL86J9H1M69L_us-gaap_IncreaseDecreaseInPrepaidExpense" xml:lang="en-US">Increase (Decrease) in Prepaid Expense</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2009/role/negatedLabel" xlink:label="lab_JL86J9H1M69L_us-gaap_IncreaseDecreaseInPrepaidExpense" xml:lang="en-US">Prepaid expenses</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_HJ64H7F9K47J_us-gaap_IncreaseDecreaseInPrepaidExpense" xlink:to="lab_JL86J9H1M69L_us-gaap_IncreaseDecreaseInPrepaidExpense"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_IncreaseDecreaseInAccountsPayable" xlink:label="loc_JG685H0639809F46GF4G_us-gaap_IncreaseDecreaseInAccountsPayable" />
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_LI807J2851021H68IH6I_us-gaap_IncreaseDecreaseInAccountsPayable" xml:lang="en-US">IncreaseDecreaseInAccountsPayable</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_LI807J2851021H68IH6I_us-gaap_IncreaseDecreaseInAccountsPayable" xml:lang="en-US">Increase in accounts payable</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:label="lab_LI807J2851021H68IH6I_us-gaap_IncreaseDecreaseInAccountsPayable" xml:lang="en-US">Accounts payable</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_JG685H0639809F46GF4G_us-gaap_IncreaseDecreaseInAccountsPayable" xlink:to="lab_LI807J2851021H68IH6I_us-gaap_IncreaseDecreaseInAccountsPayable"/>
<loc xlink:type="locator" xlink:href="oprx-20150331.xsd#oprx_RevenueSharePayable" xlink:label="loc_HJ64H7F9K47J_oprx_RevenueSharePayable" />
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_JL86J9H1M69L_oprx_RevenueSharePayable" xml:lang="en-US">Revenue share payable</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_JL86J9H1M69L_oprx_RevenueSharePayable" xml:lang="en-US">Decrease in revenue share payable</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:label="lab_JL86J9H1M69L_oprx_RevenueSharePayable" xml:lang="en-US">Revenue share payable</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2009/role/negatedLabel" xlink:label="lab_JL86J9H1M69L_oprx_RevenueSharePayable" xml:lang="en-US">Revenue share payable</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_HJ64H7F9K47J_oprx_RevenueSharePayable" xlink:to="lab_JL86J9H1M69L_oprx_RevenueSharePayable"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_IncreaseDecreaseInAccruedLiabilities" xlink:label="loc_JG685H0639809F46GF4G_us-gaap_IncreaseDecreaseInAccruedLiabilities" />
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_LI807J2851021H68IH6I_us-gaap_IncreaseDecreaseInAccruedLiabilities" xml:lang="en-US">IncreaseDecreaseInAccruedLiabilities</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:label="lab_LI807J2851021H68IH6I_us-gaap_IncreaseDecreaseInAccruedLiabilities" xml:lang="en-US">Accrued expenses</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_JG685H0639809F46GF4G_us-gaap_IncreaseDecreaseInAccruedLiabilities" xlink:to="lab_LI807J2851021H68IH6I_us-gaap_IncreaseDecreaseInAccruedLiabilities"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_IncreaseDecreaseInDeferredRevenue" xlink:label="loc_HJ64H7F9K47J_us-gaap_IncreaseDecreaseInDeferredRevenue" />
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_JL86J9H1M69L_us-gaap_IncreaseDecreaseInDeferredRevenue" xml:lang="en-US">Increase in deferred revenue</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_JL86J9H1M69L_us-gaap_IncreaseDecreaseInDeferredRevenue" xml:lang="en-US">Increase in deferred revenue</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:label="lab_JL86J9H1M69L_us-gaap_IncreaseDecreaseInDeferredRevenue" xml:lang="en-US">Deferred revenue</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_HJ64H7F9K47J_us-gaap_IncreaseDecreaseInDeferredRevenue" xlink:to="lab_JL86J9H1M69L_us-gaap_IncreaseDecreaseInDeferredRevenue"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivities" xlink:label="loc_JG685H0639809F46GF4G_us-gaap_NetCashProvidedByUsedInOperatingActivities" />
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_LI807J2851021H68IH6I_us-gaap_NetCashProvidedByUsedInOperatingActivities" xml:lang="en-US">NetCashProvidedByUsedInOperatingActivities</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:label="lab_LI807J2851021H68IH6I_us-gaap_NetCashProvidedByUsedInOperatingActivities" xml:lang="en-US">NET CASH PROVIDED BY (USED IN) OPERATING ACTIVITIES</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/totalLabel" xlink:label="lab_LI807J2851021H68IH6I_us-gaap_NetCashProvidedByUsedInOperatingActivities" xml:lang="en-US">NET CASH PROVIDED BY (USED IN) OPERATING ACTIVITIES</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_JG685H0639809F46GF4G_us-gaap_NetCashProvidedByUsedInOperatingActivities" xlink:to="lab_LI807J2851021H68IH6I_us-gaap_NetCashProvidedByUsedInOperatingActivities"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract" xlink:label="loc_HJ64H7F9K47J_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract" />
