November 19, 2018 Doug Baker Chief Financial Officer OptimizeRx Corporation 400 Water Street, Suite 200 Rochester, MI 48307 Re: OptimizeRx Corp Registration Statement on Form S-3 Filed November 13, 2018 File No. 333-228357 Dear Mr. Baker: This is to advise you that we have not reviewed and will not review your registration statement. Please refer to Rule 461 regarding requests for acceleration. We remind you that the company and its management are responsible for the accuracy and adequacy of their disclosures, notwithstanding any review, comments, action or absence of action by the staff. Please contact Mitchell Austin, Staff Attorney, at (202) 551-3574 or, in his absence, Jan Woo, Legal Branch Chief, at (202) 551-3453 with any questions. Sincerely, Division of Corporation Finance Office of Information Technologies and Services cc: Scott Doney, Esq.