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_JL86J9H1M69L_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract" xml:lang="en-US">NetCashProvidedByUsedInInvestingActivitiesAbstract</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:label="lab_JL86J9H1M69L_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract" xml:lang="en-US">CASH FLOWS FROM INVESTING ACTIVITIES:</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_HJ64H7F9K47J_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract" xlink:to="lab_JL86J9H1M69L_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract"/>
<loc xlink:type="locator" xlink:href="oprx-20150331.xsd#oprx_PatentRights" xlink:label="loc_JG685H0639809F46GF4G_oprx_PatentRights" />
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_LI807J2851021H68IH6I_oprx_PatentRights" xml:lang="en-US">PatentRights</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2009/role/negatedLabel" xlink:label="lab_LI807J2851021H68IH6I_oprx_PatentRights" xml:lang="en-US">Patent rights</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_JG685H0639809F46GF4G_oprx_PatentRights" xlink:to="lab_LI807J2851021H68IH6I_oprx_PatentRights"/>
<loc xlink:type="locator" xlink:href="oprx-20150331.xsd#oprx_WebsiteDevelopmentCosts" xlink:label="loc_HJ64H7F9K47J_oprx_WebsiteDevelopmentCosts" />
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_JL86J9H1M69L_oprx_WebsiteDevelopmentCosts" xml:lang="en-US">WebsiteDevelopmentCosts</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2009/role/negatedLabel" xlink:label="lab_JL86J9H1M69L_oprx_WebsiteDevelopmentCosts" xml:lang="en-US">Website site development costs</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_HJ64H7F9K47J_oprx_WebsiteDevelopmentCosts" xlink:to="lab_JL86J9H1M69L_oprx_WebsiteDevelopmentCosts"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivities" xlink:label="loc_JG685H0639809F46GF4G_us-gaap_NetCashProvidedByUsedInInvestingActivities" />
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_LI807J2851021H68IH6I_us-gaap_NetCashProvidedByUsedInInvestingActivities" xml:lang="en-US">NetCashProvidedByUsedInInvestingActivities</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/totalLabel" xlink:label="lab_LI807J2851021H68IH6I_us-gaap_NetCashProvidedByUsedInInvestingActivities" xml:lang="en-US">NET CASH USED IN INVESTING ACTIVITIES</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_JG685H0639809F46GF4G_us-gaap_NetCashProvidedByUsedInInvestingActivities" xlink:to="lab_LI807J2851021H68IH6I_us-gaap_NetCashProvidedByUsedInInvestingActivities"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract" xlink:label="loc_HJ64H7F9K47J_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract" />
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_JL86J9H1M69L_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract" xml:lang="en-US">NetCashProvidedByUsedInFinancingActivitiesAbstract</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:label="lab_JL86J9H1M69L_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract" xml:lang="en-US">CASH FLOWS FROM FINANCING ACTIVITIES:</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_HJ64H7F9K47J_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract" xlink:to="lab_JL86J9H1M69L_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract"/>
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<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_LI807J2851021H68IH6I_us-gaap_ProceedsFromIssuanceOfCommonStock" xml:lang="en-US">Proceeds from Issuance of Common Stock</label>
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<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_LI807J2851021H68IH6I_us-gaap_TitleOfIndividualAxis" xml:lang="en-US">Title of Individual [Axis]</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_JG685H0639809F46GF4G_us-gaap_TitleOfIndividualAxis" xlink:to="lab_LI807J2851021H68IH6I_us-gaap_TitleOfIndividualAxis"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_TitleOfIndividualWithRelationshipToEntityDomain" xlink:label="loc_HJ64H7F9K47J_us-gaap_TitleOfIndividualWithRelationshipToEntityDomain" />
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_JL86J9H1M69L_us-gaap_TitleOfIndividualWithRelationshipToEntityDomain" xml:lang="en-US">Relationship to Entity [Domain]</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_HJ64H7F9K47J_us-gaap_TitleOfIndividualWithRelationshipToEntityDomain" xlink:to="lab_JL86J9H1M69L_us-gaap_TitleOfIndividualWithRelationshipToEntityDomain"/>
<loc xlink:type="locator" xlink:href="oprx-20150331.xsd#oprx_PlacementAgentsMember" xlink:label="loc_JG685H0639809F46GF4G_oprx_PlacementAgentsMember" />
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_LI807J2851021H68IH6I_oprx_PlacementAgentsMember" xml:lang="en-US">Placement Agents [Member]</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_JG685H0639809F46GF4G_oprx_PlacementAgentsMember" xlink:to="lab_LI807J2851021H68IH6I_oprx_PlacementAgentsMember"/>
<loc xlink:type="locator" xlink:href="oprx-20150331.xsd#oprx_ThreeOfficerMember" xlink:label="loc_HJ64H7F9K47J_oprx_ThreeOfficerMember" />
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_JL86J9H1M69L_oprx_ThreeOfficerMember" xml:lang="en-US">Three Officers [Member]</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_HJ64H7F9K47J_oprx_ThreeOfficerMember" xlink:to="lab_JL86J9H1M69L_oprx_ThreeOfficerMember"/>
<loc xlink:type="locator" xlink:href="oprx-20150331.xsd#oprx_ConsultantMember" xlink:label="loc_JG685H0639809F46GF4G_oprx_ConsultantMember" />
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_LI807J2851021H68IH6I_oprx_ConsultantMember" xml:lang="en-US">Consultant [Member]</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_JG685H0639809F46GF4G_oprx_ConsultantMember" xlink:to="lab_LI807J2851021H68IH6I_oprx_ConsultantMember"/>
<loc xlink:type="locator" xlink:href="oprx-20150331.xsd#oprx_VicisMember" xlink:label="loc_HJ64H7F9K47J_oprx_VicisMember" />
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_JL86J9H1M69L_oprx_VicisMember" xml:lang="en-US">Vicis [Member]</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_HJ64H7F9K47J_oprx_VicisMember" xlink:to="lab_JL86J9H1M69L_oprx_VicisMember"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_OfficerMember" xlink:label="loc_JG685H0639809F46GF4G_us-gaap_OfficerMember" />
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_LI807J2851021H68IH6I_us-gaap_OfficerMember" xml:lang="en-US">Officer [Member]</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_JG685H0639809F46GF4G_us-gaap_OfficerMember" xlink:to="lab_LI807J2851021H68IH6I_us-gaap_OfficerMember"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DirectorMember" xlink:label="loc_HJ64H7F9K47J_us-gaap_DirectorMember" />
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_JL86J9H1M69L_us-gaap_DirectorMember" xml:lang="en-US">Director [Member]</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_JL86J9H1M69L_us-gaap_DirectorMember" xml:lang="en-US">Director [Member]</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:label="lab_JL86J9H1M69L_us-gaap_DirectorMember" xml:lang="en-US">Outside director [Member]</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_HJ64H7F9K47J_us-gaap_DirectorMember" xlink:to="lab_JL86J9H1M69L_us-gaap_DirectorMember"/>
<loc xlink:type="locator" xlink:href="oprx-20150331.xsd#oprx_AgreementAxis" xlink:label="loc_JG685H0639809F46GF4G_oprx_AgreementAxis" />
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_LI807J2851021H68IH6I_oprx_AgreementAxis" xml:lang="en-US">Agreement [Axis]</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_JG685H0639809F46GF4G_oprx_AgreementAxis" xlink:to="lab_LI807J2851021H68IH6I_oprx_AgreementAxis"/>
<loc xlink:type="locator" xlink:href="oprx-20150331.xsd#oprx_AgreementDomain" xlink:label="loc_HJ64H7F9K47J_oprx_AgreementDomain" />
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_JL86J9H1M69L_oprx_AgreementDomain" xml:lang="en-US">Agreement [Domain]</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_HJ64H7F9K47J_oprx_AgreementDomain" xlink:to="lab_JL86J9H1M69L_oprx_AgreementDomain"/>
<loc xlink:type="locator" xlink:href="oprx-20150331.xsd#oprx_SecuritiesPurchaseAgreementMember" xlink:label="loc_JG685H0639809F46GF4G_oprx_SecuritiesPurchaseAgreementMember" />
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_LI807J2851021H68IH6I_oprx_SecuritiesPurchaseAgreementMember" xml:lang="en-US">Securities Purchase Agreement [Member]</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_JG685H0639809F46GF4G_oprx_SecuritiesPurchaseAgreementMember" xlink:to="lab_LI807J2851021H68IH6I_oprx_SecuritiesPurchaseAgreementMember"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_FinancialInstrumentAxis" xlink:label="loc_HJ64H7F9K47J_us-gaap_FinancialInstrumentAxis" />
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_JL86J9H1M69L_us-gaap_FinancialInstrumentAxis" xml:lang="en-US">Financial Instrument [Axis]</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_HJ64H7F9K47J_us-gaap_FinancialInstrumentAxis" xlink:to="lab_JL86J9H1M69L_us-gaap_FinancialInstrumentAxis"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain" xlink:label="loc_JG685H0639809F46GF4G_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain" />
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_LI807J2851021H68IH6I_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain" xml:lang="en-US">Financial Instruments [Domain]</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_JG685H0639809F46GF4G_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain" xlink:to="lab_LI807J2851021H68IH6I_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_CapitalSupportAgreementMember" xlink:label="loc_HJ64H7F9K47J_us-gaap_CapitalSupportAgreementMember" />
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_JL86J9H1M69L_us-gaap_CapitalSupportAgreementMember" xml:lang="en-US">Capital Support Agreement [Member]</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_JL86J9H1M69L_us-gaap_CapitalSupportAgreementMember" xml:lang="en-US">Capital markets advisory agreement [Member]</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_HJ64H7F9K47J_us-gaap_CapitalSupportAgreementMember" xlink:to="lab_JL86J9H1M69L_us-gaap_CapitalSupportAgreementMember"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ClassOfStockLineItems" xlink:label="loc_JG685H0639809F46GF4G_us-gaap_ClassOfStockLineItems" />
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_LI807J2851021H68IH6I_us-gaap_ClassOfStockLineItems" xml:lang="en-US">Class of Stock [Line Items]</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_JG685H0639809F46GF4G_us-gaap_ClassOfStockLineItems" xlink:to="lab_LI807J2851021H68IH6I_us-gaap_ClassOfStockLineItems"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_StockRedeemedOrCalledDuringPeriodShares" xlink:label="loc_HJ64H7F9K47J_us-gaap_StockRedeemedOrCalledDuringPeriodShares" />
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_JL86J9H1M69L_us-gaap_StockRedeemedOrCalledDuringPeriodShares" xml:lang="en-US">Stock Redeemed or Called During Period, Shares</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_JL86J9H1M69L_us-gaap_StockRedeemedOrCalledDuringPeriodShares" xml:lang="en-US">Called for issuance of shares</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_HJ64H7F9K47J_us-gaap_StockRedeemedOrCalledDuringPeriodShares" xlink:to="lab_JL86J9H1M69L_us-gaap_StockRedeemedOrCalledDuringPeriodShares"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_SharesIssued" xlink:label="loc_JG685H0639809F46GF4G_us-gaap_SharesIssued" />
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_LI807J2851021H68IH6I_us-gaap_SharesIssued" xml:lang="en-US">Shares, Issued</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_LI807J2851021H68IH6I_us-gaap_SharesIssued" xml:lang="en-US">Sale of comman stock</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:label="lab_LI807J2851021H68IH6I_us-gaap_SharesIssued" xml:lang="en-US">Additional shares issued</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_JG685H0639809F46GF4G_us-gaap_SharesIssued" xlink:to="lab_LI807J2851021H68IH6I_us-gaap_SharesIssued"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_SaleOfStockNumberOfSharesIssuedInTransaction" xlink:label="loc_HJ64H7F9K47J_us-gaap_SaleOfStockNumberOfSharesIssuedInTransaction" />
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_JL86J9H1M69L_us-gaap_SaleOfStockNumberOfSharesIssuedInTransaction" xml:lang="en-US">Sale of Stock, Number of Shares Issued in Transaction</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_JL86J9H1M69L_us-gaap_SaleOfStockNumberOfSharesIssuedInTransaction" xml:lang="en-US">Sale of comman stock shares</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_HJ64H7F9K47J_us-gaap_SaleOfStockNumberOfSharesIssuedInTransaction" xlink:to="lab_JL86J9H1M69L_us-gaap_SaleOfStockNumberOfSharesIssuedInTransaction"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_SaleOfStockConsiderationReceivedOnTransaction" xlink:label="loc_JG685H0639809F46GF4G_us-gaap_SaleOfStockConsiderationReceivedOnTransaction" />
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_LI807J2851021H68IH6I_us-gaap_SaleOfStockConsiderationReceivedOnTransaction" xml:lang="en-US">Sale of Stock, Consideration Received on Transaction</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:label="lab_LI807J2851021H68IH6I_us-gaap_SaleOfStockConsiderationReceivedOnTransaction" xml:lang="en-US">Sale of common stock value</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_JG685H0639809F46GF4G_us-gaap_SaleOfStockConsiderationReceivedOnTransaction" xlink:to="lab_LI807J2851021H68IH6I_us-gaap_SaleOfStockConsiderationReceivedOnTransaction"/>
<loc xlink:type="locator" xlink:href="oprx-20150331.xsd#oprx_WarrantExercisePricePeriod" xlink:label="loc_HJ64H7F9K47J_oprx_WarrantExercisePricePeriod" />
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_JL86J9H1M69L_oprx_WarrantExercisePricePeriod" xml:lang="en-US">Warrant Exercise Price Period</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:label="lab_JL86J9H1M69L_oprx_WarrantExercisePricePeriod" xml:lang="en-US">Warrant exercise price period</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:label="lab_JL86J9H1M69L_oprx_WarrantExercisePricePeriod" xml:lang="en-US">Warrant exercise price period.</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_HJ64H7F9K47J_oprx_WarrantExercisePricePeriod" xlink:to="lab_JL86J9H1M69L_oprx_WarrantExercisePricePeriod"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_SaleOfStockPricePerShare" xlink:label="loc_JG685H0639809F46GF4G_us-gaap_SaleOfStockPricePerShare" />
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_LI807J2851021H68IH6I_us-gaap_SaleOfStockPricePerShare" xml:lang="en-US">Sale of Stock, Price Per Share</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:label="lab_LI807J2851021H68IH6I_us-gaap_SaleOfStockPricePerShare" xml:lang="en-US">Sale of stock price per share</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_JG685H0639809F46GF4G_us-gaap_SaleOfStockPricePerShare" xlink:to="lab_LI807J2851021H68IH6I_us-gaap_SaleOfStockPricePerShare"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_SharesIssuedPricePerShare" xlink:label="loc_HJ64H7F9K47J_us-gaap_SharesIssuedPricePerShare" />
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_JL86J9H1M69L_us-gaap_SharesIssuedPricePerShare" xml:lang="en-US">Shares Issued, per share value</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_JL86J9H1M69L_us-gaap_SharesIssuedPricePerShare" xml:lang="en-US">Shares Issued, per share value</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_HJ64H7F9K47J_us-gaap_SharesIssuedPricePerShare" xlink:to="lab_JL86J9H1M69L_us-gaap_SharesIssuedPricePerShare"/>
<loc xlink:type="locator" xlink:href="oprx-20150331.xsd#oprx_DebtRedemptionLongtermDebtAmount" xlink:label="loc_JG685H0639809F46GF4G_oprx_DebtRedemptionLongtermDebtAmount" />
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_LI807J2851021H68IH6I_oprx_DebtRedemptionLongtermDebtAmount" xml:lang="en-US">Debt redemption, amount</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_LI807J2851021H68IH6I_oprx_DebtRedemptionLongtermDebtAmount" xml:lang="en-US">Debt redemption, amount</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_JG685H0639809F46GF4G_oprx_DebtRedemptionLongtermDebtAmount" xlink:to="lab_LI807J2851021H68IH6I_oprx_DebtRedemptionLongtermDebtAmount"/>
<loc xlink:type="locator" xlink:href="oprx-20150331.xsd#oprx_CommissionsPercentage" xlink:label="loc_HJ64H7F9K47J_oprx_CommissionsPercentage" />
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_JL86J9H1M69L_oprx_CommissionsPercentage" xml:lang="en-US">Commissions Percentage</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_JL86J9H1M69L_oprx_CommissionsPercentage" xml:lang="en-US">Commissions percentage</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:label="lab_JL86J9H1M69L_oprx_CommissionsPercentage" xml:lang="en-US">commissions percentage.</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_HJ64H7F9K47J_oprx_CommissionsPercentage" xlink:to="lab_JL86J9H1M69L_oprx_CommissionsPercentage"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_AccruedSalesCommissionCurrent" xlink:label="loc_JG685H0639809F46GF4G_us-gaap_AccruedSalesCommissionCurrent" />
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_LI807J2851021H68IH6I_us-gaap_AccruedSalesCommissionCurrent" xml:lang="en-US">Commissions</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_LI807J2851021H68IH6I_us-gaap_AccruedSalesCommissionCurrent" xml:lang="en-US">Commissions</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_JG685H0639809F46GF4G_us-gaap_AccruedSalesCommissionCurrent" xlink:to="lab_LI807J2851021H68IH6I_us-gaap_AccruedSalesCommissionCurrent"/>
<loc xlink:type="locator" xlink:href="oprx-20150331.xsd#oprx_PurchaseOfWarrants" xlink:label="loc_HJ64H7F9K47J_oprx_PurchaseOfWarrants" />
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_JL86J9H1M69L_oprx_PurchaseOfWarrants" xml:lang="en-US">Purchase Of Warrants</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_JL86J9H1M69L_oprx_PurchaseOfWarrants" xml:lang="en-US">Purchase of warrants</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:label="lab_JL86J9H1M69L_oprx_PurchaseOfWarrants" xml:lang="en-US">Purchase of warrants.</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_HJ64H7F9K47J_oprx_PurchaseOfWarrants" xlink:to="lab_JL86J9H1M69L_oprx_PurchaseOfWarrants"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_StockAndWarrantsIssuedDuringPeriodValuePreferredStockAndWarrants" xlink:label="loc_JG685H0639809F46GF4G_us-gaap_StockAndWarrantsIssuedDuringPeriodValuePreferredStockAndWarrants" />
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_LI807J2851021H68IH6I_us-gaap_StockAndWarrantsIssuedDuringPeriodValuePreferredStockAndWarrants" xml:lang="en-US">Warrants, Value</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_LI807J2851021H68IH6I_us-gaap_StockAndWarrantsIssuedDuringPeriodValuePreferredStockAndWarrants" xml:lang="en-US">Warrants, Value</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_JG685H0639809F46GF4G_us-gaap_StockAndWarrantsIssuedDuringPeriodValuePreferredStockAndWarrants" xlink:to="lab_LI807J2851021H68IH6I_us-gaap_StockAndWarrantsIssuedDuringPeriodValuePreferredStockAndWarrants"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_SharePrice" xlink:label="loc_HJ64H7F9K47J_us-gaap_SharePrice" />
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_JL86J9H1M69L_us-gaap_SharePrice" xml:lang="en-US">Share Price</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_JL86J9H1M69L_us-gaap_SharePrice" xml:lang="en-US">Exercise price</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_HJ64H7F9K47J_us-gaap_SharePrice" xlink:to="lab_JL86J9H1M69L_us-gaap_SharePrice"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DebtInstrumentTerm" xlink:label="loc_JG685H0639809F46GF4G_us-gaap_DebtInstrumentTerm" />
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_LI807J2851021H68IH6I_us-gaap_DebtInstrumentTerm" xml:lang="en-US">Debt Instrument, Term</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_LI807J2851021H68IH6I_us-gaap_DebtInstrumentTerm" xml:lang="en-US">Term</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_JG685H0639809F46GF4G_us-gaap_DebtInstrumentTerm" xlink:to="lab_LI807J2851021H68IH6I_us-gaap_DebtInstrumentTerm"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_EmployeeRelatedLiabilitiesCurrent" xlink:label="loc_HJ64H7F9K47J_us-gaap_EmployeeRelatedLiabilitiesCurrent" />
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_JL86J9H1M69L_us-gaap_EmployeeRelatedLiabilitiesCurrent" xml:lang="en-US">Employee-related Liabilities, Current</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:label="lab_JL86J9H1M69L_us-gaap_EmployeeRelatedLiabilitiesCurrent" xml:lang="en-US">Employee Bonus</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_HJ64H7F9K47J_us-gaap_EmployeeRelatedLiabilitiesCurrent" xlink:to="lab_JL86J9H1M69L_us-gaap_EmployeeRelatedLiabilitiesCurrent"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_StockRedeemedOrCalledDuringPeriodValue" xlink:label="loc_JG685H0639809F46GF4G_us-gaap_StockRedeemedOrCalledDuringPeriodValue" />
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_LI807J2851021H68IH6I_us-gaap_StockRedeemedOrCalledDuringPeriodValue" xml:lang="en-US">Stock Redeemed or Called During Period, Value</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_LI807J2851021H68IH6I_us-gaap_StockRedeemedOrCalledDuringPeriodValue" xml:lang="en-US">Called for issuance of shares, values</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_JG685H0639809F46GF4G_us-gaap_StockRedeemedOrCalledDuringPeriodValue" xlink:to="lab_LI807J2851021H68IH6I_us-gaap_StockRedeemedOrCalledDuringPeriodValue"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_StockIssuedDuringPeriodSharesOther" xlink:label="loc_HJ64H7F9K47J_us-gaap_StockIssuedDuringPeriodSharesOther" />
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_JL86J9H1M69L_us-gaap_StockIssuedDuringPeriodSharesOther" xml:lang="en-US">Stock Issued During Period, Shares, Other</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_JL86J9H1M69L_us-gaap_StockIssuedDuringPeriodSharesOther" xml:lang="en-US">Additional shares issued</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_HJ64H7F9K47J_us-gaap_StockIssuedDuringPeriodSharesOther" xlink:to="lab_JL86J9H1M69L_us-gaap_StockIssuedDuringPeriodSharesOther"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_StockIssuedDuringPeriodValueOther" xlink:label="loc_JG685H0639809F46GF4G_us-gaap_StockIssuedDuringPeriodValueOther" />
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_LI807J2851021H68IH6I_us-gaap_StockIssuedDuringPeriodValueOther" xml:lang="en-US">Stock Issued During Period, Value, Other</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_LI807J2851021H68IH6I_us-gaap_StockIssuedDuringPeriodValueOther" xml:lang="en-US">Additional shares issued, value</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_JG685H0639809F46GF4G_us-gaap_StockIssuedDuringPeriodValueOther" xlink:to="lab_LI807J2851021H68IH6I_us-gaap_StockIssuedDuringPeriodValueOther"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_PaymentsOfStockIssuanceCosts" xlink:label="loc_HJ64H7F9K47J_us-gaap_PaymentsOfStockIssuanceCosts" />
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_JL86J9H1M69L_us-gaap_PaymentsOfStockIssuanceCosts" xml:lang="en-US">Common stock issued for equity issuance costs</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_JL86J9H1M69L_us-gaap_PaymentsOfStockIssuanceCosts" xml:lang="en-US">Common stock issued for equity issuance costs</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_HJ64H7F9K47J_us-gaap_PaymentsOfStockIssuanceCosts" xlink:to="lab_JL86J9H1M69L_us-gaap_PaymentsOfStockIssuanceCosts"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_StockIssuedDuringPeriodValueShareBasedCompensationGross" xlink:label="loc_JG685H0639809F46GF4G_us-gaap_StockIssuedDuringPeriodValueShareBasedCompensationGross" />
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_LI807J2851021H68IH6I_us-gaap_StockIssuedDuringPeriodValueShareBasedCompensationGross" xml:lang="en-US">Stock Issued During Period, Value, Share-based Compensation, Gross</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_LI807J2851021H68IH6I_us-gaap_StockIssuedDuringPeriodValueShareBasedCompensationGross" xml:lang="en-US">Employee bonus, Share</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_JG685H0639809F46GF4G_us-gaap_StockIssuedDuringPeriodValueShareBasedCompensationGross" xlink:to="lab_LI807J2851021H68IH6I_us-gaap_StockIssuedDuringPeriodValueShareBasedCompensationGross"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_StockIssuedDuringPeriodSharesShareBasedCompensationGross" xlink:label="loc_HJ64H7F9K47J_us-gaap_StockIssuedDuringPeriodSharesShareBasedCompensationGross" />
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_JL86J9H1M69L_us-gaap_StockIssuedDuringPeriodSharesShareBasedCompensationGross" xml:lang="en-US">Stock Issued During Period, Shares, Share-based Compensation, Gross</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_JL86J9H1M69L_us-gaap_StockIssuedDuringPeriodSharesShareBasedCompensationGross" xml:lang="en-US">Employee bonus, Value</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_HJ64H7F9K47J_us-gaap_StockIssuedDuringPeriodSharesShareBasedCompensationGross" xlink:to="lab_JL86J9H1M69L_us-gaap_StockIssuedDuringPeriodSharesShareBasedCompensationGross"/>
<loc xlink:type="locator" xlink:href="oprx-20150331.xsd#oprx_AdditionalWorkingCapital" xlink:label="loc_JG685H0639809F46GF4G_oprx_AdditionalWorkingCapital" />
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_LI807J2851021H68IH6I_oprx_AdditionalWorkingCapital" xml:lang="en-US">Additional Working Capital</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_LI807J2851021H68IH6I_oprx_AdditionalWorkingCapital" xml:lang="en-US">Additional working capital</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:label="lab_LI807J2851021H68IH6I_oprx_AdditionalWorkingCapital" xml:lang="en-US">Additional working capital.</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_JG685H0639809F46GF4G_oprx_AdditionalWorkingCapital" xlink:to="lab_LI807J2851021H68IH6I_oprx_AdditionalWorkingCapital"/>
<loc xlink:type="locator" xlink:href="oprx-20150331.xsd#oprx_FullyDilutedShares" xlink:label="loc_HJ64H7F9K47J_oprx_FullyDilutedShares" />
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_JL86J9H1M69L_oprx_FullyDilutedShares" xml:lang="en-US">Fully Diluted Shares</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_JL86J9H1M69L_oprx_FullyDilutedShares" xml:lang="en-US">Fully diluted shares</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:label="lab_JL86J9H1M69L_oprx_FullyDilutedShares" xml:lang="en-US">fully diluted shares.</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_HJ64H7F9K47J_oprx_FullyDilutedShares" xlink:to="lab_JL86J9H1M69L_oprx_FullyDilutedShares"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DebtIssuanceCosts" xlink:label="loc_JG685H0639809F46GF4G_us-gaap_DebtIssuanceCosts" />
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_LI807J2851021H68IH6I_us-gaap_DebtIssuanceCosts" xml:lang="en-US">Debt Issuance Cost</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:label="lab_LI807J2851021H68IH6I_us-gaap_DebtIssuanceCosts" xml:lang="en-US">Equity issuance cost</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_JG685H0639809F46GF4G_us-gaap_DebtIssuanceCosts" xlink:to="lab_LI807J2851021H68IH6I_us-gaap_DebtIssuanceCosts"/>
<loc xlink:type="locator" xlink:href="oprx-20150331.xsd#oprx_WarrantsExercised" xlink:label="loc_HJ64H7F9K47J_oprx_WarrantsExercised" />
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_JL86J9H1M69L_oprx_WarrantsExercised" xml:lang="en-US">Warrants Exercised</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:label="lab_JL86J9H1M69L_oprx_WarrantsExercised" xml:lang="en-US">Warrants exercised, number of shares</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:label="lab_JL86J9H1M69L_oprx_WarrantsExercised" xml:lang="en-US">Warrants exercised</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_HJ64H7F9K47J_oprx_WarrantsExercised" xlink:to="lab_JL86J9H1M69L_oprx_WarrantsExercised"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ShareBasedCompensation" xlink:label="loc_JG685H0639809F46GF4G_us-gaap_ShareBasedCompensation" />
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_LI807J2851021H68IH6I_us-gaap_ShareBasedCompensation" xml:lang="en-US">Stock-based compensation</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_LI807J2851021H68IH6I_us-gaap_ShareBasedCompensation" xml:lang="en-US">Stock-based compensation expense</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:label="lab_LI807J2851021H68IH6I_us-gaap_ShareBasedCompensation" xml:lang="en-US">Share Based Compensation Expense</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_JG685H0639809F46GF4G_us-gaap_ShareBasedCompensation" xlink:to="lab_LI807J2851021H68IH6I_us-gaap_ShareBasedCompensation"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_LiabilityForUnpaidClaimsAndClaimsAdjustmentExpenseReportedClaimsAmount" xlink:label="loc_HJ64H7F9K47J_us-gaap_LiabilityForUnpaidClaimsAndClaimsAdjustmentExpenseReportedClaimsAmount" />
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_JL86J9H1M69L_us-gaap_LiabilityForUnpaidClaimsAndClaimsAdjustmentExpenseReportedClaimsAmount" xml:lang="en-US">Liability for Unpaid Claims and Claims Adjustment Expense, Reported Claims, Amount</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_JL86J9H1M69L_us-gaap_LiabilityForUnpaidClaimsAndClaimsAdjustmentExpenseReportedClaimsAmount" xml:lang="en-US">Claims pertaining to damages to nonregistration of shares</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_HJ64H7F9K47J_us-gaap_LiabilityForUnpaidClaimsAndClaimsAdjustmentExpenseReportedClaimsAmount" xlink:to="lab_JL86J9H1M69L_us-gaap_LiabilityForUnpaidClaimsAndClaimsAdjustmentExpenseReportedClaimsAmount"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_LossContingencyDamagesSoughtValue" xlink:label="loc_JG685H0639809F46GF4G_us-gaap_LossContingencyDamagesSoughtValue" />
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_LI807J2851021H68IH6I_us-gaap_LossContingencyDamagesSoughtValue" xml:lang="en-US">Loss Contingency, Damages Sought, Value</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_LI807J2851021H68IH6I_us-gaap_LossContingencyDamagesSoughtValue" xml:lang="en-US">Loss pertaining to Mr. Milton Wilpon for Litigation settlement</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_JG685H0639809F46GF4G_us-gaap_LossContingencyDamagesSoughtValue" xlink:to="lab_LI807J2851021H68IH6I_us-gaap_LossContingencyDamagesSoughtValue"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_BusinessCombinationContingentConsiderationLiabilityCurrent" xlink:label="loc_HJ64H7F9K47J_us-gaap_BusinessCombinationContingentConsiderationLiabilityCurrent" />
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_JL86J9H1M69L_us-gaap_BusinessCombinationContingentConsiderationLiabilityCurrent" xml:lang="en-US">Business Combination, Contingent Consideration, Liability, Current</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_JL86J9H1M69L_us-gaap_BusinessCombinationContingentConsiderationLiabilityCurrent" xml:lang="en-US">Damage related to LDM' s breach of the agreement.</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:label="lab_JL86J9H1M69L_us-gaap_BusinessCombinationContingentConsiderationLiabilityCurrent" xml:lang="en-US">Damage related to LDM' s breach of the agreement.</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_HJ64H7F9K47J_us-gaap_BusinessCombinationContingentConsiderationLiabilityCurrent" xlink:to="lab_JL86J9H1M69L_us-gaap_BusinessCombinationContingentConsiderationLiabilityCurrent"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_BusinessCombinationContingentConsiderationLiability" xlink:label="loc_JG685H0639809F46GF4G_us-gaap_BusinessCombinationContingentConsiderationLiability" />
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_LI807J2851021H68IH6I_us-gaap_BusinessCombinationContingentConsiderationLiability" xml:lang="en-US">Business Combination, Contingent Consideration, Liability</label>
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="lab_LI807J2851021H68IH6I_us-gaap_BusinessCombinationContingentConsiderationLiability" xml:lang="en-US">Damage related to PDR's actions</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_JG685H0639809F46GF4G_us-gaap_BusinessCombinationContingentConsiderationLiability" xlink:to="lab_LI807J2851021H68IH6I_us-gaap_BusinessCombinationContingentConsiderationLiability"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ScheduleOfStockByClassTable" xlink:label="loc_HJ64H7F9K47J_us-gaap_ScheduleOfStockByClassTable" />
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_JL86J9H1M69L_us-gaap_ScheduleOfStockByClassTable" xml:lang="en-US">Schedule of Stock by Class [Table]</label>
<labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_HJ64H7F9K47J_us-gaap_ScheduleOfStockByClassTable" xlink:to="lab_JL86J9H1M69L_us-gaap_ScheduleOfStockByClassTable"/>
<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_CreationDateAxis" xlink:label="loc_JG685H0639809F46GF4G_us-gaap_CreationDateAxis" />
<label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="lab_LI807J2851021H68IH6I_us-gaap_CreationDateAxis" xml:lang="en-US">Report Date [Axis]</label>
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